Olivine-rich exposures at Bellicia and Arruntia craters on (4) Vesta from Dawn FC

We present an analysis of the olivine-rich exposures at Bellicia and Arruntia craters using Dawn Framing Camera (FC) color data. Our results confirm the existence of olivine-rich materials at these localities as described by Ammannito et al. (2013a) using Visual Infrared Spectrometer (VIR) data. Analyzing laboratory spectra of various Howardite-Eucrite-Diogenite meteorites, high-Ca pyroxenes, olivines and olivine-orthopyroxene mixtures, we derive three FC spectral band parameters that are indicators of olivine-rich materials. Combining the three band parameters allows us, for the first time, to reliably identify sites showing modal olivine contents >40%. The olivine-rich exposures at Bellicia and Arruntia are mapped using higher spatial resolution FC data. The exposures are located on the slopes of outer/inner crater walls, on the floor of Arruntia, in the ejecta, as well as in nearby fresh small impact craters. The spatial extent of the exposures ranges from a few hundred meters to few kilometers. The olivine-rich exposures are in accordance with both the magma ocean and the serial magmatism model (e.g., Righter and Drake 1997; Yamaguchi et al. 1997). However, it remains unsolved why the olivine-rich materials are mainly concentrated in the northern hemisphere (~36-42{\deg} N, 46-74{\deg} E) and are almost absent in the Rheasilvia basin.Comment: Accepted for publication in Meteoritics and Planetary Scienc

Use of Vibrio cholerae Vaccine in an Outbreak in Guinea

Producción CientíficaThe use of vaccines to prevent and control cholera is currently under debate. Shanchol is one of the two oral cholera vaccines prequalified by the World Health Organization; however, its effectiveness under field conditions and the protection it confers in the first months after administration remain unknown. The main objective of this study was to estimate the short-term effectiveness of two doses of Shanchol used as a part of the integrated response to a cholera outbreak in Africa. METHODS We conducted a matched case-control study in Guinea between May 20 and October 19, 2012. Suspected cholera cases were confirmed by means of a rapid test, and controls were selected among neighbors of the same age and sex as the case patients. The odds of vaccination were compared between case patients and controls in bivariate and adjusted conditional logistic-regression models. Vaccine effectiveness was calculated as (1-odds ratio) × 100. RESULTS Between June 8 and October 19, 2012, we enrolled 40 case patients and 160 controls in the study for the primary analysis. After adjustment for potentially confounding variables, vaccination with two complete doses was associated with significant protection against cholera (effectiveness, 86.6%; 95% confidence interval, 56.7 to 95.8; P=0.001). CONCLUSIONS In this study, Shanchol was effective when used in response to a cholera outbreak in Guinea. This study provides evidence supporting the addition of vaccination as part of the response to an outbreak. It also supports the ongoing efforts to establish a cholera vaccine stockpile for emergency use, which would enhance outbreak prevention and control strategies

Enzyme replacement therapy and/or hematopoietic stem cell transplantation at diagnosis in patients with mucopolysaccharidosis type I: results of a European consensus procedure

<p>Abstract</p> <p>Background</p> <p>Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disorder that results in the accumulation of glycosaminoglycans causing progressive multi-organ dysfunction. Its clinical spectrum is very broad and varies from the severe Hurler phenotype (MPS I-H) which is characterized by early and progressive central nervous system (CNS) involvement to the attenuated Scheie phenotype (MPS I-S) with no CNS involvement. Indication, optimal timing, safety and efficacy of the two available treatment options for MPS I, enzyme replacement therapy (ERT) and hematopoietic stem cell transplantation (HSCT), are subject to continuing debate. A European consensus procedure was organized to reach consensus about the use of these two treatment strategies.</p> <p>Methods</p> <p>A panel of specialists, including 8 specialists for metabolic disorders and 7 bone marrow transplant physicians, all with acknowledged expertise in MPS I, participated in a modified Delphi process to develop consensus-based statements on MPS I treatment. Fifteen MPS I case histories were used to initiate the discussion and to anchor decisions around either treatment mode. Before and at the meeting all experts gave their opinion on the cases (YES/NO transplantation) and reasons for their decisions were collected. A set of draft statements on MPS I treatment options composed by a planning committee were discussed and revised during the meeting until full consensus.</p> <p>Results</p> <p>Full consensus was reached on several important issues, including the following: 1) The preferred treatment for patients with MPS I-H diagnosed before age 2.5 yrs is HSCT; 2) In individual patients with an intermediate phenotype HSCT may be considered if there is a suitable donor. However, there are no data on efficacy of HSCT in patients with this phenotype; 3) All MPS I patients including those who have not been transplanted or whose graft has failed may benefit significantly from ERT; 4) ERT should be started at diagnosis and may be of value in patients awaiting HSCT.</p> <p>Conclusions</p> <p>This multidisciplinary consensus procedure yielded consensus on the main issues related to therapeutic choices and research for MPS I. This is an important step towards an international, collaborative approach, the only way to obtain useful evidence in rare diseases.</p

