La fluidez conceptual en la interlengua escrita de aprendientes alemanes de español como lengua extranjera

This paper focuses on the written interlanguage of German college students studying Spanish as a Foreign Language in four different levels (A2-C1). In order to observe the evolution of conceptual fluency, a total number of sixty participants wrote an essay about their Spanish studies without previous instruction on the Theory of Conceptual Metaphor (Lakoff/Johnson 1980). The metaphorical density index was measured with special attention paid to the differences and similarities between the German and Spanish semantic conceptual systems and the metaphors used in each stage of learning. The results show that the L1 plays a fundamental role in the typology of metaphors, while quantitative factors such as the metaphorical density index can also vary depending on the target language and the topics of the essays. Therefore, conventional metaphors play a fundamental role in foreign language learning, as the most significant examples in terms of lack of conceptual fluency have been caused by copying linguistic structures from conventional German metaphors into the target language

Terapia dos erros com aprendizagem móvil e gamificação: estudo comparativo em espanhol dos negócios

This research paper compares the results of an analysis of the evolution of written interlanguage in two groups of learners of Spanish as a foreign language (sfl). The participants wrote four essays throughout a semester, each one followed by an error-therapy session, respectively. The test group did the therapies through online platform Kahoot, which introduces gamification and allows the mobile learning methodology, while the control group did traditional activities on paper. The teachers marked the mistakes in the texts using the minimal marking criterion (Haswell, 1983), and the students then proceeded to correct their own errors. Although both methods had positive results, the test group shows a more remarkable evolution in terms of reducing the number of errors in each text.Este artículo de investigación compara los resultados de un análisis sobre la evolución de la interlengua escrita de dos grupos de aprendientes de español como lengua extranjera (ele). Los participantes realizaron cuatro redacciones a lo largo de un semestre seguidas respectivamente de una sesión de terapia de errores. El grupo de prueba realizó las terapias mediante la plataforma online Kahoot, que introduce la gamificación y permite la metodología mobile learning, mientras que el grupo de control realizó actividades tradicionales en papel. Las profesoras señalaron los errores de las redacciones mediante el criterio minimal marking (Haswell, 1983) y seguidamente los estudiantes procedieron a su autocorrección. Aunque con los dos métodos se obtuvieron resultados positivos, el grupo de prueba muestra una evolución más notable en cuanto a la reducción del número de errores de cada escrito.Este artigo de pesquisa compara as descobertas de uma análise sobre a evolução da interlíngua escrita de dois grupos de aprendentes de espanhol como língua estrangeira (ele). Os participantes realizaram quatro textos ao longo do semestre seguidos cada um de uma sessão de terapia de erros. O grupo de prova realizou a terapia por meio da plataforma online Kahoot, que introduz a gamificação e possibilita a metodologia mobile learning, enquanto o grupo de controle realizou atividades tradicionais em papel. As professoras assinalaram os erros das escritas por meio do critério minimal marking (Haswell, 1983) e em seguida os estudantes auto-corrigiram seus textos. Ainda que as duas metodologias obtiveram resultado positivos, o grupo de prova apresentou uma evolução mais evidente ao respeito da redução no número de erros de cada texto

Efecto de una dieta hipocalórica rica en proteínas preferentemente de tipo animal, en comparación con una dieta hipocalórica rica en proteínas principalmente de tipo vegetal, en el metabolismo hidrocarbonado y perfil lipídico

Objetivos: Explorar el efecto de una dieta hipocalórica rica en proteínas (con un contenido del 35% del total de calorías de la dieta), preferentemente de origen animal (80% del total de proteínas), en comparación con una dieta hipocalórica rica en proteínas (con un contenido del 35% del total de calorías de la dieta), principalmente de origen vegetal (80% del total de proteínas), en sujetos con prediabetes o DM2 y sobrepeso u obesidad, sobre el metabolismo hidrocarbonado y el perfil lipídico, tras la intervención. Materiales y Métodos: Estudio de intervención nutricional en el que los participantes son aleatorizados a: a) una dieta hipocalórica e HP, cuyo contenido proteico procede principalmente de alimentos de tipo animal; b) una dieta hipocalórica e HP, cuyo contenido proteico procede principalmente de alimentos de tipo vegetal. El estudio tiene una duración total de 6 meses, determinando parámetros clínicos, antropométricos y bioquímicos al inicio del estudio y tras 3 y 6 meses de intervención. Aunque en el estudio se prevé la inclusión de 132 sujetos, en el presente Trabajo Fin de Grado se han incluido los datos de 49 sujetos, todos ellos con prediabetes/DM2 y sobrepeso/obesidad, de acuerdo a los criterios de elegibilidad del estudio.Resultados: La intervención nutricional con una dieta HP animal, en comparación con una dieta HP vegetal, parece no mostrar diferencias significativas en la pérdida de peso, ni tampoco hay una evidencia clara en los parámetros glucídicos y lipídicos, aunque ambos tipos de dieta han obtenido beneficios en estos parámetros. Conclusión: Es necesario finalizar el estudio e incluir a todos los pacientes previstos para sacar conclusiones claras y sólidas, ya que el pequeño tamaño muestral limita el poder extraerlas, aunque, atendiendo a los resultados provisionales, parece que no existiría diferencia significativa en los beneficios de ambos tipos de dietas hipocalóricas e HP.<br /

The impact of the COVID-19 pandemic in diabetes and dyslipidemia management in a Spanish region: a retrospective study of the Aragon population

IntroductionPrevious research has indicated that the COVID-19 outbreak had a negative impact on the diagnosis and management of cardiometabolic diseases. Our aim was to analyze the impact of the COVID-19 pandemic on the management of dyslipidemia and type 2 diabetes (T2D) in the Aragon region of Spain.MethodsWe conducted an observational retrospective study, which included data from all patients diagnosed with active T2D or dyslipidemia in Aragon during 2019–2021. Data was collected from the BIGAN platform, a big database that includes all healthcare data from the Aragon population. Clinical, biochemical, and pharmacological prescription information was obtained for each patient and for each year.ResultsOut of the total population of 1,330,000 in the Aragon region, 90,000 subjects were diagnosed with T2D each year, resulting in a prevalence of approximately 7%. The COVID-19 pandemic resulted in a decrease in the prevalence of this disease and a lower incidence during the year 2020. In addition, patients with T2D experienced a deterioration of their glucose profile, which led to an increase in the number of patients requiring pharmacological therapy. The prevalence of dyslipidemia was approximately 23.5% in both 2019 and 2020 and increased to 24.5% in 2021. Despite the worsening of the anthropometric profile, the lipid profile improved significantly throughout 2020 and 2021 compared to 2019. Moreover, the number of active pharmacological prescriptions increased significantly in 2021.DiscussionOur findings suggest that the overload of the health system caused by the COVID-19 pandemic has resulted in an underdiagnosis of T2D. Moreover, patients with T2D experienced a worsening of their glycemic profile, an increase in their pharmacological requirements, and lower performance of their analytical determinations. Dyslipidemic subjects improved their lipid profile although the value of lipid profile determination decreased between 2020 and 2021

Innovación docente y creación de recursos educativos en abierto para Psicometría.

El objetivo del proyecto es el desarrollo de un banco de recursos educativos en abierto para dar soporte a metodologías docentes innovadoras en la asignatura de Psicometría y fomentar el papel activo del alumnado en su proceso de aprendizaje.Depto. de Psicobiología y Metodología en Ciencias del ComportamientoFac. de PsicologíaFALSEsubmitte

Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study

Background: The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. Methods: We did a prospective cohort study across 23 hospitals in Spain. We included patients aged 18 years or older with laboratory-confirmed SARS-CoV-2 infection who were admitted to an intensive care unit between March 16, 2020, and Feb 27, 2021. RNA of the SARS-CoV-2 nucleocapsid region 1 (N1) was quantified in plasma samples collected from patients in the first 48 h following admission, using digital PCR. Patients were grouped on the basis of N1 quantity: VIR-N1-Zero (2747 N1 copies per mL). The primary outcome was all-cause death within 90 days after admission. We evaluated odds ratios (ORs) for the primary outcome between groups using a logistic regression analysis. Findings: 1068 patients met the inclusion criteria, of whom 117 had insufficient plasma samples and 115 had key information missing. 836 patients were included in the analysis, of whom 403 (48%) were in the VIR-N1-Low group, 283 (34%) were in the VIR-N1-Storm group, and 150 (18%) were in the VIR-N1-Zero group. Overall, patients in the VIR-N1-Storm group had the most severe disease: 266 (94%) of 283 patients received invasive mechanical ventilation (IMV), 116 (41%) developed acute kidney injury, 180 (65%) had secondary infections, and 148 (52%) died within 90 days. Patients in the VIR-N1-Zero group had the least severe disease: 81 (54%) of 150 received IMV, 34 (23%) developed acute kidney injury, 47 (32%) had secondary infections, and 26 (17%) died within 90 days (OR for death 0·30, 95% CI 0·16-0·55; p<0·0001, compared with the VIR-N1-Storm group). 106 (26%) of 403 patients in the VIR-N1-Low group died within 90 days (OR for death 0·39, 95% CI 0·26-0·57; p<0·0001, compared with the VIR-N1-Storm group). Interpretation: The presence of a so-called viral storm is associated with increased all-cause death in patients admitted to the intensive care unit with severe COVID-19. Preventing this viral storm could help to reduce poor outcomes. Viral storm could be an enrichment marker for treatment with antivirals or purification devices to remove viral components from the blood.This work was supported by grants from the Instituto de Salud Carlos III (FONDO-COVID19, COV20/00110, CIBERES, 06/06/0028; AT), Proyectos de Investigación en Salud (PI19/00590; JFB-M), Miguel Servet (CP20/00041; DdG-C), Sara Borrell (CD018/0123; APT), and Predoctorales de Formación en Investigación en Salud (FI20/00278; AdF). We also received funds from Programa de Donaciones Estar Preparados, UNESPA (Madrid, Spain), and from the Canadian Institutes of Health Research (CIHR OV2–170357; DJK and JFB-M), Research Nova Scotia, Li-Ka Shing Foundation (DJK), and finally by a Research Grant 2020 from ESCMID (APT). COV20/00110, PI19/00590, CP20/00041, CD018/0123, FI20/00278 were co-funded by European Regional Development Fund and European Social Fund (A way to make Europe, and Investing in your future). We thank the IRB-Lleida Biobank 119 (B.0000682) and Plataforma Biobancos PT17/0015/0027 in Lleida, the Hospital Clinic Barcelona (HCB)-IDIBAPS biobank in Barcelona, and the National DNA Bank and the Hospital Universitario de Salamanca biobank (both in Salamanca) for their logistical support with sample processing and storage. We are indebted to the Fundació Glòria Soler for its contribution and support to the COVIDBANK of HCBIDIBAPS Biobank. This work was not supported by any pharmaceutical company or other agency.S

