10 research outputs found

    Value visualization in Product Service Systems preliminary design

    Full text link
    Emerging from a study in the European aerospace industry, this paper identifies a gap in the way value-related information is communicated to designers of hardware in the preliminary stages of Product Service System (PSS) design. To fit this gap a Lifecycle Value Representation Approach, named LiVReA, that uses color-coded 3D CAD models to enable value information to be translated into visual features, is presented. Such approach aims at enhancing designers' awareness of the value contribution of an early design concept on the overall PSS offer by complementing requirements-based information with criteria reflecting the fulfillment of customers and system value. The paper details the development of the approach, its underlying rationale, the results of preliminary validation activities and the potential for industrial application in the light of the currently available PSS representation tool

    Position paper: The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

    Get PDF
    Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology. Optical biopsy techniques — which can provide minimally invasive or noninvasive alternatives to biopsy — could offer other routes to validation and could potentially be used as point-of-care tests among the general population. This Consensus Statement identifies and reviews the most promising candidate optical biopsy technologies for applications in EED, critically assesses them against criteria identified for successful deployment in developing world settings, and proposes further lines of enquiry. Importantly, many of the techniques discussed could also be adapted to monitor the impaired intestinal barrier in other settings such as IBD, autoimmune enteropathies, coeliac disease, graft-versus-host disease, small intestinal transplantation or critical care

    Execution

    No full text
    corecore