Mental Health and Unemployment in Scotland: Understanding the impactof welfare reforms in Scotland for individuals with mental health conditions

During 2016, 30 individuals with a mental health condition (who claimed ESA, have had their ESA withdrawn and moved on to JSA, or have been directed into the WRAG group based on the decision of the WCA) were interviewed. The 30 participants were recruited throughout Scotland. In addition, we interviewed seven individuals who had involvement with various intermediaries, such as advocacy organisations, collective advocacy groups, Citizens Advice Bureau and (an ex employee of) Ingeus. Participants were recruited through advocacy organisations, voluntary groups and the local media. Overall, we established that the Work Capability Assessment (WCA) does not inspire confidence in participants in its adequacy for assessing mental health problems. There is concern that the assessors do not appear to have appropriate expertise in mental health. The WCA experience for many, caused a deterioration in people’s mental health which individuals did not recover from. In the worst cases, the WCA experience led to thoughts of suicide. People felt that that there was an inconsistency in terms of GP recommendations and the WCA recommendations. Many people were subject to further upset and distress due to communication from the DWP being lost in the post. Having a mental health condition (MHC) in parallel with being unemployed and on benefits leads individuals to be confronted with multiple and competing stigmas, which they find hard to manage and these become self-reinforcing and self-perpetuating. The WCA and other mandatory structures, work against individuals developing or retaining employability skills as voluntary work is seen as demonstrating fitness for work; education is also not possible whilst receiving ESA. The system fails to recognise that for many, volunteering is good for wellbeing and may be ‘as good as it gets’. Whilst the Scottish Government does not have control over the ESA component of Universal Credit, it needs to carefully consider how any benefits that is does have control over (e.g. DLA) are assessed and managed for people with a MHC. Moreover, as control over the Work Programme and Work Choice is to be devolved to Scotland, the Scottish Government should develop replacement programmes which are appropriate to people with mental health problems which can also work in parallel with the benefits system

Mental Health and Unemployment in Scotland: Understanding the impactof welfare reforms in Scotland for individuals with mental health conditions

During 2016, 30 individuals with a mental health condition (who claimed ESA, have had their ESA withdrawn and moved on to JSA, or have been directed into the WRAG group based on the decision of the WCA) were interviewed. The 30 participants were recruited throughout Scotland. In addition, we interviewed seven individuals who had involvement with various intermediaries, such as advocacy organisations, collective advocacy groups, Citizens Advice Bureau and (an ex employee of) Ingeus. Participants were recruited through advocacy organisations, voluntary groups and the local media. Overall, we established that the Work Capability Assessment (WCA) does not inspire confidence in participants in its adequacy for assessing mental health problems. There is concern that the assessors do not appear to have appropriate expertise in mental health. The WCA experience for many, caused a deterioration in people’s mental health which individuals did not recover from. In the worst cases, the WCA experience led to thoughts of suicide. People felt that that there was an inconsistency in terms of GP recommendations and the WCA recommendations. Many people were subject to further upset and distress due to communication from the DWP being lost in the post. Having a mental health condition (MHC) in parallel with being unemployed and on benefits leads individuals to be confronted with multiple and competing stigmas, which they find hard to manage and these become self-reinforcing and self-perpetuating. The WCA and other mandatory structures, work against individuals developing or retaining employability skills as voluntary work is seen as demonstrating fitness for work; education is also not possible whilst receiving ESA. The system fails to recognise that for many, volunteering is good for wellbeing and may be ‘as good as it gets’. Whilst the Scottish Government does not have control over the ESA component of Universal Credit, it needs to carefully consider how any benefits that is does have control over (e.g. DLA) are assessed and managed for people with a MHC. Moreover, as control over the Work Programme and Work Choice is to be devolved to Scotland, the Scottish Government should develop replacement programmes which are appropriate to people with mental health problems which can also work in parallel with the benefits system

Zoonoses: From panic to planning

Over two thirds of all human infectious diseases have their origins in animals. The rate at which these zoonotic diseases have appeared in people has increased over the past 40 years, with at least 43 newly identified outbreaks since 2004. In 2012, outbreaks included Ebola in Uganda (see Ebola box), yellow fever in the Democratic Republic of Congo and Rift Valley fever (RVF) in Mauritania. Zoonotic diseases have a huge impact – and a disproportionate one on the poorest people in the poorest countries. In low-income countries, 20% of human sickness and death is due to zoonoses. Poor people suffer further when development implications are not factored into disease planning and response strategies. A new, integrated ‘One Health’ approach to zoonoses that moves away from top-down disease-focused intervention is urgently needed. With this, we can put people first by factoring development implications into disease preparation and response strategies – and so move from panic to planning.Ecosystem Services for Poverty Alleviation (ESPA), DFI

Reporting on patient and public involvement (PPI) in research publications: Using the GRIPP2 checklists with lay co-researchers

© The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License. https://creativecommons.org/licenses/by/4.0/Background: Patient and public involvement (PPI) in health and social care research is considered important internationally, with increasing evidence that PPI improves the quality, relevance and outcomes of research. There has been a growth in research publications that describe PPI in the research process, but the frequency and detail of PPI reporting varies considerably. This paper reports on a collaborative study that aimed to describe the extent of PPI in publications from research funded by the Collaboration for Leadership in Applied Health Research and Care (CLAHRC) in the East of England (EoE), part of the National Institute of Health Research (NIHR) in England (2014-2019). Methods: A descriptive study of all research publications (1st January 2014 to 31st October 2017) funded by the NIHR CLAHRC EoE. Members of the Public Involvement in Research group (PIRg), at the University of Hertfordshire, were actively involved, with four PIRg co-researchers. We used an internationally recognised reporting checklist for PPI called the GRIPP2 (Guidance for Reporting Involvement of Patients and the Public, Version 2) to guide the reviewing process. Results: Out of 148 research papers identified, 16 (14%) reported some aspect of PPI activity and were included for review. Ten of the publications (63%) acknowledged the contributions of PPI individuals and/or groups and five had PPI co-authors. There was considerable variation in the PPI reported in the publications, with some ‘missed opportunities’ to provide detail of PPI undertaken. The perspectives of the co-researchers shaped the reporting of the results from this study. The co-researchers found the GRIPP2-SF (short form) to be useful, but the GRIPP2-LF (long form) was considered over complicated and not user-friendly. Conclusions: This is one of the first studies to involve lay co-researchers in the review of PPI reporting using the GRIPP2 reporting checklists (GRIPP2-SF and GRIPP2-LF). We make recommendations for a revised version of the GRIPP2-SF, with clearer instructions and three additional sections to record whether PPI is reported in the abstract or key words, in the acknowledgements section, and whether there are PPI co-authors. We also recommend the provision of training and support for patient and public peer reviewers.Peer reviewe

Lessons learned from early adopters of blended and online learning

In 2013, the University of Glasgow published an e-learning strategy, setting out a vision for the University’s digital education delivery between 2013 and 2020. The strategy’s aim, in part, was the creation of personalised, interactive and feedback-rich courses, and staff were noted as key enablers of the strategic priorities. As a result of this strategy, several initiatives were developed, including the creation of massive open online courses (MOOCs), the implementation of the Blended and Online Learning Development (BOLD) project, which led to the creation of fully online PGT masters programmes, blended Undergraduate courses, and eventually, the creation of a Digital Education unit. More recently, micro-credential courses have been developed, which bridge the gap between MOOCs and full online accredited programmes. Finally, in 2020, the COVID-19 pandemic led to the rapid pivot to remote teaching. In this article, we describe the roles, challenges and opportunities of early adopters in a number of these initiatives across the University, giving a reflective account of our lessons learnt and recommendations for staff involved in similar initiatives

Genes Are Often Sheltered from the Global Histone Hyperacetylation Induced by HDAC Inhibitors

Histone deacetylase inhibitors (HDACi) are increasingly used as therapeutic agents, but the mechanisms by which they alter cell behaviour remain unclear. Here we use microarray expression analysis to show that only a small proportion of genes (∼9%) have altered transcript levels after treating HL60 cells with different HDACi (valproic acid, Trichostatin A, suberoylanilide hydroxamic acid). Different gene populations respond to each inhibitor, with as many genes down- as up-regulated. Surprisingly, HDACi rarely induced increased histone acetylation at gene promoters, with most genes examined showing minimal change, irrespective of whether genes were up- or down-regulated. Many genes seem to be sheltered from the global histone hyperacetyation induced by HDACi

Calcineurin Selectively Docks with the Dynamin Ixb Splice Variant to Regulate Activity-dependent Bulk Endocytosis

Depolarization of nerve terminals stimulates rapid dephosphorylation of two isoforms of dynamin I (dynI), mediated by the calcium-dependent phosphatase calcineurin (CaN). Dephosphorylation at the major phosphorylation sites Ser-774/778 promotes a dynI-syndapin I interaction for a specific mode of synaptic vesicle endocytosis called activity-dependent bulk endocytosis (ADBE). DynI has two main splice variants at its extreme C terminus, long or short (dynIxa and dynIxb) varying only by 20 (xa) or 7 (xb) residues. Recombinant GST fusion proteins of dynIxa and dynIxb proline-rich domains (PRDs) were used to pull down interacting proteins from rat brain nerve terminals. Both bound equally to syndapin, but dynIxb PRD exclusively bound to the catalytic subunit of CaNA, which recruited CaNB. Binding of CaN was increased in the presence of calcium and was accompanied by further recruitment of calmodulin. Point mutations showed that the entire C terminus of dynIxb is a CaN docking site related to a conserved CaN docking motif (PXIXI(T/S)). This sequence is unique to dynIxb among all other dynamin variants or genes. Peptide mimetics of the dynIxb tail blocked CaN binding in vitro and selectively inhibited depolarization-evoked dynI dephosphorylation in nerve terminals but not of other dephosphins. Therefore, docking to dynIxb is required for the regulation of both dynI splice variants, yet it does not regulate the phosphorylation cycle of other dephosphins. The peptide blocked ADBE, but not clathrin-mediated endocytosis of synaptic vesicles. Our results indicate that Ca(2+) influx regulates assembly of a fully active CaN-calmodulin complex selectively on the tail of dynIxb and that the complex is recruited to sites of ADBE in nerve terminals

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts