69 research outputs found
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Cosmogenic neutron production at the Sudbury Neutrino Observatory
Neutrons produced in nuclear interactions initiated by cosmic-ray muons present an irreducible background to many rare-event searches, even in detectors located deep underground. Models for the production of these neutrons have been tested against previous experimental data, but the extrapolation to deeper sites is not well understood. Here we report results from an analysis of cosmogenically produced neutrons at the Sudbury Neutrino Observatory. A specific set of observables are presented, which can be used to benchmark the validity of geant4 physics models. In addition, the cosmogenic neutron yield, in units of 10-4 cm2/(g·μ), is measured to be 7.28±0.09(stat)-1.12+1.59(syst) in pure heavy water and 7.30±0.07(stat)-1.02+1.40(syst) in NaCl-loaded heavy water. These results provide unique insights into this potential background source for experiments at SNOLAB
Cucurbitacin I Inhibits Cell Motility by Indirectly Interfering with Actin Dynamics
Cucurbitacins are plant natural products that inhibit activation of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway by an unknown mechanism. They are also known to cause changes in the organization of the actin cytoskeleton. actin depolymerization experiments, cucurbitacin I had no effect on the rate of actin filament disassembly at the nanomolar concentrations that inhibit cell migration. At elevated concentrations, the depolymerization rate was also unaffected, although there was a delay in the initiation of depolymerization. Therefore, cucurbitacin I targets some factor involved in cellular actin dynamics other than actin itself. Two candidate proteins that play roles in actin depolymerization are the actin-severing proteins cofilin and gelsolin. Cucurbitacin I possesses electrophilic reactivity that may lead to chemical modification of its target protein, as suggested by structure-activity relationship data. However, mass spectrometry revealed no evidence for modification of purified cofilin or gelsolin by cucurbitacin I.Cucurbitacin I results in accumulation of actin filaments in cells by a unique indirect mechanism. Furthermore, the proximal target of cucurbitacin I relevant to cell migration is unlikely to be the same one involved in activation of the JAK2/STAT3 pathway
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Measurement of neutron production in atmospheric neutrino interactions at the Sudbury Neutrino Observatory
Neutron production in GeV-scale neutrino interactions is a poorly studied
process. We have measured the neutron multiplicities in atmospheric neutrino
interactions in the Sudbury Neutrino Observatory experiment and compared them
to the prediction of a Monte Carlo simulation using GENIE and a minimally
modified version of GEANT4. We analyzed 837 days of exposure corresponding to
Phase I, using pure heavy water, and Phase II, using a mixture of Cl in heavy
water. Neutrons produced in atmospheric neutrino interactions were identified
with an efficiency of and , for Phase I and II respectively.
The neutron production is measured as a function of the visible energy of the
neutrino interaction and, for charged current quasi-elastic interaction
candidates, also as a function of the neutrino energy. This study is also
performed classifying the complete sample into two pairs of event categories:
charged current quasi-elastic and non charged current quasi-elastic, and
and . Results show good overall agreement between data and
Monte Carlo for both phases, with some small tension with a statistical
significance below for some intermediate energies
Tests of Lorentz invariance at the Sudbury Neutrino Observatory
Experimental tests of Lorentz symmetry in systems of all types are critical
for ensuring that the basic assumptions of physics are well-founded. Data from
all phases of the Sudbury Neutrino Observatory, a kiloton-scale heavy water
Cherenkov detector, are analyzed for possible violations of Lorentz symmetry in
the neutrino sector. Such violations would appear as one of eight possible
signal types in the detector: six seasonal variations in the solar electron
neutrino survival probability differing in energy and time dependence, and two
shape changes to the oscillated solar neutrino energy spectrum. No evidence for
such signals is observed, and limits on the size of such effects are
established in the framework of the Standard Model Extension, including 40
limits on perviously unconstrained operators and improved limits on 15
additional operators. This makes limits on all minimal, Dirac-type Lorentz
violating operators in the neutrino sector available for the first time
Search for hep solar neutrinos and the diffuse supernova neutrino background using all three phases of the Sudbury Neutrino Observatory
A search has been performed for neutrinos from two sources, the hep reaction in the solar pp fusion chain and the νe component of the diffuse supernova neutrino background (DSNB), using the full dataset of the Sudbury Neutrino Observatory with a total exposure of 2.47 kton-years after fiducialization. The hep search is performed using both a single-bin counting analysis and a likelihood fit. We find a best-fit flux that is compatible with solar model predictions while remaining consistent with zero flux, and set a one-sided upper limit of φhep<30×103 cm-2 s-1 [90% credible interval (CI)]. No events are observed in the DSNB search region, and we set an improved upper bound on the νe component of the DSNB flux of φνeDSNB<19 cm-2 s-1 (90% CI) in the energy range 22.9<Eν<36.9 MeV
Breaking down the barriers to hepatitis C virus (HCV) treatment among individuals with HCV/HIV coinfection: Action required at the system, provider, and patient levels
The majority of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) coinfection occurs among persons who inject drugs. Rapid improvements in responses to HCV therapy have been observed, but liver-related morbidity rates remain high, given notoriously low uptake of HCV treatment. Advances in HCV therapy will have a limited impact on the burden of HCV-related disease at the population-level unless barriers to HCV education, screening, evaluation, and treatment are addressed and treatment uptake increases. This review will outline barriers to HCV care in HCV/HIV coinfection, with a particular emphasis on persons who inject drugs, proposing strategies to enhance HCV treatment uptake and outcomes
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