Masculinity Hierarchy and Its Audio-Visual Representation in the series Parks and Recreation

En este artículo se aborda el concepto de género como constructosociocultural determinante de una jerarquía que incluye y margina las personas a partir de su representación de actos masculinos o femeninos ideales para un grupo social. La diferenciación discursiva del género es el producto de varias tecnologías sociales, como los medios de comunicación, de discursos institucionales, epistemologías varias y de las acciones de la vida cotidiana. También se examina el concepto de masculinidad hegemónica y su representación en productos audiovisuales a través de un análisis semiótico de la representación de personajes masculinos en la serie Parks and Recreation (Daniels y Schur, 2009). El análisis ofrece ejemplos de la jerarquía masculina y los rasgos de las masculinidades hegemónica, subordinada, alternativa y marginal.In this article, the concept of gender is tackled as a socio culturalconstruction, which determines a hierarchy that includes and put peopleon the margin from its representation of male and female acts, idealfor a social group. Gender discourse differentiation is the product ofseveral social technologies such as communication media, institutionaldiscourses, several epistemologies, and daily life actions. The concept of hegemonic masculinity and its representation in audio-visual productsis examined through a semiotic analysis of male characters in theseries Parks and Recreation (Daniels and Schur, 2009). The analysisoffers examples of masculine hierarchy and features of hegemonic,subordinated, alternative, and marginal masculinities

Spatio-temporal dynamic clustering modeling for solar irradiance resource assessment

Nowadays, with the development of international policies and agreements to promote the integration of renewable energy sources, mainly solar and wind, modeling the solar resource by including the spatio-temporal variability is crucial to determine future PV power plant locations and estimate potential power generation performances. However, contributions involving long-term periods and different time windows to explore such potential solar resource variability are generally scarce. Under this framework, the present paper proposes a methodology focused on characterizing and clustering the spatio-temporal solar resource variability through the global horizontal irradiance analysis. Hierarchical clustering technique is firstly used to classify the spatial data. Different time windows — from short-term to long-term data — can be subsequently evaluated by using various sources of information. The Spanish territory is selected as case study, considering 22-year period data (1999–2020) and 1,936,917 observations from online satellite database. Spatial variability and geographical clustering differences are discussed and compared depending on the selected time windows, identifying relevant spatial variations for some specific months. Additionally, some years present more variability as well, in line with the sunspot peak of the solar cycles. The proposed approach gives an alternative comprehensive spatio-temporal clustering and characterization of GHI evolution, providing a suitable methodology to help the current European sustainable energy transition.These data were obtained from the NASA Langley Research Center (LaRC) POWER Project funded through the NASA Earth Science/Applied Science Program, United States. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. This work was partially funded by the research project PID2020–112754GB–I00, financially supported by the Ministerio de Ciencia e Innovación (Spain)

Can we measure mesopic pupil size with the cobalt blue light slit-lamp biomicroscopy method?

Producción CientíficaThe aim of this work is to assess a previously described slit-lamp biomicroscopy-based method (SLBM) for measuring pupil diameter and compare it to Colvard infrared pupillometry (CIP). METHODS: Two examiners performed three repeated measurements with each instrument in 40 healthy eyes. We determined the agreement of SLBM and CIP, intraobserver and interobserver repeatabilities, and interobserver concordance (kappa) and SLBM ability for detecting pupil sizes over 6.0 mm. RESULTS: The mean (±standard deviation [SD]) pupil diameter was 5.81 ± 0.70 mm with SLBM and 6.26 ± 0.68 mm with CIP (p = 0.01) averaging both examiner's results. Mean differences between the SLBM and CIP were -0.60 mm and -0.30 mm for each examiner using the average of the three readings (p = 0.02), and they were very similar using the first reading. Intraobserver reproducibility: the width of the 95% LoA ranged from 1.79 to 2.30 mm. The ICCs were 0.97 and 0.92 for SLBM, and 0.96 and 0.90 for CIP. Interobserver reproducibility: the width of the LoA ranged from 1.82 to 2.09 mm. Kappa statistics were 0.39 and 0.49 for the first and mean SLBM readings, respectively, and 0.45 for both the first and mean CIP readings. Sensitivity and specificity of SLBM for detection of pupils larger than 6 mm ranged from 55.56% to 73.68% and from 76.19% to 95.45%, respectively. The best trade-off between sensitivity and specificity ranged from 5.4 mm to 6.2 mm. CONCLUSIONS: Although the SLBM is quite repeatable, it underestimates mesopic pupil size and shows a too wide range of agreement with CIP. SLBM shows low sensitivity in detecting pupils larger than 6 mm, which may be misleading when planning anterior segment surgery. Previous grading-consensus training strategies may increase interrater reproducibility, and compensation for the systematic underestimation could improve accuracy of the SLBM

