The XMM-Newton/INTEGRAL monitoring campaign of IGR J16318-4848

IGR J16318-4848 is the prototype and one of the more extreme examples of the new class of highly obscured Galactic X-ray sources discovered by INTEGRAL. A monitoring campaign on this source has been carried out by XMM-Newton and INTEGRAL, consisting in three simultaneous observations performed in February, March and August 2004. The long-term variability of the Compton-thick absorption and emission line complexes will be used to probe the properties of the circumstellar matter. A detailed timing and spectral analysis of the three observations is performed, along with the reanalysis of the XMM-Newton observation performed in February 2003. The results are compared with predictions from numerical radiative transfer simulations to derive the parameters of the circumstellar matter. Despite the large flux dynamic range observed (almost a factor 3 between observations performed a few months apart), the source remained bright (suggesting it is a persistent source) and Compton-thick (NH >1.2x10^24 cm-2). Large Equivalent Width (EW) emission lines from Fe Kalpha, Fe Kbeta and Ni Kalpha were present in all spectra. The addition of a Fe Kalpha Compton Shoulder improves the fits, especially in the 2004 observations. Sporadic occurrences of rapid X-ray flux risings were observed in three of the four observations. The Fe Kalpha light curve followed the continuum almost instantaneously, suggesting that the emission lines are produced by illumination of small-scale optically-thick matter around the high-energy continuum source. Using the iron line EW and Compton Shoulder as diagnostic of the geometry of the matter, we suggest that the obscuring matter is in a flattened configuration seen almost edge-on.Comment: accepted by Astronomy and Astrophysic

Probing the Complex and Variable X-ray Absorption of Markarian 6 with XMM-Newton

We report on an X-ray observation of the Seyfert 1.5 galaxy Mrk 6 obtained with the EPIC instruments onboard XMM-Newton. Archival BeppoSAX PDS data from 18-120 keV were also used to constrain the underlying hard power-law continuum. The results from our spectral analyses generally favor a double partial-covering model, although other spectral models such as absorption by a mixture of partially ionized and neutral gas cannot be firmly ruled out. Our best-fitting model consists of a power law with a photon index of 1.81+/-0.20 and partial covering with large column densities up to 10^{23} cm**-2. We also detect a narrow emission line consistent with Fe Kalpha fluorescence at 6.45+/-0.04 keV with an equivalent width of ~93+/-25 eV. Joint analyses of XMM-Newton, ASCA, and BeppoSAX data further provide evidence for both spectral variability (a factor of ~2 change in absorbing column) and absorption-corrected flux variations (by ~60%) during the ~4 year period probed by the observations.Comment: 7 pages, 2 figures. accepted for publication in the Astronomical Journa

The Spectrum of the Black Hole X-ray Nova V404 Cygni in Quiescence as Measured by XMM-Newton

We present XMM observations of the black hole X-ray nova V404 Cygni in quiescence. Its quiescent spectrum can be best fitted by a simple power-law with slope 2. The spectra are consistent with that expected for the advection-dominated accretion flow (ADAF). V404 Cyg was roughly equal in luminosity compared to the previous observation of Chandra. We see variability of a factor of 4 during the observation. We find no evidence for the presence of fluorescent or H-like/He-like iron emission, with upper limits of 52 eV and 110 eV respectively. The limit on the fluorescent emission is improved by a factor of 15 over the previous estimate, and the restriction on H-like/He-like emission is lower than predicted from models by a factor of roughly 2.Comment: 6 pages, 7 figures, ApJ accepte

