Factores predictores de sobrevida en pacientes con alguna patologia cancerosa maediante análisis de regresión de cox caso: próstata

El presente trabajo investigativo desarrolla el Análisis de Sobrevida para los pacientes con Cáncer de Próstata de la Sociedad de Lucha Contra el Cáncer(SOLCA). En el Capitulo 1, enfocamos los diferentes tipos de cáncer y de manera especial lo que corresponde al cáncer de próstata, sus etapas, y sus diferentes tipos de tratamientos. En el capitulo 2, presentamos la descripción de las variables sobre las que vamos a basar nuestro estudio de igual manera se presenta la codificación de las mismas. En esta sección también se revisará los fundamentos teóricos en el que nos basaremos para la realización del trabajo. En el capitulo 3, contiene el análisis Univariado, de cada una de las características investigadas. El análisis multivariado se encuentra en el capitulo 4. las técnicas multivariadas que utilizaremos en este capitulo será el análisis de componentes principales, el método de Kaplan Meier, y por último el análisis de Regresión de Cox. Finalmente Presentaremos las conclusiones y recomendaciones que obtuvimos a partir de los resultados

Bloqueo Subaracnoideo con bupivacaina hiperbárica vrs bupivacaina hipobárica para esterilización quirúrgica, un ensayo clínico de eficacia y seguridad en el Hospital Bolonia de octubre 2018- enero 2019

Con el objetivo de comparar la eficacia y seguridad del uso de bupivacaína hiperbárica versus bupivacaína hipobárica en anestesia espinal en pacientes ambulatorios sometidos a esterilización quirúrgica se llevó a cabo un ensayo clínico controlado aleatorizado en 55 pacientes atendidos en el Hospital Bolonia, de octubre 2018- enero 2019. Entre los hallazgos más importante se encontró que el nivel de bloqueo motor y sensitivo alcanzado bajo bupivacaina hipobarica fue óptimo para dicha realización con una recuperación más temprana con respecto a la bupivacaina hiperbárica. Esto sugiere que las técnicas son efectivas. Se logró establecer que la técnica anestésica en pacientes con bloqueo espinal con bupivacaina hiperbárica persiste menos estabilidad hemodinámica con respecto a la bupivacaina hipobarica. Para ambas técnicas se presentaron mínimas complicaciones lo que sugiere que la técnica es segura. La técnica anestésica de bloqueo, espinal hipobárica para procedimientos de pacientes quirúrgicos de esterilización quirúrgica es muy útil ya que se logra una pronta recuperación anestésica en este grupo de estudio. Se recomienda el uso del bloqueo espinal con bupivacaina hipobárica para pacientes sometidos a procedimos quirúrgicos ambulatorios como una adecuada alternativa y con fines docentes. El uso de bupivacaína hipobárica en el bloqueo espinal son técnica segura que proporcionan calidad analgésica, estabilidad hemodinámica, pronta recuperación post operatoria con pocas complicaciones por lo tanto se recomienda como una opción más en la práctica diaria del anestesiólog

Assessing The Students’ Prospective Perceptions Of The Final Master Project In Actuarial Science

The final master project plays a key role in the curriculum design of the Actuarial Science Master degree at the University of Málaga. Students have to fulfil their projects at the end of the two-years study program in order to get the master’s degree. The nature of the projects requires the combination of a wide range of skills, which includes analytical and technical ones, as well as professional and soft skills. From this point of view, completing a final master project in this study program can become an interesting opportunity to experiment with real tasks of the actuarial profession before entering the labour market. Furthermore, the Actuarial Science Master degree at the University of Málaga offers the possibility of including a working actuary as a second supervisor, besides the academic one. Simulating or working with real problems in the field of Actuarial Science in the final master project, which use to be complex in nature and often multidisciplinary, also constitutes a useful way to integrate the contents of the different courses of the study program and get them in context. However, the quick transition of our students to the professional market, mainly through the internships, sometimes becomes a hurdle to properly finish the final projects in the scheduled academic calendar. In an attempt to improve the satisfaction and success rates, a group of lecturers are conducting a broad study about the final master project in Actuarial Science, that includes subjective aspects.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

La colaboración público-privada en la obtención de capacidades espaciales: evaluación a través de la metodología MAPS y optimización bajo entornos de agencia.

