Vowel-Length Contrasts and Phonetic Cues to Stress: An Investigation of their Relation

The functional load hypothesis of Berinstein (1979) put forward the idea that languages which use a suprasegmental property (duration, F0) contrastively will not use it to realise stress. The functional load hypothesis is often cited when stress correlates are discussed, both when it is observed that the language under discussion follows the hypothesis and when it fails to follow it. In the absence of a more wide-ranging assessment of how frequently languages do or do not conform to the functional load hypothesis, it is unknown whether it is an absolute, a strong tendency, a weak tendency or unsupported. The results from a database of reported stress correlates and use of contrastive duration for 140 languages are presented and discussed. No support for the functional load hypothesis is found

Axoneme-specific β-tubulin specialization a conserved C-terminal motif specifies the central pair

AbstractAxonemes are ancient organelles that mediate motility of cilia and flagella in animals, plants, and protists. The long evolutionary conservation of axoneme architecture, a cylinder of nine doublet microtubules surrounding a central pair of singlet microtubules, suggests all motile axonemes may share common assembly mechanisms. Consistent with this, α- and β-tubulins utilized in motile axonemes fall among the most conserved tubulin sequences [1, 2], and the β-tubulins contain a sequence motif at the same position in the carboxyl terminus [3]. Axoneme doublet microtubules are initiated from the corresponding triplet microtubules of the basal body [4], but the large macromolecular “central apparatus” that includes the central pair microtubules and associated structures [5] is a specialization unique to motile axonemes. In Drosophila spermatogenesis, basal bodies and axonemes utilize the same α-tubulin but different β-tubulins [6–13]. β1 is utilized for the centriole/basal body, and β2 is utilized for the motile sperm tail axoneme. β2 contains the motile axoneme-specific sequence motif, but β1 does not [3]. Here, we show that the “axoneme motif” specifies the central pair. β1 can provide partial function for axoneme assembly but cannot make the central microtubules [14]. Introducing the axoneme motif into the β1 carboxyl terminus, a two amino acid change, conferred upon β1 the ability to assemble 9 + 2 axonemes. This finding explains the conservation of the axoneme-specific sequence motif through 1.5 billion years of evolution

The RESOLVE and ECO Gas in Galaxy Groups Initiative: The Group Finder and the Group H i –Halo Mass Relation

We present a four-step group-finding algorithm for the Gas in Galaxy Groups (G3) initiative, a spin-off of the z ∼ 0 REsolved Spectroscopy Of a Local VolumE (RESOLVE) and Environmental COntext (ECO) surveys. In preparation for future comparisons to intermediate redshift (e.g., the LADUMA survey), we design the group finder to adapt to incomplete, shallow, or nonuniform data. We use mock catalogs to optimize the group finder’s performance. Compared to friends-of-friends (with false-pair splitting), the G3 algorithm offers improved completeness and halo-mass recovery with minimal loss of purity. Combining it with the volume-limited H i census data for RESOLVE and ECO, we examine the H i content of galaxy groups as a function of group halo mass. Group-integrated H i mass M H I,grp rises monotonically over halo masses M halo ∼ 1011–1014.5 M ⊙, pivoting in slope at M halo ∼ 1011.4 M ⊙, the gas-richness threshold scale. We present the first measurement of the scatter in this relation, which has a median of ∼0.3 dex and is asymmetric toward lower M H I,grp. We discuss interesting tensions with theoretical predictions and prior measurements of the M H I,grp–M halo relation. In an appendix, we release RESOLVE DR4 and ECO DR3, including updates to survey redshifts, photometry, and group catalogs, as well as a major expansion of the ECO H i inventory with value-added data products

Murine Models for Trypanosoma brucei gambiense Disease Progression—From Silent to Chronic Infections and Early Brain Tropism

Trypanosoma brucei gambiense is responsible for more than 90% of reported cases of human African trypanosomosis (HAT). Infection can last for months or even years without major signs or symptoms of infection, but if left untreated, sleeping sickness is always fatal. In the present study, different T. b. gambiense field isolates from the cerebrospinal fluid of patients with HAT were adapted to growth in vitro. These isolates belong to the homogeneous Group 1 of T. b. gambiense, which is known to induce a chronic infection in humans. In spite of this, these isolates induced infections ranging from chronic to silent in mice, with variations in parasitaemia, mouse lifespan, their ability to invade the CNS and to elicit specific immune responses. In addition, during infection, an unexpected early tropism for the brain as well as the spleen and lungs was observed using bioluminescence analysis. The murine models presented in this work provide new insights into our understanding of HAT and allow further studies of parasite tropism during infection, which will be very useful for the treatment and the diagnosis of the disease

What Makes Retirees Happier: A Gradual or 'Cold Turkey' Retirement?

This study explores the factors that affect an individual’s happiness while transitioning into retirement. Recent studies highlight gradual retirement as an attractive option to older workers as they approach full retirement. However, it is not clear whether phasing or cold turkey makes for a happier retirement. Using longitudinal data from the Health and Retirement Study, this study explores what shapes the change in happiness between the last wave of full employment and the first wave of full retirement. Results suggest that what really matters is not the type of transition (gradual retirement or cold turkey), but whether people perceive the transition as chosen or forced

Interim analysis of a phase 1 randomized clinical trial on the safety and immunogenicity of the mRNA-1283 SARS-CoV-2 vaccine in adults

This interim analysis of an ongoing phase 1 randomized clinical trial evaluated the safety, reactogenicity, and immunogenicity of mRNA-1283, a next-generation SARS-CoV-2 messenger RNA (mRNA)-based vaccine encoding two segments of the spike protein (i.e. receptor binding and N-terminal domains). Healthy adults aged 18–55 years (n = 104) were randomized (1:1:1:1:1) to receive two doses of mRNA-1283 (10, 30, or 100 µg) or mRNA-1273 (100 µg) administered 28 days apart, or a single dose of mRNA-1283 (100 µg). Safety was assessed and immunogenicity was measured by serum neutralizing antibody (nAb) or binding antibody (bAb) responses. At the interim analysis, no safety concerns were identified and no serious adverse events, adverse events of special interest, or deaths were reported. Solicited systemic adverse reactions were more frequent with higher dose levels of mRNA-1283 than with mRNA-1273. At day 57, all dose levels of the 2-dose mRNA-1283 regimen (including the lowest dose level [10 µg]) induced robust nAb and bAb responses that were comparable to those of mRNA-1273 (100 µg). mRNA-1283 was generally safe in adults, with all dose levels of the 2-dose regimen (10, 30, and 100 µg) eliciting similar immunogenicity as the 2-dose mRNA-1273 regimen (100 µg). Clinical Trials Registration: Clinicaltrials.gov, NCT04813796