Diseño y elaboración de una base de datos terminológica bilingüe (español-inglés) sobre embutidos a partir del análisis del corpus paralelo P-GEFEM

En el presente Trabajo Fin de Grado pretendemos realizar un estudio de la terminología empleada en el sector agroalimentario, en el campo de los derivados cárnicos y, en concreto, de los embutidos, a partir del análisis de los datos del corpus paralelo en español e inglés P-GEFEM. Este estudio es fundamental, dado que este sector requiere cada vez más de los servicios de traducción y que aún no existe una uniformidad entre las opciones de traducción al inglés de cada término especializado. Con los datos que se desprendan del análisis de P-GEFEM elaboraremos una base de datos terminológica bilingüe (ES/EN) sobre embutidos que facilite la labor traductológica de los traductores de este campo del saber.Grado en Traducción e Interpretació

THE ROLE OF SELF-BRAND CONNECTION IN BRAND PRIMING AND BRAND CO-CREATION CONTEXTS

This dissertation includes two essays that examine how self-brand connection influences brand-related behaviors in different contexts. Essay I investigates conditions under which brand primes can lead to decreased behavioral intentions toward the brand not shown in prior brand priming research (Berger and Fitzsimons 2008; Ferraro, Bettman, and Chartrand 2009). We identify the type of association primed (core vs. non-core) as an important factor in determining whether positive or negative brand priming effects will occur for consumers with low vs. high self-brand connection (SBC; Escalas and Bettman 2003). Studies 1 and 2 find support for the notion that high (vs. low) SBC consumers' brand associative networks have stronger links between core associations and brand and overlap between the self and core associations. Studies 3 and 4 show that when SBC is low, priming core and non-core associations leads to increased behavioral intentions found in prior work (Berger and Fitzsimons 2008). When SBC is high, however, priming a non-core association decreases behavioral intentions, while priming a core association does not affect behavioral intentions. Thus, contrary to prior research (Park et al. 2010), we show that higher SBC may result in lower behavioral intentions under certain conditions. Essay II explores the conditions under which brief brand co-creation activities are effective in enhancing high (vs. low) SBC consumers' subsequent brand engagement in social media, such as liking the brand on Facebook and sharing brand promotions with others. Many brand marketers offer interactive activities that enable consumers to participate in the ongoing development of the brand, such as telling their own stories about the brand or evaluating other consumers' stories. We offer evidence that these co-creation activities vary according to their potential to create brand knowledge. We then examine how consumers' self-brand connection and the co-creation activity's brand knowledge potential interact to affect brand engagement. Across three studies, we demonstrate that high SBC (i.e., loyal) consumers intend to engage more deeply with the brand after participating in high rather than low brand knowledge potential co-creation activities. We show that generation of original, personal brand meaning underlies the effect

There’s no place like home: Integrating pulmonary rehabilitation into the home setting

Traditional, outpatient pulmonary rehabilitation provided to stable COPD patients leads to significant improvements in dyspnea, exercise capacity and health related quality of life.  Also, when started during or shortly after a hospitalization for a COPD exacerbation, pulmonary rehabilitation improves these patient-centered outcomes and arguably reduces subsequent health care utilization and mortality.  Despite these benefits, the uptake of traditional pulmonary rehabilitation remains disappointingly poor.  Home-based pulmonary rehabilitation, a safe and effective alternative to traditional, center-based programs, can broaden access. While proven improvements in dyspnea, exercise capacity and health status justify implementation of home-based pulmonary rehabilitation, it would be helpful to know whether it can also decrease health care utilization and be cost-effective.

Umbral Calculus, Discretization, and Quantum Mechanics on a Lattice

`Umbral calculus' deals with representations of the canonical commutation relations. We present a short exposition of it and discuss how this calculus can be used to discretize continuum models and to construct representations of Lie algebras on a lattice. Related ideas appeared in recent publications and we show that the examples treated there are special cases of umbral calculus. This observation then suggests various generalizations of these examples. A special umbral representation of the canonical commutation relations given in terms of the position and momentum operator on a lattice is investigated in detail.Comment: 19 pages, Late

Poesía accesible : la subtitulación para sordos de las actuaciones del poetry Slam Barcelona

En el presente Trabajo Fin de Máster pretendemos realizar una investigación sobre el subtitulado para sordos intralingüístico en español de poesía, en concreto del slam o poesía escénica, a partir del análisis de un corpus monolingüe que se compone por los SPS de los vídeos de los poemas subtitulados durante la colaboración con el Poetry Slam Barcelona. De esta manera, podremos determinar los desafíos y características principales de este género textual y observar las soluciones resultantes de las estrategias aplicadas durante el proceso de subtitulado. Asimismo, los resultados y las conclusiones obtenidas en este estudio podrán emplearse para mejorar la accesibilidad a los materiales audiovisuales de este género que está en continuo auge y que es importante para la difusión de arte y cultura.This final project aims to research the intralinguistic subtitling of poetry for the deaf in Spanish, specifically slam or stage poetry, based on the analysis of a monolingual corpus made up of the SDH subtitles of the videos of the subtitled poems during the collaboration with the Poetry Slam Barcelona. In this way, we will be able to determine the challenges and main features of this textual genre and observe the solutions resulting from the strategies applied during the subtitling process. Likewise, the results and conclusions obtained in this study could be used to pursue improvement in the accessibility of audiovisual materials of this genre, which is continuously growing and is essential for art and culture dissemination.En el present Treball Fi de Màster investiguem la subtitulació per a sords intralingüística en espanyol de poesia, en concret de l'slam o poesia escènica, a partir de l'anàlisi d'un corpus monolingüe compost pels SPS dels vídeos dels poemes subtitulats durant la col·laboració amb el Poetry Slam Barcelona. D'aquesta manera, podrem determinar els desafiaments i característiques principals d'aquest gènere textual i observar les solucions resultants de les estratègies aplicades durant el procés de subtitulació. Així mateix, els resultats i les conclusions obtingudes en aquest estudi podran emprar-se per millorar l'accessibilitat als materials audiovisuals d'aquest gènere, que està en continu auge i que és important per a la difusió de l'art i la cultura

