Plan de negocio para una finca familiar en Nilo (Cundinamarca)

Ilustraciones, gráficosCanta Claro es una finca que quiere cumplir con las particularidades de un prestador de servicios turísticos sostenible, ecológico y rentable por medio de una adaptación a un concepto anteriormente planteado. Ofrece una experiencia diferenciadora denominada “Campesinos por un día” la cual permite que los visitantes conozcan un poco más sobre el mundo orgánico, la labor del campesino y nuestro producto distintivo, el cacao. Canta Claro es un proyecto que nace en pro de cumplir un sueño familiar basado en tener una empresa conformada por los miembros del núcleo donde cada uno desempeñe tareas desde la pasión por la naturaleza y los animales.Canta Claro is a farm that wants to fulfill the particularities of a sustainable, ecological and profitable tourist service provider through an adaptation to a previously raised concept. It offers a differentiating experience called "Peasants for a day" which allows visitors to know a little more about the organic world, the work of the peasant and our distinctive product, cocoa. Canta Claro is a project born in order to fulfill a family dream based on having a company made up of the core members where everyone performs tasks from a passion for nature and animals.PregradoAdministrador de Empresas Turísticas y Hotelera

Video-cápsulas para mejorar tus competencias como universitario (II)

Este proyecto de innovación es una continuación del PIMCD 2017_77 y como ese, trata de dar respuesta a la necesidad de un apoyo educativo innovador que mejore las habilidades del alumnado. En particular se aborda la adquisición y desarrollo de competencias transversales orientadas hacia el rendimiento académico primero y profesional después. Para ello se han producido otras cinco vídeo-cápsulas de 5 minutos (liderazgo, gestión de conflictos, innovación, comunicación oral y escrita e inteligencia emocional) a disposición de alumnos y profesores en un canal de YouTube

Primer curso de Bioderecho y los Comités de Ética en Investigación “Cuestiones fundamentales desde el Derecho, la Ética y la Ciencia"

Contenido resumen del primer curso de Bioderecho y los Comités de Ética en Investigación “Cuestiones fundamentales desde el Derecho, la Ética y la Ciencia”. Organizado por el Comité de Ética en Investigación del Centro Universitario de la Costa. Celebradas el 23 y 24 de octubre de 2014 en Puerto Vallarta, México

Competencias, TIC e Innovación. Nuevos escenarios para nuevos retos

[ES] Coordinadores: José Manuel Ríos Ariza y Julio Ruíz PalmeroISBN: 978‐84‐676‐5943‐6Depósito Legal: SE‐3771‐2011Editorial: MADAño de edición: 2011Nº Edición: 1ªLugar edición: Alcalá de Guadaíra (Sevilla)Nº páginas: 140Idioma: EspañolRaposo Rivas, M. (2012). Competencias, TIC e Innovación. Nuevos escenarios para nuevos retos. REDU. Revista de Docencia Universitaria. 10(2):467-470. https://doi.org/10.4995/redu.2012.6118OJS46747010

Competencia digital, alfabetización mediática y formación del profesorado: vinculación de la teoría y la práctica a través de la colaboración inter-nivelar

Depto. de Estudios EducativosFac. de EducaciónFALSEsubmitte

Unraveling the effect of silent, intronic and missense mutations on VWF splicing : contribution of next generation sequencing in the study of mRNA

Large studies in von Willebrand disease patients, including Spanish and Portuguese registries, led to the identification of >250 different mutations. It is a challenge to determine the pathogenic effect of potential splice site mutations on VWF mRNA. This study aimed to elucidate the true effects of 18 mutations on VWF mRNA processing, investigate the contribution of next-generation sequencing to in vivo mRNA study in von Willebrand disease, and compare the findings with in silico prediction. RNA extracted from patient platelets and leukocytes was amplified by RT-PCR and sequenced using Sanger and next generation sequencing techniques. Eight mutations affected VWF splicing: c.1533+1G>A, c.5664+2T>C and c.546G>A (p.=) prompted exon skipping; c.3223-7_3236dup and c.7082-2A>G resulted in activation of cryptic sites; c.3379+1G>A and c.7437G>A) demonstrated both molecular pathogenic mechanisms simultaneously; and the p.Cys370Tyr missense mutation generated two aberrant transcripts. Of note, the complete effect of three mutations was provided by next generation sequencing alone because of low expression of the aberrant transcripts. In the remaining 10 mutations, no effect was elucidated in the experiments. However, the differential findings obtained in platelets and leukocytes provided substantial evidence that four of these would have an effect on VWF levels. In this first report using next generation sequencing technology to unravel the effects of VWF mutations on splicing, the technique yielded valuable information. Our data bring to light the importance of studying the effect of synonymous and missense mutations on VWF splicing to improve the current knowledge of the molecular mechanisms behind von Willebrand disease. identifier:02869074

Correction : Chaparro et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J. Clin. Med. 2021, 10, 2885

The authors wish to make the following corrections to this paper [...]

Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain : Large-Scale Epidemiological Study

(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery

Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design

Introduction: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.The study was partially funded by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL, by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571), by the Conselleria de Sanitat of the Generalitat Valenciana (AP 061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country by European Commission grants FOOD-CT- 2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the The Catalan Government DURSI grant 2009SGR1489