A binary model for the UV-upturn of elliptical galaxies (MNRAS version)

The discovery of a flux excess in the far-ultraviolet (UV) spectrum of elliptical galaxies was a major surprise in 1969. While it is now clear that this UV excess is caused by an old population of hot helium-burning stars without large hydrogen-rich envelopes, rather than young stars, their origin has remained a mystery. Here we show that these stars most likely lost their envelopes because of binary interactions, similar to the hot subdwarf population in our own Galaxy. We have developed an evolutionary population synthesis model for the far-UV excess of elliptical galaxies based on the binary model developed by Han et al (2002, 2003) for the formation of hot subdwarfs in our Galaxy. Despite its simplicity, it successfully reproduces most of the properties of elliptical galaxies with a UV excess: the range of observed UV excesses, both in $(1550-V)$ and $(2000-V)$, and their evolution with redshift. We also present colour-colour diagrams for use as diagnostic tools in the study of elliptical galaxies. The model has major implications for understanding the evolution of the UV excess and of elliptical galaxies in general. In particular, it implies that the UV excess is not a sign of age, as had been postulated previously, and predicts that it should not be strongly dependent on the metallicity of the population, but exists universally from dwarf ellipticals to giant ellipticals.Comment: accepted for publication in MNRAS, 24 pages, 15 figures, 2 table

Displacement of X-Ray Sources from Star Clusters in Starburst Galaxies

We examine the spatial offsets between X-ray point sources and star clusters in three starburst galaxies. We find that the X-ray sources are preferentially located near the star clusters. Because the star clusters are very good tracers of the star formation activity in the galaxies, this indicates that the X-ray sources are young objects associated with current star formation. We find significant displacements of the X-ray sources from the clusters. These displacements are likely due to motion of the X-ray sources and indicates that they are X-ray binaries. We find that brighter X-ray sources preferentially occur closer to clusters. The absence of very bright sources at large displacements from clusters may help constrain models of the sources.Comment: to appear in MNRAS letters, 5 pages, figure 1 is in color, astro-ph version is low resolutio

Observation of hard scattering in photoproduction events with a large rapidity gap at HERA

Events with a large rapidity gap and total transverse energy greater than 5 GeV have been observed in quasi-real photoproduction at HERA with the ZEUS detector. The distribution of these events as a function of the $\gamma p$ centre of mass energy is consistent with diffractive scattering. For total transverse energies above 12 GeV, the hadronic final states show predominantly a two-jet structure with each jet having a transverse energy greater than 4 GeV. For the two-jet events, little energy flow is found outside the jets. This observation is consistent with the hard scattering of a quasi-real photon with a colourless object in the proton.Comment: 19 pages, latex, 4 figures appended as uuencoded fil

Inclusive Jet and Hadron Suppression in a Multi-Stage Approach

We present a new study of jet interactions in the Quark-Gluon Plasma created in high-energy heavy-ion collisions, using a multi-stage event generator within the JETSCAPE framework. We focus on medium-induced modifications in the rate of inclusive jets and high transverse momentum (high-$p_{\mathrm{T}}$) hadrons. Scattering-induced jet energy loss is calculated in two stages: A high virtuality stage based on the MATTER model, in which scattering of highly virtual partons modifies the vacuum radiation pattern, and a second stage at lower jet virtuality based on the LBT model, in which leading partons gain and lose virtuality by scattering and radiation. Coherence effects that reduce the medium-induced emission rate in the MATTER phase are also included. The \trento\ model is used for initial conditions, and the (2+1)D VISHNU model is used for viscous hydrodynamic evolution. Jet interactions with the medium are modeled via 2-to-2 scattering with Debye screened potentials, in which the recoiling partons are tracked, hadronized, and included in the jet clustering. Holes left in the medium are also tracked and subtracted to conserve transverse momentum. Calculations of the nuclear modification factor ($R_{\mathrm{AA}}$) for inclusive jets and high-$p_{\mathrm{T}}$ hadrons are compared to experimental measurements at RHIC and the LHC. Within this framework, we find that two parameters for energy-loss, the coupling in the medium and the transition scale between the stages of jet modification, suffice to successfully describe these data at all energies, for central and semi-central collisions, without re-scaling the jet transport coefficient $\hat{q}$.Comment: 33 pages, 23 figure

Multi-scale evolution of charmed particles in a nuclear medium

Parton energy-momentum exchange with the quark gluon plasma (QGP) is a multi-scale problem. In this work, we calculate the interaction of charm quarks with the QGP within the higher twist formalism at high virtuality and high energy using the MATTER model, while the low virtuality and high energy portion is treated via a (linearized) Boltzmann Transport (LBT) formalism. Coherence effect that reduces the medium-induced emission rate in the MATTER model is also taken into account. The interplay between these two formalisms is studied in detail and used to produce a good description of the D-meson and charged hadron nuclear modification factor RAA across multiple centralities. All calculations were carried out utilizing the JETSCAPE framework