Sexual Function in Women with Breast Cancer : An Evidence Map of Observational Studies

Breast cancer (BC) is the leading cause of cancer in women, and has implications for sexual function (SF). In this study, we used an evidence map to identify, describe, and organise the current available evidence regarding SF in women with BC. We searched the MEDLINE, PsycINFO, and CINAHL databases for observational studies assessing SF in women with BC published in English, Spanish, Portuguese, and French between 2000 and 2021 (sample ≥ 50 women). Of the 64 included studies (13,257 women with BC), 58 were published since 2010. Women who were married, partnered, or in relationships represented 74.1% of the entire sample. Only a single study was conducted on women representing a sexual minority. We identified 22 assessment instruments and 40 sexual dysfunction (SdF) domains. The number of publications on SF in women with BC has increased in the last 10 years, but still remains low. Some groups of women are underrepresented, and some SdF domains are underdiagnosed, with the assessment instrument used affecting which domains are studied. Women with BC need to be better screened, as their quality of life (QoL) is affected by Sd

Quality Evaluation of ‘Sunburst’ Cherries Harvested at Different

The sweet cherry ‘Sunburst’ is highly appreciated by consumers due to its organoleptic traits. Regional producers tend to harvest cherries sooner in order to increase their profits. With the aim of understanding the consequences of this we have tested the effect of different ripeness stages at the moment of harvesting on fruit quality. Quality parameters tested included external colour (L*, a*, b*), fruit texture, total soluble solids (TSS), and titratable acidity (TA). To evaluate nutritional quality total antioxidant activity was measured too. Once again, and in agreement with results obtained in previous studies, we conclude that there is no advantage in picking less ripe cherrie

Flood frequency analysis of historical flood data under stationary and non-stationary modelling

Historical records are an important source of information on extreme and rare floods and fundamental to establish a reliable flood return frequency. The use of long historical records for flood frequency analysis brings in the question of flood stationarity, since climatic and land-use conditions can affect the relevance of past flooding as a predictor of future flooding. In this paper, a detailed 400 yr flood record from the Tagus River in Aranjuez (central Spain) was analysed under stationary and non-stationary flood frequency approaches, to assess their contribution within hazard studies. Historical flood records in Aranjuez were obtained from documents (Proceedings of the City Council, diaries, chronicles, memoirs, etc.), epigraphic marks, and indirect historical sources and reports. The water levels associated with different floods (derived from descriptions or epigraphic marks) were computed into discharge values using a one-dimensional hydraulic model. Secular variations in flood magnitude and frequency, found to respond to climate and environmental drivers, showed a good correlation between high values of historical flood discharges and a negative mode of the North Atlantic Oscillation (NAO) index. Over the systematic gauge record (1913–2008), an abrupt change on flood magnitude was produced in 1957 due to constructions of three major reservoirs in the Tagus headwaters (Bolarque, Entrepeñas and Buendia) controlling 80% of the watershed surface draining to Aranjuez. Two different models were used for the flood frequency analysis: (a) a stationary model estimating statistical distributions incorporating imprecise and categorical data based on maximum likelihood estimators, and (b) a time-varying model based on "generalized additive models for location, scale and shape" (GAMLSS) modelling, which incorporates external covariates related to climate variability (NAO index) and catchment hydrology factors (in this paper a reservoir index; RI). Flood frequency analysis using documentary data (plus gauged records) improved the estimates of the probabilities of rare floods (return intervals of 100 yr and higher). Under non-stationary modelling flood occurrence associated with an exceedance probability of 0.01 (i.e. return period of 100 yr) has changed over the last 500 yr due to decadal and multi-decadal variability of the NAO. Yet, frequency analysis under stationary models was successful in providing an average discharge around which value flood quantiles estimated by non-stationary models fluctuate through time

Can heart tissue fatty acid profile be used as a tool to discriminate sea lamprey (Petromyzon marinus, L.) populations in several Portuguese river basins?

