Outstanding Scientific Achievement Award Lecture 2010: Deconstructing Leptin: From Signals to Circuits

Martin G. Myers Jr., MD, PhD, received the American Diabetes Association's prestigious 2010 Outstanding Scientific Achievement Award at the Association's 70th Scientific Sessions in Orlando, Florida, on 28 June 2010. The Outstanding Scientific Achievement Award recognizes outstanding scientific achievement in the field of diabetes, taking into consideration independence of thought and originality

Toward the assessment of the susceptibility of a digital system to lightning upset

Accomplishments and directions for further research aimed at developing methods for assessing a candidate design of an avionic computer with respect to susceptability to lightning upset are reported. Emphasis is on fault tolerant computers. Both lightning stress and shielding are covered in a review of the electromagnetic environment. Stress characterization, system characterization, upset detection, and positive and negative design features are considered. A first cut theory of comparing candidate designs is presented including tests of comparative susceptability as well as its analysis and simulation. An approach to lightning induced transient fault effects is included

Probing the structure of a birthplace of intermediate-mass stars: Ammonia cores in Lynds 1340

Lynds 1340, a molecular cloud forming intermediate-mass stars, has been mapped in the NH_3(1,1) and (2,2) transitions with the Effelsberg 100m telescope. We observed the whole area of the cloud where C18O emission was detected earlier, at a 40 arcsec grid, with additional positions towards the C18O peaks and optically invisible IRAS point sources. Our observations covered an area of 170 arcmin^2, corresponding to about 5.15 pc^2 at a distance of 600 pc, and revealed 10 ammonia cores. The cores, occupying some 7% of the mapped area, probably represent the highest density regions of L1340. Their total mass is 80 solar mass, about 6% of the mass traced by C18O. Six cores are associated with optically invisible IRAS point sources. Their average nonthermal line width is 0.78 kms^{-1}, while the same quantity for the four starless cores is 0.28 kms^{-1}. We suggest that the narrow-line cores are destined to form low-mass stars, whereas small groups of intermediate-mass stars are being formed in the turbulent cores. The features traced by NH_3, 13CO, C18O and HI obey the line width-size relation log Delta v_{NT} = 0.41(0.06)log R_{1/2}+ 0.12(0.06). Comparison of sizes, densities and nonthermal line widths of ammonia cores with those of C18O and 13CO structures supports the scenario in which core formation has been induced by turbulent fragmentation. The typical physical properties of the ammonia cores of L1340, R_{1/2} =0.08 pc, T_{kin}=13.8 K, Delta v_{total}=0.64 kms^{-1}, and M =9 solar mass are close to those of the high-mass star forming Perseus and Orion B clouds.Comment: 13 pages, 11 figures. Accepted by A&

Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis★

Insulin receptor substrates (Irs1, 2, 3 and Irs4) mediate the actions of insulin/IGF1 signaling. They have similar structure, but distinctly regulate development, growth, and metabolic homeostasis. Irs2 contributes to central metabolic sensing, partially by acting in leptin receptor (LepRb)-expressing neurons. Although Irs4 is largely restricted to the hypothalamus, its contribution to metabolic regulation is unclear because Irs4-null mice barely distinguishable from controls. We postulated that Irs2 and Irs4 synergize and complement each other in the brain. To examine this possibility, we investigated the metabolism of whole body Irs4−/y mice that lacked Irs2 in the CNS (bIrs2−/−·Irs4−/y) or only in LepRb-neurons (Lepr∆Irs2·Irs4−/y). bIrs2−/−·Irs4−/y mice developed severe obesity and decreased energy expenditure, along with hyperglycemia and insulin resistance. Unexpectedly, the body weight and fed blood glucose levels of Lepr∆Irs2·Irs4−/y mice were not different from Lepr∆Irs2 mice, suggesting that the functions of Irs2 and Irs4 converge upon neurons that are distinct from those expressing LepRb