La presente tesis doctoral aborda la obtención de las necesidades espaciales de un país, en particular, como parte de la Defensa del mismo.Con aproximaciones que emanan de la Economía y Gestión de las Organizaciones, se aborda el análisis de la gestión pública que rodea la adquisición de tales capacidades. En particular, apoyándose en las teorías de los costes de transacción y de agencia, se estudia la toma de decisiones y la gobernanza de los distintos modos de aprovisionarse.Desde el punto de vista aplicado, se utiliza una herramienta propuesta por la OCDE, denominada MAPS, para la evaluación de la compra pública, no solo con el fin de evaluar los procedimientos actualmente empleados, sino con el de aportar una visión crítica de la propia herramienta de evaluación y su aplicación en el contexto país actual.Con ello, se obtiene un resultado que permite determinar el modelo más adecuado para la referida obtención, dentro de una comparativa entre tres modelos de referencia: jerárquico, publico-privado o externo.El resultado del estudio no es puramente académico, sino que pretende emitir una serie de recomendaciones de gestión y organización de los modos de aprovisionar este servicio público.Del análisis de la evaluación, se obtienen los factores que refuerzan o debilitan el modelo propuesto, para ser empleados en la propuesta de modelo óptimo de gobernanza, en estos procesos de obtención.Principalmente se argumenta que el modelo de una agencia espacial, que dé cabida a las fórmulas público-privadas, dentro de la oportuna planificación estratégica y organizativa, sería el idóneo para dotar a una nación de las capacidades espaciales que ésta precise.<br /

Actividad Física y Salud: Transformación desde el componente curricular en la Educación Física

Esta investigación tuvo como objetivo determinar la realidad del tópico de actividad física y salud a partir de una revisión documental de la política pública en el área de Educación Física en los colegios públicos de Bogotá, a partir de la evidencia científica recolectada se generó el instrumento de validación para la recolección de la información sobre la evaluación del impacto del componente curricular en actividad física y salud. Es un estudio cualitativo de corte hermenéutico-interpretativo con un enfoque descriptivo, realizado en el macroproyecto de la Universidad Libre. De acuerdo con los hallazgos encontrados es recomendable abordar las necesidades de salud pública en el currículo de educación física en los colegios públicos de Bogotá. Esto incluye integrar la actividad física y la salud en el plan de estudios, desarrollar estrategias para reducir el tiempo en pantallas y fomentar un estilo de vida activo, así como actualizar los lineamientos curriculares según las últimas recomendaciones. Estas acciones podrían mejorar la salud y el bienestar de los estudiantes, promoviendo hábitos saludables desde temprana edad y aportando a sus bases sólidas.Universidad Libre- Facultad de Educación- Maestría en Educación FísicaThe objective of this research was to determine the reality of the topic of physical activity and health based on a documentary review of the public policy in the area of Physical Education in public schools in Bogota, from the scientific evidence collected, a validation instrument was generated for the collection of information on the evaluation of the impact of the curricular component on physical activity and health. It is a qualitative study of hermeneutic-interpretative cut with a descriptive approach, carried out in the macroproject of the Universidad Libre. According to the findings, it is advisable to address public health needs in the physical education curriculum in public schools in Bogota. This includes integrating physical activity and health into the curriculum, developing strategies to reduce screen time and encourage an active lifestyle, as well as updating curricular guidelines according to the latest recommendations. These actions could improve the health and well-being of students, promoting healthy habits from an early age and contributing to their solid foundations

Telemedicine platform for health assessment remotely by an integrated nanoarchitectonics FePS3/rGO and Ti3C2-based wearable device

Due to the emergence of various new infectious (viral/bacteria) diseases, the remote surveillance of infected persons has become most important, especially if hospitals need to isolate infected patients to prevent the spreading of pathogens to health care personnel. Therefore, we develop a remote health monitoring system by integrating a stretchable asymmetric supercapacitor (SASC) as a portable power source with sensors that can monitor the human physical health condition in real-time and remotely. An abnormal body temperature and breathing rate could indicate a person's sickness/infection status. Here we integrated FePS3@graphene-based strain sensor and SASC into an all-in-one textile system and wrapped it around the abdomen to continuously monitor the breathing cycle of the person. The real body temperature was recorded by integrating the temperature sensor with the SASC. The proposed system recorded physiological parameters in real-time and when monitored remotely could be employed as a screening tool for monitoring pathogen infection status.Web of Science61art. no. 7

Electrochemical Impedance Spectroscopy (bio)sensing through hydrogen evolution reaction induced by gold nanoparticles