This study proposes to evaluate the use of heart tissue fatty acid signature and multivariate analysis of fatty acid profile as a possible discriminating tool for sea lamprey P. marinus populations sampled in Portuguese river basins. Local fisherman collected adult sea lampreys in eight Portuguese river basins (Minho, Lima, Cávado, Douro, Vouga, Mondego, Tagus and Guadiana) at the beginning of their spawning migration. Heart total lipid extraction was obtained by accelerated solvent extraction (ASE) and FAMEs were prepared by transesterification with methanol-boron trifluoride and analysed by GC. FAMEs were identified by comparison of their retention times with known standards chromatographed in identical gas chromatography conditions. The fatty acid profile of the heart tissue varied among the individuals of the different river basins. In order to identify which fatty acid contributed most to the differences between river basins heart tissue, MDA was employed. The MDA proved to be statistically significant and the overall corrected classification rate estimated from cross-validation procedure was 86.2%. Although in the case of the individuals of Tagus and Guadiana 100% and 94.7 % of subjects were correctly classified, respectively, there are always a few individuals of the other 5 watersheds that have characteristics identical to those observed in these two river basins.The results are discussed in terms of fatty acid origin and hypothesis concerning the migratory behavior that could lead to these results. The fatty acid profile of heart is considered more stable than other organs, but it still exhibits some variability. This study seems to point out the potential for fatty acid compositions to discriminate sea lampreys from Portuguese river basins, which are probably related with environmental variables that they may have been exposed during early stages of their life cycle

Study of flare energy release using events with numerous type III-like bursts in microwaves

The analysis of narrowband drifting of type III-like structures in radio bursts dynamic spectra allows to obtain unique information about primary energy release mechanisms in solar flares. The SSRT spatially resolved images and a high spectral and temporal resolution allow direct determination not only the positions of its sources but also the exciter velocities along the flare loop. Practically, such measurements are possible during some special time intervals when the SSRT (about 5.7 GHz) is observing the flare region in two high-order fringes; thus, two 1D scans are recorded simultaneously at two frequency bands. The analysis of type III-like bursts recorded during the flare 14 Apr 2002 is presented. Using-muliwavelength radio observations recorded by SSRT, SBRS, NoRP, RSTN we study an event with series of several tens of drifting microwave pulses with drift rates in the range from -7 to 13 GHz/s. The sources of the fast-drifting bursts were located near the top of the flare loop in a volume of a few Mm in size. The slow drift of the exciters along the flare loop suggests a high pitch-anisotropy of the emitting electrons.Comment: 16 pages, 6 figures, Solar Physics, in press, 201

Story Map Caminhos d’O Conspirador: um percurso literário na vila de Marvão com Branquinho da Fonseca

Os autores pretendem apresentar uma nova forma de divulgação da investigação em turismo literário, num formato mais atrativo, recorrendo às novas tecnologias e bem assim, aferir as suas potencialidades. A ferramenta tecnológica utilizada foi o story map que permite combinar mapas na Web com aplicações e templates que incorporam funções interativas e mapas dinâmicos. Um dos recursos utilizados na produção do story map foi a base de dados do Museu Virtual de Turismo (MUVITUR) em cujo site o produto final será disponibilizado. Os conteúdos e itinerários turísticos literários organizados por especialistas permitem envolver os viajantes online nas geografias imaginárias, para as quais os escritores nos remetem. Experiências virtuais mais envolventes possibilitam a cada utilizador a descoberta dos melhores percursos por territórios literários. O objeto do presente trabalho foi o conto “O Conspirador”, de Branquinho da Fonseca (1905-1974) tendo o percurso na vila de Marvão sido enriquecido com desenhos e fotografias da sua autoriaThe authors intend to present a more attractive format to disseminate research in literary tourism, making use of new technologies. The story map is the technological tool used, and it allows the combination of online maps with apps and templates that incorporate interactive functions and dynamic maps. One of the resources the authors use in the production of the story map is the database of the Virtual Tourism Museum (MUVITUR) on whose website the final product will be made available. The literary content and tourist itineraries organized by specialists allow online travellers to be involved in imaginary geographies created by writers. More engaging virtual experiences enable users to discover the best routes through literary territories. The object of the present study was the short story “O Conspirador”, by Branquinho da Fonseca (1905-1974) and the itinerary in the village of Marvão was enhanced by drawings and photographs authored by the writer.info:eu-repo/semantics/publishedVersio

