Hodgkin lymphoma in people living with hiv

Despite widespread use of combined antiretroviral therapy (cART) and increased life expectancy in people living with HIV (PLWH), HIV-related lymphomas (HRL) remain a leading cause of cancer morbidity and mortality for PLWH, even in patients optimally treated with cART. While the incidence of aggressive forms of non-Hodgkin lymphoma decreased after the advent of cART, incidence of Hodgkin lymphoma (HL) has increased among PLWH in recent decades. The coinfection of Epstein-Barr virus plays a crucial role in the pathogenesis of HL in the HIV setting. Currently, PLWH with HRL, including HL, are treated similarly to HIV-negative patients and, importantly, the prognosis of HL in PLWH is approaching that of the general population. In this regard, effective cART during chemotherapy is strongly recommended since it has been shown to improve survival rates in all lymphoma subtypes, including HL. As a consequence, interdisciplinary collaboration between HIV specialists and hemato-oncologists for the management of potential drug-drug interactions and overlapping toxicities between antiretroviral and antineoplastic drugs is crucial for the optimal treatment of PLWH with HL. In this article the authors review and update the epidemiological, clinical and biological aspects of HL presenting in PLWH with special emphasis on advances in prognosis and the factors that have contributed to it

Analysing the potential use of a low-grade magnesium carbonate by-product as a filler in hot asphalt mixtures

This is an Accepted Manuscript of an article published by Taylor & Francis Group in International Journal of Pavement Engineering on 2022, available online at: http://www.tandfonline.com10.1080/10298436.2022.2083618.Climate change and natural resources depletion are leading society towards a more environmentally sustainable approach. In areas such as construction or civil engineering, waste and by-products valorisation could help in the fight against climate change, reducing the consumption of raw materials. Thus, the use of residues or by-products in asphalt mixtures manufacturing as road pavement layers has great potential due to their characteristics and the large number of natural resources required. Thus, this research aims to characterise a flotation sterile (Low-Grade Magnesium Carbonate, LG-MC) generated in the beneficiation process of natural magnesite and analyse its potential use as filler in asphalt mixtures manufacturing. The characterisation of physical, chemical, and microscopic properties of LG-MC was carried out and then its potential use as filler for asphalt mixtures was evaluated using the UCL (Universal de Caracterización de Ligantes) method. The optimum filler/bitumen ratio for the LG-MC was 1.49, higher than that of calcium carbonate, which was 1.33. Results show a protective effect of LG-MC as filler against ageing, both in the short and long-term, reducing losses due to abrasion.This work was supported under Grant FJC-2018-035747-I funded by MCIN/AEI/10.13039/501100011033; by the Magnesitas Navarras S.A. under Grant FGB 311127; and Government of Catalonia under Grant FI-DGR 2020.Peer ReviewedObjectius de Desenvolupament Sostenible::9 - Indústria, Innovació i InfraestructuraPostprint (author's final draft

Reflexiones al final de un inicio: estudio de asociación entre variables sociodemográficas y tipo de parto en la prevención de la violencia obstétrica en España

ObjectivesThe aim of our work is to approach types of childbirth at the end of pregnancy from a sociodemographic point of view, with special emphasis in the number of C sections.Material and MethodThe birth data in Spain provided by the National Institute of Statistics has been analyzed.ResultsThe results obtained from crossing the variables show that there are social determinants that should be considered in order to better understand the process of childbirth.DiscussionOur approach goes beyond the mere description and aims to show a causality that should be included in obstetric protocols.ConclusionHealth workers must be aware of the personal circumstances of the patients so that the delivery develops as easily as possible, taking into account the characteristics of the woman, and being not so much concerned with the number of cesarean sections they have to perform.ObjetivoEl objetivo de nuestro trabajo es realizar una aproximación desde el punto de vista sociodemográfico a la forma y técnica de finalización del embarazo en el momento del parto, especialmente en cuanto al porcentaje de cesáreas.Material y métodosSe han analizado los datos de nacimientos en España recogidos por el Instituto Nacional de Estadística.ResultadosLos resultados obtenidos en el cruce de variables muestran que existen determinantes sociales que harían comprender mejor los procesos de parto.DiscusiónLa perspectiva aportada va más allá de la descripción y pretende mostrar una causalidad a ser tenida en cuenta en los protocolos obstétricos.ConclusionesEl personal sanitario debe entender las circunstancias personales de las pacientes para que el parto se desarrolle con la mayor facilidad posible, atendiendo a las características de la mujer y no tanto a la preocupación por el porcentaje de cesáreas resultantes

