An AER handshake-less modular infrastructure PCB with x8 2.5Gbps LVDS serial links

Nowadays spike-based brain processing emulation is taking off. Several EU and others worldwide projects are demonstrating this, like SpiNNaker, BrainScaleS, FACETS, or NeuroGrid. The larger the brain process emulation on silicon is, the higher the communication performance of the hosting platforms has to be. Many times the bottleneck of these system implementations is not on the performance inside a chip or a board, but in the communication between boards. This paper describes a novel modular Address-Event-Representation (AER) FPGA-based (Spartan6) infrastructure PCB (the AER-Node board) with 2.5Gbps LVDS high speed serial links over SATA cables that offers a peak performance of 32-bit 62.5Meps (Mega events per second) on board-to-board communications. The board allows back compatibility with parallel AER devices supporting up to x2 28-bit parallel data with asynchronous handshake. These boards also allow modular expansion functionality through several daughter boards. The paper is focused on describing in detail the LVDS serial interface and presenting its performance.Ministerio de Ciencia e Innovación TEC2009-10639-C04-02/01Ministerio de Economía y Competitividad TEC2012-37868-C04-02/01Junta de Andalucía TIC-6091Ministerio de Economía y Competitividad PRI-PIMCHI-2011-076

Theoretical understanding of the increment of upon protonation of pyridine peripheral octupolar molecules: Toward nonlinear optical sensors

6 pages, 6 tables, 4 figures.In this article, we present a computational study of the nonlinear optical properties of pyridine-based octupolar molecules in their neutral and fully triprotonated states. The effect of the core substitution and the degree of conjugation with the periphery has been also established and confirms the possibility of fine-tuning the nonlinear optical response. Computations involving the time-dependent density-functional theory approach serve to further explore the existence of excited states with nonzero dipole moment. From these results, the origin of the high second-order nonlinear optical activity upon protonation is addressed.The present work was supported in part by the Dirección General de Enseñanza Superior DGES, MEC, Spain through research Project Nos. CTQ2006-14987-C02-01 and CTQ2005-01368. The authors are also indebted to Junta de Andalucía and Gobierno de Aragón Spain for funding their research groups FQM-0159 and E39. M.C.R.D. is grateful to the MEC/Fulbright for her Postdoctoral Fellowship at the Georgia Institute of Techology. J.C. is grateful to the MEC of Spain for an I3 professorship position of Chemistry at the University of Málaga and M.M.O. acknowledges the MEC for a personal grant.Peer reviewe

A Partially Protective Vaccine for Fasciola hepatica Induced Degeneration of Adult Flukes Associated to a Severe Granulomatous Reaction in Sheep

Fasciolosis is an important economic disease of livestock. There is a global interest in the development of protective vaccines since current anthelmintic therapy is no longer sustainable. A better knowledge of the host-parasite interaction is needed for the design of effective vaccines. The present study evaluates the microscopical hepatic lesions in sheep immunized with a partially protective vaccine (VAC1), a non-protective vaccine (VAC2), and an infected control group (IC). The nature of granulomatous inflammation associated with degeneration of adult flukes found in the VAC1 group was characterized by immunohistochemistry. Hepatic lesions (fibrous perihepatitis, chronic tracts, bile duct hyperplasia, infiltration of eosinophils and lymphocytes and plasma cells) were significantly less severe in the VAC1 group than in the IC group. Dead adult flukes within bile ducts were observed only in the VAC1 group and were surrounded by a severe granulomatous inflammation composed by macrophages and multinucleate giant cells with a high expression of lysozyme, CD163 and S100 markers, and a low expression of CD68. Numerous CD3+ T lymphocytes and scarce infiltrate of FoxP3+ Treg and CD208+ dendritic cells were present. This is the first report describing degenerated flukes associated to a severe granulomatous inflammation in bile ducts in a F. hepatica vaccine trial

Parasitism and Physiological Trade-Offs in Stressed Capybaras

Parasites play a key role in regulating wildlife population dynamics, but their impact on the host appears to be context-dependent. Evidence indicates that a synergistic interaction between stress, host condition and parasites is implicated in this phenomenon, but more studies are needed to better understand this context-dependency. With the goal to assess the net effect of two types of chronic stress on various host-parasite interactions, we conducted an experiment in capybaras to evaluate the impact of food restriction and physical restraint on the infection intensity of specific gastrointestinal nematodes and coccidia, and how these stressors affected the growth, body condition, and some immuno-physiological parameters. Our hypothesis was that both forms of stress would result in an alteration in the host-parasite interactions, with deteriorated condition and reduced immunological investment leading to high parasite burdens and vice versa. Stressed capybaras had significantly higher coccidia infection intensities; but among individuals that were smaller, those stressed consistently showed lower helminth burdens than controls. Both stress treatments had a marked negative impact on growth and body condition, but concomitantly they had a significant positive effect on some components of the immune system. Our results suggest, on the one hand, that during prolonged periods of stress capybaras preventatively invest in some components of their immunity, such as innate humoural defenses and cells that combat helminths, which could be considered a stress-dependent prophylaxis. On the other hand, stress was found to cause greater infection intensities of protozoans but lower burdens of nematodes, indicating that the relationship between stress, physiological trade-offs and infection depends on the type of parasite in question. Moreover, both findings might be related in a causal way, as one of the immunological parameters enhanced in stressed capybaras is associated with the immune response to control helminths.Centro de Estudios Parasitológicos y de Vectore