Homologous Flares and Magnetic Field Topology in Active Region NOAA 10501 on 20 November 2003

We present and interpret observations of two morphologically homologous flares that occurred in active region (AR) NOAA 10501 on 20 November 2003. Both flares displayed four homologous H-alpha ribbons and were both accompanied by coronal mass ejections (CMEs). The central flare ribbons were located at the site of an emerging bipole in the center of the active region. The negative polarity of this bipole fragmented in two main pieces, one rotating around the positive polarity by ~ 110 deg within 32 hours. We model the coronal magnetic field and compute its topology, using as boundary condition the magnetogram closest in time to each flare. In particular, we calculate the location of quasiseparatrix layers (QSLs) in order to understand the connectivity between the flare ribbons. Though several polarities were present in AR 10501, the global magnetic field topology corresponds to a quadrupolar magnetic field distribution without magnetic null points. For both flares, the photospheric traces of QSLs are similar and match well the locations of the four H-alpha ribbons. This globally unchanged topology and the continuous shearing by the rotating bipole are two key factors responsible for the flare homology. However, our analyses also indicate that different magnetic connectivity domains of the quadrupolar configuration become unstable during each flare, so that magnetic reconnection proceeds differently in both events.Comment: 24 pages, 10 figures, Solar Physics (accepted

Factors Associated With Fragility Fractures In Women Over 50 Years Of Age: A Population-based Household Survey [fatores Associados A Fraturas Por Fragilidade óssea Em Mulheres Acima De 50 Anos De Idade: Um Estudo De Base Populacional]

Purpose: To analyze the prevalence of and factors associated with fragility fractures in Brazilian women aged 50 years and older. Methods: This cross-sectional population survey, conducted between May 10 and October 31, 2011, included 622 women aged ≥50 years living in a city in southeastern Brazil. A questionnaire was administered to each woman by a trained interviewer. The associations between the occurrence of a fragility fracture after age 50 years and sociodemographic data, health-related habits and problems, self-perception of health and evaluation of functional capacity were determined by the χ2 test and Poisson regression using the backward selection criteria. Results: The mean age of the 622 women was 64.1 years. The prevalence of fragility fractures was 10.8%, with 1.8% reporting hip fracture. In the final statistical model, a longer time since menopause (PR 1.03; 95%CI 1.01-1.05; p<0.01) and osteoporosis (PR 1.97; 95%CI 1.27-3.08; p<0.01) were associated with a higher prevalence of fractures. Conclusion: These findings may provide a better understanding of the risk factors associated with fragility fractures in Brazilian women and emphasize the importance of performing bone densitometry.3511497502Instituto Brasileiro de Geografia e Estatística (IBGE) [Internet]., , http://censo2010.ibge.gov.br/resultados, Censo 2010: resultados [citado 2013 Fev 14]. Disponível emKanis, J.A., Odén, A., McCloskey, E.V., Johansson, H., Wahl, D.A., Cooper, C., A systematic review of hip fracture incidence and probability of fracture worldwide (2012) Osteoporos Int., 23 (9), pp. 2239-2256Hughson, J., Newman, J., Pendleton, R.C., Hip fracture management for the hospital-based clinician: A review of the evidence and best practices (2011) Hosp Pract (1995)., 39 (1), pp. 52-61Auron-Gomez, M., Michota, F., Medical management of hip fracture (2008) Clin Geriatr Med., 24 (4), pp. 701-719+ixPinheiro, M.M., Ciconelli, R.M., Martini, L.A., Ferraz, M.B., Clinical risk factors for osteoporotic fractures in Brazilian women and men: The Brazilian Osteoporosis Study (BRAZOS) (2009) Osteoporos Int., 20 (3), pp. 399-408Siqueira, F.V., Facchini, L.A., Hallal, P.C., The burden of fractures in Brazil: A population-based study (2005) Bone., 37 (2), pp. 261-266Pinheiro, M.M., Reis Neto, E.T., McHado, F.S., Omura, F., Yang, J.H.K., Szejnfeld, J., Risk factors for osteoporotic fractures and low bone density in pre and postmenopausal women (2010) Rev Saúde Pública., 44 (3), pp. 479-485Kanis, J.A., Johnell, O., Oden, A., Johansson, H., McCloskey, E., FRAX and the assessment of fracture probability in men and women from the UK (2008) Osteoporos Int., 19 (4), pp. 385-397Pinheiro, M.M., Eis, S.R., Epidemiology of osteoporotic fractures in Brazil: What we have and what we need (2010) Arq Bras Endocrinol Metabol., 54 (2), pp. 164-170FRAX: WHO Fracture Risk Assessment Tool [Internet]., , http://www.shef.ac.uk/FRAX/tool.aspx?country=55, Calculation tool [cited 2013 May 7]. Available fromLebrão, M.L., Duarte, Y.A.O., (2003) SABE-Saúde, bem-estar e envelhecimento-O projeto SABE no município de São Paulo: Uma abordagem inicial, , Brasília (DF): Organização Pan-Americana de Saúde(2008) Vigilância de fatores de risco e proteção para doenças crônicas não transmissíveis por entrevistas telefônicas (VIGITEL)., , http://portal.saude.gov.br/portal/arquivos/pdf/167_Q2008.pdf, Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde [Internet]. [citado 2013 Fev 14]. Disponível emGuralnik, J.M., Fried, L.P., Simonsick, E.M., Kasper, J.D., Lafferty, M.E., (1995) The women's health and aging study: Health and social characteristics of older women with disability., , editors. Bethesda: National Institute on Aging(NIH Pub. No. 95-4009)Altman, D.G., (1999) Practical statistics for medical research, , Boca Raton: Chapman & Hall/CRCBarros, A.J.D., Hirakata, V.N., Alternatives for logistic regression in cross-sectional studies: An empirical comparison of models that directly estimate the prevalence ratio (2003) BMC Med Res Methodol., 3, p. 21Baim, S., Leslie, W.D., Assessment of fracture risk (2012) Curr Osteoporos Rep., 10 (1), pp. 28-41(2010) Clinician's guide to prevention and treatment of osteoporosis, , National Osteoporosis Foundation. Washington, DC: National Osteoporosis FoundationBaccaro, L.F., McHado, V.S.S., Costa-Paiva, L., Sousa, M.H., Osis, M.J., Pinto-Neto, A.M., Treatment for menopausal symptoms and having health insurance were associated with a lower prevalence of falls among Brazilian women (2013) Maturitas., 75 (4), pp. 367-372Baccaro, L.F., McHado, V.S.S., Costa-Paiva, L., Souza, M.H., Osis, M.J., Pinto-Neto, A.M., Factors associated with osteoporosis in Brazilian women: A population-based household survey (2013) Arch Osteoporos., 8 (1-2), p. 138Kärkkäinen, M., Rikkonen, T., Kröger, H., Sirola, J., Tuppurainen, M., Salovaara, K., Association between functional capacity tests and fractures: An eight-year prospective population-based cohort study (2008) Osteoporos Int., 19 (8), pp. 1203-1210Recker, R., Lappe, J., Davies, K., Heaney, R., Characterization of perimenopausal bone loss: A prospective study (2000) J Bone Miner Res., 15 (10), pp. 1965-1973Ohta, H., Sugimoto, I., Masuda, A., Komukai, S., Suda, Y., Makita, K., Decreased bone mineral density associated with early menopause progresses for at least ten years: Cross-sectional comparisons between early and normal menopausal women (1996) Bone., 18 (3), pp. 227-231Gerdhem, P., Obrant, K.J., Bone mineral density in old age: The influence of age at menarche and menopause (2004) J Bone Miner Metab., 22 (4), pp. 372-375Portaria no 1101/GM, 12 junho 2002, , http://dtr2001.saude.gov.br/sas/PORTARIAS/Port2002/Gm/GM-1101.htm, Brasil. 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Self-perception Of Sexual Life And Associated Factors: A Population Study Conducted In Women Aged 50 Or More Years [autopercepção De Vida Sexual E Fatores Associados: Estudo Populacional Em Mulheres Com 50 Anos Ou Mais]

Purpose: To evaluate the prevalence of women aged 50 years or more who are sexually active and their self-perception with respect to their sexual lives. Associated factors were also assessed. Methods: A cross-sectional, population-based, self-reported household survey involving 622 Brazilian women aged 50 years or more. Sociodemographic, clinical, and behavioral factors were evaluated. The sexual life self-perception was classified as very good, good, fair, poor, or very poor. Data were analyzed using the χ2 test, Fisher's exact test, and Poisson multiple regression analysis. Prevalence ratios and their 95% confidence intervals were also calculated. Results: Of the women in this sample, 228 (36.7%) reported having a sexual life and, of these, 53.5% classified it as very good or good, while 46.5% considered it fair, poor, or very poor. The bivariate analysis indicated that being postmenopausal (p=0.025) and using natural remedies to treat the menopause (p=0.035) were factors associated with the woman classifying their sexual lives as fair, poor, or very poor. Multiple regression analysis showed that more women who had used or were currently using natural remedies for the menopause scored their sexual lives as fair, poor, or very poor. Conclusions: More than half the women aged 50 years or more in this study were not sexually active. A poorer sexual life self-perception was associated with the use of natural remedies to treat menopausal symptoms. This may indicate a need to improve the way in which these women are evaluated and treated. Women's assessment of their own sexual lives may prove a useful tool in clinical practice.357295300Kaiser, F.E., Sexual function and the older woman (2003) Clin Geriatr Med., 19 (3), pp. 463-472(1981) Research on the menopause., , World Health Organization Scientific Group. Geneva: World Health Organization(Technical Report Series, 670)Wierman, M.E., Nappi, R.E., Avis, N., Davis, S.R., Labrie, F., Rosner, W., Endocrine aspects of women's sexual function (2010) J Sex Med., 7 (1 PART 2), pp. 561-585The 2012 hormone therapy position statement of: The North American Menopause Society (2012) Menopause., 19 (3), pp. 257-271. , North American Menopause SocietySturdee, D.W., Panay, N., Recommendations for the management of postmenopausal vaginal atrophy (2010) Climacteric., 13 (6), pp. 509-522. , International Menopause Society Writing GroupSimon, J.A., Identifying and treating sexual dysfunction in postmenopausal women: The role of estrogen (2011) J Womens Health (Larchmt)., 20 (10), pp. 1453-1465Valadares, A.L., Pinto-Neto, A.M., Osis, M.J., Conde, D.M., Sousa, M.H., Costa-Paiva, L., Sexuality in Brazilian women aged 40 to 65 years with 11 years or more of formal education: Associated factors (2008) Menopause., 15 (2), pp. 264-269Guthrie, J.R., Dennerstein, L., Taffe, J.R., Lehert, P., Burger, H.G., The menopausal transition: A 9-year prospective population-based study. The Melbourne Women's Midlife Health Project (2004) Climacteric., 7 (4), pp. 375-389McCoy, N.L., The McCoy Female Sexuality Questionnaire (2000) Qual Life Res., 9 (1 SUPPL.), pp. 739-745Rosen, R., Brown, C., Heiman, J., Leiblum, S., Meston, C., Shabsigh, R., The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function (2000) J Sex Marital Ther., 26 (2), pp. 191-208Dennerstein, L., Anderson-Hunt, M., Dudley, E., Evaluation of a short scale to assess female sexual functioning (2002) J Sex Marital Ther., 28 (5), pp. 