Tuhan di antara Desakan dan Kerumunan: Komodifikasi Spiritualitas Makkah di Era Kapitalisasi

Artikel ini ditulis berdasarkan data etnografi berupa catatan, observasi, pengalaman langsung penulis dan beberapa wawancara ritual umrah di Makkah tang gal 12-20 Maret, 2016. Tulisan ini berusaha memotret kota Makkah modern dari relasi antara perkembangan kota ini dan bagaimana pelaksanaan ritual umrah meliputi: tawaf, sai, dan kehidupan para peziarah di sana ketika penulis melaksanakan ibadah itu. Lebih jelasnya, penulis coba menilik pencarian Tuhan di tengah kerumuman manusia dalam kehidupan modern-postmodern dalam kesibukan kota Makkah sebagai pusat ritual dan sakralitas Muslim. Proses komodifikasi ibadah dengan berbagai motif dan latar belakang bisnis dan kehidupan sosial dan ekonomi terlihat jelas dalam ibadah umrah. Pencarian Tuhan dalam ritual ini tidak pada kondisi kesepian dan menyendiri, tetapi pencarian di tengah kerumunan kapitalisasi dan komersialisasi tempat-tempat utama Makkah di sekitar area Haram. Ritual umrah dan komodifikasi ritual di tengah pasar global menunjukkan menyatunya Islam dengan kapitalisme.This article is written based on ethnographical notes, that is observation, and experience of the writer during the performance of umrah (lesser pilgrimage) to Mecca March 12-20th, 2016. Firstly, this articles portrays the modern city of Mecca and its relation to the performance of umrah which includes tawaf (Ka'ba circumambulation), sai (running between Shofa and Marwa), and the way Muslims performed the rituals. This article describes the way Muslims sought for God amids crowded city with hundreds of people visiting the sacred sites of Kakbah, drinking water Zamzam, in the complex of Mosque Haram. The process of commodification of the ritual of umrah amidts the booming business within the political, social, and economy contexts can be seen. In this regard, praying to God in the ritual is not necessarily in the quietness,but in the crowded process of capitalization and commercialization of places in the area of Haram of Mecaa. The umrah ritual and commodification of all related activities amid the global market demonstrates the unity of Islam and capitalism

Islamic Acehnese Identity, Sharia, and Christianization Rumor: a Study of the Narratives of the Attack on the Bethel Church in Penauyong Banda Aceh

This paper explores the narratives of the attack on the Bethel church (GBI/Gereja Bethel Indonesia) in Penauyong Aceh on June 17, 2012, provided for by the victims. Among these are those who hold fear of Christian missionaries, including one of the likely perpetrators, and those who dismissed these as mere rumors. After relating the incident to other violence across the nation during the reform period and to the local Aceh context, the paper delved into the interviews undertaken on July 2013, from which the sources of narratives were taken, explaining motivations behind the mob, trauma resulting from it, and other factors contributing to the incident. Through this article I argue that the sharia implementation raise the new identity formulation of Islamic Acehnese, through which the dividing line between ‘Muslims' and others ‘non-Muslims' is further stressed. This in turn nurtures, among other things, the sentiments among the Acehnese against the non-Muslims

Fears of an Open Market: Citizens' Voices of the ASEAN Economic Community (Aec)

This article presents the way in which Indonesian citizens responded to the idea of the open market in the South East Asian country established by the AEC. The article chooses some opinions published by the Indonesian media: Kompas, Dakwatuna, Koran Muria, Koran Yogya, Islam Pos, Hizbut Tahrir website, and Jawa Pos from 2014 to 2016 which show fears of and resistance against the free market. In the arguments they exhibit the fears which are motivated by the citizens' sentiments of nationalism and religion. The article also finds that the AEC is not well understood by the citizens of Indonesia, perhaps due to the lack of socialization by the government. Indeed, the AEC documents do not show any aspects outside economy as the main enterprise of the community, such as religion and nationalism which indeed motivated the fears of the Indonesian citizens. This led to difficulty by Indonesians to accept the idea of the free market who are mostly religious and hold nationalism in high regard. This paper also presents the detailed reasons and the arguments of the fears of the free market in the South East Asia

‘NOT A RELIGIOUS STATE’ A study of three Indonesian religious leaders on the relation of state and religion

This article explores the concept of a ‘secular state’ offered by three Indonesian religious leaders: a Catholic priest, Nicolaus Driyarkara (1913–1967), and two Muslim intellectuals who were also state officials, Mukti Ali (1923–2004) and Munawir Sjadzali (1925–2004). All three, who represented the immediate generation after the revolution for Indonesian independence from the Dutch (1945), defended the legitimacy of a secular state for Indonesia based on the state ideology Pancasila (Five Principles of Indonesia). In doing so, they argued that a religious state, for example an Islamic state, is incompatible with a plural nation that has diverse cultures, faiths, and ethnicities. The three also argued that the state should remain neutral about its citizens’ faith and should not be dominated by a single religion, i.e. Islam. Instead, the state is obliged to protect all religions embraced by Indonesians. This argument becomes a vital foundation in the establishment of Indonesia’s trajectory of unique ‘secularisation’. Whilst these three intellectuals opposed the idea of establishing a religious or Islamic state in Indonesia, it was not because they envisioned the decline of the role of religion in politics and the public domain but rather that they regarded religiosity in Indonesia as vital in nation building within a multi-religious society. In particular, the two Muslim leaders used religious legitimacy to sustain the New Order’s political stability, and harnessed state authority to modernise the Indonesian Islamic community

Chemically and thermally stable silica nanowires with a β-sheet peptide core for bionanotechnology

Background: A series of amyloidogenic peptides based on the sequence KFFEAAAKKFFE template the silica precursor, tetraethyl orthosilicate to form silica-nanowires containing a cross-β peptide core. Results: Investigation of the stability of these fibres reveals that the silica layers protect the silica-nanowires allowing them to maintain their shape and physical and chemical properties after incubation with organic solvents such as 2-propanol, ethanol, and acetonitrile, as well as in a strong acidic solution at pH 1.5. Furthermore, these nanowires were thermally stable in an aqueous solution when heated up to 70 °C, and upon autoclaving. They also preserved their conformation following incubation up to 4 weeks under these harsh conditions, and showed exceptionally high physical stability up to 1000 °C after ageing for 12 months. We show that they maintain their β-sheet peptide core even after harsh treatment by confirming the β-sheet content using Fourier transform infrared spectra. The silica nanowires show significantly higher chemical and thermal stability compared to the unsiliconised fibrils. Conclusions: The notable chemical and thermal stability of these silica nanowires points to their potential for use in microelectromechanics processes or fabrication for nanotechnological devices

Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres

<p>Abstract</p> <p>Background</p> <p>MicroRNAs (miRNAs), some of which function as oncogenes or tumor suppressor genes, are involved in carcinogenesis via regulating cell proliferation and/or cell death. MicroRNA miR-34 was recently found to be a direct target of p53, functioning downstream of the p53 pathway as a tumor suppressor. miR-34 targets Notch, HMGA2, and Bcl-2, genes involved in the self-renewal and survival of cancer stem cells. The role of miR-34 in gastric cancer has not been reported previously. In this study, we examined the effects of miR-34 restoration on p53-mutant human gastric cancer cells and potential target gene expression.</p> <p>Methods</p> <p>Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system, and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter. Potential target gene expression was assessed by Western blot for proteins, and by quantitative real-time RT-PCR for mRNAs. The effects of miR-34 restoration were assessed by cell growth assay, cell cycle analysis, caspase-3 activation, and cytotoxicity assay, as well as by tumorsphere formation and growth.</p> <p>Results</p> <p>Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2, Notch, and HMGA2. Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34. Restoration of miR-34 chemosensitized Kato III cells with a high level of Bcl-2, but not MKN-45 cells with a low level of Bcl-2. miR-34 impaired cell growth, accumulated the cells in G1 phase, increased caspase-3 activation, and, more significantly, inhibited tumorsphere formation and growth.</p> <p>Conclusion</p> <p>Our results demonstrate that in p53-deficient human gastric cancer cells, restoration of functional miR-34 inhibits cell growth and induces chemosensitization and apoptosis, indicating that miR-34 may restore p53 function. Restoration of miR-34 inhibits tumorsphere formation and growth, which is reported to be correlated to the self-renewal of cancer stem cells. The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2, Notch, and HMGA2, indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making. Our study suggests that restoration of the tumor suppressor miR-34 may provide a novel molecular therapy for p53-mutant gastric cancer.</p