A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study

Background: The identification of critically ill COVID-19 patients at risk of fatal outcomes remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers for clinical decision-making in critically ill patients. Second, we constructed a blood miRNA classifier for the early prediction of adverse outcomes in the ICU. Methods: This was a multicenter, observational and retrospective/prospective study including 503 critically ill patients admitted to the ICU from 19 hospitals. qPCR assays were performed in plasma samples collected within the first 48 h upon admission. A 16-miRNA panel was designed based on recently published data from our group. Results: Nine miRNAs were validated as biomarkers of all-cause in-ICU mortality in the independent cohort of critically ill patients (FDR < 0.05). Cox regression analysis revealed that low expression levels of eight miRNAs were associated with a higher risk of death (HR from 1.56 to 2.61). LASSO regression for variable selection was used to construct a miRNA classifier. A 4-blood miRNA signature composed of miR-16-5p, miR-192-5p, miR-323a-3p and miR-451a predicts the risk of all-cause in-ICU mortality (HR 2.5). Kaplan‒Meier analysis confirmed these findings. The miRNA signature provides a significant increase in the prognostic capacity of conventional scores, APACHE-II (C-index 0.71, DeLong test p-value 0.055) and SOFA (C-index 0.67, DeLong test p-value 0.001), and a risk model based on clinical predictors (C-index 0.74, DeLong test-p-value 0.035). For 28-day and 90-day mortality, the classifier also improved the prognostic value of APACHE-II, SOFA and the clinical model. The association between the classifier and mortality persisted even after multivariable adjustment. The functional analysis reported biological pathways involved in SARS-CoV infection and inflammatory, fibrotic and transcriptional pathways. Conclusions: A blood miRNA classifier improves the early prediction of fatal outcomes in critically ill COVID-19 patients.11 página

Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study

Background: The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. Methods: We did a prospective cohort study across 23 hospitals in Spain. We included patients aged 18 years or older with laboratory-confirmed SARS-CoV-2 infection who were admitted to an intensive care unit between March 16, 2020, and Feb 27, 2021. RNA of the SARS-CoV-2 nucleocapsid region 1 (N1) was quantified in plasma samples collected from patients in the first 48 h following admission, using digital PCR. Patients were grouped on the basis of N1 quantity: VIR-N1-Zero ([removed]2747 N1 copies per mL). The primary outcome was all-cause death within 90 days after admission. We evaluated odds ratios (ORs) for the primary outcome between groups using a logistic regression analysis. Findings: 1068 patients met the inclusion criteria, of whom 117 had insufficient plasma samples and 115 had key information missing. 836 patients were included in the analysis, of whom 403 (48%) were in the VIR-N1-Low group, 283 (34%) were in the VIR-N1-Storm group, and 150 (18%) were in the VIR-N1-Zero group. Overall, patients in the VIR-N1-Storm group had the most severe disease: 266 (94%) of 283 patients received invasive mechanical ventilation (IMV), 116 (41%) developed acute kidney injury, 180 (65%) had secondary infections, and 148 (52%) died within 90 days. Patients in the VIR-N1-Zero group had the least severe disease: 81 (54%) of 150 received IMV, 34 (23%) developed acute kidney injury, 47 (32%) had secondary infections, and 26 (17%) died within 90 days (OR for death 0·30, 95% CI 0·16–0·55; p<0·0001, compared with the VIR-N1-Storm group). 106 (26%) of 403 patients in the VIR-N1-Low group died within 90 days (OR for death 0·39, 95% CI 0·26–0·57; p[removed]11 página

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe