La integración de servicios sociales y de empleo en el debate entre protección y activación

La integración de servicios es una de las principales vías de reforma del estado de bienestar que ha promovido Europa para evitar la fragmentación de sus sistemas de protección social y dar respuestas más eficaces a las necesidades de los sectores más vulnerables de la población. En el ámbito de los servicios sociales y de empleo, la integración tiene por objeto, además, potenciar la activación de los perceptores de prestaciones sociales, y abre el debate en cuanto a los efectos de desprotección y control social que pueda implicar. Las reformas han tenido distinto alcance y orientación en cada país. El objetivo de este artículo es explorar las potencialidades y limitaciones que esta integración presenta en el caso español y profundizar el análisis de las reformas adoptadas en Navarra. Este caso muestra la viabilidad de una reforma orientada a potenciar la protección social de los sectores más vulnerables, a la vez que se refuerzan los mecanismos de activación y los procesos de inserción social y laboral, lo que contradice la supuesta oposición entre ambas dinámicas. En esto, la integración de los servicios sociales y de empleo y la introducción de un modelo de intervención centrada en la persona, a través del proyecto piloto ERSISI, han desempeñado un papel fundamental

A Tractable Line-of-Sight Product Channel Model: Application to Wireless Powered Communications

We here present a general and tractable fading model for line-of-sight (LOS) scenarios, which is based on the product of two independent and non-identically distributed κ- μ shadowed random variables. Simple closed-form expressions for the probability density function and cumulative distribution function are derived, which are as tractable as the corresponding expressions derived from a product of Nakagami-m random variables. This newly proposed model simplifies the challenging characterization of LOS product channels, as well as combinations of LOS channels with non-LOS ones. Results are used to analyze performance measures of interest in the context of wireless powered communications.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Progenitor properties of type II supernovae: fitting to hydrodynamical models using Markov chain Monte Carlo methods

The progenitor and explosion properties of type II supernovae (SNe~II) are fundamental to understanding the evolution of massive stars. Particular attention has been paid to the initial masses of their progenitors, but despite the efforts made, the range of initial masses is still uncertain. Direct imaging of progenitors in pre-explosion archival images suggests an upper initial mass cutoff of $\sim$18~\ms. However, this is in tension with previous studies in which progenitor masses inferred by light-curve modelling tend to favour high-mass solutions. Moreover, it has been argued that light-curve modelling alone cannot provide a unique solution for the progenitor and explosion properties of SNe II. We develop a robust method which helps us to constrain the physical parameters of SNe~II by simultaneously fitting their bolometric light curve and the evolution of the photospheric velocity to hydrodynamical models using statistical inference techniques. We created pre-supernova red supergiant models using the stellar evolution code MESA, varying the initial progenitor mass. We then processed the explosion of these progenitors through hydrodynamical simulations, where we changed the explosion energy and the synthesised nickel mass together with its spatial distribution within the ejecta. We compared the results to observations using Markov chain Monte Carlo methods. We apply this method to a well-studied set of SNe with an observed progenitor in pre-explosion images and compare with results in the literature. Progenitor mass constraints are found to be consistent between our results and those derived by pre-SN imaging and the analysis of late-time spectral modelling. We have developed a robust method to infer progenitor and explosion properties of SN II progenitors which is consistent with other methods in the literature. Our results show that hydrodynamical modelling can be used to accurately constrain the physical properties of SNe~II. This study is the starting point for a further analysis of a large sample of hydrogen-rich SNe.Fil: Martinez, Laureano. Universidad Nacional de Río Negro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: Bersten, Melina Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: Anderson, J. P.. European Southern Observatory Chile.; ChileFil: González Gaitán, S.. Centro de Astrofísica E Gravitaçäo; PortugalFil: Förster, F.. Centro de Modelado Matemático; ChileFil: Folatelli, Gaston. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; Argentin

Comparison of Mechanical and Structural Properties of Nickel-titanium Alloy with Titanium-molybdenum Alloy and Titanium-niobium Alloy as Potential Metals for Endodontic Files

Introduction: The objective of this study was to compare the mechanical and structural properties of the nickel-titanium (Ni-Ti) alloy already used in endodontics with titanium-molybdenum (Ti-Mo) and titanium-niobium (Ti-Nb) alloys to determine if these can be suggested in the manufacture of endodontic files. Methods and Materials: Orthodontic wires made of the different alloys were used. The previously mentioned alloys were characterized by energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD) and torsion tests. Cyclic fatigue tests were performed on a simulated canal with a curvature of 86° to 375 rpm. The fractured surfaces of the wires were observed by means of scanning electron microscopy (SEM). A Kruskal-Wallis test and U Mann Whitney test were used to determine significant differences in cyclic fatigue between groups. Results: In the mechanical tests, similar values of torsion were found for the three alloys. In XRD, the Ti-Nb showed less structural changes. In the cyclic fatigue test, Ti-Nb was found to be significantly more resistant with respect to Ni-Ti and Ti-Mo. Conclusion: Based on our in vitro study, Ti-Nb is suggested as a possible alloy for the manufacture of rotary files due to its impressive properties

