A genetic variant in the cytochrome P450 family 2 subfamily R member 1 determines response to vitamin D supplementation

Background Globally, about 1 billion people have inadequate levels of serum vitamin D and it is prevalent in all ethnicities and age groups. Few foods naturally contain sufficient vitamin D; therefore, most people get their requirements through supplementation. Hence vitamin D status is affected by genetic and environmental determinants including season of measurement, diet habitual, health status, body mass index and concurrent medication. Further studies are necessary to understand how genetic variation influences vitamin D metabolism. We aimed to explore the association between a potential vitamin D-related polymorphism (the rs10766197 polymorphism in the CYP2R1 gene) with the response to supplementation of vitamin D in 253 healthy Iranian girls. Material and method A total of 253 healthy subjects received 50,000 IU of vitamin D3 weekly for 9 weeks. Serum 25(OH)D concentrations and metabolic profiles were measured at baseline and after 9 weeks of supplementation. The genotypes of the CYP2R1 variant (rs10766197) were identified using TaqMan genotyping assays. Results Serum 25(OH)D during the supplementation, increased in all individuals. Subjects with a AA major genotype at this locus had higher vitamin D concentrations after intervention (Changes (%) 448.4% ± 425% in AA vs 382.7% ± 301% in GG). This genetic variant modulated the response to supplementation (p < 0.001 and p-value SNP = 0.05). Regression analysis showed that the probability of affecting serum 25(OH)D, in individuals who had homozygous major allele GG was two-fold higher than carriers of the uncommon allele A (OR = 2.1 (1–4.2); p = 0.03). Interestingly, the Hs-CRP was reduced in AA carries while was elevated in individuals with GG and AG genotypes, after high-dose vitamin D supplementation. Conclusion Changes in serum vitamin D and metabolic profile following high dose supplementation with vitamin D were associated with CYP2R1 polymorphism. Although carriers of the common G allele showed a greater response in the serum vitamin D

Numerical solutions of the problem of salt-transfer in soils

Work is devoted to work out of effective numerical methods of the decision of problems of forecasting of mineralization of a soil solution taking into account of differential porosity and sorption and dissolution processes. The algorithm of the decision of a problem consists of the following sequence action. On time are used quadrature to the formula and regional problems with any boundary conditions dare a method of differential prorace. Testing of the program realising algorithm of the offered method of calculation it is carried out by the decision of the known problems, having practical application

A contribution to ants (Hymenoptera: Formicidae) from North and Northwestern regions of Iran

This paper deals with faunistic data on the Formicidae (Hymenoptera) from north and northwestern Iran. Totally 15 species in 10 genera were collected and identified, which four species are new records for the fauna of Iran. Four species are new records for the fauna of Iran: Myrmica ruginodis Nylander, 1846, Strongylognathus rehbinderi Forel, 1904, Temnothorax interruptus (Schenck, 1852), and Tetramorium immigrans Santschi, 1927

Vertical vibrations of traction engine with viscoelastic suspension

The tasks of a traction engine with suspension elements and additional devices for converting movement (DCM) are considered. The object of protection, the estimated dynamic state, is solid with mass M and moment of inertia J relative to the center of gravity. To account the suspension material's rheological properties, the Boltzmann-Volterra principle is used. Mathematical models of the problem under consideration are obtained, which are described by the systems of integro-differential equations. A solution method based on quadrature formulas is developed, and a computer program is compiled based on its basis, the results of which are reflected in the graphs. The influence of DCM and rheological properties of the suspension material on the shape of the vertical vibrations of the object is investigated