Importance of Social Support of Parents of Children with Cancer: A Multicomponent Model Using Partial Least Squares-Path Modelling

he purpose of the present study is to build a model combining some variables that have been previously studied separately to improve our understanding on how they relate in parents of children with cancer. A total of 112 parents with an average age of 41 completed the self-assessment questionnaires containing the factors studied: social support received, social support provided, stress, adjustment of parents and life satisfaction. Two models were developed: one for social support received and one for social support provided. Structural equation models based on the variance estimated through partial least squares were used to analyze factors involved in quality of life based on an exploratory model of second order. The estimated model was robust in terms of quality of measurement (reliability and validity). According to results from the structural model, in the model of social support received, the impact of social support received on stress was considerable (β = −0.26; p = 0.02) and it explained 16% of the variance. The impact of social support received by parents on their adjustment (β = −0.56; p < 0.001) was also considerable, explaining 32% of the variance. Finally, adjustment of parents also showed an effect on life satisfaction (β = −0.33; p < 0.001) and it explained 26% of the variance. However, the relation between social support received (β = 0.15; p = 0.11) and life satisfaction, the relation between stress (β = −0.15; p = 0.08) and life satisfaction, and the relation between adjustment of parents (β = 0.20; p = 0.07) and stress were not significant. In the model of social support provided by parents, social support provided (β = 0.35; p < 0.001), and adjustment of parents (β = −0.31; p < 0.01) impacted life satisfaction, explaining 36% of the variance. Social support provided (β = −0.34; p < 0.01) impacted adjustment of parents and it explained 12% of the variance. (...)This work was supported by the Groups PAIDI, Junta de Andalucía, Spain [Grant Number HUM-590]. Partial funding for open access charge: Universidad de Málag

Impacto da poluição ambiental na superfície ocular de pacientes com síndrome de Sjögren

Purpose: To evaluate the effect of air pollution on the ocular surface of patients with Sjögren's syndrome. Methods: We investigated the ocular surfaces of thirty patients with Sjögren's syndrome and thirty healthy volunteers (control group) living in the Metropolitan Area of Buenos Aires. We used nitrogen dioxide as an indicator of exposure to air pollution. An ocular symptoms questionnaire was answered by all subjects, who also underwent a complete ocular surface ophthalmic examination-including an Ocular Surface Disease Index questionnaire, biomicroscopy, tear breakup time, Schirmer 1 test, corneal and conjunctival vital staining with fluorescein and lissamine green, tear lysozyme concentration, and impression cytology. Results: In almost all ocular surface test findings, we found a positive and significant correlation between higher levels of exposure to air pollution and higher levels of ocular surface damage in both the control group and Sjögren's syndrome patients. In Sjögren's syndrome patients, the Ocular Surface Disease Index questionnaire, tear breakup time, vital staining and impression cytology showed a significant correlation between high levels of air pollution and ocular surface disease. In the control group, the Ocular Surface Disease Index questionnaire, tear breakup time, and impression cytology showed a significant correlation between high levels of air pollution and ocular surface disease. Conclusions: Here we demonstrated that in patients with dry eye syndrome associated with Sjögren, abnormalities of the ocular surface and eye irritation related to air pollution are more severe than those in the control group. We believe that measuring air quality should be not only an integral part of the evaluation of ocular surface disease but also a therapeutic consideration.Objetivo: Avaliar o efeito da poluição do ar na superfície ocular de pacientes com síndrome de Sjögren. Métodos: Foram investigadas as superfícies oculares de trinta pacientes com síndrome de Sjögren e trinta voluntários saudáveis (grupo controle) residentes na Região Metropolitana de Buenos Aires. Usamos o dióxido de nitrogênio como um indicador de exposição à poluição do ar. Um questionário de sintomas oculares foi respondido por todos os indivíduos, que também foram submetidos a um exame oftalmológico completo da superfície ocular - incluindo um questionário do Índice da Doença da Superfície Ocular, biomicroscopia, tempo de ruptura do filme lacrimal, teste de Schirmer 1, coloração da córnea e conjuntiva com fluoresceína e lissamina verde, concentração de lisozima lacrimal e citologia de impressão. Resultados: Em quase todos os achados do teste de superfície ocular, encontramos uma correlação positiva e significativa entre níveis mais altos de exposição à poluição do ar e níveis mais elevados de danos na superfície ocular tanto no grupo controle quanto nos pacientes com síndrome de Sjögren. Em pacientes com síndrome de Sjögren, o questionário do Índice da Doença da Superfície Ocular, tempo de ruptura do filme lacrimal, coloração vital e citologia de impressão mostraram uma correlação significativa entre altos níveis de poluição do ar e doença da superfície ocular. No grupo controle, o questionário do Índice de Doenças da Superfície Ocular, tempo de ruptura do filme lacrimal e citologia de impressão mostraram uma correlação significativa entre altos níveis de poluição do ar e doença da superfície ocular. Conclusões: Aqui demonstramos que, pacientes com síndrome de olho seco associada a Sjögren, as anormalidades da superfície ocular e airritação ocular relacionadas à poluição do ar são mais graves do que aquelas no grupo controle. Acreditamos que a medição da qualidade do ar não deve ser apenas uma parte integral da avaliação da doença da superfície ocular, mas também uma consideração terapêutica.Fil: Galperín, Gustavo Javier. Hospital Oftalmológico Pedro Lagleyze; ArgentinaFil: Berra, Fabio Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Oftalmológico Pedro Lagleyze; ArgentinaFil: Marquez, Maria Isabel. Bioquímica Ocular; ArgentinaFil: Mandaradoni, Mariana. Hospital Nacional Professor Dr. Alejandro Posadas; ArgentinaFil: Tau, Julia. Laboratorio de Investigaciones Oculares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Berra, Alejandro. Laboratorio de Investigaciones Oculares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Relación de los equipos de trabajo en la organización

El objetivo concreto de este trabajo es presentar los resultados del análisis de bibliométrico de la base de datos Web of Science (WoS) concernientes a los estudios científicos referentes a la influencia que puede ejercer el líder emocionalmente inteligente en las relaciones del equipo de trabajo de una organización. El objetivo general es indagar en estudios desde sus comienzos hasta la actualidad mostrando los avances llevados a cabo al respecto en diferentes áreas. Se han considerado sólo 143 artículos escritos en inglés desde 2002 a 2021. Las clasificaciones consideradas son: Categorías WoS, años de publicación, revistas publicadas, autores. Entre otras ideas, en los últimos años se ha producido el mayor incremento de artículos publicados, con Estados Unidos a la cabeza del ranking de publicaciones. El autor que ha publicado más artículos es Astanasi con cuatro artículos. Finalmente, la revista que ha publicado más artículos ha sido Team Performance Management con 8 artículos.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

The antidepressant effect of hypericum perforatum extract Ze 117 is associated with reduced possibilities of drug interactions than hypericum perforatum extract LI 160.

Hypericum perforatum (HP) is the most extensively investigated medicinal herbs with antidepressant effect. Differences showed by HP extracts in their antidepressant effect and their clinical consequence of HP-drug interactions have been related with HP extract different composition, particularly regarding to their primary ingredients hyperforin and hypericin content. Experimental data and clinical trials have shown that low-hyperforin-content HP has a comparable antidepressant efficacy in the treatment of mild/moderate depression (1) (2). However, hyperforin is responsible for CYP3A4 induction via activation of a nuclear steroid/pregnane and xenobiotic receptor (SXR/PXR) and hypericin is a P-glycoprotein inducing compound (3), which are the main origin of HP-drug interactions. Changes in cytochrome P-450 (CYP-450) activity could modulate the effect of different drugs. Some of the reported interactions are based on findings from in vitro studies but the clinical importance of which remain to be demonstrated. Two different hypericum extracts, Ze 117 and LI 160, which are differently composed, Ze 117 (0.15-0.25% hypericin, 0.5% hyperforin) and LI 160 (0.3% hypericin, 4-6% hyperforin) were checked regarding their antidepressant-like activity vs. classical antidepressants with and without liver CYP 450 enzyme activity modulation by cimetidine. Experimental procedures followed the ECC Directives and were approved by local authorities. Male Wistar rats (n=6 per group, 6 months old, weight 314±25 g, Charles River-Spain) were injected (i.p. once a day) with Ze 117 (20 mg/kg, Zeller AG), LI 160 (20 mg/kg, Lichtwer Pharma AG), imipramine (IMI) (10.9 mg/kg, Novartis SL), fluoxetine (FLU) (5 mg/kg, Lilly and Dista) or saline (SAL), in presence and absence of cimetidine (CIM) (50 mg/kg, Rimsa) during 20 days. The forced swim test (4) was used for the evaluation of the antidepressant-like effect. The opend-field test was used for the evaluation of the motor activity. The total CYP 450 content of the liver was measure using spectrophotometry methods in liver microsomes. Results are expressed as mean±sem and were compared by Student t test and ANOVA test followed by Bonferroni post-test. The drugs antidepressant effect (reduction of the immobility time) ranking order was: i) without cimetidine’s CYP-450 inhibition: IMI 109±33s >Ze 117 163±21s =FLU165±29s >LI 160 201±234s >SAL 224±17s, pLI 160 144±13s >FLU 171±21s >Ze 117 188±10 >SAL 219±20s, pLI 160 >Ze 117 >SAL, p<0.05). LI 160 significantly reduced the liver CYP-450 total content with respect to SAL (-43.3%, p<0.05) while Ze 117 had lower effect (-25.9%, p<0.05). In conclusion, hypericum perforatum extract Ze 117 shows higher antidepressant effect and lower inhibitory effect of the total CYP 450 liver content than hypericum perforatum extract LI 160. Liver CYP 450 inhibition by cimetidine increased the antidepressant of LI 160 but did not modify the antidepressant effect of Ze 117. (1)Fiebich BL, Knörle R, Appel K et al. (2011) Fitoterapia 82(3):474-480. (2)Singer A, Schmidt M, Hauke W et al. (2011) Phytomedicine 18(8-9):739-742. (3)Mannel M. (2004) Drug Saf 27(11):773-797. (4)Castagné V, Moser P, Roux S et al. (2011) Curr Protoc Neurosci 55:8.10A.1-8.10A.14.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Aportaciones en Ciencias Agronómicas y Ambientales

de investigadores e investigadores independientes. En ese sentido, queremos otorgar un reconocimiento a quienes tuvieron la voluntad y el tino de apoyar esta iniciativa sobre trabajos relacionados con la quimica, biología, agronomía y medio ambiente

Calidad de vida de los padres de niños enfermos de cáncer: un modelo multicomponente

Introducción: El objetivo de este estudio es examinar las variables que contribuyen a la calidad de vida en padres de niños con cáncer. metodología: Un total de 112 padres con una edad media de 41 años completaron los cuestionarios de autoevaluación de las variables estudiadas referidas al apoyo social proporcionado, estrés, ajuste y satisfacción vital. La metodología de modelos de ecuaciones estructurales basados en la varianza estimado por mínimos cuadrados parciales se utilizó para examinar las variables que contribuyen a la calidad de vida a partir de un modelo exploratorio de segundo orden. Resultados: El modelo estimado fue robusto en cuanto a su calidad de medición (fiabilidad y validez). Según los resultados del modelo estructural, el apoyo social proporcionado por los padres y el ajuste de los padres influyen en la satisfacción vital y explicaron el 36 % de la varianza. El apoyo social proporcionado influye en el ajuste y explicó el 12 % de la varianza. El ajuste influye en la percepción de estrés y explica el 14 % de la varianza. Sin embargo, la relación entre apoyo social proporcionado y estrés, y la relación entre estrés y satisfacción vital, no fueron significativas. Conclusiones: El apoyo social proporcionado y el ajuste de los padres se asocian con la satisfacción vital de éstos. Además, el apoyo social proporcionado contribuye a disminuir los desajustes en diferentes áreas de la vida de los padres y a aumentar la satisfacción vital. Estos desajustes que se pueden producir aumentan el estrés y disminuyen la satisfacción vital. El modelo puede tener repercusión sobre la calidad de vida de los padres e implicaciones prácticas.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Análisis bibliométrico de Economía Azul / Bibliometric Analysis of Blue Economy

Poster del congreso VI ENCUENTRO INTERNACIONAL DE ESPECIALIZACIÓN PARA LA INVESTIGACIÓN EN ECONOMÍA Y EMPRESAThis is the first attempt at bibliometric analysis with SciMAT software from indexed article in the database Web of Science. It was conducted with general terms, only using the first original term Blue Economy. SciMat is a mapping analysis tool created to carry out mapping analysis in a longitudinal environment. Among other results, it is shown: Blue Economy is a new topic -first published as articles in 2002-. From each of the periods studied. (1) 2002-2017: the most important topics are two: 'Blue economy' and 'Economics'. (2) Secondly, between 2018-2019, the most representative words are: 'Carbon‑Economies', 'Fishing', and 'Oceans'. (3) Finally, in the last two years, 2020-2021 the most relevant cluster is the 'Blue Economy' itself. As limitations, ‘Blue-green economy' and 'Blue economy' maybe could be merged into one category or cluster, depending on whether considering or not the same definition.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Muscular function as an alternative to identify cognitive impairment : a secondary analysis from SABE Colombia

Antecedentes: La identificación del deterioro cognitivo se basa tradicionalmente en la pruebas neuropsicológicas y biomarcadores que no están ampliamente disponibles. Este estudio tuvo como objetivo establecer la asociación entre la función motora (velocidad de la marcha y fuerza) y el rendimiento cognitivo en el Mini-Examen del Estado Mental, a nivel mundial y por dominios. Un objetivo secundario fue calcular un punto de corte para la velocidad de la marcha y la prensión manual. fuerza para clasificar a los adultos mayores como con deterioro cognitivo. Métodos: Este es un análisis secundario de SABE Colombia (Salud, Bienestar & Envejecimiento), encuesta realizada en 2015 sobre salud, bienestar y envejecimiento en Colombia. Este estudio utilizó modelos de regresión lineal para buscar un asociación entre la función motora y el rendimiento cognitivo. La precisión del motor las mediciones de función en la identificación del deterioro cognitivo se evaluaron con el receptor curvas características de funcionamiento (ROC). Este estudio también analizó otros aspectos clínicos y variables sociodemográficas. Resultados: La velocidad de la marcha se asoció con la orientación (r2 = 0,16), idioma (r2 = 0.15), recordar memoria (r2 = 0.14), y contando (r2 = 0,08). Del mismo modo, la empuñadura la fuerza se asoció con la orientación (r2 = 0,175), idioma (r2 = 0.164), recordar memoria (r2 = 0.137), y contando (r2 = 0,08). Para diferenciar a los adultos mayores con y sin deterioro cognitivo, se tuvo un punto de corte de velocidad de la marcha de 0,59 m/s. un área bajo la curva (AUC) de 0,629 (0,613–0,646) y un agarre débil (resistencia por debajo de 17,5 kg) tenía un AUC de 0,653 (0,645-0,661). los puntos de corte para la fuerza de agarre y la velocidad de la marcha fueron significativamente mayores en los participantes masculinos. García-Cifuentes et al. Función muscular y deterioro cognitivo Conclusiones: La velocidad de la marcha y la fuerza de prensión se asocian de manera similar con la desempeño cognitivo, exhibiendo la asociación más extensa con la orientación y dominios lingüísticos del Mini-Examen del Estado Mental. Velocidad de marcha y prensión cualquier médico puede medir fácilmente la fuerza, y demuestran ser útiles para la detección herramientas para detectar el deterioro cognitivo. Palabras clave: velocidad de la marcha, fuerza de prensión manual, deterioro cognitivo, biomarcador, demencia preclínica, motora disfunciónQ2Q2Background: Identification of cognitive impairment is based traditionally on the neuropsychological tests and biomarkers that are not available widely. This study aimed to establish the association between motor function (gait speed and handgrip strength) and cognitive performance in the Mini-Mental State Examination, globally and by