Conventional versus automated measurement of blood pressure in primary care patients with systolic hypertension: randomised parallel design controlled trial

Objective To compare the quality and accuracy of manual office blood pressure and automated office blood pressure using the awake ambulatory blood pressure as a gold standard

Experimental simulation of closed timelike curves

Closed timelike curves are among the most controversial features of modern physics. As legitimate solutions to Einstein's field equations, they allow for time travel, which instinctively seems paradoxical. However, in the quantum regime these paradoxes can be resolved, leaving closed timelike curves consistent with relativity. The study of these systems therefore provides valuable insight into nonlinearities and the emergence of causal structures in quantum mechanics-essential for any formulation of a quantum theory of gravity. Here we experimentally simulate the nonlinear behaviour of a qubit interacting unitarily with an older version of itself, addressing some of the fascinating effects that arise in systems traversing a closed timelike curve. These include perfect discrimination of non-orthogonal states and, most intriguingly, the ability to distinguish nominally equivalent ways of preparing pure quantum states. Finally, we examine the dependence of these effects on the initial qubit state, the form of the unitary interaction and the influence of decoherence

Physical properties of interstellar filaments

We analyze the physical parameters of interstellar filaments that we describe by an idealized model of isothermal self-gravitating infinite cylinder in pressure equilibrium with the ambient medium. Their gravitational state is characterized by the ratio f_cyl of their mass line density to the maximum possible value for a cylinder in a vacuum. Equilibrium solutions exist only for f_cyl < 1. This ratio is used in providing analytical expressions for the central density, the radius, the profile of the column density, the column density through the cloud centre, and the fwhm. The dependence of the physical properties on external pressure and temperature is discussed and directly compared to the case of pressure-confined isothermal self-gravitating spheres. Comparison with recent observations of the fwhm and the central column density N_H(0) show good agreement and suggest a filament temperature of ~10 K and an external pressure p_ext/k in the range 1.5x10^4 K/cm^3 to 5x10^4 K/cm^3. Stability considerations indicate that interstellar filaments become increasingly gravitationally unstable with mass line ratio f_cyl approaching unity. For intermediate f_cyl>0.5 the instabilities should promote core formation through compression, with a separation of about five times the fwhm. We discuss the nature of filaments with high mass line densities and their relevance to gravitational fragmentation and star formation.Comment: 18 pages, 12 figures accepted for publication (13/4/2012

Photometric redshifts and quasar probabilities from a single, data-driven generative model

We describe a technique for simultaneously classifying and estimating the redshift of quasars. It can separate quasars from stars in arbitrary redshift ranges, estimate full posterior distribution functions for the redshift, and naturally incorporate flux uncertainties, missing data, and multi-wavelength photometry. We build models of quasars in flux-redshift space by applying the extreme deconvolution technique to estimate the underlying density. By integrating this density over redshift one can obtain quasar flux-densities in different redshift ranges. This approach allows for efficient, consistent, and fast classification and photometric redshift estimation. This is achieved by combining the speed obtained by choosing simple analytical forms as the basis of our density model with the flexibility of non-parametric models through the use of many simple components with many parameters. We show that this technique is competitive with the best photometric quasar classification techniques---which are limited to fixed, broad redshift ranges and high signal-to-noise ratio data---and with the best photometric redshift techniques when applied to broadband optical data. We demonstrate that the inclusion of UV and NIR data significantly improves photometric quasar--star separation and essentially resolves all of the redshift degeneracies for quasars inherent to the ugriz filter system, even when included data have a low signal-to-noise ratio. For quasars spectroscopically confirmed by the SDSS 84 and 97 percent of the objects with GALEX UV and UKIDSS NIR data have photometric redshifts within 0.1 and 0.3, respectively, of the spectroscopic redshift; this amounts to about a factor of three improvement over ugriz-only photometric redshifts. Our code to calculate quasar probabilities and redshift probability distributions is publicly available