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Weapons of mouse destruction: a 3D strategy for combating cut-and-paste plagiarism using the JISC Plagiarism Advisory Service
This article describes an action research project undertaken in the Business Information Technology (BIT) subject group of a post-1992 University Business School to combat the growing menace of cut-and-paste plagiarism. The authors regard plagiarism—the passing off as one’s own, the words and ideas of another—as an academic malpractice that should be deterred, detected and dealt with appropriately. We use these three themes, or dimensions, to structure our account here of an expanding portfolio of tools and techniques we have deployed over a period of three years. Recently the Joint Information Systems Committee’s (JISC) Plagiarism Advisory Service (PAS) has become central to our efforts, and whilst it is certainly useful in structuring student perceptions, detecting and highlighting sections of cut and paste, and providing professional disciplinary evidence, we draw attention to the potentially pivotal role it can play in structuring student perceptions of plagiarism. In particular, we advise that the JISC PAS is used carefully as part of a more considered approach to student plagiarism rather than as a quick and easy panacea. Pilot studies carried out across six undergraduate and postgraduate units have revealed a growing awareness, amongst both academic and student enthusiasts, of the strengths and limitations of this service. Potentially, these limitations, combined with the restricted sanctions available according to university regulations, could constitute a small risk that some students may calculate and be willing to take. We feel it is important whilst working within this framework to adopt other complimentary strategies in order to make the wholesale or part copying of another’s work an irrational choice, even for the desperate student. This article draws upon current plagiarism literature, field observations and a survey of plagiarism perceptions conducted on over 150 final year undergraduate students. We present the findings from our ongoing action research in the form of a ‘3D’ strategy that attempts to share best practice in deterring, detecting, and dealing appropriately with cut-and-paste plagiarism. Our findings indicate that students do perceive the JISC PAS as effective across all three dimensions, but this perception can be altered significantly depending upon how the service is presented as part of a broader set of strategies to combat student plagiarism. In particular, we have found that allowing students to see the comparison report output from the JISC PAS, not only heightens student anxiety regarding speculative accusations of plagiarism, but also significantly reduces their confidence in the service as a reliable and effective detection method
Beneficial effects of exercise: shifting the focus from body weight to other markers of health
Background: Exercise is widely promoted as a method of weight management, while the other health benefits are often ignored. The purpose of this study was to examine whether exercise-induced improvements in health are influenced by changes in body weight. Methods: Fifty-eight sedentary overweight/obese men and women (BMI 31.8 (SD 4.5) kg/m2) participated in a 12-week supervised aerobic exercise intervention (70% heart rate max, five times a week, 500 kcal per session). Body composition, anthropometric parameters, aerobic capacity, blood pressure and acute psychological response to exercise were measured at weeks 0 and 12. Results: The mean reduction in body weight was −3.3 (3.63) kg (p<0.01). However, 26 of the 58 participants failed to attain the predicted weight loss estimated from individuals’ exercise-induced energy expenditure. Their mean weight loss was only −0.9 (1.8) kg (p<0.01). Despite attaining a lower-than-predicted weight reduction, these individuals experienced significant increases in aerobic capacity (6.3 (6.0) ml/kg/min; p<0.01), and a decreased systolic (−6.00 (11.5) mm Hg; p<0.05) and diastolic blood pressure (−3.9 (5.8) mm Hg; p<0.01), waist circumference (−3.7 (2.7) cm; p<0.01) and resting heart rate (−4.8 (8.9) bpm, p<0.001). In addition, these individuals experienced an acute exercise-induced increase in positive mood. Conclusions: These data demonstrate that significant and meaningful health benefits can be achieved even in the presence of lower-than-expected exercise-induced weight loss. A less successful reduction in body weight does not undermine the beneficial effects of aerobic exercise. From a public health perspective, exercise should be encouraged and the emphasis on weight loss reduced
Large-scale curriculum redesign where technology plays a central role
VIDEO RECORDINGS: http://goo.gl/bGTaF
Materials from the conference held in Birmingham on 21 May 2012. The event was organised by the Association for Learning Technology (ALT) and the Association of Colleges (AoC).
Links to all recordings from the day are now available via http://goo.gl/bGTaF. Note that Donald Clarke's session does not contain video except slides
Changes in physical activity behavior and risk of falls over 8 years follow-up: English longitudinal study of ageing
Changes in physical activity behavior and risk of falls over 8 years follow-up: English longitudinal study of agein
A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of β-N-acetylglucosaminidases
The synthesis of an analogue of 6-epi-valienamine bearing an acetamido group and its characterisation as an inhibitor of β-N-acetylglucosaminidases are described. The compound is a good inhibitor of both human O-GlcNAcase and human β-hexosaminidase, as well as two bacterial β-N-acetylglucosaminidases. A 3-D structure of the complex of Bacteroides thetaiotaomicron BtGH84 with the inhibitor shows the unsaturated ring is surprisingly distorted away from its favoured solution phase conformation and reveals potential for improved inhibitor potency
Lightcurves of Type Ia Supernovae from Near the Time of Explosion
We present a set of 11 type Ia supernova (SN Ia) lightcurves with dense,
pre-maximum sampling. These supernovae (SNe), in galaxies behind the Large
Magellanic Cloud (LMC), were discovered by the SuperMACHO survey. The SNe span
a redshift range of z = 0.11 - 0.35. Our lightcurves contain some of the
earliest pre-maximum observations of SNe Ia to date. We also give a functional
model that describes the SN Ia lightcurve shape (in our VR-band). Our function
uses the "expanding fireball" model of Goldhaber et al. (1998) to describe the
rising lightcurve immediately after explosion but constrains it to smoothly
join the remainder of the lightcurve. We fit this model to a composite observed
VR-band lightcurve of three SNe between redshifts of 0.135 to 0.165. These SNe
have not been K-corrected or adjusted to account for reddening. In this
redshift range, the observed VR-band most closely matches the rest frame
V-band. Using the best fit to our functional description of the lightcurve, we
find the time between explosion and observed VR-band maximum to be
17.6+-1.3(stat)+-0.07(sys) rest-frame days for a SN Ia with a VR-band Delta
m_{-10} of 0.52mag. For the redshifts sampled, the observed VR-band
time-of-maximum brightness should be the same as the rest-frame V-band maximum
to within 1.1 rest-frame days.Comment: 35 pages, 18 figures, 15 tables; Higher quality PDF available at
http://ctiokw.ctio.noao.edu/~sm/sm/SNrise/index.html; AJ accepte
Archosauromorph extinction selectivity during the Triassic–Jurassic mass extinction
Many traits have been linked to extinction risk among modern vertebrates, including mode of life and body size. However, previous work has indicated there is little evidence that body size, or any other trait, was selective during past mass extinctions. Here, we investigate the impact of the Triassic–Jurassic mass extinction on early Archosauromorpha (basal dinosaurs, crocodylomorphs and their relatives) by focusing on body size and other life history traits. We built several new archosauromorph maximum-likelihood supertrees, incorporating uncertainty in phylogenetic relationships. These supertrees were then employed as a framework to test whether extinction had a phylogenetic signal during the Triassic–Jurassic mass extinction, and whether species with certain traits were more or less likely to go extinct. We find evidence for phylogenetic signal in extinction, in that taxa were more likely to become extinct if a close relative also did. However, there is no correlation between extinction and body size, or any other tested trait. These conclusions add to previous findings that body size, and other traits, were not subject to selection during mass extinctions in closely-related clades, although the phylogenetic signal in extinction indicates that selection may have acted on traits not investigated here.ISSN:0031-0239ISSN:1475-498
Velocity Segregation and Systematic Biases In Velocity Dispersion Estimates With the SPT-GMOS Spectroscopic Survey
The velocity distribution of galaxies in clusters is not universal; rather,
galaxies are segregated according to their spectral type and relative
luminosity. We examine the velocity distributions of different populations of
galaxies within 89 Sunyaev Zel'dovich (SZ) selected galaxy clusters spanning . Our sample is primarily draw from the SPT-GMOS spectroscopic
survey, supplemented by additional published spectroscopy, resulting in a final
spectroscopic sample of 4148 galaxy spectra---2868 cluster members. The
velocity dispersion of star-forming cluster galaxies is % greater than
that of passive cluster galaxies, and the velocity dispersion of bright () cluster galaxies is % lower than the velocity dispersion of
our total member population. We find good agreement with simulations regarding
the shape of the relationship between the measured velocity dispersion and the
fraction of passive vs. star-forming galaxies used to measure it, but we find a
small offset between this relationship as measured in data and simulations in
which suggests that our dispersions are systematically low by as much as 3\%
relative to simulations. We argue that this offset could be interpreted as a
measurement of the effective velocity bias that describes the ratio of our
observed velocity dispersions and the intrinsic velocity dispersion of dark
matter particles in a published simulation result. Measuring velocity bias in
this way suggests that large spectroscopic surveys can improve dispersion-based
mass-observable scaling relations for cosmology even in the face of velocity
biases, by quantifying and ultimately calibrating them out.Comment: Accepted to ApJ; 21 pages, 11 figures, 5 table
Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins.
Funder: AstraZenecaFunder: AstraZeneca postdoc fundBromodomain-containing protein 4 (BRD4) is an epigenetic reader and oncology drug target that regulates gene transcription through binding to acetylated chromatin via bromodomains. Phosphorylation by casein kinase II (CK2) regulates BRD4 function, is necessary for active transcription and is involved in resistance to BRD4 drug inhibition in triple-negative breast cancer. Here, we provide the first biophysical analysis of BRD4 phospho-regulation. Using integrative structural biology, we show that phosphorylation by CK2 modulates the dimerization of human BRD4. We identify two conserved regions, a coiled-coil motif and the Basic-residue enriched Interaction Domain (BID), essential for the BRD4 structural rearrangement, which we term the phosphorylation-dependent dimerization domain (PDD). Finally, we demonstrate that bivalent inhibitors induce a conformational change within BRD4 dimers in vitro and in cancer cells. Our results enable the proposal of a model for BRD4 activation critical for the characterization of its protein-protein interaction network and for the development of more specific therapeutics
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