Gas Detection with a Micro FTIR Spectrometer in the MIR Region

We report on the application of a silicon micromachined lamellar grating interferometer in a Fourier Transform Infrared (FTIR) spectrometer for the detection of gases in the mid-infrared (MIR) region. The FTIR spectrometer was equipped with MIR optical fibers for light coupling. Gas measurements in the MIR region were focused on specific gases (CO2, CH4) in order to determine the limit of detection and the selectivity that could be obtained using such a micro-spectrometer. The influence of humidity on the gas response has also been investigated. Using two different spectral regions we were able to detect concentrations of carbon dioxide over a span from 100 ppm to 9000 ppm with a theoretical detection limit evaluated at 10 ppm. The performed gas measurements showed the proof of principle of a miniaturised FTIR gas analyzer based on a micromachined spectrometer

Applications of SOI-based optical MEMS

After microelectromechanical systems (MEMS) devices have been well established, components of higher complexity are now developed. Particularly, the combination with optical components has been very successful and have led to optical MEMS. The technology of choice for us is the silicon-on-insulator (SOI) technology, which has also been successfully used by other groups. The applications presented here give an overview over what is possible with this technology. In particular, we demonstrate four completely different devices: a) a 2 × 2 optical cross connector (OXC) with an insertion loss of about 0.4 dB at a switching time of 500 μs and its extension to a 4 × 4 OXC, b) a variable optical attenuators (VOA), which has an attenuation range of more than 50 dB, c) a Fourier transform spectrometer (FTS) with a spectral resolution of 6 nm in the visible, and d) an accelerometer with optical readout that achieves a linear dynamic range of 40 dB over ±6 g. Except for the FTS, all the applications utilized optical fibers, which are held and self-aligned within the MEMS component by U-grooves and small leaf springs. All devices show high reliability and a very low power consumption

Area of Concern: A new paradigm in life cycle assessment for the development of footprint indicators

Purpose As a class of environmental metrics, footprints have been poorly defined, have shared an unclear relationship to Life Cycle Assessment (LCA), and the variety of approaches to quantification have sometimes resulted in confusing and contradictory messages in the marketplace. In response, a task force operating under the auspices of the UNEP/SETAC Life Cycle Initiative project on environmental Life Cycle Impact Assessment (LCIA) has been working to develop generic guidance for developers of footprint metrics. The purpose of this paper is to introduce a universal footprint definition and related terminology as well as to discuss modelling implications. Methods The task force has worked from the perspective that footprints should be underpinned by the same data systems and models as used in LCA. However, there are important differences in purpose and orientation relative to LCA impact category indicators. Footprints have a primary orientation toward society and nontechnical stakeholders. They are also typically of narrow scope, having the purpose of reporting only in relation to specific topics. In comparison, LCA has a primary orientation toward stakeholders interested in comprehensive evaluation of overall environmental performance and trade-offs among impact categories. These differences create tension between footprints, the existing LCIA framework based on the Area of Protection paradigm, and the core LCA standards ISO14040/44. Results In parallel to Area of Protection, we introduce Area of Concern as the basis for a universal footprint definition. In the same way that LCA uses impact category indicators to assess impacts that follow a common cause-effect pathway toward Areas of Protection, footprint metrics address Areas of Concern. The critical difference is that Areas of Concern are defined by the interests of stakeholders in society rather than the LCA community. In addition, Areas of Concern are stand-alone and not necessarily part of a framework intended for comprehensive environmental performance assessment. The Area of Concern paradigm is needed to support the development of footprints in a way that fulfils their distinctly different purpose. It is also needed as a mechanism to extricate footprints from some of the provisions of ISO 14040/44 which are not considered relevant. Specific issues are identified in relation to double counting, aggregation, and the selection of relevant indicators. Conclusions The universal footprint definition and related terminology introduced in this paper create a foundation that will support the development of footprint metrics in parallel with LCA

Comparative study of paediatric prescription drug utilization between the spanish and immigrant population

<p>Abstract</p> <p>Background</p> <p>The immigrant population has increased greatly in Spain in recent years to the point where immigrants made up 12% of the infant population in 2008. There is little information available on the profile of this group with regard to prescription drug utilization in universal public health care systems such as that operating in Spain. This work studies the overall and specific differences in prescription drug utilization between the immigrant and Spanish population.</p> <p>Methods</p> <p>Use was made of the Aragonese Health Service databases for 2006. The studied population comprises 159,908 children aged 0-14 years, 13.6% of whom are foreign nationals. Different utilization variables were calculated for each group. Prescription-drug consumption is measured in Defined Daily Doses (DDD) and DDD/1000 persons/day/(DID).</p> <p>Results</p> <p>A total of 833,223 prescriptions were studied. Utilization is lower for immigrant children than in Spanish children for both DID (66.27 v. 113.67) and average annual expense (€21.55 v. €41.14). Immigrant children consume fewer prescription drugs than Spanish children in all of the therapy groups, with the most prescribed (in DID) being: respiratory system, anti-infectives for systemic use, nervous system, sensory organs. Significant differences were observed in relation to the type of drugs and the geographical background of immigrants.</p> <p>Conclusion</p> <p>Prescription drug utilization is much greater in Spanish children than in immigrant children, particularly with reference to bronchodilators (montelukast and terbutaline) and attention-disorder hyperactivity drugs such as methylphenidate. There are important differences regarding drug type and depending on immigrants' geographical backgrounds that suggest there are social, cultural and access factors underlying these disparities.</p

Mainstreaming life cycle thinking through a consistent approach to footprints

Over recent years, footprints have emerged as an important means of reporting environmental performance. Some individual footprints have become quite sophisticated in their calculation procedures. However, as an overallclass of environmental metrics they have been poorly defined, having a variety of conceptual foundations and an unclear relationship to LCA. The variety and sometimes contradictory approaches to quantification have also led to confusing and contradictory messages in the marketplace which have undermined their acceptance by industry and governments.In response, a task force operating under the auspices of the UNEP/SETAC Life Cycle Initiative project on environmental Life Cycle Impact Assessment has been working to develop generic guidance for developers of footprint metrics. The initial work involved forming a consensual position on the difference between footprints and existing LCA impact category indicators. In short, footprints are deemed to have a primary orientation toward society and nontechnical stakeholders and report only on selected topics of concern. On the other hand, LCA impact category indicators have a primary orientation toward technical stakeholders and report in relation to a larger framework designed for comprehensive evaluation of environmental performance and trade-offs. The task force has also developed a universal footprint definition. In parallel to Area of Protection, we introduce Area of Concern. In the same way that LCA uses impact category indicators to assess impacts that follow a common cause-effect pathway toward Areas of rotection, ootprint metrics address Areas of Concern. The critical difference is that Areas of Concern are defined by the interests of stakeholders in society rather than the LCA community. In addition, Areas of Concern are stand-alone and not part of a framework intended for comprehensive environmental performance assessment. Accordingly, footprints are universally defined as metrics used to report life cycle assessment results addressing an Area of Concern

HTLV-1 infection in solid organ transplant donors and recipients in Spain

Background: HTLV-1 infection is a neglected disease, despite infecting 10–15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated illnesses due to immunosuppression, screening is being widely considered in the transplantation setting. Herein, we report the experience with universal HTLV testing of donors and recipients of solid organ transplants in a survey conducted in Spain. Methods: All hospitals belonging to the Spanish HTLV network were invited to participate in the study. Briefly, HTLV antibody screening was performed retrospectively in all specimens collected from solid organ donors and recipients attended since the year 2008. Results: A total of 5751 individuals were tested for HTLV antibodies at 8 sites. Donors represented 2312 (42.2%), of whom 17 (0.3%) were living kidney donors. The remaining 3439 (59.8%) were recipients. Spaniards represented nearly 80%. Overall, 9 individuals (0.16%) were initially reactive for HTLV antibodies. Six were donors and 3 were recipients. Using confirmatory tests, HTLV-1 could be confirmed in only two donors, one Spaniard and another from Colombia. Both kidneys of the Spaniard were inadvertently transplanted. Subacute myelopathy developed within 1 year in one recipient. The second recipient seroconverted for HTLV-1 but the kidney had to be removed soon due to rejection. Immunosuppression was stopped and 3 years later the patient remains in dialysis but otherwise asymptomatic. Conclusion: The rate of HTLV-1 is low but not negligible in donors/recipients of solid organ transplants in Spain. Universal HTLV screening should be recommended in all donor and recipients of solid organ transplantation in Spain. Evidence is overwhelming for very high virus transmission and increased risk along with the rapid development of subacute myelopath