Challenges in the COVID-19 vaccination era: Prioritization of vaccines among essential workers in Mexico

The coronavirus disease-2019 (COVID-19) pandemic gave rise to a massive global health concern that has placed an unprecedented strain on healthcare systems, education and economy. The recent vaccine roll-out gave humanity a glimpse of hope. However, more than 50% of the vaccine supply has been acquired by high-income countries, forcing low- and middle-income countries to prioritize who should be vaccinated. In Mexico, the first phase of the vaccination program prioritized healthcare personnel working in front-line COVID-19 public institutions. The second phase was planned for the remaining healthcare workers attending at both COVID and non-COVID areas. The government, however, aiming to reopen schools, decided to vaccinate teachers instead. This raised several concerns, since Mexico tops the ranking of deaths among healthcare workers due to COVID-19 worldwide. Furthermore, the possible framing of vaccines as a political tool has caused commotion among the Mexican people and media, especially since 2021 is the Midterm Election year in Mexico, and the Teachers’ Union has historically played an essential role in this matter. Therefore, it is relevant to share the vaccination experience in resource-constrained settings to provide help and advice to reach an optimal strategy and deflate this pandemic

Rules for biological regulation based on error minimization

The control of gene expression involves complex mechanisms that show large variation in design. For example, genes can be turned on either by the binding of an activator (positive control) or the unbinding of a repressor (negative control). What determines the choice of mode of control for each gene? This study proposes rules for gene regulation based on the assumption that free regulatory sites are exposed to nonspecific binding errors, whereas sites bound to their cognate regulators are protected from errors. Hence, the selected mechanisms keep the sites bound to their designated regulators for most of the time, thus minimizing fitness-reducing errors. This offers an explanation of the empirically demonstrated Savageau demand rule: Genes that are needed often in the natural environment tend to be regulated by activators, and rarely needed genes tend to be regulated by repressors; in both cases, sites are bound for most of the time, and errors are minimized. The fitness advantage of error minimization appears to be readily selectable. The present approach can also generate rules for multi-regulator systems. The error-minimization framework raises several experimentally testable hypotheses. It may also apply to other biological regulation systems, such as those involving protein-protein interactions.Comment: biological physics, complex networks, systems biology, transcriptional regulation http://www.weizmann.ac.il/complex/tlusty/papers/PNAS2006.pdf http://www.pnas.org/content/103/11/3999.ful

Ecosystem-bedrock interaction changes nutrient compartmentalization during early oxidative weathering

Ecosystem-bedrock interactions power the biogeochemical cycles of Earth's shallow crust, supporting life, stimulating substrate transformation, and spurring evolutionary innovation. While oxidative processes have dominated half of terrestrial history, the relative contribution of the biosphere and its chemical fingerprints on Earth's developing regolith are still poorly constrained. Here, we report results from a two-year incipient weathering experiment. We found that the mass release and compartmentalization of major elements during weathering of granite, rhyolite, schist and basalt was rock-specific and regulated by ecosystem components. A tight interplay between physiological needs of different biota, mineral dissolution rates, and substrate nutrient availability resulted in intricate elemental distribution patterns. Biota accelerated CO2 mineralization over abiotic controls as ecosystem complexity increased, and significantly modified stoichiometry of mobilized elements. Microbial and fungal components inhibited element leaching (23.4% and 7%), while plants increased leaching and biomass retention by 63.4%. All biota left comparable biosignatures in the dissolved weathering products. Nevertheless, the magnitude and allocation of weathered fractions under abiotic and biotic treatments provide quantitative evidence for the role of major biosphere components in the evolution of upper continental crust, presenting critical information for large-scale biogeochemical models and for the search for stable in situ biosignatures beyond Earth.Comment: 41 pages (MS, SI and Data), 16 figures (MS and SI), 6 tables (SI and Data). Journal article manuscrip

Restrictive ID policies: implications for health equity

We wish to thank Synod Community Services for their critical work to develop, support, and implement a local government-issued ID in Washtenaw County, MI. We also thank Yousef Rabhi of the Michigan House of Representatives and Janelle Fa'aola of the Washtenaw ID Task Force, Lawrence Kestenbaum of the Washtenaw County Clerk's Office, Sherriff Jerry Clayton of the Washtenaw County Sherriff's Office, and the Washtenaw ID Task Force for their tireless commitment to developing and supporting the successful implementation of the Washtenaw ID. Additionally, we thank Vicenta Vargas and Skye Hillier for their contributions to the Washtenaw ID evaluation. We thank the Curtis Center for Research and Evaluation at the University of Michigan School of Social Work, the National Center for Institutional Diversity at the University of Michigan, and the University of California-Irvine Department of Chicano/Latino Studies and Program in Public Health for their support of the Washtenaw ID community-academic research partnership. Finally, we thank the reviewers for their helpful comments on earlier drafts of this manuscript. (Curtis Center for Research and Evaluation at the University of Michigan School of Social Work; National Center for Institutional Diversity at the University of Michigan; University of California-Irvine Department of Chicano/Latino Studies; Program in Public Health)https://link.springer.com/content/pdf/10.1007/s10903-017-0579-3.pdfPublished versio