Formulation of liposomes loading lentisk oil to ameliorate topical delivery, attenuate oxidative stress damage and improve cell migration in scratch assay

Pistacia lentiscus L. is a sclerophyllous shrub capable of growing under harsh climatic conditions especially in the Mediterranean Basin. Different products can be obtained from this plant, such as essential oil, mastic gum or even fixed oil. The last is well known for its flavor which is mainly exploited in the food industry. Additionally, it has been traditionally used in the treatment of skin diseases, but, at the moment, any suitable formulation for skin delivery has been formulated and its biological effects was not deeply confirmed. Given that, in the present study, the lentisk oil has been formulated in liposomes at different concentrations (10, 20, 30 mg/ml) and their physicochemical, technological and main biological properties have been evaluated. Vesicles were prepared by using natural soy lecithin and a green and organic solvent free method, thus obtaining spherical, small (~ 118 nm), homogeneously dispersed (0.27) and highly negatively charged (~ -62 mV) vesicles. The used amount of oil loaded in liposomes (10, 20, 30 mg/ml) modulated the penetration ability of vesicles in the skin, favoring the deposition of the payload in the deeper strata. The loading in the vesicles potentiated the ability of oil to counteract the damaging effects caused by hydrogen peroxide in keratinocytes and fibroblasts and facilitate their migration in a cell monolayer lesion. Overall findings suggested that the incorporation of lentisk oil in liposomes made from soy lecithin can be an alternative and natural approach to exploit it in pharmaceutical ad cosmetical applications and manufacturing natural products suitable for the treatment of skin lesions

El Libro Blanco de la Ingeniería en Informática: el proyecto EICE

En primer lugar, se dibuja el marco contextual y normativo en el que se ha desarrollado el proyecto EICE: el Libro Blanco sobre las titulaciones de Ingeniería Informática en España en el contexto del EEES, encargado por la ANECA. Se describen, a continuación y de forma esquemática, los principales resultados acordados en el seno del proyecto en los aspectos principales objetos del mismo: consideraciones sobre la oferta y la demanda de los estudios de informática, panorama europeo de la titulación, objetivos de la titulación, modelo propuesto, competencias y perfiles profesionales y contenidos formativos comunes propuestos

Nutriosomes: prebiotic delivery systems combining phospholipid, soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation

Nutriosomes, new phospholipid nanovesicles specifically designed for intestinal protection were developed by simultaneously loading a water-soluble dextrine (Nutriose® FM06) and a natural antioxidant (curcumin). Nutriosomes were easily fabricated in a one-step, organic solvent-free procedure. The stability and the delivery performances of the vesicles were improved by adding hydroxypropylmetylcellulose. All the vesicles were small in size (mean diameter ~168 nm), negatively charged (zeta potential ~-38 mV, irrespective of their composition), self-assembled predominantly in unilamellar vesicles stabilized by the presence of Nutriose® , which was located in both the inter-lamellar and inter-vesicle medium, as confirmed by cryo-TEM and SAXS investigation. The dextrin acted also as a cryo-protector, avoiding vesicle collapse during the lyophilization process, and as a protector against high ionic strength and pH changes encountered in the gastrointestinal environment. Thanks to the antioxidant properties of curcumin, nutriosomes provided an optimal protective effect against hydrogen peroxide-induced oxidative stress in Caco-2 cells. Moreover, these innovative vesicles showed promising efficacy in vivo, as they improved the bioavailability and the biodistribution of both curcumin and dextrin upon oral administration, which acted synergically in reducing colonic damage chemically-induced in rats

Prognostic heterogeneity of adult B-cell precursor acute lymphoblastic leukaemia patients with t(1;19)(q23;p13)/TCF3-PBX1 treated with measurable residual disease-oriented protocols

