2,785 research outputs found
Cephalometric evaluation of the airway space and hyoid bone in children with normal and atypical deglutition: correlation study
Coordenação de Aperfeiçoamento de Pessoal de NÃvel Superior (CAPES)CONTEXT AND OBJECTIVE: Although there is a close relationship between swallowing and breathing, there are no studies evaluating the radiographic anatomy of the airway and its possible correlation with the radiographic position of the hyoid bone. The aim of this study was to evaluate the possible correlation of the radiographic position of the hyoid bone and airway space (PAS) in lateral radiographs on children with atypical deglutition, in comparison with those with normal swallowing. DESIGN AND SETTING: Cross-sectional analytical study with control group in a public university. METHODS: Using cephalometric analysis on lateral teleradiographs, the distance from the hyoid bone to the mandibular plane (MP-H) and the distance from the hyoid bone to the tuber (T-H) were correlated with the PAS measurement (airway) in two groups: 55 teleradiographs in the experimental group (with atypical deglutition) and 55 teleradiographs in the control group (normal deglutition). Both groups included subjects at the mixed dentition stage. RESULTS: The variable T-H presented a statistically significant correlation with PAS (0.0286) and the variable MP-H had a significant correlation with the variable PAS (0.0053). This positive correlation was significant only in the control group and not in the group with atypical swallowing. CONCLUSIONS: There was a positive correlation between the MP-H and PAS measurements and between the T-H and PAS measurements only in the group with normal swallowing. These correlations were not observed in the group with atypical swallowing.1304236241Coordenação de Aperfeiçoamento de Pessoal de NÃvel Superior (CAPES)Coordenação de Aperfeiçoamento de Pessoal de NÃvel Superior (CAPES)CAPES [2008/995978
Sacroiliac joint radiographic progression - speed and determinants
Non-radiographic axial spondyloarthritis (nr-axSpA) and radiographic axial spondyloarthritis (r-axSpA) are considered to be different spectra of the same disease. Accumulating data suggest a low transition rate from nr-axSpA to r-axSpA in patients with early disease and identify inflammation, smoking and HLA-B27 positivity as factors associated with transition
SOCS2 Influences LPS Induced Human Monocyte-Derived Dendritic Cell Maturation
Dendritic cells (DCs) are highly specific antigen presenting cells, which link innate and adaptive immune responses and participate in protecting hosts from invading pathogens. DCs can be generated in vitro by culturing human monocytes with GM-CSF and IL-4 followed by LPS induced DC maturation. We set out to study the suppressor of cytokine signaling (SOCS) proteins during maturation and activation of human monocyte-derived DCs from peripheral blood in vitro. We found that the expression of SOCS2 mRNA and protein is dramatically up-regulated during DC maturation. Silencing of SOCS2 using siRNA, inhibited DC maturation as evidenced by a decreased expression of maturation markers such as CD83, co-stimulatory molecules CD40, CD86 and HLA-DR. Furthermore, silencing of SOCS2 decreased LPS induced activation of MAP kinases (SAKP/JNK, p38, ERK), IRF3, decreased the translocation of the NF-κB transcription factor and reduced downstream gene mRNA expression. These results suggest a role for SOCS2 in the MyD88-dependent and -independent TLR4 signaling pathways. In conclusion, our results demonstrate that SOCS2 is required for appropriate TLR4 signaling in maturating human DCs via both the MyD88-dependent and -independent signaling pathway
Tipos de cultura organizacional y S?ndrome de Burnout
El objetivo principal de la presente investigaci?n es determinar la relaci?n entre los tipos de cultura organizacional basados en el Modelo de Valores de Competencia de Cameron & Quinn y el modelo tridimensional del S?ndrome de Burnout de Maslach con la intenci?n de saber si, gestionando debidamente la cultura organizacional de una empresa, se podr?a prevenir la aparici?n del S?ndrome de Burnout, el cual puede llevar a la personas a contraer problemas de salud adicionales como depresi?n, abuso de f?rmacos y enfermedades coronarias, entre otros. El an?lisis de la relaci?n existente entre los tipos de cultura organizacional con cada una de las dimensiones del S?ndrome de Burnout considera tambi?n variables demogr?ficas como edad, tiempo de servicio, puesto y ubicaci?n. Las conclusiones a las que se arriba luego del an?lisis hacen referencia a la necesidad de una adecuada gesti?n de los tipos de cultura organizacional en las empresas, con la finalidad de reducir riesgos psicosociales asociados a la actividad laboral como es el S?ndrome de Burnout. Finalmente, este estudio se considera un referente para trabajar en la creaci?n de iniciativas organizacionales que generen un impacto positivo en la salud organizacional y en la salud de la poblaci?n en general
Parallaxes and proper motions for 20 open clusters as based on the new Hipparcos catalogue
A new reduction of the astrometric data as produced by the Hipparcos mission
has been published, claiming that the accuracies for nearly all stars brighter
than magnitude are improved, by up to a factor 4, compared to
the original catalogue. As correlations between the underlying abscissa
residuals have also been reduced by more than an order of magnitude to an
insignificant level, our ability to determine reliable parallaxes and proper
motions for open clusters should be improved. The new Hipparcos astrometric
catalogue is used to derive mean parallax and proper motion estimates for 20
