Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS)

Objectives: The aim of this study was to develop a critical appraisal (CA) tool that addressed study design and reporting quality as well as the risk of bias in cross-sectional studies (CSSs). In addition, the aim was to produce a help document to guide the non-expert user through the tool. Design: An initial scoping review of the published literature and key epidemiological texts was undertaken prior to the formation of a Delphi panel to establish key components for a CA tool for CSSs. A consensus of 80% was required from the Delphi panel for any component to be included in the final tool. Results: An initial list of 39 components was identified through examination of existing resources. An international Delphi panel of 18 medical and veterinary experts was established. After 3 rounds of the Delphi process, the Appraisal tool for Cross-Sectional Studies (AXIS tool) was developed by consensus and consisted of 20 components. A detailed explanatory document was also developed with the tool, giving expanded explanation of each question and providing simple interpretations and examples of the epidemiological concepts being examined in each question to aid non-expert users. Conclusions: CA of the literature is a vital step in evidence synthesis and therefore evidence-based decision-making in a number of different disciplines. The AXIS tool is therefore unique and was developed in a way that it can be used across disciplines to aid the inclusion of CSSs in systematic reviews, guidelines and clinical decision-making

The Complex Structure of the Multi-Phase Galactic Wind in a Starburst Merger

Neutral outflows have been detected in many ultraluminous infrared galaxies (ULIRGs) via the Na I D $\lambda\lambda 5890, 5896$ absorption-line doublet. For the first time, we have mapped and analyzed the 2-D kinematics of a cool neutral outflow in a ULIRG, F10565+2448, using the integral field unit (IFU) on Gemini North to observe the Na I D feature. At the same time we have mapped the ionized outflow with the [NII] and H$\alpha$ emission lines. We find a systemic rotation curve that is consistent with the rotation of the molecular disk determined from previous CO observations. The absorption lines show evidence of a nuclear outflow with a radial extent of at least 3 kpc, consistent with previous observations. The strength of the Na I D lines have a strong, spatially resolved correlation with reddening, suggesting that dust is present in the outflow. Surprisingly, the outflow velocities of the neutral gas show a strong asymmetry in the form of a major-axis gradient that is opposite in sign to disk rotation. This is inconsistent with entrained material rotating along with the galaxy or with a tilted minor-axis outflow. We hypothesize that this unusual behavior is due to an asymmetry in the distribution of the ambient gas. We also see evidence of asymmetric ionized outflow in the emission-line velocity map, which appear to be decoupled from the neutral outflow. Our results strengthen the hypothesis that ULIRG outflows differ in morphology from those in more quiescent disk galaxies.Comment: Accepted to Ap

Use of clinical vignette questionnaires to investigate the variation in management of keratoconjunctivitis sicca and acute glaucoma in dogs

There is little peer-reviewed research assessing therapeutic effectiveness in canine eye disease. Current treatments used in first opinion and ophthalmology referral practices are also somewhat poorly documented. The aim of this study was to investigate the current management of canine keratoconjunctivitis sicca (KCS) and acute primary angle-closure glaucoma (PACG) by veterinary surgeons. Questionnaires using clinical vignettes were administered to a cross section of general practitioners (‘GPs’) and veterinarians engaged in or training for postgraduate ophthalmology practice (’PGs’). Similar treatment recommendations for KCS (topical cyclosporine, lubricant, antibiotic) were given by both groups of veterinarians with the single exception of increased topical antibiotic use by GPs. Treatment of acute glaucoma diverged between groups: PGs were much more likely to recommend topical prostaglandin analogues (PGAs) and a wider array of both topical and systemic treatments were recommended by both groups. Systemic ocular hypotensive agents were suggested infrequently. Our results suggest that treatments may vary substantially in ocular conditions, particularly in conditions for which neither guidelines nor high quality evidence exists. This study highlights the need for novel strategies to address evidence gaps in veterinary medicine, as well as for better evaluation and dissemination of current treatment experience

Demographics and economic burden of un-owned cats and dogs in the UK: results of a 2010 census

