Survival of the weakest: signaling aided by endosomes

The tyrosine kinase receptor c-Met plays a key role in cell proliferation, morphogenesis, and motility in response to hepatocyte growth factor. C-Met is often altered in cancer and is a major target for therapeutic intervention. Despite knowing a great deal of the molecular machinery downstream of this receptor tyrosine kinase, the spatiotemporal regulation of c-Met signaling still remains elusive. In this issue of the Journal of Cell Biology, Kermorgant and Parker (Kermorgant, S. and P.J. Parker. 2008. J. Cell Biol. 182:855–863) provide evidence for a model in which the c-Met–activated STAT3 signal is mediated by endosomal trafficking. This study elegantly highlights how weak signals can be effectively transmitted to the nucleus by exploiting endosomal compartments, raising important mechanistic implications for the signaling research community

Incivility and Public Participation

UIDB/05021/2020 UIDP/05021/2020publishersversionpublishe

Verso la riconversione di settori utilizzatori di amianto. Risultati di un'indagine sul campo

WP 08/1996; This paper examines the behaviour of the main operators in friction car components and in asbestos-cement during the transitional phase to alternative tecnologies after the introduction of law N. 257 in 1992. It considers the safety measures started up, the waste treatment in asbestos processing, the technical and economic features of substitute materials, the importance of the process changeover fixed by the new law. It also analyses the stimulating role of industrial policy tools directed to support the reorganization and quantifies the drop in import-export flows. In the second part of the paper the financial results of a panel of firms are analysed and compared with those of the industry they belong to during the period of the reorganization (1990-1992)

A Combination of screening and computational approaches for the identification of novel compounds that decrease mast cell degranulation

High-content screening of compound libraries poses various challenges in the early steps in drug discovery such as gaining insights into the mode of action of the selected compounds. Here, we addressed these challenges by integrating two biological screens through bioinformatics and computational analysis. We screened a small-molecule library enriched in amphiphilic compounds in a degranulation assay in rat basophilic leukemia 2H3 (RBL-2H3) cells. The same library was rescreened in a high-content image-based endocytosis assay in HeLa cells. This assay was previously applied to a genome-wide RNAi screen that produced quantitative multiparametric phenotypic profiles for genes that directly or indirectly affect endocytosis. By correlating the endocytic profiles of the compounds with the genome-wide siRNA profiles, we identified candidate pathways that may be inhibited by the compounds. Among these, we focused on the Akt pathway and validated its inhibition in HeLa and RBL-2H3 cells. We further showed that the compounds inhibited the translocation of the Akt-PH domain to the plasma membrane. The approach performed here can be used to integrate chemical and functional genomics screens for investigating the mechanism of action of compounds

UNA MODALITÀ DI REALIZZAZIONE DEL SERVICE LEARNING: IL PROGRAMMA MENTOR-UP

Nell’articolo, dopo una breve introduzione sul modello del mentoring con i minori a rischio, viene presentata una sintetica rassegna della letteratura sulle connessioni tra mentoring e service learning e successivamente su quali processi attiva una relazione di mentoring

UNA MODALITÀ DI REALIZZAZIONE DEL SERVICE LEARNING: IL PROGRAMMA MENTOR-UP

Nell’articolo, dopo una breve introduzione sul modello del mentoring con i minori a rischio, viene presentata una sintetica rassegna della letteratura sulle connessioni tra mentoring e service learning e successivamente su quali processi attiva una relazione di mentoring

UNA MODALITÀ DI REALIZZAZIONE DEL SERVICE LEARNING: IL PROGRAMMA MENTOR-UP

Nell’articolo, dopo una breve introduzione sul modello del mentoring con i minori a rischio, viene presentata una sintetica rassegna della letteratura sulle connessioni tra mentoring e service learning e successivamente su quali processi attiva una relazione di mentoring

Biocidal epoxy coatings with improved aesthetic properties

Se formularon y elaboraron recubrimientos epoxídicos, modificados con cationes Ag⁺ y Zn²⁺ incorporados en una zeolita A, con el objetivo de hallar los niveles que proporcionen un desempeño biocida adecuado sin afectar las propiedades estéticas de la película. Se sintetizó una zeolita A, dado que proporciona la mayor capacidad de intercambio catiónico.Facultad de Ciencias Agrarias y Forestale

Impacto de las metodologías de enseñanza en el aprendizaje del Álgebra en alumnos de primer año de las carreras de Contador Público y de Licenciatura en Economía

El presente trabajo muestra los resultados obtenidos de una investigación que indaga acerca del impacto que producen las metodologías de enseñanza de la Matemática vinculadas al rendimiento académico de los estudiantes, específicamente cuando se debe enseñar Matemática en carreras no matemáticas. Particularmente aquí se trabaja el caso de los estudiantes de las carreras de Contador Público y de Licenciatura en Economía de la Facultad de Ciencias Económicas de la Universidad Nacional de Entre Ríos, en la asignatura Álgebra Aplicada a las Ciencias Económicas. Como metodología los contenidos teóricos se desarrollan a partir de un problema de naturaleza económica, de modo tal que la teoría se aborda paulatinamente para dar respuesta a las necesidades que se originan a partir de cada situación, para culminar la clase con la solución e interpretación del problema, logrando mayor motivación y la anticipación de la respuesta a la pregunta ¿para qué me sirve esto?  ARK: http://id.caicyt.gov.ar/ark:/s22504559/96zqb65k

Observational Mass-to-Light Ratio of Galaxy Systems: from Poor Groups to Rich Clusters

We study the mass-to-light ratio of galaxy systems from poor groups to rich clusters, and present for the first time a large database for useful comparisons with theoretical predictions. We extend a previous work, where B_j band luminosities and optical virial masses were analyzed for a sample of 89 clusters. Here we also consider a sample of 52 more clusters, 36 poor clusters, 7 rich groups, and two catalogs, of about 500 groups each, recently identified in the Nearby Optical Galaxy sample by using two different algorithms. We obtain the blue luminosity and virial mass for all systems considered. We devote a large effort to establishing the homogeneity of the resulting values, as well as to considering comparable physical regions, i.e. those included within the virial radius. By analyzing a fiducial, combined sample of 294 systems we find that the mass increases faster than the luminosity: the linear fit gives M\propto L_B^{1.34 \pm 0.03}, with a tendency for a steeper increase in the low--mass range. In agreement with the previous work, our present results are superior owing to the much higher statistical significance and the wider dynamical range covered (about 10^{12}-10^{15} M_solar). We present a comparison between our results and the theoretical predictions on the relation between M/L_B and halo mass, obtained by combining cosmological numerical simulations and semianalytic modeling of galaxy formation.Comment: 25 pages, 12 eps figures, accepted for publication in Ap