Charting a New Sustainability Course for Luxury Game Lodges in Africa: A Hybrid Analytical Framework for Analysing the Key Coupled Human and Natural System Components

This paper introduces a hybrid analytical framework to comprehensively assess luxury game lodges within protected areas such as Coupled Human and Natural Systems (CHANS). The framework, developed through a synthesis of diverse Social-Ecological Systems (SES) models and tools, encompasses eight key steps, from sustainability context assessment to creating a tailored managerial-ecology model. By systematically analysing ecological, social, and economic dimensions, this framework empowers stakeholders to make informed decisions that balance biodiversity conservation, sustainability, and community engagement in luxury game lodge operations. Its practical application promises to advance the coexistence of ecotourism and environmental protection, fostering the long-term viability of these vital tourism destinations within protected areas

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe