Lupe e paisagem

Trata-se de um relato pessoal em que o autor rememora sua convivência com Lupe Cotrim, de quem foi aluno na então recém-fundada Escola de Comunicações, no conturbado período da ditadura militar.In this personal report, the author recollects his acquaintanceship with Lupe Cotrim, who was his professor at the School of Communications, then newly founded, in the troubled period of Brazilian military dictatorship

Biblioteca pública: do século XIX para o XXI

As bibliotecas públicas brasileiras estão entre dois tempos: o seu próprio modelo, que remete ao século XIX, e a necessidade de trazê-las para o século XXI. Enquanto o primeiro tempo deve ser superado, o segundo ainda deverá ser alcançado, como desafio técnico e político-social. Enquanto o primeiro oferece recursos conhecidos e acessíveis, o segundo depende de decisões que ultrapassam o campo técnico. As bases desse esboço ligam-se ao uso da tecnologia para preservar e fortalecer valores da informação pública: democracia, diversidade e informação necessária e de qualidade como base do desenvolvimento material e imaterial da nação.Brazilian public libraries are poised between two eras: their own model, which dates back to the 19th century, and the need to bring them up to the 21st century. While the first era is likely to be overcome, the latter is yet to be experienced, as it is a social, political and technical challenge. While the first offers accessible and known resources, the latter hinges on decisions which go beyond technical competence. The bases of this plan are linked to the use of technology to preserve and strengthen values of public information: democracy, diversity, and necessary and quality information as a foundation for the material and immaterial development of the country

Prevention of Herpesviridae Infections by Cationic PEGylated Carbosilane Dendrimers

Infections caused by viruses from the Herpesviridae family produce some of the most prevalent transmitted diseases in the world, constituting a serious global public health issue. Some of the virus properties such as latency and the appearance of resistance to antiviral treatments complicate the development of effective therapies capable of facing the infection. In this context, dendrimers present themselves as promising alternatives to current treatments. In this study, we propose the use of PEGylated cationic carbosilane dendrimers as inhibitors of herpes simplex virus 2 (HSV-2) and human cytomegalovirus (HCMV)infections. Studies of mitochondrial toxicity, membrane integrity, internalization and viral infection inhibition indicated that G2-SN15-PEG, G3-SN31-PEG, G2-SN15-PEG fluorescein isothiocyanate (FITC) labeled and G3-SN31-PEG-FITC dendrimers are valid candidates to target HSV-2 and HCMV infections since they are biocompatible, can be effectively internalized and are able to significantly inhibit both infections. Later studies (including viral inactivation, binding inhibition, heparan sulphate proteoglycans (HSPG)binding and surface plasmon resonance assays) confirmed that inhibition takes place at first infection stages. More precisely, these studies established that their attachment to cell membrane heparan sulphate proteoglycans impede the interaction between viral glycoproteins and these cell receptors, thus preventing infection. Altogether, our research confirmed the high capacity of these PEGylated carbosilane dendrimers to prevent HSV-2 and HCMV infections, making them valid candidates as antiviral agents against Herpesviridae infections

ANÁLISE MULTITEMPORAL DA OCUPAÇÃO IRREGULAR NAS ÁREAS DE PRESERVAÇÃO PERMANENTE (APP) SUB-BACIA DO ARROIO MANRESA - PORTO ALEGRE/RS

O propósito deste estudo é identificar possíveis implicações socioambientais ocasionadas pela ocupação irregular em Áreas de Preservação Permanente do Arroio Manresa e seus afluentes por meio de análise multitemporal. Neste estudo, foi considerado uma escala temporal de 12 anos, no período de 2002 a 2014. Foram utilizadas imagens de satélite disponibilizadas pelo programa Google Earth Pro. Na delimitação das APPs utilizou-se a extração da rede de drenagem obtida pela plataforma TerraHidro, segundo modelagem hidrológica. Identificou-se por meio dos produtos cartográficos desenvolvidos que a ocupação irregular nas APPs da sub-bacia do Arroio Manresa tem exercido pressão sobre a biodiversidade e potencializado a vulnerabilidade social a desastres. Palavras-chave: Análise multitemporal, ocupação irregular, Área de Preservação Permanente – APP, Arroio Manresa. DOI: 10.5902/2236499419165

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries