Ejaculate allocation by male sand martins, Riparia riparia

Males of many species allocate sperm to ejaculates strategically in response to variation in the risk and intensity of sperm competition. The notable exception is passerine birds, in which evidence for strategic allocation is absent. Here we report the results of a study testing for strategic ejaculate allocation in a passerine bird, the sand martin (Riparia riparia). Natural ejaculates were collected from males copulating with a model female. Ejaculates transferred in the presence of a rival male contained significantly more sperm than ejaculates transferred in the absence of a rival male. There was no evidence that this difference was due to the confounding effects of the year of ejaculate collection, the identity of the model female, the colony, the stage of season or the period of the day in which ejaculates were collected. A more detailed examination of the ejaculate patterns of individual males, achieved by the DNA profiling of ejaculates, provided additional evidence for strategic allocation of sperm

Occasional essay: upper motor neuron syndrome in amyotrophic lateral sclerosis

The diagnosis of amyotrophic lateral sclerosis (ALS) requires recognition of both lower (LMN) and upper motor neuron (UMN) dysfunction.1 However, classical UMN signs are frequently difficult to identify in ALS.2 LMN involvement is sensitively detected by electromyography (EMG)3 but, as yet, there are no generally accepted markers for monitoring UMN abnormalities,4 the neurobiology of ALS itself, and disease spread through the brain and spinal cord,.5 Full clinical assessment is therefore necessary to exclude other diagnoses and to monitor disease progression. In part, this difficulty regarding detection of UMN involvement in ALS derives from the definition of ‘the UMN syndrome’. Abnormalities of motor control in ALS require reformulation within an expanded concept of the UMN, together with the neuropathological, neuro-imaging and neurophysiological abnormalities in ALS. We review these issues here

"Come i secchi nel pozzo". Scienza ed etica negli scritti contro la vivisezione delle femministe britanniche (1870-1910)

Il saggio ripercorre le riflessioni teoriche delle femministe britanniche su scienza ed etica in relazione al dibattito sulla vivisezion

Metadata report for the City of London 3D geological model

This report describes the City of London 3D geological model, created by Constance Martin, a BSc student at the University of Birmingham, and Ricky Terrington and Helen Burke from the British Geological Survey. The work was carried out as part of a final year geology mapping project, using existing data held by the BGS and computer modelling in place of more traditional field mapping techniques to explore the subsurface geology of the developed area of the City of London. The City of London model covers an area covering approximately 3km2 in Central London, where the financial district, St Paul’s Cathedral and the Tower of London are located. Eleven geological units are modelled, comprising artificial ground, superficial deposits and bedrock to a cut-off depth of 100 m below Ordnance Datum

Amphotericin forms an extramembranous and fungicidal sterol sponge.

For over 50 years, amphotericin has remained the powerful but highly toxic last line of defense in treating life-threatening fungal infections in humans with minimal development of microbial resistance. Understanding how this small molecule kills yeast is thus critical for guiding development of derivatives with an improved therapeutic index and other resistance-refractory antimicrobial agents. In the widely accepted ion channel model for its mechanism of cytocidal action, amphotericin forms aggregates inside lipid bilayers that permeabilize and kill cells. In contrast, we report that amphotericin exists primarily in the form of large, extramembranous aggregates that kill yeast by extracting ergosterol from lipid bilayers. These findings reveal that extraction of a polyfunctional lipid underlies the resistance-refractory antimicrobial action of amphotericin and suggests a roadmap for separating its cytocidal and membrane-permeabilizing activities. This new mechanistic understanding is also guiding development of what are to our knowledge the first derivatives of amphotericin that kill yeast but not human cells

Activation of Ventral Tegmental Area 5-HT2C Receptors Reduces Incentive Motivation

FUNDING AND DISCLOSURE The research was funded by Wellcome Trust (WT098012) to LKH; and National Institute of Health (DK056731) and the Marilyn H. Vincent Foundation to MGM. The University of Michigan Transgenic Core facility is partially supported by the NIH-funded University of Michigan Center for Gastrointestinal Research (DK034933). The remaining authors declare no conflict of interest. ACKNOWLEDGMENTS We thank Dr Celine Cansell, Ms Raffaella Chianese and the staff of the Medical Research Facility for technical assistance. We thank Dr Vladimir Orduña for the scientific advice and technical assistance.Peer reviewedPublisher PD

Detection of Potential Transit Signals in Sixteen Quarters of Kepler Mission Data