domains. A secondary goal was calculating a cut-off point for gait speed and handgrip strength to classify older adults as cognitively impaired. Methods: This is a secondary analysis of SABE Colombia (Salud, Bienestar & Envejecimiento), a survey that was conducted in 2015 on health, wellbeing, and aging in Colombia. This study used linear regression models to search for an association between motor function and cognitive performance. The accuracy of motor function measurements in identifying cognitive impairment was assessed with receiver operating characteristic (ROC) curves. This study also analyzed other clinical and sociodemographical variables. Results: Gait speed was associated with orientation (r2 = 0.16), language (r2 = 0.15), recall memory (r2 = 0.14), and counting (r2 = 0.08). Similarly, handgrip strength was associated with orientation (r2 = 0.175), language (r2 = 0.164), recall memory (r2 = 0.137), and counting (r2 = 0.08). To differentiate older adults with and without cognitive impairment, a gait speed cut-off point of 0.59 m/s had an area under the curve (AUC) of 0.629 (0.613–0.646), and a weak handgrip (strength below 17.5 kg) had an AUC of 0.653 (0.645-0.661). The cut-off points for handgrip strength and gait speed were significantly higher in male participants. Conclusions: Gait speed and handgrip strength are similarly associated with the cognitive performance, exhibiting the most extensive association with orientation and language domains of the Mini-Mental State Examination. Gait speed and handgrip strength can easily be measured by any clinician, and they prove to be useful screening tools to detect cognitive impairment.https://orcid.org/0000-0001-5680-7880https://scholar.google.com/citations?view_op=search_authors&mauthors=carlos+alberto+cano-gutierrez&hl=es&oi=aohttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000054895&lang=nullRevista Nacional - Indexad

Smart Solar Micro-exchangers for Sustainable Mobility of University Camps

Publicado el resumen en: https://www.wmcaus.org/files/WMCAUS2020_Book.pdf. Pendiente de publicación de las contribuciones en IOP Conference Series: Materials Science and Engineering.A significant number of universities have several campuses located in urban or rural settings, or with scattered university buildings that require the use of means of transportation. This implies the mobility and potential displacement of a large community of students, professors and researchers. The use of electric bicycles (e-bikes) is an intermediate alternative between the bicycle and electric cars. It can be an important stimulus for the promotion of the decarbonisation of the University Campus, avoiding the traffic congestion and reducing space requirements for parking. This paper presents the smart solar micro-exchanger model managed through a sustainable mobility web platform, applied to the case study of the University of Malaga (Spain). It is a solar charging station for e-bike, whose design is based on the principles of solar architecture (providing great security to e-bike). It managed by a web platform and app that allows the user to make reservations and learn about the savings in CO2 emissions. The system allows performing an aerobic sports activity without sweating problems when you reach the job. The platform also incorporates a database of quiet and safe routes for e-bike users.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Bioética. El final de la vida y las voluntades anticipadas

Esta obra contiene textos elaborados por investigadores de diferentes áreas del conocimiento: medicina, filosofía, derecho, entre otras especialidades, pertenecientes a distintos países: España, Chile y México. El objetivo principal de este libro es servir de referente teórico a otros investigadores de bioética, y especialmente a los que son o desean estar especializados en la comprensión del final de la vida y las voluntades anticipadas en el ámbito sanitario en cualquier país del mundo