OH Masers and Supernova Remnants

OH(1720 MHz) masers are created by the interaction of supernova remnants with molecular clouds. These masers are pumped by collisions in warm, shocked molecular gas with OH column densities in the range 10^{16}--10^{17} cm^{-2}. Excitation calculations suggest that inversion of the 6049 MHz OH line may occur at the higher column densities that have been inferred from main-line absorption studies of supernova remnants with the Green Bank Telescope. OH(6049 MHz) masers have therefore been proposed as a complementary indicator of remnant-cloud interaction. This motivated searches for 6049 MHz maser emission from supernova remnants using the Parkes 63 m and Effelsberg 100 m telescopes, and the Australia Telescope Compact Array. A total of forty-one remnants have been examined by one or more of these surveys, but without success. To check the accuracy of the OH column densities inferred from the single-dish observations we modelled OH absorption at 1667 MHz observed with the Very Large Array towards three supernova remnants, IC 443, W44 and 3C 391. The results are mixed -- the OH column is revised upwards in IC443, downwards in 3C391, and is somewhat reduced in W44. We conclude that OH columns exceeding 10^{17} cm^{-2} are indeed present in some supernova remnants and so the lack of any detections is not explained by low OH column density. We discuss the possibility that non-local line overlap is responsible for suppressing the inversion of the 6049 MHz line.Comment: 8pages, to appear in Proc IAU 287, Cosmic Masers: from OH to H_0, R. Booth, E. Humphries and W. Vlemmings, ed

Social work and the idea of object

The article considers the possibility of expressing the contested nature of social work via objects and their stories. Two Collections of objects and their stories (object/stories) are analysed and compared – an English language Collection (Obj1) and a Latin American Spanish language Collection (Obj2). A thematic analysis results in a schema of three categories of object/story: practical, symbolic, and totemic. The object/stories vary in the degree to which they reflect a social work that is community-oriented or focused on the individual. The two Collections are analysed for similarities and differences, and the authors consider wider applications of the learning from the project

The assembly and alignment of the 4MOST Wide Field Corrector

The 4-metre Multi-Object Spectroscopic Telescope (4MOST) is a fibre-fed multi-object spectrograph for the VISTA telescope at the ESO Paranal Observatory in Chile. The goal of the 4MOST project is to create a general-purpose and highly efficient spectroscopic survey facility for astronomers in the 4MOST consortium and the ESO community. The instrument itself will record 2436 simultaneous spectra over a ∼4.2 square degree field of view and consists of an optical Wide-Field Corrector (WFC), a fibre positioner system based on a tilting spine design, and three spectrographs giving both high and low spectral dispersion. The WFC comprises of 6 lenses grouped into 4 elements, 2 of which are cemented doublets that act as an atmospheric dispersion corrector (ADC). The first lens element is 0.9m in diameter whilst the diameter of the other elements is 0.65m. For the instrument to meet its science goals, each lens needs to be aligned to ∼50µm – a major challenge. This is achieved using contact metrology methods supplemented by pencil beam laser probes. In particular, a novel off-axis laser beam system has been implemented to test the optics’ alignment before and after shipment. This paper details the alignment and assembly methods and presents the latest results on the achieved lens positioning and projected performance of the WF

Understanding foot-and-mouth disease virus transmission biology: identification of the indicators of infectiousness

The control of foot-and-mouth disease virus (FMDV) outbreaks in non-endemic countries relies on the rapid detection and removal of infected animals. In this paper we use the observed relationship between the onset of clinical signs and direct contact transmission of FMDV to identify predictors for the onset of clinical signs and identify possible approaches to preclinical screening in the field. Threshold levels for various virological and immunological variables were determined using Receiver Operating Characteristic (ROC) curve analysis and then tested using generalized linear mixed models to determine their ability to predict the onset of clinical signs. In addition, concordance statistics between qualitative real time PCR test results and virus isolation results were evaluated. For the majority of animals (71%), the onset of clinical signs occurred 3–4 days post infection. The onset of clinical signs was associated with high levels of virus in the blood, oropharyngeal fluid and nasal fluid. Virus is first detectable in the oropharyngeal fluid, but detection of virus in the blood and nasal fluid may also be good candidates for preclinical indicators. Detection of virus in the air was also significantly associated with transmission. This study is the first to identify statistically significant indicators of infectiousness for FMDV at defined time periods during disease progression in a natural host species. Identifying factors associated with infectiousness will advance our understanding of transmission mechanisms and refine intra-herd and inter-herd disease transmission models

Students' perceptions of international social work: A comparative study in the USA, UK, and Georgia

The field of social work worldwide has been increasingly influenced by globalization, migration, and other conditions that require professionals to be responsive and knowledgeable in addressing them. This collaborative project examined students’ perceptions of international social work at three universities in the United States, United Kingdom, and Georgia. Students’ responses indicated an overall strong interest and widespread agreement that there is a link between local and global social issues. The findings suggest that social work education needs to be globalized and tailored to students’ needs, which will help them identify social work strongly as part of a profession and affect change across the globe

Students' perceptions of international social work: A comparative study in the USA, UK, and Georgia

The field of social work worldwide has been increasingly influenced by globalization, migration, and other conditions that require professionals to be responsive and knowledgeable in addressing them. This collaborative project examined students’ perceptions of international social work at three universities in the United States, United Kingdom, and Georgia. Students’ responses indicated an overall strong interest and widespread agreement that there is a link between local and global social issues. The findings suggest that social work education needs to be globalized and tailored to students’ needs, which will help them identify social work strongly as part of a profession and affect change across the globe

W(h)ither the academy? An exploration of the role of university social work in shaping the future of social work in Europe

A controversial proposal to pilot the training of child protection social workers through an intensive work-based route in England is being supported and funded by the UK Government. Frontline, the brainchild of a former teacher, locates social work training within local authorities (‘the agency’) rather than university social work departments (‘the academy’) and has stimulated debate amongst social work academics about their role in shaping the direction of the profession. As a contribution to this debate, this paper explores the duality of social work education, which derives its knowledge from both the academic social sciences and the experience of practice within social work agencies. While social work education has traditionally been delivered by the academy, this paper also explores whether the delivery of training in the allied professions of probation and nursing by ‘the agency’ is equally effective. Finally, this paper explores the Helsinki model which achieves a synergy of ‘academy’ and ‘agency’. It suggests that there are alternative models of social work education, practice and research which avoid dichotomies between the ‘academy’ and the ‘agency’ and enable the profession to be shaped by both social work academics and practitioners

Frequency of Tongue Cleaning Impacts the Human Tongue Microbiome Composition and Enterosalivary Circulation of Nitrate

The oral microbiome has the potential to provide an important symbiotic function in human blood pressure physiology by contributing to the generation of nitric oxide (NO), an essential cardiovascular signaling molecule. NO is produced by the human body via conversion of arginine to NO by endogenous nitric oxide synthase (eNOS) but eNOS activity varies by subject. Oral microbial communities are proposed to supplement host NO production by reducing dietary nitrate to nitrite via bacterial nitrate reductases. Unreduced dietary nitrate is delivered to the oral cavity in saliva, a physiological process termed the enterosalivary circulation of nitrate. Previous studies demonstrated that disruption of enterosalivary circulation via use of oral antiseptics resulted in increases in systolic blood pressure. These previous studies did not include detailed information on the oral health of enrolled subjects. Using 16S rRNA gene sequencing and analysis, we determined whether introduction of chlorhexidine antiseptic mouthwash for 1 week was associated with changes in tongue bacterial communities and resting systolic blood pressure in healthy normotensive individuals with documented oral hygiene behaviors and free of oral disease. Tongue cleaning frequency was a predictor of chlorhexidine-induced changes in systolic blood pressure and tongue microbiome composition. Twice-daily chlorhexidine usage was associated with a significant increase in systolic blood pressure after 1 week of use and recovery from use resulted in an enrichment in nitrate-reducing bacteria on the tongue. Individuals with relatively high levels of bacterial nitrite reductases had lower resting systolic blood pressure. These results further support the concept of a symbiotic oral microbiome contributing to human health via the enterosalivary nitrate-nitrite-NO pathway. These data suggest that management of the tongue microbiome by regular cleaning together with adequate dietary intake of nitrate provide an opportunity for the improvement of resting systolic blood pressure

Nitrate-responsive oral microbiome modulates nitric oxide homeostasis and blood pressure in humans

© 2018 The Author(s) Imbalances in the oral microbial community have been associated with reduced cardiovascular and metabolic health. A possible mechanism linking the oral microbiota to health is the nitrate (NO3-)-nitrite (NO2-)-nitric oxide (NO) pathway, which relies on oral bacteria to reduce NO3- to NO2-. NO (generated from both NO2- and L-arginine) regulates vascular endothelial function and therefore blood pressure (BP). By sequencing bacterial 16S rRNA genes we examined the relationships between the oral microbiome and physiological indices of NO bioavailability and possible changes in these variables following 10 days of NO3- (12 mmol/d) and placebo supplementation in young (18–22 yrs) and old (70–79 yrs) normotensive humans (n = 18). NO3- supplementation altered the salivary microbiome compared to placebo by increasing the relative abundance of Proteobacteria (+225%) and decreasing the relative abundance of Bacteroidetes (−46%; P < 0.05). After NO3-supplementation the relative abundances of Rothia (+127%) and Neisseria (+351%) were greater, and Prevotella (−60%) and Veillonella (−65%) were lower than in the placebo condition (all P < 0.05). NO3- supplementation increased plasma concentration of NO2- and reduced systemic blood pressure in old (70–79 yrs), but not young (18–22 yrs), participants. High abundances of Rothia and Neisseria and low abundances of Prevotella and Veillonella were correlated with greater increases in plasma [NO2-] in response to NO3- supplementation. The current findings indicate that the oral microbiome is malleable to change with increased dietary intake of inorganic NO3-, and that diet-induced changes in the oral microbial community are related to indices of NO homeostasis and vascular health in vivo

Toward Adaptive X-Ray Telescopes

Future x-ray observatories will require high-resolution (less than 1 inch) optics with very-large-aperture (greater than 25 square meter) areas. Even with the next generation of heavy-lift launch vehicles, launch-mass constraints and aperture-area requirements will limit the surface areal density of the grazing-incidence mirrors to about 1 kilogram per square meter or less. Achieving sub-arcsecond x-ray imaging with such lightweight mirrors will require excellent mirror surfaces, precise and stable alignment, and exceptional stiffness or deformation compensation. Attaining and maintaining alignment and figure control will likely involve adaptive (in-space adjustable) x-ray optics. In contrast with infrared and visible astronomy, adaptive optics for x-ray astronomy is in its infancy. In the middle of the past decade, two efforts began to advance technologies for adaptive x-ray telescopes: The Generation-X (Gen-X) concept studies in the United States, and the Smart X-ray Optics (SXO) Basic Technology project in the United Kingdom. This paper discusses relevant technological issues and summarizes progress toward adaptive x-ray telescopes