School Based Responses to Non-Suicidal Self Injury and Suicide: Literature Considerations When Framing a Policy Response

Deliberate Non-Suicidal Self Injury (NSSI) and suicide present distinct but related concerns for schools. An Australian study of over 6,300 families containing children/ adolescents aged 4 to 17 years found that one in 10 young people had engaged with NSSI – with three quarters of this cohort having harmed themselves in the previous twelve months (Lawrence, 2015). The same study found that within the 12 to 17 year old age group, one in 13 individuals had considered suicide in the previous 12 months, with one in 40 having made attempts (Lawrence, 2015). This article seeks to articulate key themes from literature that demand consideration by schools seeking to construct their own framework or pastoral response, balancing the prioritization of student safety whilst also attending to the realities of staff competencies. Given the age group presented in the Lawrence (2015) study, it should not be surprising that adolescents in the school context may disclosure the presence of intrusive thoughts pertaining to at-risk behaviours. Consequently, schools are well placed to deliver prevention services and simultaneously, need to be prepared to respond to situations of NSSI and suicide attempts. Drawing on the expertise of staff from an Edmund Rice Education Australia (EREA) school located in Brisbane, this paper draws links to existing policy determinants of pastoral care from within this Catholic school, whilst considering the issue of risk-to-self with relevant themes organized according to the three action areas outlined by the Queensland Suicide Action Prevention Plan (Queensland Mental Health Commission, 2015) namely: prevention; intervention; and postvention

Deciphering the role of Epstein-Barr virus in the pathogenesis of T and NK cell lymphoproliferations

Epstein-Barr virus (EBV) is a highly successful herpesvirus, colonizing more than 90% of the adult human population worldwide, although it is also associated with various malignant diseases. Primary infection is usually clinically silent, and subsequent establishment of latency in the memory B lymphocyte compartment allows persistence of the virus in the infected host for life. EBV is so markedly B-lymphotropic when exposed to human lymphocytes in vitro that the association of EBV with rare but distinct types of T and NK cell lymphoproliferations was quite unexpected. Whilst relatively rare, these EBV-associated T and NK lymphoproliferations can be therapeutically challenging and prognosis for the majority of patients is dismal. In this review, we summarize the current knowledge on the role of EBV in the pathogenesis of these tumours, and the implications for treatment. \ud \u

Primal and Shadow functions, Dual and Dual-Shadow functions for a circular crack and a circular 90 degree V-notch with Neumann boundary conditions

This report presents explicit analytical expressions for the primal, primal shadows, dual and dual shadows functions for the Laplace equation in the vicinity of a circular singular edge with Neumann boundary conditions on the faces that intersect at the singular edge. Two configurations are investigated: a penny-shaped crack and a 90^o V-notch

Sexism, abuse and threatening behaviour: experiences of women football referees in amateur and semi-professional men’s football in the UK

Recent events in football, such as the all-female officiating team of Stéphanie Frappart, Neuza Back and Karen Díaz at the 2022 men’s World Cup, and the coverage of England’s Lionesses in UEFA Women’s Euro, have raised the profile of women in football. Despite this, literature has demonstrated the difficulties faced by women who officiate football. Experiences include being subject to sexism and abuse, and belittling language from players, coaches and parents of young players. This research presents experiences from seven women who referee men’s football in the UK. Participants referee at varying levels, from grassroots to semi-professional football. Participants chose to be part of observation and interviews or complete a qualitative questionnaire with the potential for follow-up questions. A number of Foucault’s ideas were then used to analyse and explain data. Findings demonstrate experiences of sexist language and abuse, sometimes related to traditional gender roles or incompetence of women referees, and sometimes represented as extreme and threatening behaviour. Additionally, some women in this study expressed the pressure of representing all women football officials when they were completing the qualification and later when refereeing. Despite these obstacles and the frequent ‘othering’ of women referees within the football environment, their persistent involvement and occasional overt challenges to remarks or actions demonstrated their resistance to dominant discourses and the normalising judgements, showcasing the ability and determination of women officials. Overall, more support, including mental health support, needs to be available for women who referee football at all levels. Harsher punishments should be administered for those that harass or threaten women, and clear and effective structures should be in place to address women’s experiences of harassment, ensuring that women feel confident in making complaints and are assured by the resulting actions taken

CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition.

Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a genetically heterogeneous subtype of B-cell ALL characterized by chromosomal rearrangements and mutations that result in aberrant cytokine receptor and kinase signaling. In particular, chromosomal rearrangements resulting in the overexpression of cytokine receptor-like factor 2 (CRLF2) occur in 50% of Ph-like ALL cases. CRLF2 overexpression is associated with particularly poor clinical outcomes, though the molecular basis for this is currently unknown. Glucocorticoids (GCs) are integral to the treatment of ALL and GC resistance at diagnosis is an important negative prognostic factor. Given the importance of GCs in ALL therapy and the poor outcomes for patients with CRLF2 overexpression, we hypothesized that the aberrant signal transduction associated with CRLF2 overexpression might mediate intrinsic GC insensitivity. To test this hypothesis, we exposed Ph-like ALL cells from patient-derived xenografts to GCs and found that CRLF2 rearranged (CRLF2R) leukemias uniformly demonstrated reduced GC sensitivity in vitro. Furthermore, targeted inhibition of signal transduction with the MEK inhibitor trametinib and the Akt inhibitor MK2206, but not the JAK inhibitor ruxolitinib, was sufficient to augment GC sensitivity. These data suggest that suboptimal GC responses may in part underlie the poor clinical outcomes for patients with CRLF2 overexpression and provide rationale for combination therapy involving GCs and signal transduction inhibitors as a means of enhancing GC efficacy

An Evaluation of Factors Leading to Mentor Satisfaction

This study assessed for factors related to mentor satisfaction. Eighty-one youth mentors were surveyed to evaluate for the effect of training, agency support, and confidence on mentor satisfaction. Linear regressions showed that greater perceived training and confidence significantly predicted greater mentor confidence, and agency support marginally supported this relationship. These findings show the need for agencies to provide initial training, ongoing support, and to ensure their mentors are confident in their abilities to be a mentor to guarantee that their mentors are satisfied

Measuring the effective complexity of cosmological models

We introduce a statistical measure of the effective model complexity, called the Bayesian complexity. We demonstrate that the Bayesian complexity can be used to assess how many effective parameters a set of data can support and that it is a useful complement to the model likelihood (the evidence) in model selection questions. We apply this approach to recent measurements of cosmic microwave background anisotropies combined with the Hubble Space Telescope measurement of the Hubble parameter. Using mildly non-informative priors, we show how the 3-year WMAP data improves on the first-year data by being able to measure both the spectral index and the reionization epoch at the same time. We also find that a non-zero curvature is strongly disfavored. We conclude that although current data could constrain at least seven effective parameters, only six of them are required in a scheme based on the Lambda-CDM concordance cosmology.Comment: 9 pages, 4 figures, revised version accepted for publication in PRD, updated with WMAP3 result

The DM Environment: From Annotation to Dissemination

DM (formerly Digital Mappaemundi) is an online environment that allows users to easily assemble collections of images and texts for study, produce their own rich analysis data, and publish online resources for individual, group or public use. DM is ready for multi-year work with five partner projects (including a new partnership with the British Library) to implement a publicly available user-friendly environment that enables users to 1) assemble collections of resources from any combination of accessible repositories; 2) create richly linked data (e.g., annotation networks involving combinations of images, texts, fragments, web resources, and other annotations) and collections, sequences and indices that organize this data; 3) export data in a number of linked data formats; and 4) easily produce publicly accessible and interactive websites based on such data and linked data published elsewhere

Sub-Poissonian statistics of Rydberg-interacting dark-state polaritons

Interfacing light and matter at the quantum level is at the heart of modern atomic and optical physics and enables new quantum technologies involving the manipulation of single photons and atoms. A prototypical atom-light interface is electromagnetically induced transparency, in which quantum interference gives rise to hybrid states of photons and atoms called dark-state polaritons. We have observed individual dark-state polaritons as they propagate through an ultracold atomic gas involving Rydberg states. Strong long-range interactions between Rydberg atoms give rise to an effective interaction blockade for dark-state polaritons, which results in large optical nonlinearities and modified polariton number statistics. The observed statistical fluctuations drop well below the quantum noise limit indicating that photon correlations modified by the strong interactions have a significant back-action on the Rydberg atom statistics.Comment: 7 pages, 4 figure