open clusters. The HR-diagrams of the nearest clusters are compared and
combined to provide future input to sets of observational isochrones. The
positions of the cluster HR diagrams are consistent within different groups of
clusters shown for example by the near-perfect alignment of the sequences for
the Hyades and Praesepe, for Coma Ber and UMa, and for the Pleiades, NGC 2516,
and Blanco 1. The groups are mutually consistent when systematic differences in
are taken into account, where the effect of these differences on
the absolute magnitudes has been calibrated using field-star observations.Comment: 34 pages, 36 figures, 7 tables. Accepted for publication by A&
Implications of the Daya Bay observation of \theta_{13} on the leptonic flavor mixing structure and CP violation
The Daya Bay Collaboration has recently reported its first \bar{\nu}_e \to
\bar{\nu}_e oscillation result which points to \theta_{13} \simeq 8.8^\circ \pm
0.8^\circ (best-fit \pm 1\sigma range) or \theta_{13} \neq 0^\circ at the
5.2\sigma level. The fact that this smallest neutrino mixing angle is not
strongly suppressed motivates us to look into the underlying structure of
lepton flavor mixing and CP violation. Two phenomenological strategies are
outlined: (1) the lepton flavor mixing matrix U consists of a constant leading
term U_0 and a small perturbation term \Delta U; and (2) the mixing angles of U
are associated with the lepton mass ratios. Some typical patterns of U_0 are
reexamined by constraining their respective perturbations with current
experimental data. We illustrate a few possible ways to minimally correct U_0
in order to fit the observed values of three mixing angles. We point out that
the structure of U may exhibit an approximate \mu-\tau permutation symmetry in
modulus, and reiterate the geometrical description of CP violation in terms of
the leptonic unitarity triangles. The salient features of nine distinct
parametrizations of U are summarized, and its Wolfenstein-like expansion is
presented by taking U_0 to be the democratic mixing pattern.Comment: RevTeX 25 pages, 1 figure, minor changes, version for publicatio
Vacuum Instabilities with a Wrong-Sign Higgs-Gluon-Gluon Amplitude
The recently discovered 125 GeV boson appears very similar to a Standard
Model Higgs, but with data favoring an enhanced h to gamma gamma rate. A number
of groups have found that fits would allow (or, less so after the latest
updates, prefer) that the h-t-tbar coupling have the opposite sign. This can be
given meaning in the context of an electroweak chiral Lagrangian, but it might
also be interpreted to mean that a new colored and charged particle runs in
loops and produces the opposite-sign hGG amplitude to that generated by
integrating out the top, as well as a contribution reinforcing the W-loop
contribution to hFF. In order to not suppress the rate of h to WW and h to ZZ,
which appear to be approximately Standard Model-like, one would need the loop
to "overshoot," not only canceling the top contribution but producing an
opposite-sign hGG vertex of about the same magnitude as that in the SM. We
argue that most such explanations have severe problems with fine-tuning and,
more importantly, vacuum stability. In particular, the case of stop loops
producing an opposite-sign hGG vertex of the same size as the Standard Model
one is ruled out by a combination of vacuum decay bounds and LEP constraints.
We also show that scenarios with a sign flip from loops of color octet charged
scalars or new fermionic states are highly constrained.Comment: 20 pages, 8 figures; v2: references adde
MRI lesions in the sacroiliac joints of patients with spondyloarthritis: an update of definitions and validation by the ASAS MRI working group
OBJECTIVES: The Assessment of SpondyloArthritis international Society (ASAS) MRI working group (WG) was convened to generate a consensus update on standardised definitions for MRI lesions in the sacroiliac joint (SIJ) of patients with spondyloarthritis (SpA), and to conduct preliminary validation. // METHODS: The literature pertaining to these MRI lesion definitions was discussed at three meetings of the group. 25 investigators (20 rheumatologists, 5 radiologists) determined which definitions should be retained or required revision, and which required a new definition. Lesion definitions were assessed in a multi-reader validation exercise using 278 MRI scans from the ASAS classification cohort by global assessment (lesion present/absent) and detailed scoring (inflammation and structural). Reliability of detection of lesions was analysed using kappa statistics and the intraclass correlation coefficient (ICC). // RESULTS: No revisions were made to the current ASAS definition of a positive SIJ MRI or definitions for subchondral inflammation and sclerosis. The following definitions were revised: capsulitis, enthesitis, fat lesion and erosion. New definitions were developed for joint space enhancement, joint space fluid, fat metaplasia in an erosion cavity, ankylosis and bone bud. The most frequently detected structural lesion, erosion, was detected almost as reliably as subchondral inflammation (κappa/ICC:0.61/0.54 and 0.60/0.83) . Fat metaplasia in an erosion cavity and ankylosis were also reliably detected despite their low frequency (κappa/ICC:0.50/0.37 and 0.58/0.97). // CONCLUSION: The ASAS-MRI WG concluded that several definitions required revision and some new definitions were necessary. Multi-reader validation demonstrated substantial reliability for the most frequently detected lesions and comparable reliability between active and structural lesions
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