Hierarchy and Competition in CSCW applications: Model and case study

CSCW applications need to adapt themselves to the functional and organizational structures of people that use them. However they do not usually support division in groups with a certain hierarchical structure among them. In this paper, we propose and study a theoretical model of groupware appliations that reflects those hierarchical interactions. The proposed model is also intended to evaluate the effects in performance derived from competitive and collaborative relationships among the components of a hierarchy of groups. In order to demonstrate the above ideas, a groupware game, called Alymod, was designed and implemented using a modified version of a well-known CSCW Toolkit, namely Groupkit. Groupkit was modified in order to support group interactions in the same CSCW application. In Alymod, participants compete or collaborate within a hierarchical structure to achieve a common goal (completing gaps in a text, finishing numerical series, resolving University course examinations, etc.).Publicad

On the second Feng-Rao distance of Algebraic Geometry codes related to Arf semigroups

Producción CientíficaWe describe the second (generalized) Feng-Rao distance for elements in an Arf numerical semigroup that are greater than or equal to the conductor of the semigroup. This provides a lower bound for the second Hamming weight for one point AG codes. In particular, we can obtain the second Feng-Rao distance for the codes defined by asymptotically good towers of function fields whose Weierstrass semigroups are inductive. In addition, we compute the second Feng-Rao number, and provide some examples and comparisons with previous results on this topic. These calculations rely on Apéry sets, and thus several results concerning Apéry sets of Arf semigroups are presented.Ministerio de Economía, Industria y Competitividad; y Fondo Europeo de Desarrollo Regional FEDER( Projects MTM2014-55367-P / MTM2015-65764-C3-1-P)Junta de Andalucía (Grant FQM-343)Fundação para a Ciência e a Tecnologia (Project UID/MAT/00297/2013

Inoculation with rumen fluid in early life as a strategy to optimize the weaning process in intensive dairy goat systems

Ruminants are born with an undeveloped physical, metabolic, and microbial rumen. Rumen development is limited under artificial rearing systems when newborn animals are separated from the dam, fed on milk replacer, and weaned at an early age. This study aims to evaluate the effects of early-life inoculation of young ruminants with rumen fluid from adult animals. Eighty newborn goat kids were randomly allocated to 1 of 4 experimental treatments and inoculated daily from d 1 to wk 11 with autoclaved rumen fluid (AUT), fresh rumen fluid obtained from adult goats fed either a forage diet (RFF) or concentrate-rich diet (RFC), or absence of inoculation (CTL). Goat kids were artificially reared with ad libitum access to milk replacer, starter concentrate, and forage hay. Blood was sampled weekly and rumen microbial fermentation was monitored at 5 (preweaning), 7 (weaning), and 9 wk of age (postweaning). Results indicated that inoculation with fresh rumen fluid accelerated the rumen microbial and fermentative development before weaning. As a result, RFC and RFF animals had higher solid feed intake (+73%), rumen concentrations of ammonia-N (+26%), total volatile fatty acids (+46%), butyrate (+50%), and plasma β-hydroxybutyrate (+48%), and lower milk intake (−6%) than CTL and AUT animals at wk 5. Inoculation with fresh inoculum also promoted early rumen colonization by a complex and abundant protozoal community, whereas CTL animals remained protozoa free. Although all kids experienced moderate growth retardation during 1 wk after weaning, inoculation with fresh rumen fluid favored the weaning process, leading to 2.2 times higher weight gain than CTL and AUT animals during wk 8. Some of these advantages were retained during the postweaning period and RFF and RFC animals showed higher forage intake (up to +44%) than CTL and AUT animals with no detrimental effects on feed digestibility or stress levels. The superior microbial load of RFC compared with RFF inoculum tended to provide further improvements in terms of forage intake, plasma β-hydroxybutyrate, and rumen protozoa, whereas AUT inoculation provided minor (if any) advantages with respect to CTL animals. Although no differences were noted on animal growth, this study suggests that early life inoculation of goat kids with rumen microbiota can represent an effective strategy to accelerate the rumen development, facilitating a smooth transition from milk to solid feed and to the potential implementation of early weaning strategies.This study was funded by the Spanish government through the project AGL2017-86938-R and the Training Program for Academics grant, Madrid, Spain (FPU16/01981)

