Selecting Insulating Materials for Building Envelope: A Life Cycle Approach

This paper aims at assessing the embodied energy and greenhouse gas emissions (GHGs) of two building envelopes, designed for a two floors semi-detached house located in the Central Italy. The analysis is performed by applying the Life Cycle Assessment methodology, following a from cradle-to-gate approach. Fixtures (windows and doors), external and internal opaque walls, roof and floors (including interstorey floors) make the building envelopes. Their stratigraphy allows for achieving the thermal transmittance values established in the Italian Decree on energy performance of buildings. The two examined envelopes differ only for the insulation material: extruded expanded polystyrene (XPS) or cellulose fibers. The results shows that the envelope using cellulose fibers has better performance than that using XPS: it allows for reducing the embodied energy and the GHGs of about 13% and 9.3%, respectively. A dominance analysis allows to identify the envelope components responsible of the higher impacts and the contribution of the insulating material to the impacts. The study is part of the Italian research “Analysis of the energy impacts and greenhouse gas emissions of technologies and components for the energy efficiency of buildings from a life cycle perspective” funded by the Three-year Research Plan within the National Electricity System 2019-2021

Impaired sense of smell in a Drosophila Parkinson's model.

Parkinson’s disease (PD) is one of the most common neurodegenerative disease characterized by the clinical triad: tremor, akinesia and rigidity. Several studies have suggested that PD patients show disturbances in olfaction at the earliest onset of the disease. The fruit fly Drosophila melanogaster 32 is becoming a powerful model organism to study neurodegenerative diseases. We sought to use this system to explore olfactory dysfunction, if any, in PINK1 mutants, which is a model for PD. PINK1 mutants display many important diagnostic symptoms of the disease such as akinetic motor behavior. In the present study, we describe for the first time, to the best of our knowledge, neurophysiological and neuroanatomical results concerning the olfactory function in PINK1 mutant flies. Electroantennograms were recorded in response to synthetic and natural volatiles (essential oils) from groups of PINK1 mutant adults at three different time points in their life cycle: one from 3-5 day-old flies, from 15-20 and from 27-30 days. The results obtained were compared with the same age-groups of wild type flies. We found that mutant adults showed a decrease in the olfactory response to 1-hexanol, α-pinene and essential oil volatiles. This olfactory response in mutant adults decreased even more as the flies aged. Immunohistological analysis of the antennal lobes in these mutants revealed structural abnormalities, especially in the expression of Bruchpilot protein, a marker for synaptic active zones. The combination of electrophysiological and morphological results suggests that the altered synaptic organization may be due to a neurodegenerative process. Our results indicate that this model can be used as a tool for understanding PD pathogensis and pathophysiology. These results help to explore the potential of using olfaction as a means of monitoring PD progression and developing new treatments

Twenty years of the Italian Fanconi Anemia Registry: where we stand and what remains to be learned

The natural history of Fanconi anemia remains hard to establish because of its rarity and its heterogeneous clinical presentation; since 1994, the Italian Fanconi Anemia Registry has collected clinical, epidemiological and genetic data of Italian Fanconi Anemia patients. This registry includes 180 patients with a confirmed diagnosis of Fanconi anemia who have either been enrolled prospectively, at diagnosis, or later on. After enrollment, follow-up data were periodically collected to assess the clinical course, possible complications and long-term survival; the median follow up was 15.6 years. The main goal of the study was to describe the natural history of Fanconi anemia, focusing on the following variables: family history, disease presentation, development of hematological manifestations, development of malignancies, occurrence of hematopoietic stem cell transplantation and survival. Typical morphological and/or hematological abnormalities and/or growth retardation were the most common manifestations at diagnosis; the majority of patients (77%) exhibited hematological abnormalities at the initial presentation, and almost all (96%) eventually developed hematological manifestations. More than half of the patients (57%) underwent a bone-marrow transplant. The occurrence of cancer was quite rare at diagnosis, whereas the cumulative incidence of malignancies at 10, 20 and 30 years was 5%, 8% and 22%, respectively, for hematological cancers and 1%, 15% and 32%, respectively, for solid tumors. Overall survival at 10, 20 and 30 years were 88%, 56% and 37%, respectively; the main causes of death were cancer, complications of the hematological presentation and complications of transplantation. These data clearly confirm the detrimental outcome of Fanconi anemia, with no major improvement in the past decades

