A comparative study of feminisms in the writings of Jane Austen and Mary Wollstonecraft

Les romans de Jane Austen sont souvent perçus comme étant une narration parfaite de la vie domestique au dix-neuvième siècle. La plupart des intrigues sont centrées autour de quelques familles et d'une héroïne qui, à la fin du roman, est récompensée à travers son mariage avec l'homme de son choix (qui s'avère souvent riche et muni d'une bonne position sociale). Puisque les romans d'Austen se terminent généralement par un mariage conventionnel et apparaissent d'une envergure limitée, les analyses des thèmes féministes sous-jacents ne sont pas apparues avant le vingtième siècle. Plusieurs études ont révélé qu'au dessous de ces romans à caractère domestique se cache des arguments féministes en faveur de l'éducation des femmes et une critique des inégalités entre les sexes et des codes de conduite. L'étude qui suit comparera le féminisme d'Austen à celui de Mary Wollstonecraft, à partir de ses essais A Vindication of the Rights of Woman, A Vindication of the Rights of Men, ainsi que ses romans Mary et The Wrongs of Woman. Cette analyse portera aussi sur trois des romans d'Austen : Northanger Abbey, Sense and Sensibility et Mansfield Park. Ces romans reflètent clairement la situation des femmes de l'époque et s'attardent sur l'importance de l'éducation des femmes, les stéréotypes socialement définis, les relations homme-femme et les situations de violence dans le mariage et la famille. En comparant son engagement avec cette problématique aux oeuvres de Wollstonecraft, cette étude démontre que, au travers de ses romans, Austen était beaucoup plus consciente et engagée avec la société dans laquelle elle vivait qu'on ne l'imaginai

Toward dynamic pain expressions in avatars : perceived realism and pain level of diffrent action unit orders

The facial expression of pain can be decomposed in three sets of Action Units (AUs), the smallest discriminating facial movements: Brow lowering (B), Nose wrinkling + Upper lip raising (N), and Orbit tightening + Eyelid closure (O). This study compared the perception of realism and pain level from different onset orders of AUs in avatars. Seven videos of facial expressions of pain were created with four different avatars (2 women): six sequential onsets combining the three sets of AUs and one synchronized onset. 45 healthy adults (22 women; aged 23.6 ± 5.2 years) rated the realism of facial movements, and the level of intensity and unpleasantness of perceived pain. A more realistic expression was associated with the onset of O before or at the same time as N, a more intense expression was associated when B occurred last, and a higher level of unpleasantness was associated with the onset of N before B. Therefore, the sequence ONB yielded the highest ratings on both measures of realism and pain levels. These findings describe the perceived content of different orders of facial movements that could contribute to the creation of realistic pain-expressing virtual agents designed to study human-computer interactions

Nonverbal expression of empathy in healthy human populations : a scoping review protocol

The present scoping review aims to understand the extent and type of evidence related to the nonverbal expression of empathy (and empathic concern) in healthy human (or human-like) empathizers across contexts

Investigating Gene–Gene and Gene–Environment Interactions in the Association Between Overnutrition and Obesity-Related Phenotypes

Introduction: Animal studies suggested that NFKB1, IKBKB, and SOCS3 genes could be involved in the association between overnutrition and obesity. This study aims to investigate interactions involving these genes and macronutrient intakes affecting obesity-related phenotypes.Methods: We used a traditional statistical method, logistic regression, and compared it to alternative statistical method, multifactor dimensionality reduction (MDR) and penalized logistic regression (PLR), to better detect genes/environment interactions in the Toronto Nutrigenomics and Health Study (n = 1639) using dichotomized body mass index (BMI) and waist circumference as obesity-related phenotypes. Exposure variables included genotype on 54 single nucleotide polymorphisms (NFKB1: 18, IKBKB: 9, SOCS3: 27), macronutrient (carbohydrates, protein, fat) and alcohol intakes and ethno-cultural background.Results: After correction for multiple testing, no interaction was found using logistic regression. MDR identified interactions between SOCS3 rs6501199 and rs4969172, and IKBKB rs3747811 affecting BMI in the Caucasian population; SOCS3 rs6501199 and NFKB1 rs1609798 affecting WC in the Caucasian population; and SOCS3 rs4436839 and IKBKB rs3747811 affecting WC in the South Asian population. PLR found a main effect of SOCS3 rs12944581 on BMI among the South Asian population.Conclusion: While MDR and PLR had discordant results, some models support results from previous studies. These results emphasize the need to use alternative statistical methods to investigate high-order interactions and suggest that variants in the nutrient-responsive hypothalamic IKKB/NF-kB signaling pathway may be involved in obesity pathogenesis

Multifaceted intervention to decrease the rate of severe postpartum haemorrhage: the PITHAGORE6 cluster-randomised controlled trial.: Intervention to decrease severe postpartum haemorrhage