The First INTEGRAL AGN Catalog

We present the first INTEGRAL AGN catalog, based on observations performed from launch of the mission in October 2002 until January 2004. The catalog includes 42 AGN, of which 10 are Seyfert 1, 17 are Seyfert 2, and 9 are intermediate Seyfert 1.5. The fraction of blazars is rather small with 5 detected objects, and only one galaxy cluster and no star-burst galaxies have been detected so far. A complete subset consists of 32 AGN with a significance limit of 7 sigma in the INTEGRAL/ISGRI 20-40 keV data. Although the sample is not flux limited, the distribution of sources shows a ratio of obscured to unobscured AGN of 1.5 - 2.0, consistent with luminosity dependent unified models for AGN. Only four Compton-thick AGN are found in the sample. Based on the INTEGRAL data presented here, the Seyfert 2 spectra are slightly harder (Gamma = 1.95 +- 0.01) than Seyfert 1.5 (Gamma = 2.10 +- 0.02) and Seyfert 1 (Gamma = 2.11 +- 0.05).Comment: 17 pages, 12 figures, accepted for publication in Ap

Radiative Transfer in Obliquely Illuminated Accretion Disks

The illumination of an accretion disk around a black hole or neutron star by the central compact object or the disk itself often determines its spectrum, stability, and dynamics. The transport of radiation within the disk is in general a multi-dimensional, non-axisymmetric problem, which is challenging to solve. Here, I present a method of decomposing the radiative transfer equation that describes absorption, emission, and Compton scattering in an obliquely illuminated disk into a set of four one-dimensional transfer equations. I show that the exact calculation of the ionization balance and radiation heating of the accretion disk requires the solution of only one of the one-dimensional equations, which can be solved using existing numerical methods. I present a variant of the Feautrier method for solving the full set of equations, which accounts for the fact that the scattering kernels in the individual transfer equations are not forward-backward symmetric. I then apply this method in calculating the albedo of a cold, geometrically thin accretion disk.Comment: 16 pages, 3 figures; to appear in The Astrophysical Journa

BreastDefend enhances effect of tamoxifen in estrogen receptor-positive human breast cancer in vitro and in vivo

BACKGROUND: Tamoxifen (TAM) has been widely used for the treatment of estrogen receptor (ER)-positive breast cancer and its combination with other therapies is being actively investigated as a way to increase efficacy and decrease side effects. Here, we evaluate the therapeutic potential of co-treatment with TAM and BreastDefend (BD), a dietary supplement formula, in ER-positive human breast cancer. METHODS: Cell proliferation and apoptosis were determined in ER-positive human breast cancer cells MCF-7 by MTT assay, quantitation of cytoplasmic histone-associated DNA fragments and expression of cleaved PARP, respectively. The molecular mechanism was identified using RNA microarray analysis and western blotting. Tumor tissues from xenograft mouse model were analyzed by immunohistochemistry. RESULTS: Our data clearly demonstrate that a combination of 4-hydroxytamoxifen (4-OHT) with BD lead to profound inhibition of cell proliferation and induction of apoptosis in MCF-7 cells. This effect is consistent with the regulation of apoptotic and TAM resistant genes at the transcription and translation levels. Importantly, TAM and BD co-treatment significantly enhanced apoptosis, suppressed tumor growth and reduced tumor weight in a xenograft model of human ER-positive breast cancer. CONCLUSION: BD sensitized ER-positive human breast cancer cells to 4-OHT/TAM treatment in vitro and in vivo. BreastDefend can be used in an adjuvant therapy to increase the therapeutic effect of tamoxifen in patients with ER-positive breast cancer

Testing Comptonizing coronae on a long BeppoSAX observation of the Seyfert 1 galaxy NGC 5548

We test accurate models of Comptonization spectra over the high quality data of the BeppoSAX long look at NGC 5548, allowing for different geometries of the scattering region, different temperatures of the input soft photon field and different viewing angles. We find that the BeppoSAX data are well represented by a plane parallel or hemispherical corona viewed at an inclination angle of 30$^{\circ}$. For both geometries the best fit temperature of the soft photons is close to 15$^{+3}_{-9}$ eV. The corresponding best fit values of the hot plasma temperature and optical depth are $kT_{\rm e}\simeq$ 250--260 keV and $\tau\simeq$ 0.16--0.37 for the slab and hemisphere respectively. These values are substantially different from those derived fitting the data with a power-law + cut off approximation to the Comptonization component (kT_{\rm e}\lta 60 keV, $\tau\simeq$ 2.4). This is due to the fact that accurate Comptonization spectra in anisotropic geometries show "intrinsic" curvature which reduces the necessity of a high energy cut-off. The Comptonization parameter derived for the slab model {is} larger than predicted for a two phase plane parallel corona in energy balance, suggesting that a more ``photon-starved'' geometry is necessary. The spectral softening detected during a flare which occurred in the central part of the observation corresponds to a decrease of the Comptonization parameter, probably associated with an increase of the soft photon luminosity, the {hard} photon luminosity remaining constant.Comment: 36 pages, 9 figures, accepted by Ap

