Estudio morfodinámico de una playa lineal. Aplicación al caso de Gandía

El propósito de este trabajo es caracterizar la evolución espacio-temporal de una playa lineal, empleando para ello el software de simulación denominado Sistema de Modelado Costero (SMC) desarrollado por la Universidad de Cantabria (UC) y el Instituto de Hidráulica Ambiental de Cantabria (IH Cantabria). Como ejemplo de este tipo de playa se considerará el caso de la playa Norte de Gandía. Se pretende determinar, dentro de las limitaciones impuestas por los parámetros conocidos, la evolución previsible de la línea de costa, la influencia del oleaje, y las corrientes costeras, así como los tipos de estructuras sedimentarias que se forman. Este trabajo pretende caracterizar el tipo de playa que se está analizando (si es reflectiva o disipativa) así como determinar las estructuras sedimentarias que se generan en la playa y establecer su relación con las condiciones existentes del clima marítimo. Para ello se estudiará la reacción de la playa a diferentes eventos meteorológicos, desde condiciones de calma a casos excepcionales de temporal, y comparar para ver como la dinámica marina influye en la morfología costeraThe purpose of this project is to characterize the spatiotemporal evolution of a linear beach by employing simulation software called Coastal Modelling System (CMS), developed by the University of Cantabria and the Institute of Environmental Hydraulics of Cantabria. As an example of this type of beach the case of the beach Norte de Gandía is considered. The goal is to predict¿within the constraints imposed by the known parameters¿the evolution of the coastline, the influence of the surf, the coastal currents, and the types of sedimentary structures that form as a result. This work aims to characterize the type of beach that is being analyzed (if it is reflective or dissipative) and to determine the sedimentary structures that are generated on the beach and establish how they relate to the existing conditions of the maritime climate. In order to do this, we will study the reaction of the beach to different meteorological events from calm to extreme weather conditions and compare to gain insight about how maritime dynamics influence coastal morphology.Martínez Ramos, S. (2013). Estudio morfodinámico de una playa lineal. Aplicación al caso de Gandía. Universitat Politècnica de València. http://hdl.handle.net/10251/34979Archivo delegad

Multicentre, randomised, single-blind, parallel group trial to compare the effectiveness of a Holter for Parkinson's symptoms against other clinical monitoring methods: study protocol

Introduction In recent years, multiple studies have aimed to develop and validate portable technological devices capable of monitoring the motor complications of Parkinson's disease patients (Parkinson's Holter). The effectiveness of these monitoring devices for improving clinical control is not known. Methods and analysis This is a single-blind, cluster-randomised controlled clinical trial. Neurologists from Spanish health centres will be randomly assigned to one of three study arms (1:1:1): (a) therapeutic adjustment using information from a Parkinson?s Holter that will be worn by their patients for 7 days, (b) therapeutic adjustment using information from a diary of motor fluctuations that will be completed by their patients for 7 days and (c) therapeutic adjustment using clinical information collected during consultation. It is expected that 162 consecutive patients will be included over a period of 6 months. The primary outcome is the efficiency of the Parkinson?s Holter compared with traditional clinical practice in terms of Off time reduction with respect to the baseline (recorded through a diary of motor fluctuations, which will be completed by all patients). As secondary outcomes, changes in variables related to other motor complications (dyskinesia and freezing of gait), quality of life, autonomy in activities of daily living, adherence to the monitoring system and number of doctor?patient contacts will be analysed. The noninferiority of the Parkinson's Holter against the diary of motor fluctuations in terms of Off time reduction will be studied as the exploratory objective. Ethics and dissemination approval for this study has been obtained from the Hospital Universitari de Bellvitge Ethics Committee. The results of this study will inform the practical utility of the objective information provided by a Parkinson's Holter and, therefore, the convenience of adopting this technology in clinical practice and in future clinical trials. We expect public dissemination of the results in 2022.Funding This work is supported by AbbVie S.L.U, the Instituto de Salud Carlos III [DTS17/00195] and the European Fund for Regional Development, 'A way to make Europe'

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Celebrating a face-to-face congress of young researchers in Optics after the pandemic years: the I NW MYRO

This contribution reports the organization and celebration after the Covid-19 pandemic of a singular scientific conference focused on early-career researchers from the Spanish universities of Santiago de Compostela and Salamanca: the “I Northwest Meeting of Young Researchers in Optics (I NW MYRO)”