Estigmatización y usos léxicos en el tratamiento informativo del vih/sida en cinco diarios mexicanos de 2012 a 2013

The goal of this work was to find out if the information about hiv/aids published in five Mexican newspapers denoted any kind of stigmatization. The content analysis resulted in the presence of neutral vocabulary. The disease wasn't linked to the topic of death and alarmist information was not used.El presente trabajo averigua si la información sobre el vih/sida publicada en cinco periódicos mexicanos conllevaba algún tipo de estigmatización. El análisis de contenido arrojó que se utilizó un lenguaje neutro; no se relacionó a la enfermedad con la muerte y no se utilizaron datos alarmistas

The design and development of a mobile workflow learning application

The aim of this research is the implementation of a Software Reference Architecture for WfLMS (Workflow Learning Management Systems) with Mobile, Cloud and Collaborative functionalities in order to develop a WFLMS as a native application for the iOS platform. Workflow Learning is the adaptation of WfMS (Workflow Management Systems) from the business domain in the learning domain. Cesarini et al. (2004) support the e-learning process with a WfMS and makes a perfect adaptation of the learning process as a Workflow, explains in a simple way that a Workflow which is made by participants, actions, documents and a set of procedural rules, can be adapted in a learning environment, the actors involved in the learning process are the participants, the learning activities are the actions, the artifacts students can produce are the documents and the relationship among the learning topics are the procedural rules. The Reference Architecture has been adapted in order to provide the best WfLMS solution, taking advantage of the cloud, mobile and collaborative functionalities for the learning environment. The Notification Tools module in the Reference Architecture contains the notification tools for keeping the user updated about the state of the Workflow Learning instances, tasks and activities where the user is collaborating. Push notifications and Twitter were used as the principal notification tools. The Collaboration and Storage Applications in the Cloud module is the repository of the cloud collaborative applications and the storage management applications in the cloud. Google Drive, Dropbox and Evernote are the mobile cloud applications for supporting the collaboration in the WfLMS. The Mobile Services Tool module contains the API’s for accessing the mobile services available in the cloud, in that way the mobile workflow learning application can extend its functionalities. The functionalities that social media services offer are key for the collaboration in the WfLMS. Cloud Content Management System Tool module contains the API’s for connecting with the storage services in the cloud (Dropbox, Drive and Evernote), in order to provide the functionality of a content management system (CMS) in the WfLMS The implementation of the software architecture was the development of a native application for the iOS platform. The application was published in the Apple Store with the name of WOLF (Work Linear Flow). In the WOLF application, the users can create projects and associate Workflows to them, a Twitter hashtag is created for each project so in that way the users can post tweets about the learning activities that are related to the Workflows, the project and communicate with other users for collaboration. The users can open Twitter inside WOLF in order to see the list of tweets related to the hashtags of the projects.Postprint (published version