Scapular winging: anatomical review, diagnosis, and treatments

Scapular winging is a rare debilitating condition that leads to limited functional activity of the upper extremity. It is the result of numerous causes, including traumatic, iatrogenic, and idiopathic processes that most often result in nerve injury and paralysis of either the serratus anterior, trapezius, or rhomboid muscles. Diagnosis is easily made upon visible inspection of the scapula, with serratus anterior paralysis resulting in medial winging of the scapula. This is in contrast to the lateral winging generated by trapezius and rhomboid paralysis. Most cases of serratus anterior paralysis spontaneously resolve within 24 months, while conservative treatment of trapezius paralysis is less effective. A conservative course of treatment is usually followed for rhomboid paralysis. To allow time for spontaneous recovery, a 6–24 month course of conservative treatment is often recommended, after which if there is no recovery, patients become candidates for corrective surgery

Acceptance and commitment therapy for people living with motor neuron disease: an uncontrolled feasibility study

Background Motor neuron disease (MND) is a fatal, progressive neurodegenerative disease that causes progressive weakening and wasting of limb, bulbar, thoracic and abdominal muscles. Clear evidence-based guidance on how psychological distress should be managed in people living with MND (plwMND) is lacking. Acceptance and Commitment Therapy (ACT) is a form of psychological therapy that may be particularly suitable for this population. However, to the authors' knowledge, no study to date has evaluated ACT for plwMND. Consequently, the primary aim of this uncontrolled feasibility study was to examine the feasibility and acceptability of ACT for improving the psychological health of plwMND. Methods PlwMND aged ≥ 18 years were recruited from 10 UK MND Care Centres/Clinics. Participants received up to 8 one-to-one ACT sessions, developed specifically for plwMND, plus usual care. Co-primary feasibility and acceptability outcomes were uptake (≥ 80% of the target sample [N = 28] recruited) and initial engagement with the intervention (≥ 70% completing ≥ 2 sessions). Secondary outcomes included measures of quality of life, anxiety, depression, disease-related functioning, health status and psychological flexibility in plwMND and quality of life and burden in caregivers. Outcomes were assessed at baseline and 6 months. Results Both a priori indicators of success were met: 29 plwMND (104%) were recruited and 76% (22/29) attended ≥ 2 sessions. Attrition at 6-months was higher than anticipated (8/29, 28%), but only two dropouts were due to lack of acceptability of the intervention. Acceptability was further supported by good satisfaction with therapy and session attendance. Data were possibly suggestive of small improvements in anxiety and psychological quality of life from baseline to 6 months in plwMND, despite a small but expected deterioration in disease-related functioning and health status. Conclusions There was good evidence of acceptability and feasibility. Limitations included the lack of a control group and small sample size, which complicate interpretation of findings. A fully powered RCT to evaluate the clinical and cost-effectiveness of ACT for plwMND is underway

METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: an initiative of the Joint Programme for Neurodegenerative Disease Research

Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer's disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel disease, is hampered by imprecise data, including the incidence and prevalence of symptomatic and clinically “silent” cerebrovascular disease, long-term outcomes (cognitive, stroke, or functional), and risk factors. New large collaborative studies with long follow-up are expensive and time consuming, yet substantial data to advance the field are available. In an initiative funded by the Joint Programme for Neurodegenerative Disease Research, 55 international experts surveyed and assessed available data, starting with European cohorts, to promote data sharing to advance understanding of how vascular disease affects brain structure and function, optimize methods for cerebrovascular disease in neurodegeneration research, and focus future research on gaps in knowledge. Here, we summarize the results and recommendations from this initiative. We identified data from over 90 studies, including over 660,000 participants, many being additional to neurodegeneration data initiatives. The enthusiastic response means that cohorts from North America, Australasia, and the Asia Pacific Region are included, creating a truly global, collaborative, data sharing platform, linked to major national dementia initiatives. Furthermore, the revised World Health Organization International Classification of Diseases version 11 should facilitate recognition of vascular-related brain damage by creating one category for all cerebrovascular disease presentations and thus accelerate identification of targets for dementia prevention