Programa para el Tratamiento de Hemopatias Malignas (PETHEMA) Group (Spanish Society of Hematology, SEHH).The prognosis of t(1;19)(q23;p13)/transcription factor 3-pre-B-cell leukaemia homeobox 1 (TCF3-PBX1) in adolescent and adult patients with acute lymphoblastic leukaemia (ALL) treated with measurable residual disease (MRD)-oriented trials remains controversial. In the present study, we analysed the outcome of adolescent and adult patients with t(1;19)(q23;p13) enrolled in paediatric-inspired trials. The patients with TCF3-PBX1 showed similar MRD clearance and did not have different survival compared with other B-cell precursor ALL patients. However, patients with TCF3-PBX1 had a significantly higher cumulative incidence of relapse, especially among patients aged ≥35 years carrying additional cytogenetic alterations. These patients might benefit from additional/intensified therapy (e.g. immunotherapy in first complete remission with or without subsequent haematopoietic stem cell transplantation).This work was supported in part by CERCA/Generalitat de Catalunya SGR 2017 288 (GRC), a restricted grant from ‘La Caixa’ and Healthcare Alliance for Resourceful Medicine Offensive against Neoplasms (HARMONY)

Analgesic efficacy of zoledronic acid and its effect on functional status of prostate cancer patients with metastasis

Objectives: A multi-centered observational study evaluated the efficacy of zoledronic acid for improving pain and mobility, and preventing skeletal-related events (SRE) (fracture, spinal compression, pain-relieving radiotherapy), in patients with prostate cancer and bone metastasis. Materials and Methods: Males (n = 218) with prostate cancer and bone metastasis undergoing oncologic therapy received zoledronic acid (4 mg iv/month) for 6 months. Parameters evaluated were: 1) pain and movement after 2 consecutive doses; 2) quality of life; 3) SRE incidence and time-to-appearance. Medication tolerance and treatment satisfaction were assessed using a questionnaire. Results: A total of 170 that matched all the inclusion criteria (78%) out of 218 were evaluable for efficacy. There was a measurable statistically significant reduction in pain at rest and on movement as well as an improvement in the quality of life compared with baseline. Best results were obtained with early treatment. Overall incidence of bone events was 11.2%. Of the 212 patients (97.2%) evaluable for safety, 16% suffered adverse events and 66% expressed satisfaction with the treatment Discussion: Zoledronic acid is effective for reducing pain, improving mobility, and increasing the quality of life in patients with prostate cancer with bone metastasis. Its easy administration and good tolerability make zoledronic acid one of the principal therapeutic tools in the management of patients with pain associated with bone metastasis from prostate cancer.Ye

Prognostic heterogeneity of adult B‐cell precursor acute lymphoblastic leukaemia patients with t(1;19)(q23;p13)/ TCF3‐PBX1 treated with measurable residual disease‐oriented protocols

The prognosis of t(1;19)(q23;p13)/transcription factor 3-pre-B-cell leukaemia homeobox 1 (TCF3-PBX1) in adolescent and adult patients with acute lymphoblastic leukaemia (ALL) treated with measurable residual disease (MRD)-oriented trials remains controversial. In the present study, we analysed the outcome of adolescent and adult patients with t(1;19)(q23;p13) enrolled in paediatric-inspired trials. The patients with TCF3-PBX1 showed similar MRD clearance and did not have different survival compared with other B-cell precursor ALL patients. However, patients with TCF3-PBX1 had a significantly higher cumulative incidence of relapse, especially among patients aged ≥35 years carrying additional cytogenetic alterations. These patients might benefit from additional/intensified therapy (e.g. immunotherapy in first complete remission with or without subsequent haematopoietic stem cell transplantation)

Competencias profesionales del Grado en Ingeniería Informática

Los planes de Estudios del EEES deben ser diseñados a partir de competencias profesionales, de forma que al final de sus estudios el egresado se convierta en un profesional competente en el mercado laboral. En este artículo se propone una lista de competencias ponderada para un título de Grado en Ingeniería Informática clasificadas en dos grupos: transversales y técnicas. Dentro de las técnicas se definen cinco itinerarios distintos: computer engineering, computer science, information systems, software engineering e information and communication technology.Este trabajo ha sido financiado por la Facultat d’Informàtica de Barcelona y por la AQU