Homologous recombination DNA repair defects in PALB2-associated breast cancers

© 2019, The Author(s). Mono-allelic germline pathogenic variants in the Partner And Localizer of BRCA2 (PALB2) gene predispose to a high-risk of breast cancer development, consistent with the role of PALB2 in homologous recombination (HR) DNA repair. Here, we sought to define the repertoire of somatic genetic alterations in PALB2-associated breast cancers (BCs), and whether PALB2-associated BCs display bi-allelic inactivation of PALB2 and/or genomic features of HR-deficiency (HRD). Twenty-four breast cancer patients with pathogenic PALB2 germline mutations were analyzed by whole-exome sequencing (WES, n = 16) or targeted capture massively parallel sequencing (410 cancer genes, n = 8). Somatic genetic alterations, loss of heterozygosity (LOH) of the PALB2 wild-type allele, large-scale state transitions (LSTs) and mutational signatures were defined. PALB2-associated BCs were found to be heterogeneous at the genetic level, with PIK3CA (29%), PALB2 (21%), TP53 (21%), and NOTCH3 (17%) being the genes most frequently affected by somatic mutations. Bi-allelic PALB2 inactivation was found in 16 of the 24 cases (67%), either through LOH (n = 11) or second somatic mutations (n = 5) of the wild-type allele. High LST scores were found in all 12 PALB2-associated BCs with bi-allelic PALB2 inactivation sequenced by WES, of which eight displayed the HRD-related mutational signature 3. In addition, bi-allelic inactivation of PALB2 was significantly associated with high LST scores. Our findings suggest that the identification of bi-allelic PALB2 inactivation in PALB2-associated BCs is required for the personalization of HR-directed therapies, such as platinum salts and/or PARP inhibitors, as the vast majority of PALB2-associated BCs without PALB2 bi-allelic inactivation lack genomic features of HRD

Homologous recombination DNA repair defects in PALB2- associated breast cancers

Abstract: Mono-allelic germline pathogenic variants in the Partner And Localizer of BRCA2 (PALB2) gene predispose to a high-risk of breast cancer development, consistent with the role of PALB2 in homologous recombination (HR) DNA repair. Here, we sought to define the repertoire of somatic genetic alterations in PALB2-associated breast cancers (BCs), and whether PALB2-associated BCs display bi-allelic inactivation of PALB2 and/or genomic features of HR-deficiency (HRD). Twenty-four breast cancer patients with pathogenic PALB2 germline mutations were analyzed by whole-exome sequencing (WES, n = 16) or targeted capture massively parallel sequencing (410 cancer genes, n = 8). Somatic genetic alterations, loss of heterozygosity (LOH) of the PALB2 wild-type allele, large-scale state transitions (LSTs) and mutational signatures were defined. PALB2-associated BCs were found to be heterogeneous at the genetic level, with PIK3CA (29%), PALB2 (21%), TP53 (21%), and NOTCH3 (17%) being the genes most frequently affected by somatic mutations. Bi-allelic PALB2 inactivation was found in 16 of the 24 cases (67%), either through LOH (n = 11) or second somatic mutations (n = 5) of the wild-type allele. High LST scores were found in all 12 PALB2-associated BCs with bi-allelic PALB2 inactivation sequenced by WES, of which eight displayed the HRD-related mutational signature 3. In addition, bi-allelic inactivation of PALB2 was significantly associated with high LST scores. Our findings suggest that the identification of bi-allelic PALB2 inactivation in PALB2-associated BCs is required for the personalization of HR-directed therapies, such as platinum salts and/or PARP inhibitors, as the vast majority of PALB2-associated BCs without PALB2 bi-allelic inactivation lack genomic features of HRD

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.

Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divided into training and validation sets. Samples were genotyped using genome-wide arrays, and single-nucleotide polymorphisms (SNPs) were selected by stepwise regression or lasso penalized regression. The best performing PRSs were validated in an independent test set comprising 11,428 case subjects and 18,323 control subjects from 10 prospective studies and 190,040 women from UK Biobank (3,215 incident breast cancers). For the best PRSs (313 SNPs), the odds ratio for overall disease per 1 standard deviation in ten prospective studies was 1.61 (95%CI: 1.57-1.65) with area under receiver-operator curve (AUC) = 0.630 (95%CI: 0.628-0.651). The lifetime risk of overall breast cancer in the top centile of the PRSs was 32.6%. Compared with women in the middle quintile, those in the highest 1% of risk had 4.37- and 2.78-fold risks, and those in the lowest 1% of risk had 0.16- and 0.27-fold risks, of developing ER-positive and ER-negative disease, respectively. Goodness-of-fit tests indicated that this PRS was well calibrated and predicts disease risk accurately in the tails of the distribution. This PRS is a powerful and reliable predictor of breast cancer risk that may improve breast cancer prevention programs

Şantierul arheologic Caşolţ-Boiţa / Le chantier archéologique de Casolț-Boița

Macrea Mihail. Şantierul arheologic Caşolţ-Boiţa / Le chantier archéologique de Casolț-Boița. In: Materiale şi cercetări arheologice, N°6 1959. pp. 407-443