In situ monitoring of laser-induced periodic surface structures formation on polymer films by grazing incidence small-angle X-ray scattering

9 pags.; 9 figs.© 2015 American Chemical Society. The formation of laser-induced periodic surface structures (LIPSS) on model spin-coated polymer films has been followed in situ by grazing incidence small-angle X-ray scattering (GISAXS) using synchrotron radiation. The samples were irradiated at different repetition rates ranging from 1 up to 10 Hz by using the fourth harmonic of a Nd:YAG laser (266 nm) with pulses of 8 ns. Simultaneously, GISAXS patterns were acquired during laser irradiation. The variation of both the GISAXS signal with the number of pulses and the LIPSS period with laser irradiation time is revealing key kinetic aspects of the nanostructure formation process. By considering LIPSS as one-dimensional paracrystalline lattice and using a correlation found between the paracrystalline disorder parameter, g, and the number of reflections observed in the GISAXS patterns, the variation of the structural order of LIPSS can be assessed. The role of the laser repetition rate in the nanostructure formation has been clarified. For high pulse repetition rates (i.e., 10 Hz), LIPSS evolve in time to reach the expected period matching the wavelength of the irradiating laser. For lower pulse repetition rates LIPSS formation is less effective, and the period of the ripples never reaches the wavelength value. Results support and provide information on the existence of a feedback mechanism for LIPSS formation in polymer films.The authors gratefully acknowledge financial support from the MINECO (MAT2011-23455, MAT2012-33517 and CTQ 2013-43086-P). E.R., I.M.-F., and A.R-R. also thank MINECO for a Ramon y Cajal contract (RYC-2011-08069) and FPI ́ fellowships (BES-2010-030074 and BES-2013-062620).Peer Reviewe

IMF - metallicity: a tight local relation revealed by the CALIFA survey

Variations in the stellar initial mass function (IMF) have been invoked to explain the spectroscopic and dynamical properties of early-type galaxies. However, no observations have yet been able to disentangle the physical driver. We analyse here a sample of 24 early-type galaxies drawn from the CALIFA survey, deriving in a homogeneous way their stellar population and kinematic properties. We find that the local IMF is tightly related to the local metallicity, becoming more bottom-heavy towards metal-rich populations. Our result, combined with the galaxy mass-metallicity relation, naturally explains previous claims of a galaxy mass-IMF relation, derived from non-IFU spectra. If we assume that - within the star formation environment of early-type galaxies - metallicity is the main driver of IMF variations, a significant revision of the interpretation of galaxy evolution observables is necessary.Comment: Accepted for publication in ApJL. 6 pages, 4 figure

Clinical and Economic Evaluation after Adopting Contingent Cell-Free DNA Screening for Fetal Trisomies in South Spain.

Contingent cell-free (cf) DNA screening on the basis of the first-trimester combined test (FCT) results has emerged as a cost-effective strategy for screening of trisomy 21 (T21). Objectives: To assess performance, patients’ uptake, and cost of contingent cfDNA screening and to compare them with those of the established FCT. Methods: This is a prospective cohort study including all singleton pregnancies attending to their FCT for screening of T21 at 2 university hospitals in South Spain. When the FCT risk was ≥1:50, there were major fetal malformations, or the nuchal translucency was ≥3.5 mm, women were recommended invasive testing (IT); if the risk was between 1:50 and 1:270, women were recommended cfDNA testing; and for risks bellow 1:270, no further testing was recommended. Detection rate (DR), false-positive rate (FPR), patients’ uptake, and associated costs were evaluated. Results: We analyzed 10,541 women, including 46 T21 cases. DR of our contingent strategy was 89.1% (41/46) at 1.4% (146/10,541) FPR. Uptake of cfDNA testing was 91.2% (340/373), and overall IT rate was 2.0%. The total cost of our strategy was €1,462,895.7, similar to €1,446,525.7 had cfDNA testing not been available. Conclusions: Contingent cfDNA screening shows high DR, low IT rate, and high uptake at a similar cost than traditional screening.pre-print133 K