Background The population of dogs and cats passing through rescue shelters may be subject to compromised welfare and increased susceptibility to disease. Little information exists to describe this population, its dynamics and associated management practices. The aim of this study was to carry out a census of un-owned cats and dogs in the UK in 2010, and to document the origins, destinations, husbandry and costs associated with the care of these animals. Results A sampling frame was constructed by searching the databases of publicly registered charities for England, Scotland and Wales, registers of breed rescues, and by internet searches of animal welfare websites. Overall, 2,352 contacts for 1,380 organisations were identified. All were sent a postal questionnaire asking for data on the number of dogs and cats housed, their origins and eventual outcomes, and details of husbandry between January 1st and December 31st 2010. For those which were registered charities (595), financial records were also obtained. A response rate of 38.8% was obtained. Overall, in 2010, 89,571 dogs and 156,826 cats entered the care of the participating organisations. Approximately half of these animals were relinquished by their owners. Other origins included being found as strays or confiscated for welfare purposes. Seventy-five per cent of dogs and 77.1% of cats were rehomed. The next most common outcome was euthanasia, accounting for 10.4% of dogs and 13.2% cats. For dogs and cats, 44.3% and 62% of participants respectively reported having a waiting list, which frequently exceeded the actual capacity of the facility. Over 19,000 people were involved in the care of these animals, on a paid or voluntary basis. Financial records were available for 519/595 (87.2%) of the registered charities, and their total expenditure in 2010 was £340 million. Conclusions This study showed that a large number of animals become un-owned each year, which could have considerable implications for their welfare. Despite the resources expended, demand still exceeds capacity for many organisations, and a substantial number of both cats and dogs are euthanased, suggesting that further understanding of how and why these animals become un-owned is essential in order to target interventions

Radiation Pressure Driven Galactic Winds from Self-Gravitating Discs

(Abridged) We study large-scale winds driven from uniformly bright self-gravitating discs radiating near the Eddington limit. We show that the ratio of the radiation pressure force to the gravitational force increases with height above the disc surface to a maximum of twice the value of the ratio at the disc surface. Thus, uniformly bright self-gravitating discs radiating at the Eddington limit are fundamentally unstable to driving large-scale winds. These results contrast with the spherically symmetric case, where super-Eddington luminosities are required for wind formation. We apply this theory to galactic winds from rapidly star-forming galaxies that approach the Eddington limit for dust. For hydrodynamically coupled gas and dust, we find that the asymptotic velocity of the wind is v_\infty ~ 1.5 v_rot and that v_\infty SFR^{0.36}, where v_rot is the disc rotation velocity and SFR is the star formation rate, both of which are in agreement with observations. However, these results of the model neglect the gravitational potential of the surrounding dark matter halo and an old passive stellar bulge or extended disc, which act to decrease v_\infty. A more realistic treatment shows that the flow can either be unbound, or bound, forming a "fountain flow" with a typical turning timescale of t_turn ~ 0.1-1 Gyr. We provide quantitative criteria and scaling relations for assessing whether or not a rapidly star-forming galaxy of given properties can drive unbound flows via the mechanism described in this paper. Importantly, we note that because t_turn is longer than the star formation timescale in the rapidly star-forming galaxies and ULIRGs for which our theory is most applicable, if rapidly star-forming galaxies are selected as such, they may be observed to have strong outflows, even though their winds are eventually bound on large scales.Comment: 10 pages, 6 figures, Accepted for publication in MNRA

Evidence for ablated flows in the shell of nova DQ Her

High-resolution longslit Halpha spectra of the shell of the old nova DQ Her have been obtained with the William Herschel Telescope using the ISIS spectrograph. An equatorial expansion velocity of 370+/-14 km/s is derived from the spectra which, in conjunction with a narrowband Halpha image of the remnant, allows a distance estimate of 525+/-28 pc. An equatorial ring which exhibits enhanced [NII] emission has also been detected and the inclination angle of the shell is found to be 86.8+/-0.2 degrees with respect to the line of sight. The spectra also reveal tails extending from the clumps in the shell, which have a radial velocity increasing along their length. This suggests the presence of a stellar wind, collimated in the polar direction, which ablates fragments of material from the clumps and accelerates them into its stream up to a terminal velocity of order 800-900 km/s.Comment: 7 pages, 6 figure

Irish Universities in the Knowledge Society: Society's Sentinels and the Citizen's vade mecum.