A new gold nanoparticle (AuNP) based detection strategy using Electrochemical Impedance Spectroscopy (EIS) through hydrogen evolution reaction (HER) is proposed. This EIS-HER method is used as an alternative to the conventional EIS based on [Fe(CN)] or [Ru(NH)] indicators. The proposed method is based on the HER induced by AuNPs. EIS measurements for different amounts of AuNP are registered and the charge transfer resistance (R) was found to correlate and be useful for their quantification. Moreover the effect of AuNP size on electrical properties of AuNPs for HER using this sensitive technique has been investigated. Different EIS-HER signals generated in the presence of AuNPs of different sizes (2, 5, 10, 15, 20, and 50nm) are observed, being the corresponding phenomena extendible to other nanoparticles and related catalytic reactions. This EIS-HER sensing technology is applied to a magneto-immunosandwich assay for the detection of a model protein (IgG) achieving improvements of the analytical performance in terms of a wide linear range (2-500ngmL) with a good limit of detection (LOD) of 0.31ngmL and high sensitivity. Moreover, with this methodology a reduction of one order of magnitude in the LOD for IgG detection, compared with a chroamperometric technique normally used was achieved

Network-coded cooperation and multi-connectivity for massive content delivery

[EN] Massive content delivery is in the spotlight of the research community as both data traffic and the number of connected mobile devices are increasing at an incredibly fast pace. The enhanced mobile broadband (eMBB) is one of the main use cases for the fifth generation of mobile networks (5G), which focuses on transmitting greater amounts of data at higher data rates than in the previous generations, but also on increasing the area capacity (given in bits per second per square meter) and reliability. However, the broadcast and multicast implementation in 5G and presents several drawbacks such as unexpected disconnections and the lack of device-specific QoS guarantees. As a result, whenever the exact same content is to be delivered to numerous mobile devices simultaneously, this content must be replicated. Hence, the same number of parallel unicast sessions as users are needed. Therefore, novel systems that provide efficient massive content delivery and reduced energy consumption are needed. In this paper, we present a network-coded cooperation (NCC) protocol for efficient massive content delivery and the analytical model that describes its behavior. The NCC protocol combines the benefits of cooperative architectures known as mobile clouds (MCs) with Random Linear Network Coding (RLNC). Our results show the benefits of our NCC protocol when compared to the establishment of numerous parallel unicast sessions are threefold: offload data traffic from the cellular link, reduce the energy consumption at the cooperating users, and provide throughput gains when the cellular bandwidth is insufficient.This work was supported in part by the European Union's H2020 Research and Innovation Program under Grant H2020-MCSA-ITN-2016-SECRET 722424. The work of Vicent Pla and Jorge Martinez-Bauset was supported under Grant PGC2018-094151-B-I00 and Grant RED2018-102585-T (MCIU/AEI/FEDER,UE)Leyva-Mayorga, I.; Torre, R.; Pla, V.; Pandi, S.; Nguyen, GT.; Martínez Bauset, J.; Fitzek, FHP. (2020). Network-coded cooperation and multi-connectivity for massive content delivery. IEEE Access. 8:15656-15672. https://doi.org/10.1109/ACCESS.2020.29672781565615672

Black phosphorous-based human-machine communication interface

Assistive technology involving auditory feedback is generally utilized by those who are visually impaired or have speech and language difficulties. Therefore, here we concentrate on an auditory human-machine interface that uses audio as a platform for conveying information between visually or speech-disabled users and society. We develop a piezoresistive tactile sensor based on a black phosphorous and polyaniline (BP@PANI) composite by the facile chemical oxidative polymerization of aniline on cotton fabric. Taking advantage of BP’s puckered honeycomb lattice structure and superior electrical properties as well as the vast wavy fabric surface, this BP@PANI-based tactile sensor exhibits excellent sensitivity, low-pressure sensitivity, reasonable response time, and good cycle stability. For a real-world application, a prototype device employs six BP@PANI tactile sensors that correspond to braille characters and can convert pressed text into audio on reading or typing to assist visually or speech-disabled persons. Overall, this research offers promising insight into the material candidates and strategies for the development of auditory feedback devices based on layered and 2D materials for human-machine interfaces.Web of Science14

Nanostructured Hybrid BioBots for Beer Brewing

The brewing industry will amass a revenue above 500 billion euros in 2022, and the market is expected to grow annually. This industrial process is based on a slow sugar fermentation by yeast (commonly Saccharomyces cerevisiae). Herein, we encapsulate yeast cells into a biocompatible alginate (ALG) polymer along Fe3O4 nanoparticles to produce magneto/catalytic nanostructured ALG@yeast-Fe3O4 BioBots. Yeast encapsulated in these biocompatible BioBots keeps their biological activity (growth, reproduction, and catalytic fermentation) essential for brewing. Catalytic fermentation of sugars into CO2 gas caused a continuous oscillatory motion of the BioBots in the solution. This BioBot motion is employed to enhance the beer fermentation process compared to static-free yeast cells. When the process is finished, magnetic actuation of BioBots is employed for their retrieval from the beer samples, which avoids the need of additional filtration steps. All in all, we demonstrate how an industrial process such as beer production can be benefited by miniaturized autonomous magneto/catalytic BioBots