The effects of the overriding plate thermal state on the slab dip in an ocean-continent subduction system

To evaluate the effects of variations in the thermal state of the overriding plate on the slab dip in an ocean-continent subduction system, a 2-D finite element thermo-mechanical model was implemented. The lithosphere base was located at the depth of the 1600 K isotherm. Numerical simulations were performed while taking into account four different initial thicknesses for the oceanic lithosphere (60, 80, 95 and 110 km) and five different thicknesses of the overriding plate, as compared in terms of the continental-oceanic plate thickness ratio (100, 120, 140, 160 and 200% of the oceanic lithosphere thickness). The results of numerical modeling indicate that a high variability of the subducting plate geometry occurs for an oceanic lithosphere thickness ranging from 60 to 80 km, while the variability decreases where the oceanic plates are thicker (95 and 110 km). Furthermore, the slab dip strongly depends on the thermal state of the overriding plate, and, in particular, the slab dip decreases with the increase in the upper plate thickness. The model predictions also confirm that a direct correlation between the slab dip and the age of the oceanic lithosphere does not exist, at least for subduction plates thinner that 110 km. These conclusions are supported by the good agreement between the model results and the natural data referring to worldwide ocean-continent subduction zones.Comment: 7 figures, 1 tabl

Functional and morphological correlates in the drosophila LRRK2 loss-of-function model of Parkinson's disease: drug effects of Withania somnifera (Dunal) administration

The common fruit fly Drosophila melanogaster (Dm) is a simple animal species that contributed significantly to the development of neurobiology whose leucine-rich repeat kinase 2 mutants (LRRK2) loss-of-function in the WD40 domain represent a very interesting tool to look into physiopathology of Parkinson's disease (PD). Accordingly, LRRK2 Dm have also the potential to contribute to reveal innovative therapeutic approaches to its treatment. Withania somnifera Dunal, a plant that grows spontaneously also in Mediterranean regions, is known in folk medicine for its anti-inflammatory and protective properties against neurodegeneration. The aim of this study was to evaluate the neuroprotective effects of its standardized root methanolic extract (Wse) on the LRRK2 loss-of-function Dm model of PD. To this end mutant and wild type (WT) flies were administered Wse, through diet, at different concentrations as larvae and adults (L+/A+) or as adults (L-/A+) only. LRRK2 mutants have a significantly reduced lifespan and compromised motor function and mitochondrial morphology compared toWT flies 1% Wse-enriched diet, administered to Dm LRRK2 as L-/A+and improved a) locomotor activity b) muscle electrophysiological response to stimuli and also c) protected against mitochondria degeneration. In contrast, the administration of Wse to Dm LRRK2 as L+/A+, no matter at which concentration, worsened lifespan and determined the appearance of increased endosomal activity in the thoracic ganglia. These results, while confirming that the LRRK2 loss-of-function in the WD40 domain represents a valid model of PD, reveal that under appropriate concentrations Wse can be usefully employed to counteract some deficits associated with the disease. However, a careful assessment of the risks, likely related to the impaired endosomal activity, is require

The Gravity Effect of Topography: A Comparison among Three Different Methods

In this paper, three different methods for computing the terrain correction have been compared. The terrain effect has been accounted for by using the standard right parallelepiped closed formula, the spherical tesseroid and the flat tesseroid formulas. Particularly, the flat tesseroid approximation is obtained by flattening the top and the bottom sides of the spherical tesseroid. Its gravitational effect can be computed as the gravitational effect of a polyhedron, i.e. a three-dimensional body with flat polygonal faces, straight edges and sharp corners or vertices. These three methods have been applied in the context of a Bouguer reduction scheme. Two tests were devised in the Alpine area in order to quantify possible discrepancies. In the first test, the terrain correction has been evaluated on a grid of points on the DTM. In the second test, Bouguer gravity anomalies were computed on sparse observed gravity data points. The results prove that the three methods are practically equivalent even in an area of rough topography though, in the second test, the Bouguer anomalies obtained by using the tesseroid and the flat tesseroid formulas have slightly smaller RMSs than the one obtained by applying the standard right parallelepiped formula