New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools

BACKGROUND: Ovarian cancer is the leading cause of gynecologic cancer-related death, due in part to a late diagnosis and a high rate of recurrence. Primary and acquired platinum resistance is related to a low response probability to subsequent lines of treatment and to a poor survival. Therefore, a comprehensive understanding of the mechanisms that drive platinum resistance is urgently needed. METHODS: We used bioinformatics analysis of public databases and RT-qPCR to quantitate the relative gene expression profiles of ovarian tumors. Many of the dysregulated genes were cancer stem cell (CSC) factors, and we analyzed its relation to therapeutic resistance in human primary tumors. We also performed clustering and in vitro analyses of therapy cytotoxicity in tumorspheres. RESULTS: Using bioinformatics analysis, we identified transcriptional targets that are common endpoints of genetic alterations linked to platinum resistance in ovarian tumors. Most of these genes are grouped into 4 main clusters related to the CSC phenotype, including the DNA damage, Notch and C-KIT/MAPK/MEK pathways. The relative expression of these genes, either alone or in combination, is related to prognosis and provide a connection between platinum resistance and the CSC phenotype. However, the expression of the CSC-related markers was heterogeneous in the resistant tumors, most likely because there were different CSC pools. Furthermore, our in vitro results showed that the inhibition of the CSC-related targets lying at the intersection of the DNA damage, Notch and C-KIT/MAPK/MEK pathways sensitize CSC-enriched tumorspheres to platinum therapies, suggesting a new option for the treatment of patients with platinum-resistant ovarian cancer. CONCLUSIONS: The current study presents a new approach to target the physiology of resistant ovarian tumor cells through the identification of core biomarkers. We hypothesize that the identified mutations confer platinum resistance by converging to activate a few pathways and to induce the expression of a few common, measurable and targetable essential genes. These pathways include the DNA damage, Notch and C-KIT/MAPK/MEK pathways. Finally, the combined inhibition of one of these pathways with platinum treatment increases the sensitivity of CSC-enriched tumorspheres to low doses of platinum, suggesting a new treatment for ovarian cancerSpanish Ministry of Education FPU12/01380Spanish Ministry of Economy and Competitivity, Plan Estatal de I + D + I 2013–2016Spanish Ministry of Science, Innovation and Universities (RTI2018–097455-B-I00)CIBER de Cáncer (CD16/12/00275)Spanish Consejería de Salud of the Junta de Andalucia (PI-0397-2017

A Fuzzy Delphi Consensus Methodology Based on a Fuzzy Ranking

Delphi multi-round survey is a procedure that has been widely and successfully used to aggregate experts’ opinions about some previously established statements or questions. Such opinions are usually expressed as real numbers and some commentaries. The evolution of the consensus can be shown by an increase in the agreement percentages, and a decrease in the number of comments made. A consensus is reached when this percentage exceeds a certain previously set threshold. If this threshold has not been reached, the moderator modifies the questionnaire according to the comments he/she has collected, and the following round begins. In this paper, a new fuzzy Delphi method is introduced. On the one hand, the experts’ subjective judgments are collected as fuzzy numbers, enriching the approach. On the other hand, such opinions are collected through a computerized application that is able to interpret the experts’ opinions as fuzzy numbers. Finally, we employ a recently introduced fuzzy ranking methodology, satisfying many properties according to human intuition, in order to determine whether the expert’s fuzzy opinion is favorable enough (comparing with a fixed fuzzy number that indicates Agree or Strongly Agree). A cross-cultural validation was performed to illustrate the applicability of the proposed method. The proposed approach is simple for two reasons: it does not need a defuzzification step of the experts’ answers, and it can consider a wide range of fuzzy numbers not only triangular or trapezoidal fuzzy numbers

El papel de la amplificación somatosensorial en la predicción de síntomas respiratorios