We present the results of a search for potential transit signals in four years of photometry data acquired by the Kepler Mission. The targets of the search include 111,800 stars which were observed for the entire interval and 85,522 stars which were observed for a subset of the interval. We found that 9,743 targets contained at least one signal consistent with the signature of a transiting or eclipsing object, where the criteria for detection are periodicity of the detected transits, adequate signal-to-noise ratio, and acceptance by a number of tests which reject false positive detections. When targets that had produced a signal were searched repeatedly, an additional 6,542 signals were detected on 3,223 target stars, for a total of 16,285 potential detections. Comparison of the set of detected signals with a set of known and vetted transit events in the Kepler field of view shows that the recovery rate for these signals is 96.9%. The ensemble properties of the detected signals are reviewed.Comment: Accepted by ApJ Supplemen

Unexplained Graft Dysfunction after Heart Transplantation—Role of Novel Molecular Expression Test Score and QTc-Interval: A Case Report

In the current era of immunosuppressive medications there is increased observed incidence of graft dysfunction in the absence of known histological criteria of rejection after heart transplantation. A noninvasive molecular expression diagnostic test was developed and validated to rule out histological acute cellular rejection. In this paper we present for the first time, longitudinal pattern of changes in this novel diagnostic test score along with QTc-interval in a patient who was admitted with unexplained graft dysfunction. Patient presented with graft failure with negative findings on all known criteria of rejection including acute cellular rejection, antibody mediated rejection and cardiac allograft vasculopathy. The molecular expression test score showed gradual increase and QTc-interval showed gradual prolongation with the gradual decline in graft function. This paper exemplifies that in patients presenting with unexplained graft dysfunction, GEP test score and QTc-interval correlate with the changes in the graft function

The Grizzly, April 10, 1981

Sigma Pi Sigma Chapter Comes to the Campus • Men Draw for Rooms Thursday • College Choir to Present The Creation April 11 • Gulf Oil Aids Students • Lindback Nominations Requested by Dean • Saturday Night Live de Espanol • Cub and Key Selected • Co-ed Housing: Is it Possible at Ursinus? • Counseling Services in Collegeville • Ursinus Astronomy Forum • Departmental Focus: Psychology; German • Music News • Transplanted Texan • Raykes Deserve More Attention • Paradise Theatre Reopens in Philly • Portrait Schedule Announced • Platforms for Class Office Candidates • Sports Profile: Rob Randelman • Women\u27s Lacrosse • Track Runs Away With Another Perfect Week • Baseball Looking Good • Men\u27s Lacrosse Wins in Overtimehttps://digitalcommons.ursinus.edu/grizzlynews/1058/thumbnail.jp

Galactic winds driven by cosmic-ray streaming

Galactic winds are observed in many spiral galaxies with sizes from dwarfs up to the Milky Way, and they sometimes carry a mass in excess of that of newly formed stars by up to a factor of ten. Multiple driving processes of such winds have been proposed, including thermal pressure due to supernova-heating, UV radiation pressure on dust grains, or cosmic ray (CR) pressure. We here study wind formation due to CR physics using a numerical model that accounts for CR acceleration by supernovae, CR thermalization, and advective CR transport. In addition, we introduce a novel implementation of CR streaming relative to the rest frame of the gas. We find that CR streaming drives powerful and sustained winds in galaxies with virial masses M_200 < 10^{11} Msun. In dwarf galaxies (M_200 ~ 10^9 Msun) the winds reach a mass loading factor of ~5, expel ~60 per cent of the initial baryonic mass contained inside the halo's virial radius and suppress the star formation rate by a factor of ~5. In dwarfs, the winds are spherically symmetric while in larger galaxies the outflows transition to bi-conical morphologies that are aligned with the disc's angular momentum axis. We show that damping of Alfven waves excited by streaming CRs provides a means of heating the outflows to temperatures that scale with the square of the escape speed. In larger haloes (M_200 > 10^{11} Msun), CR streaming is able to drive fountain flows that excite turbulence. For halo masses M_200 > 10^{10} Msun, we predict an observable level of H-alpha and X-ray emission from the heated halo gas. We conclude that CR-driven winds should be crucial in suppressing and regulating the first epoch of galaxy formation, expelling a large fraction of baryons, and - by extension - aid in shaping the faint end of the galaxy luminosity function. They should then also be responsible for much of the metal enrichment of the intergalactic medium.Comment: 25 pages, 14 figures, accepted by MNRA