Stereospecific synthesis of syn-alpha-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids

A stereospecific multicomponent reaction among isocyanides, nitrile N-oxides and carboxylic acids provides an efficient synthesis of biologically relevant syn \u3b1-oximinoimides

Revisione critica della letteratura internazionale di pertinenza internistica prodotta nel biennio 2007-2008 sul tema della nefrolitiasi

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Efficient Synthesis of alpha -Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and alpha -Isocyanoacetamides

Acyl chlorides R1COCl [R1 = Et, n-pentyl, PhCH2CH2, 2-cyclopentylethyl, (S)-PhCHEt] efficiently reacted with alpha -isocyanoacetamides R2R3NCOCH(NC)R4 (R2 = H, R3 = n-Bu, PhCH2, HC==CCH2; R2 = Me, R3 = HC==CCH2, PhCH2; R2R3N = 4-morpholinyl; R4 = H, Me, PhCH2) in dichloromethane in the presence of triethylamine to give 2-acyl-5-aminooxazoles I. Subsequent acid hydrolysis of the 5-aminooxazole moiety leads to alpha -ketoamides II in good overall yields. [on SciFinder (R)

The melatonin receptor 1A (MTNR1A) gene is associated with recurrent and idiopathic calcium nephrolithiasis

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The invasion history of Elodea canadensis and E. nuttallii (Hydrocharitaceae) in Italy from herbarium accessions, field records and historical literature

We analysed the invasion history of two North American macrophytes (Elodea canadensis and E. nuttallii) in Italy, through an accurate census of all available herbarium and field records, dating between 1850 and 2019, and a rich literature col- lection describing the initial introduction and natu- ralisation phase that supports the results obtained by the occurrence records. Elodea canadensis arrived in Italy before 1866 and had two invasion phases, between the 1890s and 1920s and between the 1990s and 2000s; E. nuttallii, probably arrived in the 1970s, started invading in 2000 and the invasion is still ongoing. Botanical gardens and fish farming played a crucial role in dispersal and naturalisation of both species. The current invasion range of both species is centred in northern Italy, with scattered occurrences of E. canadensis in central and southern regions. River Po represents a dispersal barrier to the Medi- terranean region and a strategic monitoring site to prevent the invasion in the peninsula. The study detects differences in the niches of the two species during the introduction and naturalisation phase and a habitat switch occurred after 1980 in E. canadensis and after 2000 in E. nuttallii, during their expansion phases. For E. canadensis the switch corresponds to the second invasion round. Further research can clarify whether the second invasion round is due to confusion of the recently introduced E. nuttallii with E. canadensis, to a cryptic introduction of a new genotype, to post-introduction evolution, or just to an increased scientific interest in biological invasions