Análisis de los errores en el picking y verificación de unidades sueltas en el centro de distribución de comercial Nutresa Bogotá

Para el centro de distribución de Comercial Nutresa, el proceso de preparación de pedidos tiene dos conceptos fundamentales: eficiencia y efectividad. La eficiencia se refiere a la velocidad con la que realizan el alistamiento de los pedidos, mientras que la efectividad corresponde a la exactitud con que se alista la mercancía que se había solicitado. La promesa de servicio al cliente consiste en entregarle los productos solicitados, en el plazo pactado y en las cantidades acordadas. Cuando existen errores en el proceso de alistamiento de mercancía que no son solucionados antes del envío al cliente, se corre el riesgo de perder ventas y generar molestias. Actualmente, Comercial Nutresa presenta errores constantes en las ordenes despachadas, a pesar de realizar una verificación del 100% de los alistamientos, solo logra identificar el 40% de los casos con novedades en las cantidades alistadas. Con el objetivo de disminuir la cantidad de errores y optimizar recursos en el proceso alistamiento, se propone una lista de recomendaciones y buenas prácticas, acompañadas de un modelo de aprendizaje automático capaz de reconocer alistamientos con alta probabilidad de ser defectuosos. La propuesta logra reducir un 70% la cantidad de alistamientos a verificar, logrando identificar el 60% de los errores. En términos de negocio, esto representa ahorros operativos cercanos a 320 millones de pesos colombianos anuales.At Comercial Nutresa distribution center, the order picking process has two fundamental concepts: efficiency and effectiveness. The efficiency consists of the time taken to complete orders packaging, while the effectiveness is the accuracy in which the merchandise requested was delivered. The customer service level agreement consists of the delivery of requested products, at the right moment and in the required quantities. Before sending merchandise to the customers, orders should fulfill all commercial requirements, otherwise the risk of losing sales and generating discomfort increases. Currently, Comercial Nutresa constantly presents issues in the product sent to its customers. Despite performing a 100% verification of the enlistments, Comercial Nutresa has only been able to identify 40% of faulty picking orders. In order to reduce the number of errors and optimize resources in the enlistment process, a list of recommendations and good practices are proposed, along with a machine learning model capable of recognizing enlistments with a high probability of being defective. The proposal manages to reduce the number of enlistments to be verified by 70% while identifying 60% of the errors. In terms of business, this represents operating savings close to 320 million Colombian pesos annually.Magíster en Analítica para la Inteligencia de NegociosMaestrí

Emotional intelligence and subjective happiness in social work students

La felicidad subjetiva es uno de los indicadores de la calidad de vida laboral más importantes en Trabajo Social, que depende del desarrollo de la inteligencia emocional. El objetivo de este estudio fue analizar la relación entre inteligencia emocional (atención, claridad y reparación emocional) y felicidad subjetiva en una muestra de 187 estudiantes de Trabajo Social del sur de España (Edad media = 20.38 años, 89.30% mujeres), usando un diseño transversal y mediante el uso de cuestionarios. Mayores niveles de felicidad subjetiva se asociaron positiva y significativamente con mayores puntuaciones en claridad y reparación emocional, pero no con atención. La formación debería otorgar mayor peso a la inteligencia emocional. El desarrollo de la inteligencia emocional por medio de cursos implementados en facultades y en centros de servicios sociales posibilitaría a estudiantes y profesionales de Trabajo Social adquirir mecanismos de afrontamiento más eficaces y, por tanto, aumentar su felicidad y calidad de vida.In the discipline of Social Work, subjective happiness is regarded as a major indicator of quality of work life. Subjective happiness depends on the development of emotional intelligence. The objective of this study was to analyse the relationship between emotional intelligence (attention, clarity and emotional repair) and subjective happiness in a sample of 187 social work students from southern Spain (Average age = 20.38 years, 89.30% women), using questionnaires and a cross-sectional design. Higher levels of subjective happiness were positively and significantly associated with higher scores on clarity and emotional repair but were not associated with attention. Thus, Social Work training should give a greater weight to emotional intelligence. In this sense, developing emotional intelligence by implementing courses in faculties and social service centres would enable social work students and professionals to acquire more effective coping mechanisms and, therefore, increase their happiness and quality of life.Mario Millán Franco señala que este artículo se ha elaborado durante la estancia de investigación posdoctoral realizada en la Universidad Nacional de Irlanda (Maynooth), 2019, financiada por el Plan Propio de Investigación y Transferencia de la Universidad de Málaga