DNA methylation pattern in high-grade cervical intraepithelial neoplasia and cancer revealed by genomewide methylation analysis of cervical DNA

Cancer of the uterine cervix is caused by a subset of oncogenic human Papillomavirus (HPV)-types with mucosal tropism. Besides the known effects of the viral oncoproteins on cellular functions there is evidence suggesting that cervical carcinogenesis involves epigenetic changes in the host DNA. In this study, we have examined the global promoter methylation profile associated with progression to cervical cancer at wide genome scale. The methylation pattern of nearly 14,000 genes was analyzed in cervical swabs at different stages of cervical carcinogenesis: low-grade cervical intraepithelial neoplasia (CIN I and II), high-grade CIN (CIN III) and invasive cancer, as well as healthy individuals. Unsupervised analysis (Hierarchical Clustering) identified two groups: A) healthy, CIN I and CIN II; and B) CIN III/cancer. Supervised T-Test analysis showed 1069 promoter regions hypermethylated and 85 hypomethylated in CIN III/cancer compared to CIN I/CIN II and healthy samples (p<0.0001). Overall, the differentially methylated genes act in transcription, cell cycle, apoptosis and cell adhesion pathways. Of the hypermethylated genes, 132 (12.3%) were down-regulated in a matched cervical cancer group. In turn, only 4 (4.7%) of the hypomethylated genes were overexpressed in that group.Centro de Investigaciones Inmunológicas Básicas y Aplicada

Investigation of photoprotective, anti-inflammatory, antioxidant capacities and lc–esi–ms phenolic profile of astragalus gombiformis pomel

Plant-derived compounds have recently been gaining popularity as skincare factors due to their ability to absorb ultraviolet radiations and their anti-inflammatory, and antioxidant properties. In this light, this work aimed to evaluate in vitro the pharmacological activities of the butanolic extract prepared from the aerial parts of Astragalus gombiformis Pomel, an endemic species to southern Algeria. The sun protection factor was used to assess the photoprotective effect (SPF), the protein denaturation method to determine the anti-inflammatory activity, and brine shrimp nauplii and OxHLIA assay, respectively, to assess the cytotoxicity and antioxidant capacity of A. gombiformis. In addition, LC–ESI–MS analysis was employed for the characterization of the phenolic constituents of A. gombiformis. The results showed that A. gombiformis had high capacity for absorbing UV radiations with an SPF of 37.78 ± 0.85 and significant anti-inflammatory activity with a percentage inhibition of 75.38% which is close to that of diclofenac and ketoprofen. In addition, A. gombiformis was found to have effective cytotoxicity against Artemia nauplii with a DC50 value of about 44.7 µg/mL, but a weak hemolytic effect against human erythrocytes. LC–ESI–MS results detected the presence of 17 phenolic compounds with a predominance of cirsiliol, silymarin, quercitrin (quercetin-3-O-rhamnoside), and kaempferol. Taken together, these results suggest that A. gombiformis extract could be used as a skincare agent in cosmetic formulations, providing excellent antioxidant and anti-inflammatory protection, allowing the treatment of skin conditions, as well as a pharmaceutical agent with multidimensional applications.The authors are grateful to the Algerian Ministry of Higher Education and Scientific Research and the National Centre for Biotechnology Research (C.R.B.T) for their respective financial and material supports