This is not an attempt to explore what the proper core role of universities should be through the insights o f educators and of the great liberal traditions to which many subscribe, precious and excellent though they may be. Instead, this is an attempt to explore the essential requirements o f society from universities, requirements that are necessarily implicit in the currently conventional vision of our future as a technically and economically advanced economy in an even more rapidly changing world, the Knowledge Society. If these two approaches tend to converge in their findings then we must think that the role of universities is made so much the clearer

Kepler Observations of V447 Lyr: An Eclipsing U Gem Cataclysmic Variable

We present the results of an analysis of data covering 1.5 years of the dwarf nova V447 Lyr. We detect eclipses of the accretion disk by the mass donating secondary star every 3.74 hrs which is the binary orbital period. V447 Lyr is therefore the first dwarf nova in the Kepler field to show eclipses. We also detect five long outbursts and six short outbursts showing V447 Lyr is a U Gem type dwarf nova. We show that the orbital phase of the mid-eclipse occurs earlier during outbursts compared to quiescence and that the width of the eclipse is greater during outburst. This suggests that the bright spot is more prominent during quiescence and that the disk is larger during outburst than quiescence. This is consistent with an expansion of the outer disk radius due to the presence of high viscosity material associated with the outburst, followed by a contraction in quiescence due to the accretion of low angular momentum material. We note that the long outbursts appear to be triggered by a short outburst, which is also observed in the super-outbursts of SU UMa dwarf novae as observed using Kepler.Comment: Accepted by MNRA

Effects Of Circum-nuclear Disk Gas Evolution And The Spin Of Central Black Holes

Mass and spin are the only two parameters needed to completely characterize black holes in General Relativity. However, the interaction between black holes and their environment is where complexity lies, as the relevant physical processes occur over a large range of scales. That is particularly relevant in the case of super-massive black holes (SMBHs), hosted in galaxy centers, and surrounded by swirling gas and various generations of stars. These compete with the SMBH for gas consumption and affect both dynamics and thermodynamics of the gas itself. How the behavior of such fiery environment influence the angular momentum of the gas accreted onto SMBHs, and, hence, black-hole spins is uncertain. We explore the interaction between SMBHs and their environment via first 3D sub-parsec resolution simulations (ranging from 0.1 pc to 1 kpc scales) that study the evolution of the SMBH spin by including the effects of star formation, stellar feedback, radiative transfer, and metal pollution according to the proper stellar yields and lifetimes. This approach is crucial to investigate the impact of star formation processes and feedback effects on the angular momentum of the material that could accrete on the central hole. We find that star formation and feedback mechanisms can locally inject significant amounts of entropy in the surrounding medium, and impact on the inflow inclination angles and Eddington fractions. As a consequence, the resulting trends show upper-intermediate equilibrium values for the spin parameter, a, of about 0.6 - 0.9, corresponding to radiative efficiencies \epsilon = 9% - 15%. These results suggest that star formation feedback taking place in the circum-nuclear disk during the in-fall cannot induce alone very strong chaotic trends in the gas flow, quite independently from the different numerical parameters.Comment: Changes in title and updates in references. Inclusion of additional runs and parameter studies. Conclusions unaffected. Accepte

An HI shell-like structure associated with nova V458 Vulpeculae?

We report the radio detection of a shell-like HI structure in proximity to, and probably associated with, the nova V458 Vul. High spectral resolution observation with the Giant Metrewave Radio Telescope has made it possible to study the detailed kinematics of this broken and expanding shell. Unlike the diffuse Galactic HI emission, this is a single velocity component emission with significant clumping at ~ 0.5' scales. The observed narrow line width of ~ 5 km/s suggests that the shell consists of mostly cold gas. Assuming a distance of 13 kpc to the system, as quoted in the literature, the estimated HI mass of the nebula is about 25 M_sun. However, there are some indications that the system is closer than 13 kpc. If there is a physical association of the HI structure and the nova system, the asymmetric morphology and the off-centred stellar system indicates past strong interaction of the mass loss in the asymptotic giant branch phase with the surrounding interstellar medium. So far, this is the second example, after GK Per, of a large HI structure associated with a classical nova.Comment: 6 pages, 2 table, 3 figures. Accepted for publication in MNRAS Letters. The definitive version will be available at http://www.blackwell-synergy.com