A simulation analysis of a microalgal-production plant for the transformation of inland-fisheries wastewater in sustainable feed

The present research evaluates the simulation of a system for transforming inland-fisheries wastewater into sustainable fish feed using Designer® software. The data required were obtained from the experimental cultivation of Chlorella sp. in wastewater supplemented with N and P. According to the results, it is possible to produce up to 11,875 kg/year (31.3 kg/d) with a production cost of up to 18 (USD/kg) for dry biomass and 0.19 (USD/bottle) for concentrated biomass. Similarly, it was possible to establish the kinetics of growth of substrate-dependent biomass with a maximum production of 1.25 g/L after 15 days and 98% removal of available N coupled with 20% of P. It is essential to note the final production efficiency may vary depending on uncontrollable variables such as climate and quality of wastewater, among others

Constraints on Decaying Dark Matter from Fermi Observations of Nearby Galaxies and Clusters

We analyze the impact of Fermi gamma-ray observations (primarily non-detections) of selected nearby galaxies, including dwarf spheroidals, and of clusters of galaxies on decaying dark matter models. We show that the fact that galaxy clusters do not shine in gamma rays puts the most stringent limits available to-date on the lifetime of dark matter particles for a wide range of particle masses and decay final states. In particular, our results put strong constraints on the possibility of ascribing to decaying dark matter both the increasing positron fraction reported by PAMELA and the high-energy feature in the electron-positron spectrum measured by Fermi. Observations of nearby dwarf galaxies and of the Andromeda Galaxy (M31) do not provide as strong limits as those from galaxy clusters, while still improving on previous constraints in some cases.Comment: 27 pages, 5 figures, submitted to JCAP, revised version with some additions and correction

Implications of the Fermi-LAT diffuse gamma-ray measurements on annihilating or decaying Dark Matter

We analyze the recently published Fermi-LAT diffuse gamma-ray measurements in the context of leptonically annihilating or decaying dark matter (DM) with the aim to explain simultaneously the isotropic diffuse gamma-ray and the PAMELA, Fermi and HESS (PFH) anomalous $e^\pm$ data. Five different DM annihilation/decay channels $2e$, $2\mu$, $2\tau$, $4e$, or $4\mu$ (the latter two via an intermediate light particle $\phi$) are generated with PYTHIA. We calculate both the Galactic and extragalactic prompt and inverse Compton (IC) contributions to the resulting gamma-ray spectra. To find the Galactic IC spectra we use the interstellar radiation field model from the latest release of GALPROP. For the extragalactic signal we show that the amplitude of the prompt gamma-emission is very sensitive to the assumed model for the extragalactic background light. For our Galaxy we use the Einasto, NFW and Isothermal DM density profiles and include the effects of DM substructure assuming a simple subhalo model. Our calculations show that for the annihilating DM the extragalactic gamma-ray signal can dominate only if rather extreme power-law concentration-mass relation $C(M)$ is used, while more realistic $C(M)$ relations make the extragalactic component comparable or subdominant to the Galactic signal. For the decaying DM the Galactic signal always exceeds the extragalactic one. In the case of annihilating DM the PFH favored parameters can be ruled out only if power-law $C(M)$ relation is assumed. For DM decaying into $2\mu$ or $4\mu$ the PFH favored DM parameters are not in conflict with the Fermi gamma-ray data. We find that, due to the (almost) featureless Galactic IC spectrum and the DM halo substructure, annihilating DM may give a good simultaneous fit to the isotropic diffuse gamma-ray and to the PFH $e^\pm$ data without being in clear conflict with the other Fermi-LAT gamma-ray measurements.Comment: Accepted for publication in JCAP, added missing references, new Figs. 9 \& 10, 35 page

Rickettsia slovaca Infection: DEBONEL/TIBOLA

Producción CientíficaThis study describes the epidemiological, clinical, and microbiological characteristics of a new tick-borne disease in Spain—Dermacentor-borne necrosis erythema lymphadenopathy (DEBONEL). The clinical presentations include an eschar at the site of the tick bite, surrounded by an erythema and painful regional lymphadenopathy. The disease appears during the colder months and its vector is Dermacentor marginatus (D. marginatus). From January 1990 to December 2004, 54 patients presented at Hospital of La Rioja with these clinical and epidemiological data. The ratio of females to males was 32/22. The average age was 37 years. In all cases tick bites were located on the upper body (90% on the scalp). The median incubation period was 4.7 days. Signs and symptoms were mild in all cases. Only a small number of patients presented mild and nonspecific abnormalities in a complete blood cell count and mild elevation of erythrocyte sedimentation rates and C-protein reactive and liver enzyme levels. Serological evidence of acute rickettsiosis was observed in 19 patients (61%). In 29% sera tested by polymerase chain reactions (PCRs) were positive. The sequence obtained from a PCR product revealed 98% identity with Rickettsia sp. strains RpA4, DnS14, and DnS28. All ticks removed from patients were PCR-positive. Sequencing showed 8 of them identified as R. slovaca and 2 as Rickettsia sp. strains RpA4, DnS14, and DnS28