Efficacy of memantine in the treatment of fibromyalgia: A double-blind, randomised, controlled trial with 6-month follow-up.

Fibromyalgia (FM) is a prevalent and disabling chronic disease. Recent studies have found elevated levels of glutamate in several brain regions, leading to hypotheses about the usefulness of glutamate-blocking drugs such as memantine in the treatment of FM. The aim of this study was to evaluate the efficacy of memantine in the treatment of pain and other clinical variables (global function, clinical impression, depression, anxiety, quality of life) in FM patients. A double-blind, parallel randomised controlled trial was developed. A total of 63 patients diagnosed with FM were recruited from primary health care centres in Zaragoza, Spain. Memantine was administered at doses of 20mg/d after 1 month of titration. Assessments were carried out at baseline, posttreatment, and 3- and 6-month follow-up. Compared with a placebo group, memantine significantly decreased ratings on a pain visual analogue scale (Cohen's d=1.43 at 6 months) and pain measured with a sphygmomanometer (d=1.05). All other secondary outcomes except anxiety also improved, with moderate-to-large effect sizes at 6 months. Compared with placebo, the absolute risk reduction obtained with memantine was 16.13% (95% confidence interval=2.0% to 32.6%), and the number needed to treat was 6.2 (95% confidence interval=3 to 47). Tolerance was good, with dizziness (8 patients) and headache (4 patients) being the most frequent side effects of memantine. Although additional studies with larger sample sizes and longer follow-up times are needed, this study provides preliminary evidence of the utility of memantine for the treatment of FM

Molecular phylogeny and diversification history of Prosopis (Fabaceae: Mimosoideae)

The genus Prosopis is an important member of arid and semiarid environments around the world. To study Prosopis diversification and evolution, a combined approach including molecular phylogeny, molecular dating, and character optimization analysis was applied. Phylogenetic relationships were inferred from five different molecular markers (matK-trnK, trnL-trnF, trnS-psbC, G3pdh, NIA). Taxon sampling involved a total of 30 Prosopis species that represented all Sections and Series and the complete geographical range of the genus. The results suggest that Prosopis is not a natural group. Molecular dating analysis indicates that the divergence between Section Strombocarpa and Section Algarobia plus Section Monilicarpa occurred in the Oligocene, contrasting with a much recent diversification (Late Miocene) within each of these groups. The diversification of the group formed by species of Series Chilenses, Pallidae, and Ruscifoliae is inferred to have started in the Pliocene, showing a high diversification rate. The moment of diversification within the major lineages of American species of Prosopis is coincident with the spreading of arid areas in the Americas, suggesting a climatic control for diversification of the group. Optimization of habitat parameters suggests an ancient occupation of arid environments by Prosopis species.Fil: Catalano, Santiago Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Tucumán. Unidad Ejecutora Lillo; ArgentinaFil: Vilardi, Juan Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaFil: Tosto, Daniela Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas; ArgentinaFil: Saidman, Beatriz Ofelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentin

A Preliminary Conspectus of the Allon Flora from the Late Cretaceous (Late Santonian) of Central Georgia, U.S.A

Volume: 86Start Page: 407End Page: 47

Efficacy of memantine in the treatment of fibromyalgia: A double-blind, randomised, controlled trial with 6-month follow-up

a b s t r a c t Fibromyalgia (FM) is a prevalent and disabling chronic disease. Recent studies have found elevated levels of glutamate in several brain regions, leading to hypotheses about the usefulness of glutamate-blocking drugs such as memantine in the treatment of FM. The aim of this study was to evaluate the efficacy of memantine in the treatment of pain and other clinical variables (global function, clinical impression, depression, anxiety, quality of life) in FM patients. A double-blind, parallel randomised controlled trial was developed. A total of 63 patients diagnosed with FM were recruited from primary health care centres in Zaragoza, Spain. Memantine was administered at doses of 20 mg/d after 1 month of titration. Assessments were carried out at baseline, posttreatment, and 3-and 6-month follow-up. Compared with a placebo group, memantine significantly decreased ratings on a pain visual analogue scale (Cohen's d = 1.43 at 6 months) and pain measured with a sphygmomanometer (d = 1.05). All other secondary outcomes except anxiety also improved, with moderate-to-large effect sizes at 6 months. Compared with placebo, the absolute risk reduction obtained with memantine was 16.13% (95% confidence interval = 2.0% to 32.6%), and the number needed to treat was 6.2 (95% confidence interval = 3 to 47). Tolerance was good, with dizziness (8 patients) and headache (4 patients) being the most frequent side effects of memantine. Although additional studies with larger sample sizes and longer follow-up times are needed, this study provides preliminary evidence of the utility of memantine for the treatment of FM.

European Expert Network for the Reduction of Uncertainties in Severe Accident Safety Issues (EURSAFE)

EURSAFE thematic network was a concerted action in the 6th Framework Programme of the European Commission. It established a large consensus among the main actors in Nuclear Safety on the Severe Accident issues where large uncertainties still subsist. As the result of an action involving R&D governmental institutions, regulatory bodies, nuclear industry, utilities and universities from 6 EU member States (Finland, France, Germany, Spain, Sweden, United Kingdom) plus JRC, 3 European third countries (Czech Republic, Hungary, Switzerland), and the USA, EURSAFE represents a significant step towards harmonisation and credibility of the approaches, and resolution of the remaining Severe Accident issues.JRC.F.4-Nuclear design safet

Climatic reconstruction of two Pliocene floras from Mexico

The role that climate plays in influencing the physiognomy of modern and fossil plant communities is widely acknowledged and forms the basis for several palaeoclimate proxies. In this work, both univariate Leaf Margin Analysis and multivariate Climate/Leaf Analysis Multivariate Program (CLAMP) were used for the climatic reconstruction of two fossil localities of the Atotonilco El Grande Formation. Using the predominantly North American and Asian calibration data set PHYSG3BRC, supplemented with new African material, results from two sites, Los Baños (present position 20°18′18″N, 98°42′44.4″W) and Sanctorum (20°18′18.5″N and 98°46′52.2″W), indicate that during the Pliocene a mesothermal climate existed with mean annual temperatures between 12 and 22°C, with the most likely being approximately 15°C, and a mean annual temperature range of 21°C. A distinct seasonal variation in rainfall is evident with a mean annual relative humidity of 60–70%. Differences between the sites can be explained by differences in depositional regime and spatial heterogeneity in the predominantly Quercus-dominated woodland. The continuous subsequent uplift of the Sierra Madre Oriental, the resulting development of a rain shadow, and the eventual disappearance of a palaeolake appear to have caused a transition to the modern xerophytic shrub vegetation