141 research outputs found
Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis
- Author
- Alegre Sancho JJ.
- Balsa Criado Alejandro
- Blanco Alonso Ricardo
- Carreira P.
- Castañeda S.
- Corrales A.
- Fernández Gutiérrez B.
- Ferraz Amaro I.
- Genre Fernanda
- González Juanatey Carlos
- González Álvaro Isidoro
- González-Gay Mantecón Miguel Ángel
- Gómez Vaquero C.
- Llorca Díaz Francisco Javier
- López Longo FJ.
- López Mejías R.
- Magro C.
- Martín J.
- Mijares V.
- Miranda Filloy JA.
- Mínguez Sánchez MD.
- Pascual Salcedo D.
- Pina Murcia Trinitario
- Ramírez Huaranga Marco A.
- Raya E.
- Remuzgo Martínez S.
- Robustillo Villarino M.
- Rodríguez Rodríguez Luis
- Tejera Segura B.
- Ubilla B.
- Vicente E.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis and cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 exert an influence on elevated CRP serum levels in non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes in the development of CV events and subclinical atherosclerosis in RA patients. Three tag CRP polymorphisms and HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were genotyped in 2,313 Spanish patients by TaqMan. Subclinical atherosclerosis was determined in 1,298 of them by carotid ultrasonography (by assessment of carotid intima-media thickness-cIMT-and presence/absence of carotid plaques). CRP serum levels at diagnosis and at the time of carotid ultrasonography were measured in 1,662 and 1,193 patients, respectively, by immunoturbidimetry. Interestingly, a relationship between CRP and CRP serum levels at diagnosis and at the time of the carotid ultrasonography was disclosed. However, no statistically significant differences were found when CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were evaluated according to the presence/absence of CV events, carotid plaques and cIMT after adjustment. Our results do not confirm an association between these genes and CV disease in RA
Efficiency and effectiveness of the use of an acenocoumarol pharmacogenetic dosing algorithm versus usual care in patients with venous thromboembolic disease initiating oral anticoagulation: study protocol for a randomized controlled trial
- Author
- AH Wu
- Alberto M Borobia
- AM Borobia
- AM López-Parra
- Antonio J Carcas
- C Kearon
- C Moreau
- CA Naranjo
- Carmen Fernández-Capitán
- CF Zambon
- CJ van Dongen
- EA Millican
- EA Sconce
- FJ van der Meer
- FR Rosendaal
- Francisco Abad-Santos
- G Palareti
- HD White
- J Cadamuro
- JA Nieto
- JL Anderson
- JL Lobo
- K Meijer
- L Bodin
- LE Visser
- M Spreafico
- M Teichert
- M Teichert
- Manuel Quintana Díaz
- Marta Velasco
- MD Caldwell
- MD Caldwell
- N Oake
- Nuria Ruiz-Giménez
- Olga Madridano
- P Lenzini
- Pilar Llamas Sillero
- R Guijarro
- RM Van Schie
- RM VanSchie
- S Schulman
- S Stehle
- SJ Connolly
- SZ Goldhaber
- TE Klein
- V Pérez-Andreu
- V Pérez-Andreu
- Y Caraco
- Z Verde
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo
- Author
- AM Moura-da-Silva
- AM Soares
- B Francis
- B Lomonte
- B Lomonte
- B Lomonte
- B Lomonte
- B Lomonte
- B Lomonte
- B Lomonte
- B Lomonte
- BG Fry
- Bruno Lomonte
- C Díaz
- C Díaz-Oreiro
- C Montecucco
- CAH Fernandes
- CE Núñez
- Cesare Montecucco
- Chi Zhang
- D Morgenstern
- Diana Mora-Obando
- DL Scott
- H Kihara
- IH Tsai
- II Kaiser
- J Fernández
- J Fernández
- JB Harris
- JI dos Santos
- JI dos Santos
