Comparative Study between Sequential Automatic and Manual Home Respiratory Polygraphy Scoring Using a Three-Channel Device: Impact of the Manual Editing of Events to Identify Severe Obstructive Sleep Apnea

Objective. According to current guidelines, autoscoring of respiratory events in respiratory polygraphy requires manual scoring. The aim of this study was to evaluate the agreement between automatic analysis and manual scoring to identify patients with suspected OSA. Methods. This retrospective study analyzed 791 records from respiratory polygraphy (RP) performed at home. The association grade between automatic scoring and manual scoring was evaluated using Kappa coefficient and the agreement using Bland and Altman test and intraclass correlation coefficient (CCI). To determine the accuracy in the identification of AHI ≥ 30 eV/h, the ROC curve analysis was used. Results. The population analyzed consisted of 493 male (62.3%) and 298 female patients, with an average age of 54.7 ± 14.20 years and BMI of 32.7 ± 8.21 kg/m 2 . There was no significant difference between automatic and manual apnea/hypopnea indexes (aAHI, mAHI): aAHI 17.25 (SD: 17.42) versus mAHI 21.20 ± 7.96 (p; NS). The agreement between mAHI and aAHI to AHI ≥ 30 was 94%, with a Kappa coefficient of 0.83 ( < 0.001) and a CCI of 0.83. The AUC-ROC, sensitivity, and specificity were 0.99 (CI 95%: 0.98-0.99, < 0.001), 86% (CI 95%: 78.7-91.4), and 97% (CI 95%: 96-98.3), respectively. Conclusions. We observed good agreement between automatic scoring and sequential manual scoring to identify subjects with AHI ≥ 30 eV/h

Emerging needs in OSH: a new master in occupational safety and health by ILO and University of Turin

Javne i privatne organizacije diljem svijeta sve se više bave unapređenjem zaštite na radu i u stalnoj su potrazi za obrazovanim stručnjacima. Stručnjakom zaštite na radu postaje se tijekom multidisciplinarnog osposobljavanja. Od 2012. Sveučilište u Torinu u suradnji s Međunarodnim centrom za osposobljavanje pri Međunarodnoj organizaciji rada (ITC-ILO) i Međunarodnoj komisiji za zaštitu na radu (ICOH) odgovorilo je na izazov i otvorilo studij na razini magisterija iz zaštite na radu. Cilj je utvrditi sustavnost i učinkovitost predloženog obrazovanja. Program je otvoren sudionicima iz razvijenih zemalja i zemalja u razvoju. Pored pripremne obrazovne faze putem interneta kojom sudionici različitih predznanja postižu odgovarajuću razinu znanja, ovaj program uključuje i rezidencijalni dio, na koji se nastavlja još jedno razdoblje učenja na daljinu kao priprema za disertaciju. Rezidencijalna faza u Torinu sastoji se od rada u učionici, studijskih posjeta odabranim poduzećima i, s tim u vezi, odgovarajućem osposobljavanju. Između 2007. i 2018. više od 300 sudionika prijavilo se za postdiplomski studij, a zatim za magisterij iz zaštite na radu. Dolazili su iz različitih sredina: javnih institucija, privatnih tvrtki i sveučilišta. Sudionika 65,7 % (SD 8,1%) upisalo je rezidencijalni program, a prosječna im je dob bila 38 godina (SD 7,4), 55,9 % (SD 5,2) završilo je magisterij. Korištene su različite strategije vrednovanja programa. Proječna ocjena zadovoljstva bila je visoka (4,28; SD 0,67). Na kraju osposobljavanja sudionici su naučili upravljati postupcima i tehnikama zaštite na radu kao i sustavima upravljanja zdravljem. Rezultati upitnika o učinkovitosti programa pokazuju korisnost i zadovoljstvo programom.Public and private sector organizations worldwide are increasingly concerned with improving occupational safety and health (OSH) and increasingly seek skilled OSH professionals. Becoming an OSH professional requires a multidisciplinary training. Since 2012, the University of Turin, along with the International Training Centre of the International Labour Organization (ITC-ILO), the International Labour Office (ILO) and the International Commission of Occupational Health (ICOH) collected this challenge and opened a master course in OSH. The aim is to assess the consistency and effectiveness of the emerging educational proposal. The proposed programme is opened to participants from both developing and developed countries. Besides a preparatory Internet-based Distance Learning Phase, enabling participants with different backgrounds to reach an adequate level of knowledge, this one-year programme includes a residential period, followed by another distance phase for the preparation of the dissertation. Residential Phase of Turin includes classroom training, study visits to selected enterprises and related training sessions. From 2007 to 2018 more than 300 participants applied first to the Postgraduate course and then to the Master in OSH, with variable occupational backgrounds such as public institutions, private companies and Universities. 65,7% (SD 8,1%) of the participants were enrolled to the Residential Phase, with a mean age of 38 years (SD 7,4), 55,9% (SD 5,2%) achieved the Master Degree. Different evaluation strategies were used. The average satisfaction survey score was high (4,28; SD 0,67). At the end of the training period, participants learnt to manage the use of OSH procedures and techniques and health management systems. The results of the profit and satisfaction questionnaires demonstrate the effectiveness of the course

Differential expression of long non-coding RNAs are related to proliferation and histological diversity in follicular lymphomas

Long non‐coding RNAs (lncRNAs) comprise a family of non‐coding transcripts that are emerging as relevant gene expression regulators of different processes, including tumour development. To determine the possible contribution of lncRNA to the pathogenesis of follicular lymphoma (FL) we performed RNA‐sequencing at high depth sequencing in primary FL samples ranging from grade 1‐3A to aggressive grade 3B variants using unpurified (n = 16) and purified (n = 12) tumour cell suspensions from nodal samples. FL grade 3B had a significantly higher number of differentially expressed lncRNAs (dif‐lncRNAs) with potential target coding genes related to cell cycle regulation. Nine out of the 18 selected dif‐lncRNAs were validated by quantitative real time polymerase chain reaction in an independent series (n = 43) of FL. RP4‐694A7.2 was identified as the top deregulated lncRNA potentially involved in cell proliferation. RP4‐694A7.2 silencing in the WSU‐FSCCL FL cell line reduced cell proliferation due to a block in the G1/S phase. The relationship between RP4‐694A7.2 and proliferation was confirmed in primary samples as its expression levels positively related to the Ki‐67 proliferation index. In summary, lncRNAs are differentially expressed across the clinico‐biological spectrum of FL and a subset of them, related to cell cycle, may participate in cell proliferation regulation in these tumours

Tularaemia: A challenging zoonosis

In recent years, several emerging zoonotic vector-borne infections with potential impact on human health have been identified in Europe, including tularaemia, caused by Francisella tularensis.This remarkable pathogen, one of the most virulent microorganisms currently known, has been detected in increasingly new settings and in a wide range of wild species, including lagomorphs, rodents, carnivores, fish and invertebrate arthropods. Also, a renewed concern has arisen with regard to F. tularensis: its potential use by bioterrorists. Based on the information published concerning the latest outbreaks, the aim of this paper is to review the main features of the agent, its biology, immunology and epidemiology. Moreover, special focus will be given to zoonotic aspects of the disease, as tularaemia outbreaks in human populations have been frequently associated with disease in animals

La renovación de la palabra en el bicentenario de la Argentina : los colores de la mirada lingüística

El libro reúne trabajos en los que se exponen resultados de investigaciones presentadas por investigadores de Argentina, Chile, Brasil, España, Italia y Alemania en el XII Congreso de la Sociedad Argentina de Lingüística (SAL), Bicentenario: la renovación de la palabra, realizado en Mendoza, Argentina, entre el 6 y el 9 de abril de 2010. Las temáticas abordadas en los 167 capítulos muestran las grandes líneas de investigación que se desarrollan fundamentalmente en nuestro país, pero también en los otros países mencionados arriba, y señalan además las áreas que recién se inician, con poca tradición en nuestro país y que deberían fomentarse. Los trabajos aquí publicados se enmarcan dentro de las siguientes disciplinas y/o campos de investigación: Fonología, Sintaxis, Semántica y Pragmática, Lingüística Cognitiva, Análisis del Discurso, Psicolingüística, Adquisición de la Lengua, Sociolingüística y Dialectología, Didáctica de la lengua, Lingüística Aplicada, Lingüística Computacional, Historia de la Lengua y la Lingüística, Lenguas Aborígenes, Filosofía del Lenguaje, Lexicología y Terminología

Prediction of mortality in premature neonates. An updated systematic review

Introducción La prematuridad extrema se asocia a altas tasas de mortalidad. Para profesionales y familias, es prioritario establecer de forma individualizada las probabilidades de muerte en diferentes momentos. El objetivo de este estudio es efectuar una revisión sistemática de modelos predictivos de mortalidad en prematuros publicados recientemente. Métodos Doble búsqueda de artículos publicados en PubMed sobre modelos predictivos de muerte en prematuros. Población estudiada: prematuros con edad gestacional ≤ 30 semanas o peso al nacer ≤ 1.500 g. Inclusión: trabajos publicados con nuevos modelos desde junio del 2010 hasta julio del 2019, tras revisión sistemática de Medlock (2011). Se valoran: población, características de modelos, variables utilizadas, medidas de funcionamiento y validación. Resultados De 7.744 referencias (primera búsqueda) y 1.435 (segunda búsqueda), se seleccionaron 31 trabajos, incluyéndose al final 8 nuevos modelos. Cinco modelos (62,5%) se desarrollaron en América del Norte y 2 (25%) en Europa. Un modelo secuencial (Ambalavanan) permite realizar predicciones de muerte al nacer, 7, 28 días de vida y 36 semanas posmenstruales. Análisis de regresión logística múltiple en el 87,5% de modelos. La discriminación poblacional se midió por odds ratio (75%) y área bajo la curva (50%). La «validación» se ha realizado en 5 modelos (interna). Tres modelos disponen de acceso online. No hay modelos predictivos validados en España. Conclusiones La toma de decisiones basada en modelos predictivos permite una mayor individualización de la atención dada a un niño prematuro y una mejor utilización de recursos. Es necesario desarrollar modelos de predicción de mortalidad en prematuros de España.Peer ReviewedPostprint (published version