Impact of the SARS-CoV-2 lockdown measures in Southern Spain on PM10 trace element and gaseous pollutant concentrations

Trace element concentrations within PM10, gaseous pollutants (NO2 and SO2), and PM10 levels were studied during the Covid-19 lockdown at a regional level in Southern Spain (Andalusia). Pollutant concentrations were compared considering different mobility periods (pre-lockdown, lockdown, and relaxation) in 2020 and previous years (2013–2016). An acute decrease in NO2 levels (<50%) was observed as a consequence of traffic diminution during the confinement period. Moreover, a lower reduction in PM10 levels and a non-clear pattern for SO2 levels were observed. During the lockdown period, PM10 elements released from traffic emissions (Sn and Sb) showed the highest concentration diminution in the study area. Regarding the primary industrial sites, there were no significant differences in V, Ni, La, and Cr concentration reduction during 2020 associated with industrial activity (stainless steel and oil refinery) in Algeciras Bay. Similarly, concentrations of Zn showed the same behaviour at Cordoba, indicating that the Zn-smelter activity was not affected by the lockdown. Nevertheless, stronger reductions of Cu, Zn, and As in Huelva during the confinement period indicated a decrease in the nearby Cu-smelter emissions. Brick factories in Bailen were also influenced by the confinement measures, as corroborated by the marked decrease in concentrations of Ni, V, Cu, and Zn during the lockdown compared to that from previous years. This work has shown the baseline concentrations of trace elements of PM10, which is of great value to air quality managers in order to minimise pollution levels by applying the confinement of the population, affecting both traffic and industrial anthropogenic activities.We would like to acknowledge the project of the Ministry of Science, Innovation and Universities of Spain (Project RTI2018-095937-B-I00), the co-financed project by the Andalusian Government and the EU (PY18-2332), and the Environmental Agency of Andalusia for financial and technical support. Funding for open access charge: Universidad de Huelva / CBUA

Contribution of anthropogenic and natural sources in PM10 during North African dust events in Southern Europe

The influence of North African (NAF) dust events on the air quality at the regional level (12 representative monitoring stations) in Southern Europe during a long time series (2007–2014) was studied. PM10 levels and chemical composition were separated by Atlantic (ATL) and NAF air masses. An increase in the average PM10 concentrations was observed on sampling days with NAF dust influence (42 µg m- 3 ) when compared to ATL air masses (29 µg m- 3 ). Major compounds such as crustal components and secondary inorganic compounds (SIC), as well as toxic trace elements derived from industrial emissions, also showed higher concentrations of NAF events. A source contribution analysis using positive matrix factorisation (PMF) 5.0 of the PM10 chemical data, discriminating ATL and NAF air mass origins, allowed the identification of five sources: crustal, sea salt, traffic, regional, and industrial. A higher contribution (74%) of the natural sources to PM10 concentrations was confirmed under NAF episodes compared with ATL. Furthermore, there was an increase in anthropogenic sources during these events (51%), indicating the important influence of the NAF air masses on these sources. The results of this study highlight that environmental managers should take appropriate actions to reduce local emissions during NAF events to ensure good air quality

Genetics and sports performance: the present and future in the identification of talent for sports based on DNA testing.

The impact of genetics on physiology and sports performance is one of the most debated research aspects in sports sciences. Nearly 200 genetic polymorphisms have been found to influence sports performance traits, and over 20 polymorphisms may condition the status of the elite athlete. However, with the current evidence, it is certainly too early a stage to determine how to use genotyping as a tool for predicting exercise/sports performance or improving current methods of training. Research on this topic presents methodological limitations such as the lack of measurement of valid exercise performance phenotypes that make the study results difficult to interpret. Additionally, many studies present an insufficient cohort of athletes, or their classification as elite is dubious, which may introduce expectancy effects. Finally, the assessment of a progressively higher number of polymorphisms in the studies and the introduction of new analysis tools, such as the total genotype score (TGS) and genome-wide association studies (GWAS), have produced a considerable advance in the power of the analyses and a change from the study of single variants to determine pathways and systems associated with performance. The purpose of the present study was to comprehensively review evidence on the impact of genetics on endurance- and power-based exercise performance to clearly determine the potential utility of genotyping for detecting sports talent, enhancing training, or preventing exercise-related injuries, and to present an overview of recent research that has attempted to correct the methodological issues found in previous investigations.post-print1358 K

The association between mites and the Agave L. snout weevil, more than phoresis

Objective: to identify the phoretic mites associated with the Agave (Maguey) snout weevil Scyphophorus acupunctatus. Materials and methods: manual collections of Scyphophorus acupunctatus were carried out in Agave plantations. The daily behavior of mite-infested weevils was documented. The latter were observed and classified according to specialized taxonomic keys. Results and Conclusions: there was an anomalous behavior of the agave weevil possibly favored by the infestation by mites, which can play an important role in the detriment of the vitality of that pest. Scyphophorus acupunctatus (Coleoptera: Curculionidae) interacted with three groups of mites; Macrocheles merdarius (Acari: Mesostigmata: Macrochelidae), Tridiplogynium sp. (Acari: Mesostigmata: Diplogyniidae) and Curculanoetus sp. (Acari: Sarcoptiformes: Histiostomatidae). Implications: this study is the first to document the presence of phoretic mites on S. acupunctatus. It is the first report to document the association between the agave weevil and the aforementioned arachnids (Acari: acari) that participate and play a desirable role in the biological control of S. acupunctatus

Genetic profiles to identify talents in elite endurance athletes and professional football players.

The genetic profile that is needed to identify talents has been studied extensively in recent years. The main objective of this investigation was to approach, for the first time, the study of genetic variants in several polygenic profiles and their role in elite endurance and professional football performance by comparing the allelic and genotypic frequencies to the non-athlete population. In this study, genotypic and allelic frequencies were determined in 452 subjects: 292 professional athletes (160 elite endurance athletes and 132 professional football players) and 160 non-athlete subjects. Genotyping of polymorphisms in liver metabolisers (CYP2D6, GSTM1, GSTP and GSTT), iron metabolism and energy efficiency (HFE, AMPD1 and PGC1a), cardiorespiratory fitness (ACE, NOS3, ADRA2A, ADRB2 and BDKRB2) and muscle injuries (ACE, ACTN3, AMPD1, CKM and MLCK) was performed by Polymerase Chain Reaction-Single Nucleotide Primer Extension (PCR-SNPE). The combination of the polymorphisms for the “optimal” polygenic profile was quantified using the genotype score (GS) and total genotype score (TGS). Statistical differences were found in the genetic distributions between professional athletes and the non-athlete population in liver metabolism, iron metabolism and energy efficiency, and muscle injuries (p<0.001). The binary logistic regression model showed a favourable OR (odds ratio) of being a professional athlete against a non-athlete in liver metabolism (OR: 1.96; 95% CI: 1.28–3.01; p = 0.002), iron metabolism and energy efficiency (OR: 2.21; 95% CI: 1.42–3.43; p < 0.001), and muscle injuries (OR: 2.70; 95% CI: 1.75–4.16; p < 0.001) in the polymorphisms studied. Genetic distribution in professional athletes as regards endurance (professional cyclists and elite runners) and professional football players shows genetic selection in these sports disciplines.post-print1592 K

Effects of Caffeine Ingestion on Physical Performance in Elite Women Handball Players: A Randomized, Controlled Study.