Somatosensory amplification (ASS) is the tendency to experience somatic sensations as intense, harmful and disruptive (Barsky, 1992). Besides being involved in hypochondria disorders, it could ex-plain the differences in physical symptoms between patients with the same pathologies. Previous studies have found that ASS is the best predictor of some respiratory symptoms, as opposed to other variables such as anxiety, depression or several objective indicators (Muramatsu et al., 2002). Our goal is to examine the role of somatosensory amplification in the manifestation of respiratory symp-toms, in a non-clinical population sample. Hierarchical logistic regression models were used to deter-mine the predictive capacity of ASS, after adjustment for sex, age, tobacco smoking, anxiety and health concern. Our findings show that smoking is the variable that best predicts the appearance of symptoms. ASS only shows limited predictive capacity as to dyspnoea.La amplificación somatosensorial (ASS) es la tendencia a experimentar sensaciones somáticas como intensas, nocivas y perturbadoras (Barsky, 1992). Además de estar involucrada en los trastornos hipocondríacos, también podría explicar las diferencias en síntomas físicos que muestran pacientes con las mismas patologías. Estudios previos han comprobado que la ASS es el mejor predictor de algunos síntomas respiratorios, frente a otras variables como la ansiedad, la depresión o algunos indicadores objetivos (Muramatsu et al., 2002). Nuestro objetivo es examinar el papel de la ASS en la manifestación de síntomas respiratorios en población no clínica. Se han empleado técnicas de regre-sión logística jerárquica para determinar la capacidad predictiva de la ASS, controlando el efecto de sexo, edad, consumo de tabaco, ansiedad y preocupación por la salud. La variable que mejor predice la manifestación de síntomas es el consumo de tabaco. La ASS sólo muestra cierta capacidad predic-tiva en el caso de la disnea

Casa del Migrante de Saltillo. Health and solidarity in the phenomenon of Central American migration in transit through Mexico

La investigación expone los puntos geográficos que mayor riesgo a la salud presentan para la población migrante de origen centroamericano en su ruta por México hacia los Estados Unidos debido a las condiciones políticas y de inseguridad que caracterizan actualmente a la zona, así como las prácticas de resiliencia y autocuidado que los actores vinculados al proceso migratorio (personas migrantes, instituciones, organismos de la sociedad civil) promueven bajo una conceptualización no uniforme -o libre de conflictos- de solidaridad. Se analizan los significados y las prácticas solidarias ligados a la salud y a la enfermedad del colectivo de actores sociales relacionados con la migración en México, que han ido desarrollando al tiempo en que este fenómeno ha transformado su experiencia vital. La recolección de datos se realizó en la Casa del Migrante de Saltillo a través de entrevistas semi-estructuradas a sus administrativos y cuerpo de voluntarios, de grupos de enfoque y sondeo con personas migrantes del año 2015 al 2018.The investigation starts with the identification of the geographical points that present risks to the health of the Central American migrant population in their passage through Mexico to the United States, given the political and insecurity conditions that currently characterize the area. Also, the resilience and self-care practices promoted by the actors linked to the migration process (migrants, institutions, civil society organizations) are identified under a conceptualization of solidarity that is not uniform - or is free from conflicts. The meanings and solidarity practices that they have developed around health and disease are analyzed at the same time that this phenomenon has transformed their life experience. Data collection was carried out from 2015 to 2018 at Casa del Migrante de Saltillo, through nine semi-structured interviews applied to its administrators, 2 focus groups conducted with its volunteers, 3 focus groups carried out with migrants and a survey applied to forty-seven migrants

Aproximación a la evaluación de un programa de "formación fuera del aula" en la Universidad

The present time of a world in constant change invites of a special way to the educational ones of any scope, to look for new ways to imply the student. In order to be able to approach I tot the deepest reality of the educative process: to be able to remove the best thing from each one. The present case shows a program that looks for to us, through different activities outside the classroom, to introduce to the college student, not in the paradigms and own lessons of each subject, but in something more general than are in the base of all university education. One is keys like the search of the truth, the synthesis of knowledge's, the integral formation and the service to the society.La actualidad de un mundo en constante cambio invita de una manera especial a los docentes de cualquier ámbito a buscar nuevas maneras de implicar al alumno en su propia formación, para acercarlo a la realidad más profunda del proceso educativo y poder sacar lo mejor de cada uno. El presente estudio nos muestra un programa que busca, a través de diferentes actividades fuera del aula, introducir al universitario, no en los paradigmas y enseñanzas propios de cada asignatura, sino en algo más general que está en la base de toda educación universitaria. Se trata de claves de sentido, como la búsqueda de la verdad, la síntesis de saberes, la formación integral y el servicio a la sociedad