13 research outputs found
Treatment of acidic wastewater arising from the refining of vegetable oil by crossflow microfiltration at very low transmembrane pressure
The refining process of vegetable oils generates acidic wastewater with the following characteristics: pH (1-1.5), COD (10-30 g O-2 L-1), suspended solids (7-12 g L-1) and fats (2-4 g L-1). In order to reduce the effluent load and recover a fraction of the fats without using any additives. a microfiltration (0.2-1.4 mu m) process involving ceramic membranes at very low transmembrane pressure values (0.1-1 bar) was assessed. Four batches of acidic wastewater from different manufacturing runs were tested. Trials with a constant volumetric reduction ratio of 30 were carried out for periods of more than 5 It. With a 0.5 mu m membrane it was possible to maintain a permeate flux of 100 L h(-1) m(-2) for 24 h and achieve a 91% reduction in SS, a 96% reduction in fat and a COD reduction of more than 60%. In addition, the retentate thus extracted separated spontaneously into two phases, both of which could be exploited: the upper phase mainly consisting of fats as a by-product and the lower clarified phase which could be mixed into the permeate
The p62 P392L Mutation Linked to Paget’s Disease Induces Activation of Human Osteoclasts
Quantitative analysis of antineoplastic drug residues in emanations from incineration at 850°C
Mitral transcatheter edge to edge repair versus isolated mitral surgery for severe mitral regurgitation: A French nationwide study
International audienceBackground and aims: Mitral valve surgery and more recently mitral transcatheter edge-to-edge repair (TEER) are the two treatments of severe mitral regurgitation in eligible patients. Clinical comparison of both therapies remains limited by the number of patients analysed. The objective of this study was to analyse the outcomes of mitral TEER versus isolated mitral valve surgery at a nationwide level in France.Methods: Based on the French administrative hospital-discharge database, the study collected information for all consecutive patients treated for mitral regurgitation with isolated TEER or isolated mitral valve surgery between 2012 and 2022. Propensity score matching was used for the analysis of outcomes.Results: A total of 57,030 patients were found in the database. After matching on baseline characteristics, 2,160 patients were analysed in each arm. At 3-year follow-up, TEER was associated with significantly lower incidence of cardiovascular death (HR 0.685, 95% CI 0.563-0.832; p < 0.001), pacemaker implantation and stroke. Non-cardiovascular death (HR 1.562, 95% CI 1.238-1.971; p = 0.0001), recurrent pulmonary edema and cardiac arrest were more frequent after TEER. No significant differences between the two groups were observed regarding all-cause death (HR 0.967, 95% CI 0.835-1.118; p = 0.65), endocarditis, major bleeding and atrial fibrillation and myocardial infarction.Conclusions: Our results suggest that TEER for severe mitral regurgitation was associated with lower cardiovascular mortality than mitral surgery at long-term follow-up. Pacemaker implantation and stroke were less frequently observed after TEER
Involvement of kinase PKC-zeta in the p62/p62P392L-driven activation of NF-ÎşB in human osteoclasts
Truncated prelamin A expression in HGPS-like patients: a transcriptional study
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154354.pdf (publisher's version ) (Closed access)Premature aging syndromes are rare genetic disorders mimicking clinical and molecular features of aging. A recently identified group of premature aging syndromes is linked to mutation of the LMNA gene encoding lamins A and C, and is associated with nuclear deformation and dysfunction. Hutchinson-Gilford progeria syndrome (HGPS) was the first premature aging syndrome linked to LMNA mutation and its molecular bases have been deeply investigated. It is due to a recurrent de novo mutation leading to aberrant splicing and the production of a truncated and toxic nuclear lamin A precursor (prelamin ADelta50), also called progerin. In this work and based on the literature data, we propose to distinguish two main groups of premature aging laminopathies: (1) HGPS and HGP-like syndromes, which share clinical features due to hampered processing and intranuclear toxic accumulation of prelamin A isoforms; and (2) APS (atypical progeria syndromes), due to dominant or recessive missense mutations affecting lamins A and C. Among HGPS-like patients, several deleted prelamin A transcripts (prelamin ADelta50, ADelta35 and ADelta90) have been described. The purpose of this work was to characterize those transcripts in eight patients affected with HGP-like rare syndromes. When fibroblasts were available, the relationships between the presence and ratios of these transcripts and other parameters were studied, aiming to increase our understanding of genotype-phenotype relationships in HGPS-like patients. Altogether our results evidence that progerin accumulation is the major pathogenetic mechanism responsible for HGP-like syndromes due to mutations near the donor splice site of exon 11