Extracellular Vesicle lincRNA-p21 Expression in Tumor-Draining Pulmonary Vein Defines Prognosis in NSCLC and Modulates Endothelial Cell Behavior

Hypoxia-induced upregulation of lincRNA-p21 in tumor tissue was previously shown by our group to be related to poor prognosis in resected non-small cell lung cancer (NSCLC) patients. In the present study, we have evaluated the presence of lincRNA-p21 in extracellular vesicles (EVs) from NSCLC patients and assessed its potential as a prognostic biomarker. High EV lincRNA-p21 levels in blood from the tumor-draining vein were associated with shorter time to relapse and shorter overall survival. Moreover, the multivariate analysis identified high lincRNA-p21 levels as an independent prognostic marker. In addition, lincRNA-p21 was overexpressed in H23 and HCC44 NSCLC cell lines and their derived EVs under hypoxic conditions. Functional assays using human umbilical vein endothelial cells (HUVECs) showed that tumor-derived EVs enriched in lincRNA-p21 affected endothelial cells by promoting tube formation and enhancing tumor cell adhesion to endothelial cells. Additionally, the analysis of selected EV microRNAs related to angiogenesis and metastasis showed that the microRNAs correlated with EV lincRNA-p21 levels in both patients and cell lines. Finally, EV co-culture with HUVEC cells increased the expression of microRNAs and genes related to endothelial cell activation. In conclusion, EV lincRNA-p21 acts as a novel prognosis marker in resected NSCLC patients, promoting angiogenesis and metastasis

Role of the epithelial-mesenchymal transition-related circular RNA, circ-10720, in non-small-cell lung cancer

Background: Circular RNAs (circRNAs) are non-coding RNAs with a circular structure that have recently emerged as important regulators of tumorogenesis. Recently, several circRNAS, including circ-10720 have been related to epithelial-mesenchymal transition (EMT) process. In the present study, we have analyzed the role of circ-10720 in non-small-cell lung cancer (NSCLC) and studied its prognostic relevance in resected stage I-IIIa NSCLC patients. Methods: Circ-10720 expression was analyzed using a custom TaqMan assay in four NSCLC cell lines (HCC44, A549, H23 and H1299) and in the normal immortalized lung cell line BEAS2B. Silencing of circ10720 was performed using two custom siRNAs which were transfected using lipofectamine 2000. Protein levels were evaluated by Western blot and immunofluorescence. Wound healing and invasion assays were performed to evaluate the impact the circRNA on cell motility. Apoptosis was analyzed by evaluation of Caspase 3-7 activity and proliferation by MTS assay. Moreover, the expression levels of the circRNA were studied in 119 resected NSCLC patients. The expression in tumor tissue was correlated with the main clinicopathological characteristics and with time to relapse (TTR). Results: Circ-10720 was overexpressed in HCC44 and A549 and underexpressed in H23 and H1299 NSCLC cell lines in comparison to BEAS2B normal immortalized lung cell line. CircRNA knockdown in the two circ-10720 overexpressing cell lines was associated with a decrease of Vimentin (VIM) and an increase of E-cadherin (CDH1) protein levels, loss of mesenchymal phenotype, and a significant reduction of migration and invasion capacity. After silencing circ-10720, the apoptosis rate increased and the proliferation was significantly reduced. Furthermore, circ-10720 was upregulated in tumor vs. normal tissue from 119 resected NSCLC patients. In the group of patients not receiving adjuvant treatment, those with high levels of circ-10720 had a shorter TTR than those with low levels and emerged as an independent prognostic value in the multivariate analysis. In tumor tissue, circ-10720 levels positively correlated with the EMT gene Twist1 levels. Conclusions: Circ-10720 regulates EMT, apoptosis and proliferation and acts as a biomarker of relapse in NSCLC

Comparison of the optical light curves of hydrogen-rich and hydrogen-poor type II supernovae

