The role of extracellular vesicles in cutaneous remodeling and hair follicle dynamics

Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are cell-derived membranous structures that were originally catalogued as a way of releasing cellular waste products. Since the discovery of their function in intercellular communication as carriers of proteins, lipids, and DNA and RNA molecules, numerous therapeutic approaches have focused on the use of EVs, in part because of their minimized risk compared to cell-based therapies. The skin is the organ with the largest surface in the body. Besides the importance of its body barrier function, much attention has been paid to the skin in regenerative medicine because of its cosmetic aspect, which is closely related to disorders affecting pigmentation and the presence or absence of hair follicles. The use of exosomes in therapeutic approaches for cutaneous wound healing has been reported and is briefly reviewed here. However, less attention has been paid to emerging interest in the potential capacity of EVs as modulators of hair follicle dynamics. Hair follicles are skin appendices that mainly comprise an epidermal and a mesenchymal component, with the former including a major reservoir of epithelial stem cells but also melanocytes and other cell types. Hair follicles continuously cycle, undergoing consecutive phases of resting, growing, and regression. Many biomolecules carried by EVs have been involved in the control of the hair follicle cycle and stem cell function. Thus, investigating the role of either naturally produced or therapeutically delivered EVs as signaling vehicles potentially involved in skin homeostasis and hair cycling may be an important step in the attempt to design future strategies towards the efficient treatment of several skin disordersThis research was funded by the Fondo de Investigación Sanitaria, Instituto de Salud Carlos III (CP 14/00219), Fondo Europeo de Desarrollo Regional (FEDER), H2020-EU.1.1.—European Research Council (ERC-2016-StG 715322-EndoMitTalk), and Instituto de Salud Carlos III (FIS16/188). E.C. was supported by the Atracción de Talento Investigador grant 2017-T2/BMD-5766 (Comunidad de Madrid and Universidad Autónoma de Madrid). G.S.-H. was funded by an FPI grant (Universidad Autónoma de Madrid). M.M. was supported by the Miguel Servet program (Instituto de Investigación del Hospital 12 de Octubre

Localized Dispersive States in Nonlinear Coupled Mode Equations for Light Propagation in Fiber Bragg Gratings.

Dispersion effects induce new instabilities and dynamics in the weakly nonlinear description of light propagation in fiber Bragg gratings. A new family of dispersive localized pulses that propagate with the group velocity is numerically found, and its stability is also analyzed. The unavoidable different asymptotic order of transport and dispersion effects plays a crucial role in the determination of these localized states. These results are also interesting from the point of view of general pattern formation since this asymptotic imbalance is a generic situation in any transport-dominated (i.e., nonzero group velocity) spatially extended system

Inhomogeneous nucleation in quark hadron phase transition

The effect of subcritical hadron bubbles on a first-order quark-hadron phase transition is studied. These subcritical hadron bubbles are created due to thermal fluctuations, and can introduce a finite amount of phase mixing (quark phase mixed with hadron phase) even at and above the critical temperature. For reasonable choices of surface tension and correlation length, as obtained from the lattice QCD calculations, we show that the amount of phase mixing at the critical temperature remains below the percolation threshold. Thus, as the system cools below the critical temperature, the transition proceeds through the nucleation of critical-size hadron bubbles from a metastable quark-gluon phase (QGP), within an inhomogeneous background populated by an equilibrium distribution of subcritical hadron bubbles. The inhomogeneity of the medium results in a substantial reduction of the nucleation barrier for critical bubbles. Using the corrected nucleation barrier, we estimate the amount of supercooling for different parameters controlling the phase transition, and briefly discuss its implications to cosmology and heavy-ion collisions.Comment: LaTeX, 14 pages with 8 Postscript figures. Discussion added in introduction and conclusion, Fig. 8 added, few more references added, Typographical errors corrected. Version to appear in Phys. Rev.

Why we failed to approve the new Chilean constitution: the need for a cultural transformation

On 4 September, Chile voted to reject a new constitution to replace the current one, which was written under the dictatorship of Augusto Pinochet. Although 78% of voters approved changing the constitution in a referendum in 2020, the plebiscite in 2022 faced a significant rejection. After that turmoil, the country needs to address the need for cultural transformation, María Carrasco (Atlantic Fellow for Social and Economic Equity, LSE) argues

Three dreams for Chile’s new constitution

In October 2020, the people of Chile voted overwhelmingly to create a new constitution. If we are to capitalise on this historic opportunity, we Chileans must dare to dream of bold new ways to address our problems and guide our institutions. Focusing on the environment, happiness, and economies of care and meaning would be a ... Continue

Introducción al Derecho Penal

El contenido se estructura en bloques temáticos a través de los cuales se desarrollará la asignatura. Además del material docente teórico y práctico, se incluirá Glosario, Legislación, Canal de Derecho y Cine, Biblioteca, Noticias y Enlaces. Todo ello como instrumento complementario para el desarrollo de la materia

Notas de flora hispánica, VII

In this paper we present seven taxa of vascular plants with chorological interest collected in Spain and Portugal. Four of them are first provincial records and one is the second provincial record. Among them, Sideritis montana has been collected for the first time in Cádiz; this taxon had previously been found only in Cordoba of all Occidental Andalusia. The sheets that testified that are kept in the herbarium of Faculty of Biological Sciences of the University Complutense of Madrid (MACB). The register numbers of the sheets are included.En este trabajo se publican siete taxones de plantas vasculares recolectadas en España y Portugal cuyas citas tienen interés corológico. Entre ellos destaca Sideritis montana, citada en Andalucía occidental únicamente en la provincia de Córdoba y que ahora señalamos en Cádiz; otras tres son primeras citas provinciales y una es la segunda cita provincial. Los pliegos testigo están depositados en el herbario MACB de la Facultad de Ciencias Biológicas de la Universidad Complutense cuyos números de registro se incluyen

El artículo 316 CP como norma penal en blanco y su compatibilidad con el principio de legalidad: análisis jurisprudencial

Un tipo penal cerrado, claro, preciso y que proporcione al Juzgador la imagen del hecho punible es la materialización del principio nullum crimen sine lege. No obstante, y sin perjuicio del postulado de tipicidad, se torna imprescindible el procedimiento del reenvío para determinar las exigencias típicas de algunos delitos, dada la complejidad o el carácter cambiante de la materia

Teaching proposal for data analysis subject of physical activity and sport sciences degree

Título, resumen y palabras clave también en inglésResumen basado en el de la publicaciónLa guía docente constituye una herramienta básica para alcanzar los principios que guían el proceso de convergencia en la creación del Espacio Europeo de Educación Superior (EEES). La planificación de la asignatura debe situarse sobre un doble eje: el contenido y el trabajo del estudiante en base a ese contenido. Por tanto, una guía docente debe especificar la selección y ordenación de contenidos académicos, cómo se trabajaran dichos contenidos y la forma de evaluación de los estudiantes. La propuesta que se presenta pretende dar unas orientaciones sobre las competencias a adquirir por parte de los estudiantes, la estructura de los contenidos de la materia, qué enseñar y aprender a partir de los contenidos, el desarrollo didáctico para alcanzar los aprendizajes, la dedicación del estudiante y los procedimientos de evaluación y calificación del aprendizaje, para la asignatura Análisis de Datos del Grado en Ciencias de la Actividad Física y del Deporte perteneciente a la Universidad Católica San Antonio de Murcia (UCAM), para favorecer el proceso de enseñanza-aprendizaje de los estudiantes.ES

Aproximación a la Nueva Babilonia de Constant

El artista holandés Constant Nieuwenhuys, recientemente fallecido, dio forma material a las propuestas de la Internacional Situacionista sobre el urbanismo del futuro con su ciudad utópica, New Babylon. Durante casi veinte años, su proyecto se desarrolló a través de maquetas, dibujos, grabados, collages, etc., así como en una serie de ensayos. En este artículo repasamos las claves de New Babylon y sus relaciones con la crítica urbana situacionista.The Dutch artist Constant Nieuwenhuys, recently deceased, gave substance to the proposals of the International Situationist for the future urbanism through his utopian city, New Babylon. For almost twenty years, his project developed through maquettes, drawings, engravings, collages, etc., as well as several essays. This article revises the key elements of New Babylon and its connections with the situationist urban criticism