International audienceOBJECTIVE: Decreasing the prevalence of severe postpartum haemorrhages (PPH) is a major obstetrical challenge. These are often considered to be associated with substandard initial care. Strategies to increase the appropriateness of early management of PPH must be assessed. We tested the hypothesis that a multifaceted intervention aimed at increasing the translation into practice of a protocol for early management of PPH, would reduce the incidence of severe PPH. DESIGN: Cluster-randomised trial. POPULATION: 106 maternity units in six French regions. METHODS: Maternity units were randomly assigned to receive the intervention, or to have the protocol passively disseminated. The intervention combined outreach visits to discuss the protocol in each local context, reminders, and peer reviews of severe incidents, and was implemented in each maternity hospital by a team pairing an obstetrician and a midwife. MAIN OUTCOME MEASURES: The primary outcome was the incidence of severe PPH, defined as a composite of one or more of: transfusion, embolisation, surgical procedure, transfer to intensive care, peripartum haemoglobin decrease of 4 g/dl or more, death. The main secondary outcomes were PPH management practices. RESULTS: The mean rate of severe PPH was 1.64% (SD 0.80) in the intervention units and 1.65% (SD 0.96) in control units; difference not significant. Some elements of PPH management were applied more frequently in intervention units-help from senior staff (P = 0.005), or tended to - second-line pharmacological treatment (P = 0.06), timely blood test (P = 0.09). CONCLUSION: This educational intervention did not affect the rate of severe PPH as compared with control units, although it improved some practices

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Décours temporel de l'expression faciale dynamique de la douleur à l'aide d'avatars virtuels

L’informatique affective vise à développer des systèmes informatiques capables de reconnaître et de recréer en réalité virtuelle certains états internes de l’humain. La douleur est un de ces états internes qui est décrit comme une expérience subjective à la fois sensorielle et affective. Pour communiquer aux autres notre douleur, les expressions faciales sont un moyen adaptatif. Si la composition en termes de mouvements faciaux est bien connue pour la douleur, le décours temporel de ces mouvements a peu été abordé. L’objectif du mémoire est de comparer le niveau de réalisme de différents décours temporels de l’expression faciale de la douleur chez des avatars et d’évaluer leur effet sur la douleur observée. Une étude empirique a été réalisée auprès de 45 adultes (22 femmes). Six ordres d’apparition de mouvements faciaux de la douleur et une apparition synchronisée ont été présentés aux participants par le biais de quatre avatars (deux femmes). Les participants ont jugé le niveau de réalisme des mouvements faciaux, ainsi que l’intensité et le niveau de désagrément de la douleur. Les résultats révèlent que les expressions de douleur sont perçues comme plus réalistes lorsque les mouvements autour des yeux apparaissent avant ceux autour du nez et de la bouche, comme plus intensément douloureuses lorsque les mouvements des sourcils sont les derniers à apparaître, et avec un niveau de désagrément plus élevé lorsque les mouvements autour du nez et de la bouche apparaissent avant ceux des sourcils. La séquence « Yeux, Nez/Bouche et Sourcils » était la seule qui était perçue comme étant la plus élevée au niveau du réalisme et de la douleur. Ce mémoire soulève l’importance de l’ordre d’apparition des mouvements faciaux dans la perception d’expressions de douleur, contribuant ainsi à l’avancement des connaissances sur le décodage et la production d’expressions de douleur en réalité virtuelle.Affective computing aims to develop computer-based systems that can recognize and recreate some human internal states through virtual reality. Pain is one such internal states described as both a sensory and an affective subjective experience. To communicate our pain to others, facial expressions are an adaptive mean. Although the still pain facial expression is well defined, the sequential order of movements that compose it has rarely been addressed in research. The objective of this thesis is to compare the various levels of realism as well as pain intensity and unpleasantness level attributed to different sequential orders of avatars’ facial expressions of pain. An empirical study has been conducted with 45 adults (22 women), who rated seven orders of appearance of different facial pain movements (six sequences and one synchronized apparition) of four avatars (two women). The results showed that pain expressions were perceived: 1) as more realistic when the eye-related movements appeared before the nose- and mouth- related movements; 2) as more intensely painful when browsrelated movements were the last to appear; 3) as depicting higher unpleasantness level when the noseand mouth-related movements appeared before the brows-related movements. In fact, the sequence “Eyes, Nose/Mouth, Brows” was the only one that was perceived as the highest on both realism and pain level. The results of this study raise the importance of the order of appearance of facial movements in the perception of pain expressions. Thus, this thesis contributes to the field of affective computing through the advancement of knowledge on decoding and producing pain expressions in virtual reality

Validation Experiments of Digital Characters from the EEVEE Platform

This project briefly describes validation experiments of new digital human characters from the Empathy-Enhancing Virtual Evolving Environment (EEVEE; Jackson et al., 2015) for future studies (e.g., on pain, emotions, and empathy). All Rights Reserved