Change detection of isolated housing using a new hybrid approach based on object classification with optical and TerraSAR-X data

Optical and microwave high spatial resolution images are now available for a wide range of applications. In this work, they have been applied for the semi-automatic change detection of isolated housing in agricultural areas. This article presents a new hybrid methodology based on segmentation of high-resolution images and image differencing. This new approach mixes the main techniques used in change detection methods and it also adds a final segmentation process in order to classify the change detection product. First, isolated building classification is carried out using only optical data. Then, synthetic aperture radar (SAR) information is added to the classification process, obtaining excellent results with lower complexity cost. Since the first classification step is improved, the total change detection scheme is also enhanced when the radar data are used for classification. Finally, a comparison between the different methods is presented and some conclusions are extracted from the study. © 2011 Taylor & Francis.Vidal Pantaleoni, A.; Moreno Cambroreno, MDR. (2011). Change detection of isolated housing using a new hybrid approach based on object classification with optical and TerraSAR-X data. International Journal of Remote Sensing. 32(24):9621-9635. doi:10.1080/01431161.2011.571297S962196353224BLAES, X., VANHALLE, L., & DEFOURNY, P. (2005). Efficiency of crop identification based on optical and SAR image time series. Remote Sensing of Environment, 96(3-4), 352-365. doi:10.1016/j.rse.2005.03.010Chen, Y., Shi, P., Fung, T., Wang, J., & Li, X. (2007). Object‐oriented classification for urban land cover mapping with ASTER imagery. International Journal of Remote Sensing, 28(20), 4645-4651. doi:10.1080/01431160500444731Dalla Mura, M., Benediktsson, J. A., Bovolo, F., & Bruzzone, L. (2008). An Unsupervised Technique Based on Morphological Filters for Change Detection in Very High Resolution Images. IEEE Geoscience and Remote Sensing Letters, 5(3), 433-437. doi:10.1109/lgrs.2008.917726Dell’Acqua, F., & Gamba, P. (2006). Discriminating urban environments using multiscale texture and multiple SAR images. International Journal of Remote Sensing, 27(18), 3797-3812. doi:10.1080/01431160600557572Haralick, R. M., Shanmugam, K., & Dinstein, I. (1973). Textural Features for Image Classification. IEEE Transactions on Systems, Man, and Cybernetics, SMC-3(6), 610-621. doi:10.1109/tsmc.1973.4309314Im, J., Jensen, J. R., & Tullis, J. A. (2008). Object‐based change detection using correlation image analysis and image segmentation. International Journal of Remote Sensing, 29(2), 399-423. doi:10.1080/01431160601075582Lhomme, S., He, D., Weber, C., & Morin, D. (2009). A new approach to building identification from very‐high‐spatial‐resolution images. International Journal of Remote Sensing, 30(5), 1341-1354. doi:10.1080/01431160802509017LOBO, A., CHIC, O., & CASTERAD, A. (1996). Classification of Mediterranean crops with multisensor data: per-pixel versus per-object statistics and image segmentation. International Journal of Remote Sensing, 17(12), 2385-2400. doi:10.1080/01431169608948779Lu, D., Mausel, P., Brondízio, E., & Moran, E. (2004). Change detection techniques. International Journal of Remote Sensing, 25(12), 2365-2401. doi:10.1080/0143116031000139863Shimabukuro, Y. E., Almeida‐Filho, R., Kuplich, T. M., & de Freitas, R. M. (2007). Quantifying optical and SAR image relationships for tropical landscape features in the Amazônia. International Journal of Remote Sensing, 28(17), 3831-3840. doi:10.1080/01431160701236829Stramondo, S., Bignami, C., Chini, M., Pierdicca, N., & Tertulliani, A. (2006). Satellite radar and optical remote sensing for earthquake damage detection: results from different case studies. International Journal of Remote Sensing, 27(20), 4433-4447. doi:10.1080/01431160600675895Yuan, D., & Elvidge, C. D. (1996). Comparison of relative radiometric normalization techniques. ISPRS Journal of Photogrammetry and Remote Sensing, 51(3), 117-126. doi:10.1016/0924-2716(96)00018-

Hypovitaminosis D and cardiometabolic risk factors in adolescents with severe obesity

Background/Objectives. Obesity is associated with cardiometabolic risk factors and with Vitamin D deficiency. The aim of this study was to examine the relationship between 25(OH)D concentrations and cardiometabolic risk factors in adolescents with severe obesity. Subjects/Methods. A cross-sectional clinical assessment (body mass index, fat mass index, fat-free mass index, waist-to-height ratio, and blood pressure) and metabolic study (triglycerides, total cholesterol, HDL-C, LDL-C, glucose, insulin, HOMA-IR, leptin, calcium, phosphorous, calcidiol, and PTH) were carried out in 236 adolescents diagnosed with severe obesity (BMI z-score > 3.0, 99th percentile), aged 10.2–15.8 years. The criteria of the US Endocrine Society were used for the definition of Vitamin D status. Results. Subjects with Vitamin D deficiency had significantly elevated values (p < 0.05) for BMI z-score, waist circumference, waist z-score, body fat percentage, fat mass index, systolic and diastolic blood pressure, total cholesterol, triglycerides, LDL-C, insulin, HOMA-IR, leptin, and PTH than subjects with normal Vitamin D status. There was a significant negative correlation (p < 0.05) of serum 25(OH)D levels with body fat percentage, FMI, systolic BP, total cholesterol, triglyceride, LDL-C, glucose, insulin, HOMA-IR, leptin, and PTH. Conclusions. Low Vitamin D levels in adolescents with severe obesity were significantly associated with some cardiometabolic risk factors, including body mass index, waist circumference, fat mass index, high blood pressure, impaired lipid profile, and insulin resistance

Comunicar ciencia en México. Discursos y espacios sociales

La generación y divulgación de la ciencia y la tecnología es una tarea que implica contribuir al desarrollo de una cultura que vaya más allá del registro y difusión de los hechos y nombres científicos, al suponer la comprensión crítica de la labor propia como proceso socialmente contextualizado, enraizado en factores históricos, políticos, económicos y éticos. Los trabajos aquí presentados proponen asumir que la comunicación pública del conocimiento expresa también las controversias socio–científicas y la relación social de ciencia y tecnología en las condiciones imperantes de transición vertiginosa en la producción cultural, científica y tecnológica.ITESO, A.C.Consejo de Ciencia y Tecnología del Estado de Jalisc

Comparative dynamics of peritoneal cell immunophenotypes in sheep during the early and late stages of the infection with Fasciola hepatica by flow cytometric analysis

Background: The peritoneal cell populations (PCP) are thought to play a crucial role during the early immune response in Fasciola hepatica infection while newly excysted juveniles (NEJ) are migrating in the peritoneal cavity (PC) towards the liver. In this study, we aimed to determine the immunophenotypes of the PCP and to analyse the dynamics of the recruitment of the PCP during the early and late stage of the infection in sheep infected with F. hepatica. Methods: Thirty-seven sheep were divided into three groups: Group 1 (n = 20) and 2 (n = 10) were challenged with F. hepatica, Group 3 (n = 7) was not infected and remained as uninfected control (UC). After the slaughtering, peritoneal lavages were carried out to isolate peritoneal cell populations at 1, 3, 9 and 18 days post-infection (dpi) for Group 1 and at 14 weeks post-infection (wpi) for Group 2 and 3. Flow cytometry was conducted to assess the dynamics of peritoneal cavity cell populations. Results: TCD4 cells showed a significant decrease at 1 and 18 dpi when compared to UC; no statistical differences were detected for TCD8 and WC1+ γδ during the early stage of the infection with respect to the UC. CD14 cells exhibited a decreasing trend, with a significant decrease at 9 and 18 dpi when compared to the UC. The dynamics of MHCII and CD83 cells showed a similar increasing pattern from 3 to 18 dpi. During the chronic stage, both TCD4 and TCD8 cells showed no significant differences when compared to the UC, although a slight but statistically significant higher level of WC1+ γδ cells was observed. A lower percentage of antigen-presenting cells (APCs) was detected with respect to the UC. Conclusions: The recruitment of the lymphocytes subsets did not show a significant increase during the course of the infection and only WC1+ γδ cells displayed a significant increase at the chronic stage. For the CD14, a decreasing trend was observed during the early stage, which was statistically significant at the chronic stage of the infection. Peritoneal CD83 and MHCII cells developed an increasing trend during the early stage of infection, and showed a significant decrease at the late stage of the infection.This study was funded by the European Union Grant H2020-635408- PARAGONE and by National Grant AGL2015-67023-C2-1-R. RPC was supported by an FPU grant of the Spanish Ministry of Education, Culture and Sport. Funding bodies were neither involved in the design of the study nor in analysis and interpretation of the dataVeterinari

Apoptosis of peritoneal leucocytes during early stages of Fasciola hepatica infections in sheep

Several immunomodulatory properties have been described in Fasciola hepatica infections. Apoptosis has been shown to be an effective mechanism to avoid the immune response in helminth infections. The aim of the present work was to study apoptosis in peritoneal leucocytes of sheep experimentally infected with F. hepatica during the early stages of infection. Five groups (n = 5) of sheep were used. Groups 2–5 were orally infected with 200 metacercariae (mc) and sacrificed at 1, 3, 9 and 18 days post-infection (dpi), respectively. Group 1 was used as the uninfected control (UC). Apoptosis was detected using three different methods 1) immunocytochemistry (ICC) with a polyclonal antibody anti-active caspase-3; 2) an annexin V flow cytometry assay using the Annexin V-FITC/propidium iodide (PI); and 3) transmission electron microscopy (TEM). The differential leucocyte count revealed that the majority of peritoneal granulocytes were eosinophils, which increased significantly at 9 and 18 dpi with respect to the uninfected controls. The ICC study revealed that the percentage of caspase-3+ apoptotic peritoneal leucocytes increased significantly from 3 dpi onwards with respect to the uninfected controls. The flow cytometry annexin V assay detected a very significant (P < 0.001) increase of apoptotic peritoneal macrophages, lymphocytes and granulocytes, which remained higher than in the UC until 18 dpi. Transmission electron microscopy studies also confirmed the presence of apoptosis in peritoneal eosinophils at 18 dpi. This is the first report of apoptosis induced by F. hepatica in the peritoneal leucocytes of sheep in vivo. The results of this work suggest the importance of apoptosis induction for the survival of the juvenile parasites in the peritoneal migratory stages of infection.This work was supported by EU grants (H2020-635408-PARAGONE) and the Spanish Ministry of Science grant AGL2015-67023-C2-1-R. The TEM studies were carried out by the Central Research Services (SCAI) of the University of CórdobaAccepted manuscriptVeterinari

The impact by the use of agrochemicals, upper side of the Chorro Hondo micro watershed, Marinilla, 2011

ABSTRACT: To determine the impact generated by the use of agrochemicals in the upper area of the Chorro Hondo micro watershed in the municipality of Marinilla (Colombia)in order to develop measures contributing to environmental and quality of life improvement. Methodology: a cross sectional,descriptive study with a univariate and bivariate analysis of the surveys answered by 6 suppliers and 35 farmers who were located in their respective agricultural lands. Additionally, the study included direct observations of the properties located within the first 2000 meters of the micro watershed. Likewise, water, soil and air samples were analyzed in search of Chlorothalonil and Mancozeb, the most common active ingredients of the agrochemicals used in this area. Results: in all of the 35 properties, 86% of the farmers performed some kind of agricultural activity and 74% used agrochemicals.Similarly, 58% of the farmers knew the risks associated with the use of these products, intoxication being the most common(occurring in 47% of the individuals). Moreover, 42% did not use a special suit and 31% felt that the water was contaminated with agrochemicals. The concentration of the active ingredients in the water, air and soil was below the detection limit of the methods. Discussion: Marinilla has a complex set of problems regarding agrochemical handling; Chlorothalonil is carcinogenic, and the sale license for Mancozeb has been canceled; the farmers do not meet the basic requirements for: agrochemical storage, transportation and waste disposal; finally,the farmer do not usethe appropriate personal protectiongear.RESUMEN: Determinar el impacto generado por el manejo de agroquímicos en la parte alta de la microcuenca Chorro Hondo en el municipio Marinilla, para el establecimiento de acciones que contribuyan al mejoramiento de la calidad de vida y del ambiente. Metodología: Estudio descriptivo de corte transversal con análisis univariado y bivariado de encuestas a treinta y cinco campesinos en su respectivo predio y seis proveedores, observaciones directas en predios ubicados en los primeros dos mil metros de la microcuenca y muestras de agua, suelo y aire, donde se analizó la presencia de Clorotalonil y Mancozeb, ingredientes activos más comunes entre los agroquímicos utilizados. Resultados: En los treinta y cinco predios, 86% de los campesinos realizaba alguna actividad agropecuaria y 74% aplicaba agroquímicos, asimismo el 58% conocía los riesgos asociados de los productos utilizados, destacándose la intoxicación (47%), el 42% no usaba traje especial y 31% consideraba que el agua estaba contaminada con agroquímicos. La concentración de los ingredientes activos en agua, aire y suelo fue menor del límite de detección de los métodos. Discusión: Marinilla presenta una problemática compleja en el manejo de agroquímicos; el Clorotalonil es cancerígeno y el Mancozeb tiene cancelada la licencia de venta; no se cumplen las condiciones básicas de almacenamiento de agroquímicos, transporte y disposición final de sus residuos; y no se utilizan adecuadamente los elementos de protección personal