MOS Meets NEMS: The Born of Hybrid Devices

Nowadays, the semiconductor industry is reaching an impasse due to the scaling-down process according to Moore’s Law, initiated back in 1960s, for the Metal-Oxide-Technology in use. To overcome such issue, the semiconductor industry started to foresee novel materials that allow the development of nanodevices with a broad variety of characteristics such as high switching speed, low power consumption, robust, among others; that can overcome the inherent issues for Silicon. A few “exotic materials” appear such as Graphene, MoS2, BN-h, among others. However, the time for the novel technology to be mature is a few decades in the future. To allow the “exotic materials” to mature, the semiconductor industry requires of novel nano-structures that can overcome a few of the issues that Silicon-based technology is facing today. A key alternative is based on hybrid structures. Hybrid structures encompass two dissimilar technologies nano-electromechanical systems with the well known Metal-Oxide-Technology. The hybrid nano-structure provides a broad variety of options to be used in such as transistors, memories and sensors. These hybrid devices can give enough time for the technology based on “exotic materials” to be reliable as Silicon based is

Consumption of bakery products, sweetened soft drinks and yogurt among children aged 6-7 years: association with nutrient intake and overall diet quality

The present study tests the hypothesis that higher consumption of bakery products, sweetened soft drinks and yogurt is associated with higher intake of energy, saturated fats, sugars and worse overall diet quality among Spanish children. This is a cross-sectional study covering 1112 children aged 6.0-7.0 years in four Spanish cities. Nutrient and food intake were obtained through a food-frequency questionnaire, and overall diet quality calculated using the healthy-eating index (HEI) developed by Kennedy et al. (1995). Standardized methods were used to measure anthropometric variables. Associations of interest were summarized as the difference in nutrient and food consumption between the value of the fifth and the first quintile of consumption (dq) of bakery products, sweetened soft drinks or yogurt, adjusted for energy intake and BMI. Bakery products, sweetened soft drinks and yogurt supplied 15.5, 1.0 and 5.6 % energy intake respectively. Higher consumption of these three foods was associated with greater energy intake (P<0.001), but not with higher BMI. Consumption of bakery products was associated with the proportion of energy derived from intake of total carbohydrates (dq 4.5 %, P<0.001) and sugars (dq 2 %, P<0.001), but did not show association with the HEI. Consumption of sweetened soft drinks was associated with a lower consumption of milk (dq -88 ml, P<0.001) and Ca (dq -175 mg/d, P<0.001), and worse HEI (dq -2, P<0.01). Consumption of yogurt, while associated with higher energy intake from saturated fats (dq 1.77 %, P<0.001) and sugars (dq 2.02 %, P<0.001), showed no association with the HEI. Differences in the intake of nutrients and foods across quintiles of consumption of bakery products, sweetened soft drinks and yogurt were usually very small. We conclude that the impact of the consumption of bakery products, sweetened soft drinks and yogurt on the quality of the diet of Spanish children is only modest, although it may contribute to aggravating certain unhealthy characteristics of their diet, particularly excess energy, saturated fats and sugars. Therefore, consumption of bakery products and sweetened soft drinks should be moderated, and priority given to consumption of low-fat, low-sugar yogurt.This study was partly funded by grants from the Inter-national Olive Oil Board (Consejo Oleı ́cola Internacional),Comunidad de Madrid, Fundacio ́n Pedro Barrie ́de laMaza, and Fundacio ́n Eugenio Rodrı ́guez PascualS

Diagnóstico del proceso de evaluación de la competencia didáctica de los profesores de Estomatología

Fundamentación: El proceso de evaluación actual de la competencia didáctica en la Educación Médica requiere de un perfeccionamiento. Objetivo: Caracterizar el proceso de evaluación de la competencia didáctica de los profesores de Estomatología. Metodología: Se realizó un estudio descriptivo durante el curso 2015-2016 en la Universidad de Ciencias Médicas de Sancti Spíritus. La población estuvo conformada por 3 ejecutivos y 65 profesores de la carrera Estomatología, se emplearon métodos del nivel teórico, empírico y estadístico-matemático. Resultados: Los resultados de la observación a las actividades mostraron que en todos los aspectos observados, predominó el nivel bajo de la escala utilizada. Se constató insuficiente evidencia de pronunciamientos específicos en los documentos con relación al proceso de evaluación de la competencia didáctica de los profesores, las disposiciones y recomendaciones se expresan en términos muy generales. Los ejecutivos presentan limitaciones en su preparación para desarrollar este proceso y el 49,23 % de los profesores no tienen definido los elementos que deben tener en cuenta en él. Conclusiones: El proceso de evaluación de la competencia didáctica de los profesores de estomatología en Sancti Spíritus tiene limitaciones que lo alejan del carácter sistemático, sistémico, objetivo y formativo. DeCS: MEDICINA ORAL/educación; EDUCACIÓN PROFESIONAL; COMPETENCIA PROFESIONAL; ENSEÑANZA/educación. Palabras clave: Evaluación de competencia; competencia didáctica; medicina oral y educación; educación profesional; competencia profesional; enseñanza y educación. ABSTRACT Background: the nowadays process of evaluation of didactic competence in medical education requires an improvement. Objective: to characterize the evaluation process of the didactic competence of dentistry professors. Methodology: A descriptive study was carried out form 2015 to 2016 at Sancti Spiritus medical university. The population was composed by 3 executives and 65 professors belonging to the dentistry university studies. Theoretical, empirical and statistical methods were used. Results: Observation of activities showed that low level of the scale used was the most relevant. It was verified insufficient evidence of specific pronouncements in the documents related to the process of evaluation of didactic competence on the part of professors, dispositions and recommendations were expressed in extremely general terms. Executives showed limitations in their preparation to develop this project and it was also found that 49, 23 % of professors have not defined the elements to be taken into account in it.  Conclusion: The evaluation process of didactic competence of dentistry professors in Sancti Spiritus has limitations which are far from the systemic, systematic, objective and formative character it should have. MeSH: ORAL MEDICINE/education; EDUCATION PROFESSIONAL; PROFESSIONAL COMPETENCE; TEACHING/education. Keywords: Competence evaluation; didactic competence; oral medicine/education; professional education; professional competence; teaching/education

Prevalencia De Parasitismo Intestinal Y Su Asociacion Con El Estado Nutricional En Niños Del Municipio De Galapa, Atlántico-Colombia

The purpose of this research is to characterize the prevalence of intestinal parasites in children between two to ten years old, and its relation with their nutritional status. 123 children were assessed, from a secondary school in the town of Galapa at the Atlantico department, in the Colombian Caribbean region (Colombia). After informed consent from their parents, after children were weighed and carved, stool samples were collected in triplicate/duplicate. Samples were processed using the sedimentation technique by centrifugation and kato katz. Our results showed parasitism in 39% of the population with a 38% of the individuals infected by protozoa and a 0.8 % with helminths. Analysis by gender showed that there were not statistical significant difference with 20.3% boys were infected compared with 17.1% of the girls. Furthermore, parasites prevalence was not statistically different when analyzed by gender. The parasites with the highest prevalence were: Giardia duodenalis (7.7 %), Blastocystis spp (6.8 %) and Endolimax nana (3.0 %) and children were found infected with polyparasitism by G. duodenalis + Blastocystis spp (1.7 %) y Entamoeba histolytica + Endolimax nana (0.4 %). The children that presented parasitism had a normal size and average weight of 124.8 cm 27.5g respectively. Most children with parasitism had a normal nutritional status (21.1 %), some were overweight (8.1 %) and obesity (4.9 %), and there were no children at risk of thinness and malnutrition. Our findings suggest that there is not significant correlation between the presence of parasites and the dietary habits in this population