389-397Valadares, A.L., Pinto-Neto, A.M., Osis, M.J., Sousa, M.H., Costa-Paiva, L., Conde, D.M., Prevalence of sexual dysfunction and its associated factors in women aged 40-65 years with 11 years or more of formal education: A population-based household survey (2008) Clinics (Sao Paulo)., 63 (6), pp. 775-782Valadares, A.L., Pinto-Neto, A.M., de Sousa, M.H., Osis, M.J., Sociocultural adaptation of the short personal experiences questionnaire (SPEQ) in Brazil (2010) Rev Bras Ginecol Obstet., 32 (2), pp. 72-76. , PortugueseBem, D.J., Self-perception: An alternative interpretation of cognitive dissonance phenomena (1967) Psychol Rev., 74 (3), pp. 183-200Ali, M.M., Fang, H., Rizzo, J.A., Body weight, self-perception and mental health outcomes among adolescents (2010) J Ment Health Policy Econ., 13 (2), pp. 53-63Paula, J.S., Leite, I.C., Almeida, A.B., Ambrosano, G.M., Pereira, A.C., Mialhe, F.L., The influence of oral health conditions, socioeconomic status and home environment factors on schoolchildren's self-perception of quality of life (2012) Health Qual Life Outcomes., 10, p. 6Maier, H., Smith, J., Psychological predictors of mortality in old age (1999) J Gerontol B Psychol Sci Soc Sci., 54 (1), pp. P44-P54Levy, B.R., Slade, M.D., Kunkel, S.R., Kasl, S.V., Longevity increased by positive self-perceptions of aging (2002) J Pers Soc Psychol., 83 (2), pp. 261-270(2007) Distribuição da população por sexo, segundo os grupos de idade:Campinas (SP)., , http://www.censo2010.ibge.gov.br/sinopse/webservice/frm_piramide.php?codigo=350950&corhomem=3d4590&cormulher=9cdbfc, Instituto Brasileiro de Geografia e Estatística [Internet]. [citado 2011 Mar 6]. Disponível emAltman, D.G., (1999) Practical statistics for medical research., , Boca Raton: Chapman & Hall/CRCJohnson, R.A., Wichern, D.W., (1982) Applied multivariate statistical analysis., , Upper Saddle River: Prentice HallBarros, A.J., Hirakata, V.N., Alternatives for logistic regression in cross-sectional studies: An empirical comparison of models that directly estimate the prevalence ratio (2003) BMC Med Res Methodol., 3, p. 21Lindau, S.T., Schumm, L.P., Laumann, E.O., Levinson, W., O'Muircheartaigh, C.A., Waite, L.J., A study of sexuality and health among older adults in the United States (2007) N Engl J Med., 357 (8), pp. 762-774Freeman, E.W., Sammel, M.D., Lin, H., Liu, Z., Gracia, C.R., Duration of menopausal hot flushes and associated risk factors (2011) Obstet Gynecol., 117 (5), pp. 1095-1104Col, N.F., Guthrie, J.R., Politi, M., Dennerstein, L., Duration of vasomotor symptoms in middle-aged women: A longitudinal study (2009) Menopause., 16 (3), pp. 453-457McLennan, A.H., Broadbent, J.L., Lester, S., Moore, V., Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes (2004) Cochrane Database Syst Rev., (4), pp. CD002978The role of soy isoflavones in menopausal health: Report of The North American Menopause Society/Wulf H. Utian Translational Science (2011) Menopause., 18 (7), pp. 732-753. , North American Menopause Society, Symposium in Chicago, IL (October 2010)Borrelli, F., Ernst, E., Alternative and complementary therapies for the menopause (2010) Maturitas., 66 (4), pp. 333-343Patisaul, H.B., Luskin, J.R., Wilson, M.E., A soy supplement and tamoxifen inhibit sexual behavior in female rats (2004) Horm Behav., 45 (4), pp. 270-277Patisaul, H.B., Dindo, M., Whitten, P.L., Young, L.J., Soy isoflavone supplements antagonize reproductive behavior and estrogen receptor alpha-and beta-dependent gene expression in the brain (2001) Endocrinology., 142 (7), pp. 2946-295