8 research outputs found
Lupe e paisagem
Trata-se de um relato pessoal em que o autor rememora sua convivĂȘncia com Lupe Cotrim, de quem foi aluno na entĂŁo recĂ©m-fundada Escola de ComunicaçÔes, no conturbado perĂodo da ditadura militar.In this personal report, the author recollects his acquaintanceship with Lupe Cotrim, who was his professor at the School of Communications, then newly founded, in the troubled period of Brazilian military dictatorship
Biblioteca pĂșblica: do sĂ©culo XIX para o XXI
As bibliotecas pĂșblicas brasileiras estĂŁo entre dois tempos: o seu prĂłprio modelo, que remete ao sĂ©culo XIX, e a necessidade de trazĂȘ-las para o sĂ©culo XXI. Enquanto o primeiro tempo deve ser superado, o segundo ainda deverĂĄ ser alcançado, como desafio tĂ©cnico e polĂtico-social. Enquanto o primeiro oferece recursos conhecidos e acessĂveis, o segundo depende de decisĂ”es que ultrapassam o campo tĂ©cnico. As bases desse esboço ligam-se ao uso da tecnologia para preservar e fortalecer valores da informação pĂșblica: democracia, diversidade e informação necessĂĄria e de qualidade como base do desenvolvimento material e imaterial da nação.Brazilian public libraries are poised between two eras: their own model, which dates back to the 19th century, and the need to bring them up to the 21st century. While the first era is likely to be overcome, the latter is yet to be experienced, as it is a social, political and technical challenge. While the first offers accessible and known resources, the latter hinges on decisions which go beyond technical competence. The bases of this plan are linked to the use of technology to preserve and strengthen values of public information: democracy, diversity, and necessary and quality information as a foundation for the material and immaterial development of the country
Prevention of Herpesviridae Infections by Cationic PEGylated Carbosilane Dendrimers
Infections caused by viruses from the Herpesviridae family produce some of the most prevalent transmitted diseases in the world, constituting a serious global public health issue. Some of the virus properties such as latency and the appearance of resistance to antiviral treatments complicate the development of effective therapies capable of facing the infection. In this context, dendrimers present themselves as promising alternatives to current treatments. In this study, we propose the use of PEGylated cationic carbosilane dendrimers as inhibitors of herpes simplex virus 2 (HSV-2) and human cytomegalovirus (HCMV)infections. Studies of mitochondrial toxicity, membrane integrity, internalization and viral infection inhibition indicated that G2-SN15-PEG, G3-SN31-PEG, G2-SN15-PEG fluorescein isothiocyanate (FITC) labeled and G3-SN31-PEG-FITC dendrimers are valid candidates to target HSV-2 and HCMV infections since they are biocompatible, can be effectively internalized and are able to significantly inhibit both infections. Later studies (including viral inactivation, binding inhibition, heparan sulphate proteoglycans (HSPG)binding and surface plasmon resonance assays) confirmed that inhibition takes place at first infection stages. More precisely, these studies established that their attachment to cell membrane heparan sulphate proteoglycans impede the interaction between viral glycoproteins and these cell receptors, thus preventing infection. Altogether, our research confirmed the high capacity of these PEGylated carbosilane dendrimers to prevent HSV-2 and HCMV infections, making them valid candidates as antiviral agents against Herpesviridae infections
ANĂLISE MULTITEMPORAL DA OCUPAĂĂO IRREGULAR NAS ĂREAS DE PRESERVAĂĂO PERMANENTE (APP) SUB-BACIA DO ARROIO MANRESA - PORTO ALEGRE/RS
O propĂłsito deste estudo Ă© identificar possĂveis implicaçÔes socioambientais ocasionadas pela ocupação irregular em Ăreas de Preservação Permanente do Arroio Manresa e seus afluentes por meio de anĂĄlise multitemporal. Neste estudo, foi considerado uma escala temporal de 12 anos, no perĂodo de 2002 a 2014. Foram utilizadas imagens de satĂ©lite disponibilizadas pelo programa Google Earth Pro. Na delimitação das APPs utilizou-se a extração da rede de drenagem obtida pela plataforma TerraHidro, segundo modelagem hidrolĂłgica. Identificou-se por meio dos produtos cartogrĂĄficos desenvolvidos que a ocupação irregular nas APPs da sub-bacia do Arroio Manresa tem exercido pressĂŁo sobre a biodiversidade e potencializado a vulnerabilidade social a desastres. Palavras-chave: AnĂĄlise multitemporal, ocupação irregular, Ărea de Preservação Permanente â APP, Arroio Manresa. DOI: 10.5902/2236499419165
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and lowâmiddle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of âsingle-useâ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for lowâmiddle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both highâ and lowâmiddleâincome countries