- JM Gutiérrez
- JM Gutiérrez
- JM Gutiérrez
- JM Gutiérrez
- JM Gutiérrez
- JM Maraganore
- José María Gutiérrez
- Julián Fernández
- KI Nakashima
- L Chioato
- M Cintra-Francischinelli
- M Cintra-Francischinelli
- M Cintra-Francischinelli
- M Holzer
- MD McCue
- RJ Ward
- RK Arni
- RM Kini
- S Rufini
- T Petan
- VJ Lynch
- Y Angulo
- Y Angulo
- Y Angulo
- Z Shen
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 07/10/2014
- Field of study
artículo (arbitrado) -- Universidad de Costa Rica, Instituto de investigaciones Clodomiro Picado. 2014Two subtypes of phospholipases A2 (PLA2s) with the ability to induce myonecrosis, ‘Asp49’ and ‘Lys49’ myotoxins, often coexist in viperid snake venoms. Since the latter lack catalytic activity, two different mechanisms are involved in their myotoxicity. A synergism between Asp49 and Lys49 myotoxins from Bothrops asper was previously observed in vitro, enhancing Ca2+ entry and cell death when acting together upon C2C12 myotubes. These observations are extended for the first time in vivo, by demonstrating a clear enhancement of myonecrosis by the combined action of these two toxins in mice. In addition, novel aspects of their synergism were revealed using myotubes. Proportions of Asp49 myotoxin as low as 0.1% of the Lys49 myotoxin are sufficient to enhance cytotoxicity of the latter, but not the opposite. Sublytic amounts of
Asp49 myotoxin also enhanced cytotoxicity of a synthetic peptide encompassing the toxic region of Lys49 myotoxin. Asp49 myotoxin rendered myotubes more susceptible to osmotic lysis, whereas Lys49 myotoxin did not. In contrast to myotoxic Asp49 PLA2, an acidic non-toxic PLA2 from the same venom did not markedly synergize with Lys49 myotoxin, revealing a functional difference between basic and acidic PLA2 enzymes. It is suggested that Asp49 myotoxins synergize with Lys49 myotoxins by virtue of their PLA2 activity. In addition to the membrane-destabilizing effect of this activity, Asp49 myotoxins
may generate anionic patches of hydrolytic reaction products, facilitating electrostatic interactions with Lys49 myotoxins. These data provide new evidence for the evolutionary adaptive value of the two subtypes of PLA2 myotoxins acting synergistically in viperid venoms.Funding support by the Graduate Studies Program, Universidad de Costa Rica; International Centre for Genetic Engineering and Biotechnology, Italy (CRP/COS13-01); and Vicerrectoria de Investigacion, Universidad de Costa Rica (741-B4-100).UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP
Trace elements in the Fontinalis antipyretica from rivers receiving sewage of lignite and glass sand mining industry
- Author
- A Kabata-Pendias
- A Kłos
- A Muszer
- A Samecka-Cymerman
- A Sarris
- A Siebert
- A Valavanidis
- A Łuszczkiewicz
- Aleksandra Samecka-Cymerman
- Alexander J. Kempers
- Anna Brudzińska-Kosior
- B Najbar
- B Wei
- BA Markert
- C Bleuela
- C Mouvet
- CM Lytle
- CR Traubenberg de
- D Argaç
- E Apeagyei
- E Remon
- E Yoshimura
- G Lithner
- G Rasmussen
- Grzegorz Kosior
- H Zar
- I Suchara
- IP Vaughan
- J Badura
- J López
- J Machajski
- JA Fernández
- KM Vuori
- Krzysztof Kolon
- L Marks
- L Pekka
- M Cesa
- M Dazy
- M Jasion
- MB Brown
- MD Vázquez
- MD Vázquez
- P Krems
- P Legendre
- PJ Say
- RJE Martins
- RJE Martins
- S Díaz
- S Ladislas
- S Rau
- SCJ Palmer
- SK Maiti
- SR Díaz
- TD Davies
- Waldemar Bena