Seminario de Economía Mexicana

Serie de ponencias referentes al Seminario de Economía Mexicana. Memorias del Seminario de Economía Mexicana de 199

Multicentre, randomised, single-blind, parallel group trial to compare the effectiveness of a Holter for Parkinson's symptoms against other clinical monitoring methods: study protocol

Introduction In recent years, multiple studies have aimed to develop and validate portable technological devices capable of monitoring the motor complications of Parkinson's disease patients (Parkinson's Holter). The effectiveness of these monitoring devices for improving clinical control is not known. Methods and analysis This is a single-blind, cluster-randomised controlled clinical trial. Neurologists from Spanish health centres will be randomly assigned to one of three study arms (1:1:1): (a) therapeutic adjustment using information from a Parkinson?s Holter that will be worn by their patients for 7 days, (b) therapeutic adjustment using information from a diary of motor fluctuations that will be completed by their patients for 7 days and (c) therapeutic adjustment using clinical information collected during consultation. It is expected that 162 consecutive patients will be included over a period of 6 months. The primary outcome is the efficiency of the Parkinson?s Holter compared with traditional clinical practice in terms of Off time reduction with respect to the baseline (recorded through a diary of motor fluctuations, which will be completed by all patients). As secondary outcomes, changes in variables related to other motor complications (dyskinesia and freezing of gait), quality of life, autonomy in activities of daily living, adherence to the monitoring system and number of doctor?patient contacts will be analysed. The noninferiority of the Parkinson's Holter against the diary of motor fluctuations in terms of Off time reduction will be studied as the exploratory objective. Ethics and dissemination approval for this study has been obtained from the Hospital Universitari de Bellvitge Ethics Committee. The results of this study will inform the practical utility of the objective information provided by a Parkinson's Holter and, therefore, the convenience of adopting this technology in clinical practice and in future clinical trials. We expect public dissemination of the results in 2022.Funding This work is supported by AbbVie S.L.U, the Instituto de Salud Carlos III [DTS17/00195] and the European Fund for Regional Development, 'A way to make Europe'

Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 +/- 19.2 years) recruited from 29 international centers. RESULTS At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% +/- 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of <= 35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Anales del III Congreso Internacional de Vivienda y Ciudad "Debate en torno a la nueva agenda urbana"

Acta de congresoEl III Congreso Internacional de Vivienda y Ciudad “Debates en torno a la NUEVa Agenda Urbana”, ha sido una apuesta de alto compromiso por acercar los debates centrales y urgentes que tensionan el pleno ejercicio del derecho a la ciudad. Para ello las instituciones organizadoras (INVIHAB –Instituto de Investigación de Vivienda y Hábitat y MGyDH-Maestría en Gestión y Desarrollo Habitacional-1), hemos convidado un espacio que se concretó con potencia en un debate transdisciplinario. Convocó a intelectuales de prestigio internacional, investigadores, académicos y gestores estatales, y en una metodología de innovación articuló las voces académicas con las de las organizaciones sociales y/o barriales en el Foro de las Organizaciones Sociales que tuvo su espacio propio para dar voz a quienes están trabajando en los desafíos para garantizar los derechos a la vivienda y los bienes urbanos en nuestras ciudades del Siglo XXI

Gestión del conocimiento. Perspectiva multidisciplinaria. Volumen 17

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, Volumen 17 de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro es una publicación internacional, seriada, continua, arbitrada, de acceso abierto a todas las áreas del conocimiento, orientada a contribuir con procesos de gestión del conocimiento científico, tecnológico y humanístico. Con esta colección, se aspira contribuir con el cultivo, la comprensión, la recopilación y la apropiación social del conocimiento en cuanto a patrimonio intangible de la humanidad, con el propósito de hacer aportes con la transformación de las relaciones socioculturales que sustentan la construcción social de los saberes y su reconocimiento como bien público