STEM escape rooms for public engagement

Escape rooms are a relatively new cultural phenomenon, attracting a wide range of audiences to test their puzzle-solving skills. While this format has been trialled in an educational context, there has been little exploration of it as a tool for engagement. We ran a STEM-based escape room, open to the public, over five days at a science centre in Malta. This was an exploratory exercise to determine whether escape rooms could be successful in an informal science engagement context. Over seventy players attempted the game and completed our evaluation. Our results suggest that escape rooms can be used in engagement contexts as they provide a positive experience that encourages future interactions with science. They may also draw audiences not normally interested in science and help them engage with scientific content in a more accessible manner. Interestingly, players were able to persist in engaging with content they found difficult while still finding it enjoyable, which has implications for the science communication of complex topics. Finally, players perceived that they were able to learn science through the escape room, which may increase their self-efficacy

Macroalgal Monitoring in the Great Bay Estuary: 2018 Annual Report

Since 2013, the abundance and taxa of intertidal macroalgae have been assessed at fixed locations throughout the Great Bay Estuary in New Hampshire. Algal abundance may be influenced by environmental conditions such as nutrient levels, water temperature, light and invasive species. Therefore, abundance of different algal groups can provide insights into the overall health of the estuary and signal ecological change. In 2018, intertidal abundance data for percentage cover and biomass were collected, as planned, from five of the eight sites. For the first time, subtidal sampling arrays were also incorporated at all four sites in Great Bay proper to monitor macroalgae at lower elevations and to collect data on eelgrass communities coexisting with the algae

A flexible one-step synthesis of dienamides: approaches towards a total synthesis of the Crocacins

Dienamides are prevalent in many biologically active natural products and pharmaceutical drug leads. A number of different approaches have been reported for the synthesis of dienamides. These mathods have varying degrees of success in terms of yield and selectivity. In particular, the control of double bond geometry presents a significant challenge. Presented, is an efficient one-step synthesis of dienamide units starting from previously established N-formyl imide building blocks. This approach presents an attractive alternative to other methods available currently in terms of the number of steps, yield and overall simplicity. The one-step approach to the synthesis of dienamides relies on olefination of N-formyl imides through the use of conjugated ylides. A number of final dienamide compounds have been synthesised, characterised and published thus far. In all cases the sole or major isomer observed was the (Z,E)-dienamide. The Crocacins are a group of linear dipeptides incorporating a reactive N-acyl enamine or enamide unit, crucial to their biological activity. Retrosynthetically, Crocacins A, B and D are derived from Crocacin C via an enamide linkage. It is proposed that Crocacins A, B and D can be synthesised from Crocacin C using the dienamide methodology developed previously. Although several syntheses of the individual members of the Crocacins have been reported, this method represents a potential route to a convergent synthesis for the whole family of compounds. Presented, are the approaches towards the total synthesis of Crocacin C

Large-scale multielectrode recording and stimulation of neural activity

Large circuits of neurons are employed by the brain to encode and process information. How this encoding and processing is carried out is one of the central questions in neuroscience. Since individual neurons communicate with each other through electrical signals (action potentials), the recording of neural activity with arrays of extracellular electrodes is uniquely suited for the investigation of this question. Such recordings provide the combination of the best spatial (individual neurons) and temporal (individual action-potentials) resolutions compared to other large-scale imaging methods. Electrical stimulation of neural activity in turn has two very important applications: it enhances our understanding of neural circuits by allowing active interactions with them, and it is a basis for a large variety of neural prosthetic devices. Until recently, the state-of-the-art in neural activity recording systems consisted of several dozen electrodes with inter-electrode spacing ranging from tens to hundreds of microns. Using silicon microstrip detector expertise acquired in the field of high-energy physics, we created a unique neural activity readout and stimulation framework that consists of high-density electrode arrays, multi-channel custom-designed integrated circuits, a data acquisition system, and data-processing software. Using this framework we developed a number of neural readout and stimulation systems: (1) a 512-electrode system for recording the simultaneous activity of as many as hundreds of neurons, (2) a 61-electrode system for electrical stimulation and readout of neural activity in retinas and brain-tissue slices, and (3) a system with telemetry capabilities for recording neural activity in the intact brain of awake, naturally behaving animals. We will report on these systems, their various applications to the field of neurobiology, and novel scientific results obtained with some of them. We will also outline future directions

Predictive validity of the UK clinical aptitude test in the final years of medical school:a prospective cohort study

Peer reviewedPublisher PD

Hospital survey on patient safety culture (HSOPSC) : a multi-method approach for target-language instrument translation, adaptation, and validation to improve the equivalence of meaning for cross-cultural research

Altres ajuts: This research project was partially funded through a research dissemination grant from the Universidad Cooperativa de Colombia received by Dr. Doriam E. Camacho-Rodríguez.The Hospital Survey on Patient Safety Culture (HSOPSC) is widely utilized in multiple languages across the world. Despite culture and language variations, research studies from Latin America use the Spanish language HSOPSC validated for Spain and the United States. Yet, these studies fail to report the translation method, cultural adaptation process, and the equivalence assessment strategy. As such, the psychometric properties of the HSOPSC are not well demonstrated for cross-cultural research in Latin America, including Peru. The purpose of this study was to develop a target-language HSOPSC for cross-cultural research in Peru that asks the same questions, in the same manner, with the same intended meaning, as the source instrument. This study used a mixed-methods approach adapted from the translation guideline recommended by Agency for Healthcare Research and Quality. The 3-phase, 7-step process incorporated translation techniques, pilot testing, cognitive interviews, clinical participant review, and subject matter expert evaluation. The instrument was translated and evaluated in 3 rounds of cognitive interview (CI). There were 37 problem items identified in round 1 (14 clarity, 12 cultural, 11 mixed); and resolved to 4 problems by round 3. The pilot-testing language clarity inter-rater reliability was S-CVI/Avg = 0.97 and S-CVI/UA = 0.86; and S-CVI/Avg = 0.96 and S-CVI/UA = 0.83 for cultural relevance. Subject matter expert agreement in matching items to the correct dimensions was substantially equivalent (Kappa = 0.72). Only 1 of 12 dimensions had a low Kappa (0.39), borderline fair to moderate. The remaining dimensions performed well (7 = almost perfect, 2 = substantial, and 2 = moderate). The HSOPSC instrument developed for Peru was markedly different from the other Spanish-language versions. The resulting items were equivalent in meaning to the source, despite the new language and different cultural context. The analysis identified negatively worded items were problematic for target-language translation. With the limited literature about negatively worded items in the context of cross-cultural research, further research is necessary to evaluate this finding and the recommendation to include negatively worded items in instruments. This study demonstrates cross-cultural research with translated instruments should adhere to established guidelines, with cognitive interviews, based on evidence-based strategies

Ceramics studio to podiatry clinic: The impact of multi-media resources in the teaching of practical skills across diverse disciplines

This paper draws on the experiences of students from two vastly different disciplines to both explore the theoretical background supporting the use of multimedia resources to teach practical skills and provide a qualitative evaluation of student perceptions and experiences of using bespoke resources. Within ceramics and podiatry, practical skills are traditionally taught via an apprenticeship model within small groups. We explore the practical and pedagogic benefits of developing bespoke multimedia resources to teach practical skills, identifying common themes from these disparate discipline areas. Student focus groups revealed that, practically, the opportunity for repeated viewing at convenient times promoted less reliance on lecturers and better preparation prior to practical demonstrations. Pedagogically, time for reflection and sense making underpinned an increase in confidence which in turn led to increased creativity. The student voice was also used to identify recommendations and challenges driving future change