Type II supernovae (SNe II) show strong hydrogen features in their spectra throughout their whole evolution, while type IIb supernovae (SNe IIb) spectra evolve from dominant hydrogen lines at early times to increasingly strong helium features later on. However, it is currently unclear whether the progenitors of these SN types form a continuum in pre-SN hydrogen mass or whether they are physically distinct. SN light-curve morphology directly relates to progenitor and explosion properties such as the amount of hydrogen in the envelope, the pre-SN radius, the explosion energy, and the synthesized mass of radioactive material. In this work, we study the morphology of the optical-wavelength light curves of hydrogen-rich SNe II and hydrogen-poor SNe IIb to test whether an observational continuum exists between the two. Using a sample of 95 SNe (73 SNe II and 22 SNe IIb), we define a range of key observational parameters and present a comparative analysis between both types. We find a lack of events that bridge the observed properties of SNe II and IIb. Light-curve parameters such as rise times and post-maximum decline rates and curvatures clearly separate both SN types and we therefore conclude that there is no continuum, with the two SN types forming two observationally distinct families. In the V band a rise time of 17 d (SNe II lower and SNe IIb higher), and a magnitude difference between 30 and 40 d post-explosion of 0.4 mag (SNe II lower and SNe IIb higher) serve as approximate thresholds to differentiate both types.Fil: Pessi, Priscila Jael. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: Folatelli, Gaston. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Anderson, J. P.. European Southern Observatory Chile.; ChileFil: Bersten, Melina Cecilia. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Burns, C.. Observatories Of The Carnegie Institution For Science; Estados UnidosFil: Contreras, C.. Las Campanas Observatory; Chile. Space Telescope Science Institute; Estados UnidosFil: Davis, S.. Florida State University; Estados UnidosFil: Englert Urrutia, Brenda Nahir. Ministerio de Ciencia. Tecnología e Innovación Productiva. Agencia Nacional de Promoción Científica y Tecnológica; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: Hamuy, M.. Universidad de Chile; ChileFil: Hsiao, Eric. Florida State University; Estados UnidosFil: Martinez, Laureano. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Morrell, Nidia Irene. Las Campanas Observatory; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Phillips, M. M.. Las Campanas Observatory; ChileFil: Suntzeff, N.. Texas A&M University; Estados UnidosFil: Stritzinger, M. D.. University Aarhus; Dinamarc

Characterization of the MicroRNA Cargo of Extracellular Vesicles Isolated from a Pulmonary Tumor-Draining Vein Identifies miR-203a-3p as a Relapse Biomarker for Resected Non-Small Cell Lung Cancer.

In resected non-small cell lung cancer (NSCLC), post-surgical recurrence occurs in around 40% of patients, highlighting the necessity to identify relapse biomarkers. An analysis of the extracellular vesicle (EV) cargo from a pulmonary tumor-draining vein (TDV) can grant biomarker identification. We studied the pulmonary TDV EV-miRNAome to identify relapse biomarkers in a two-phase study (screening and validation). In the screening phase, a 17-miRNA relapse signature was identified in 18 selected patients by small RNAseq. The most expressed miRNA from the signature (EV-miR-203a-3p) was chosen for further validation. Pulmonary TDV EV-miR-203a-3p was studied by qRT-PCR in a validation cohort of 70 patients, where it was found to be upregulated in relapsed patients (p = 0.0194) and in patients with cancer spread to nearby lymph nodes (N+ patients) (p = 0.0396). The ROC curve analysis showed that TDV EV-miR-203a-3p was able to predict relapses with a sensitivity of 88% (AUC: 0.67; p = 0.022). Moreover, patients with high TDV EV-miR-203a-3p had a shorter time to relapse than patients with low levels (43.6 vs. 97.6 months; p = 0.00703). The multivariate analysis showed that EV-miR-203a-3p was an independent, predictive and prognostic post-surgical relapse biomarker. In conclusion, pulmonary TDV EV-miR-203a-3p is a promising new relapse biomarker for resected NSCLC patients

Monitoring HOTTIP levels on extracellular vesicles for predicting recurrence in surgical non-small cell lung cancer patients.

In resected non-small cell lung cancer (NSCLC), postsurgical recurrence is the major factor affecting long-term survival. The identification of biomarkers in extracellular vesicles (EV) obtained from serial blood samples after surgery could enhance early detection of relapse and improve NSCLC outcome. Since EV cargo contains long non-coding RNAs (lncRNAs), we aimed to analyze whether the oncogenic lncRNA HOTTIP, which higher expression in tumor tissue was related to worse outcome in NSCLC, could be detected in EV from NSCLC patients and serve as recurrence biomarker. After purification of EVs by ultracentrifugation in 52 serial samples from 18 NSCLC patients, RNA was isolated and HOTTIP was quantified by Real time PCR. We observed that patients that relapsed after surgery displayed increased postsurgical EV HOTTIP levels in comparison with presurgical levels. In the relapsed patients with several samples available between surgery and relapse, we observed an increment in the EV HOTTIP levels when approaching to relapse, which indicated its potential utility for monitoring disease recurrence. When we focused in EV HOTTIP levels in the first post-surgical sample, we observed that the detection of an increment of the expression levels in comparison to presurgical sample, predicted recurrence with high sensitivity (85.7%) and specificity (90.9%) and that patients had shorter time to relapse and shorter overall survival. In conclusion, our pilot study showed that EV HOTTIP is a potential biomarker for monitoring disease recurrence after surgery in NSCLC