The X-ray spectra and spectral variability of intermediate type Seyfert galaxies: ASCA observations of NGC 4388 and ESO 103-G35

The X-ray spectra of two intermediate type Seyfert galaxies are investigated using ASCA observations separated by more than a year. Both NGC 4388 and ESO 103-G35 exhibit strong, narrow Fe K alpha line emission and absorption by cold neutral gas with a column density ~ 10^23 cm^-2, characteristic of the X-ray spectra of type 2 Seyfert galaxies. The power law continuum flux has changed by a factor of 2 over a time-scale of ~ 2 years for both objects, declining in the case of NGC 4388 and rising in ESO 103-G35. No variation was observed in the equivalent width of the Fe K alpha line in the spectra of NGC 4388, implying that the line flux declined with the continuum. We find that the strength of the line cannot be accounted for by fluorescence in line-of-sight material with the measured column density unless a `leaky-absorber' model of the type favored for IRAS 04575-7537 is employed. The equivalent width of the Fe K alpha emission line is seen to decrease between the observations of ESO 103-G35 while the continuum flux increased. The 1996 observation of ESO 103-G35 can also be fitted with an absorption edge at 7.4 $\pm$ 0.2 keV due to partially ionized iron, and when an ionized absorber model is fitted to the data it is found that the equivalent column of neutral hydrogen rises to 3.5 x 10^23 cm^-2. The Fe K alpha line flux can be accounted by fluorescence in this material alone and this model is also a good representation of the 1988 and 1991 Ginga observations. There is then no requirement for a reflection component in the ASCA spectra of ESO 103-G35 or NGC 4388.Comment: 45 pages, 5 tables, 11 figures. Accepted for publication in the Astrophysical Journa

FERO: Finding Extreme Relativistic Objects. I. Statistics of Relativistic Fe Kalpha lines in Radio-Quiet Type 1 AGN

Accretion models predict that fluorescence lines broadened by relativistic effects should arise from reflection of X-ray emission onto the inner region of the accretion disc surrounding the central black hole of active galactic nuclei (AGN). The theory behind the origin of relativistic lines is well established, and observational evidence from a moderate number of sources seems to support the existence of these lines. The aim of this work is to establish the fraction of AGN with relativistic Fe Kalpha lines, and study possible correlations with source physical properties. An XMM-Newton collection of 149 radio-quiet Type 1 AGN has been systematically and uniformly analyzed in order to search for significant evidence of a relativistically broadened Fe Kalpha line. To enable statistical studies, an almost complete, flux-limited subsample of 31 sources has been defined. The 2-10 keV spectra of the FERO sources have been compared with a complex model including most of the physical components observed in the X-ray spectra of Seyfert galaxies: a power law primary continuum modified by non-relativistic Compton reflection and warm absorption, plus a series of narrow Fe line reflection features. The observed fraction of sources in the flux-limited sample that show significant evidence of a relativistic Fe Kalpha line is 36%. The average line Equivalent Width (EW) is of the order of 100 eV, while the average disc inclination angle is 28+/-5 deg and the average power-law index of the radial disc emissivity law is 2.4+/-0.4. The spin value is well constrained only in 2 cases (MCG-6-30-15 and MRK509), and in the rest of the cases, whenever a constraint can be placed, it always implies the rejection of the static black hole solution. The Fe Kalpha line EW does not correlate with disc parameters or with system physical properties, such as black hole mass, accretion rate and hard X-ray luminosity.Comment: 22 pages, 7 figures. Accepted for publication in A&