SMOS soil moisture product validation in croplands

A validation campaign has been carried out to evaluate the Level 2 Soil Moisture (SM) product (version 5.51) given by the European Space Agency (ESA) Soil Moisture and Ocean Salinity (SMOS) satellite in the Pampean Region of Argentina. The study region was selected because it is a plain, avoiding topography problems, with an SMOS nominal land use class (low vegetation crops, 1-2m height). Transects of ground SM measurements were collected at 5-cm and 6-cm depth using Delta-T ThetaProbe ML2x and Stevens Hydra Probe II SM sensors, respectively. The volumetric measurements were calibrated using gravimetric and bulk density data collected at the same time as the SM sensor measurements. The SM transects covered ISEA-grid SMOS nodes over four extensive agricultural areas with prevalence of soy crops (site 1: -32.982N, -62.505E; site 2: -32.510N, -62.788E; site 3: -32.024N, -63.692E; and site 4: -37.315N, -58.868E, WGS84). The validation sites were selected taking as reference the locations of permanent SM stations property of the Argentinean Comisión Nacional de Actividades Espaciales (CONAE, National Commission of Space Activities), Instituto Nacional de Tecnología Agropecuaria (INTA, National Institute of Farming Technology) and Instituto de Hidrología de Llanuras (IHLLA, Plain Hydrology Institute). Therefore, additionally to validate the SMOS SM product with the ground data collected during the experimental campaign, the measurements are useful to evaluate the station SM data reliability at the SMOS spatial resolution with the aim of using station data series as reference to test different versions of the SMOS SM product. Previously to the campaign, SMOS SM data variability, ESA Globcover land use classification, soil edaphic properties, water bodies and topography were analyzed around the station locations to select the best sites and the experimental methodology. Temperature vegetation dryness index (TVDI) temporal and spatial variability was also studied at the sites. Additionally, transects of land surface temperature were carried out with Cimel Electronique CE312 6-band radiometers concurrently with thermal-infrared (TIR) satellite overpasses. In previous works, we studied the dependence of land surface emissivities on SM. The analysis of concurrent TIR and SM data make possible to evaluate the utility of the SMOS SM product to improve land surface emissivities and temperature determinations from satellite, giving an added value to the research

STAG3 is a strong candidate gene for male infertility

Oligo- and azoospermia are severe forms of male infertility. However, known genetic factors account only for a small fraction of the cases. Recently, whole-exome sequencing in a large consanguineous family with inherited premature ovarian failure (POF) identified a homozygous frameshift mutation in the STAG3 gene leading to a premature stop codon. STAG3encodes a meiosis-specific subunit of the cohesin complex, alarge proteinaceous ring with DNA-entrapping ability that ensures sister chromatid cohesion and enables correct synapsis and segregation of homologous chromosomes during meiosis. The pathogenicity of the STAG3 mutations was functionally validated with a loss- of-function mouse model for STAG3 in oogenesis.However,and sincenone of the male members of this family was homozygous for the mutant allele, we only could hypothesized its putative involvement inmale infertility. In this report,we show that male mice devoid of Stag3 display a severe meiotic phenotype that includes a meiotic arrest at zygonema-like shortening of their chromosome axial elements/lateral elements, partial loss of centromeric cohesion at early prophase and maintenance of the ability to initiate but not complete RAD51- and DMC1-mediated double-strand break repair,demonstrating that STAG3 is a crucial cohesin subunit in mammalian gametogenesis and supporting our proposal that STAG3 is a strong candidate gene for human male infertility. © The Author 2014. Published by Oxford University Press. All rights reserved.This work was supported by grant SAF2011-25252 and Junta de Castilla y León (EL and AMP). SC and RAV are supported by the University Paris Diderot-Paris7, the Ligue Nationale contre le Cancer, the Centre National de la Recherche Scientifique (CNRS) and the GIS-Institut des Maladies Rares.Peer Reviewe