Purpose: To investigate the effects of acute caffeine (CAFF) intake on physical performance in elite women handball players. Methods: A total of 15 elite women handball players participated in a randomized, double-blind study. In 2 different trials, participants ingested either a placebo (cellulose) or 3 mg of CAFF per kilogram of body mass (mg/kg bm) before undergoing a battery of neuromuscular tests consisting of handball throws, an isometric handgrip strength test, a countermovement jump, a 30-m sprint test (SV) and a modified version of the agility T test. Then, participants performed a simulated handball game (2 × 20 min), and movement patterns were recorded with a local positioning system. Results: Compared with the placebo, CAFF increased ball velocity in all ball throws (P = .021–.044; effect size [ES] = 0.39–0.49), strength in isometric handgrip strength test (350.8 [41.2] vs 361.6 [46.1] N, P = .034; ES = 0.35), and countermovement-jump height (28.5 [5.5] vs 29.8 [5.5] cm; P = .006; ES = 0.22). In addition, CAFF decreased running time in the SV (4.9 [0.2] vs 4.8 [0.3] s; P = .042; ES = −0.34). In the simulated game, CAFF increased the frequency of accelerations (18.1 [1.2] vs 18.8 [1.0] number/min; P = .044; ES = 0.54), decelerations (18.0 [1.2] vs 18.7 [1.0] number/min; P = .032; ES = 0.56), and body impacts (20 [8] vs 22 [10] impacts/min; P = .032; ES = 0.30). However, postexercise surveys about self-reported feelings of performance indicate that players did not feel increased performance with CAFF. Conclusion: Preexercise ingestion of 3 mg/kg bm of CAFF improved ball-throwing velocity, jump, and sprint performance and the frequency of in-game accelerations and decelerations in elite women handball players.pre-print676 K

Acquiring Medical Statistical Competencies in a Demanding Evidence-Based World: Thoughts and Experience from a Student Statistical Team in a Mexican Academic Center

Training and encouraging students to critically review the evidence and make evidence-based decisions should be one of the goals of medical education. We report our experience developing an extracurricular university student statistical team that offer statistical aid to other students and faculty. This includes supervised training sessions and mentoring in diverse scientific research fields performed in our university

Activated Lymphocytes and Increased Risk of Dermatologic Adverse Events during Sorafenib Therapy for Hepatocellular Carcinoma

Altres ajuts: Asociación Española Contra el Cáncer PI044031Hepatocellular carcinoma is the second cause of cancer-related death worldwide. Of those advanced-stage patients who are treated with sorafenib, those who develop early dermatologic adverse events have a better prognosis. These events are possibly immune-related. Therefore, we analyzed the phenotype of 52 sorafenib-treated patients' circulating lymphocytes throughout treatment. We found that different co-stimulatory and immune exhaustion markers, such as Programmed cell death protein 1 (PD-1) and DNAX accessory molecule 1 (DNAM-1) amongst others, correlate with the probability of developing these adverse events, both before and during the treatment. We also compared the phenotype of those lymphocytes expressing DNAM-1 with those that do not, and while NK DNAM-1-expressing cells have a co-stimulatory phenotype, T DNAM-1-expressing cells are immune-suppressors. Overall, we set a rationale for the combination of sorafenib and immune-targeted therapies; and for the use of immune markers (such as DNAM-1) for patients' prognosis evaluation. Advanced hepatocellular carcinoma patients treated with sorafenib who develop early dermatologic adverse events (eDAEs) have a better prognosis. This may be linked to immune mechanisms, and thus, it is relevant to assess the association between peripheral immunity and the probability of developing eDAEs. Peripheral blood mononuclear cells of 52 HCC patients treated with sorafenib were analyzed at baseline and throughout the first eight weeks of therapy. T, B, Natural Killer cells, and their immune checkpoints expression data were characterized by flow cytometry. Cytokine release and immune-suppression assays were carried out ex vivo. Cox baseline and time-dependent regression models were applied to evaluate the probability of increased risk of eDAEs. DNAM-1, PD-1, CD69, and LAG-3 in T cells, plus CD16 and LAG-3 in NK cells, are significantly associated with the probability of developing eDAEs. While NK DNAM-1 + cells express activation markers, T DNAM-1 + cells induce immune suppression and show immune exhaustion. This is the first study to report an association between immune checkpoints expression in circulating immune cells and the increased incidence of eDAEs. Our results support the hypothesis for an off-target role of sorafenib in immune modulation. We also describe a novel association between DNAM-1 and immune exhaustion in T cells