- Y Nazzal
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Review on the transmission porcine reproductive and respiratory syndrome virus between pigs and farms and impact on vaccination
- Author
- A Bouma
- A Bøtner
- A Kittawornrat
- A Romagosa
- A Stegeman
- B Roic
- C Alonso
- C Charpin
- C Nathues
- C Prieto
- C Trincado
- C Trincado
- CL Loving
- CM Evans
- D Klinkenberg
- DA Benfield
- DA Benfield
- DC Horter
- DCL Linhares
- DJ Holtkamp
- E Albina
- E Albina
- E Mateu
- E Mondaca-Fernández
- E Pileri
- EA Wagstrom
- EFSA Panel on Animal Health and Welfare
- EJ Neumann
- Emanuela Pileri
- Enric Mateu
- FA Osorio
- FJ Martínez-Lobo
- G Nodelijk
- G Nodelijk
- G Nodelijk
- G Nodelijk
- G Reiner
- GG Labarque
- GP Kwong
- GW Stevenson
- H Guarino
- I Díaz
- I Díaz
- I Kang
- IFA Linden Van Der
- IFA Linden Van Der
- IJ Yoon
- IS Frydas
- IS Frydas
- IS Frydas
- J Beyer
- J Christopher-Hennings
- J Christopher-Hennings
- J Christopher-Hennings
- J Prickett
- J Shirai
- JA Baroch
- JA Schurrer
- JA Schurrer
- JE Lowe
- JG Cho
- JG Cho
- JH Sur
- JJ Zimmerman
- JP Cano
- JP Cano
- JR Hermann
- JR Hermann
- KD Rossow
- KD Rossow
- KJ Yoon
- KK Thakur
- KL Klinge
- KM Lager
- KM Lager
- KM Lager
- L Lamontagne
- M Allerson
- M Bloemraad
- M Scortti
- M Torremorell
- M Velasova
- MC Jong De
- MD Bierk
- MP Murtaugh
- MP Murtaugh
- N Nieuwenhuis
- N Rose
- O Diekmann
- OJ Lopez
- P Bonilauri
- P Martelli
- PG Halbur
- PGW Plagemann
- R Allende
- R Bilodeau
- R Larochelle
- R Magar
- R Thanawongnuwech
- RD Moon
- RRR Rowland
- RW Wills
- RW Wills
- RW Wills
- RW Wills
- RW Wills
- S Mortensen
- S Otake
- S Otake
- S Otake
- S Otake
- S Otake
- S Otake
- S Vilcek
- SA Dee
- SA Dee
- SA Dee
- SA Dee
- SA Dee
- SA Dee
- SA Dee
- SA Dee
- SH Done
- SJ Tousignant
- SL Swenson
- SR Baker
- SR Lawson
- T Rosendal
- T Stadejek
- TD Cutler
- TL Nielsen
- U Carlsson
- U Oslage
- UU Karniychuk
- UU Karniychuk
- W Hall
- WA Meier
- WG Alstine Van
- WT Christianson
- X Duan
- X Li
- Y Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry
- Author
- Abbadie F
- Achkar A
- Ackroyd A
- Adamczyk A
- Adarraga Cansino Md
- Addala A
- Adnet F
- Agarwal G
- Ageno W
- Agnelli G
- Agnelli G
- Al Ahmad W
- Al-Refaie F
- Alexandra Jf
- Alikhan R
- Allameddine A
- Altarriba Es
- Amado Fernández C
- Amitrano M
- Amore M
- Angelini E
- Antignani Pl
- Aquilanti S
- Aranda Blazquez R
- Arden C
- Arellano Rodrigo E
- Armengou Arxe A
- Arone A
- Asaro G
- Attanzio Mt
- Attinasi V
- Austin A
- Axthelm C
- Axthelm P
- Bakhai A
- Balbarini A
- Ballaz Quincoces A
- Banfi E
- Banyai M
- Barcellona D
- Barillari G
- Bartolini C
- Barton T
- Bartone M
- Bauersachs R
- Bauersachs R
- Beato Pérez Jl
- Bedate Díaz P
- Belhassane A
- Bellanuova I
- Bellisi M
- Bellizzi A
- Benaroya B
- Bergmann K
- Berremili T
- Beschorner U
- Bianchi M
- Bianchini G
- Binias Kh
- Birr V
- Blanco-Molina Ma
- Boari B
- Body R
- Bonnin C
- Boral M
- Bortoluzzi C
- Bosler F
- Bramlage P
- Bratsch H
- Brauer G
- Bresin Durand Mg
- Brisot D
- Brodmann M
- Brousse C
- Brucoli C
- Burghard S
- Calandra G
- Calvo Mijares N
- Camporese G
- Canafoglia L
- Cancellieri E
- Cannavacciuolo F
- Caprioli C
- Carlizza A
- Carnovali M
- Carrasco Expósito M
- Carrasco Mas A
- Carugati A
- Casarsa C
- Castellote Mc
- Castrodeza Sanz R
- Catalini R
- Cavazza S
- Cayman C
- Cazaubon M
- Cañas Alcántara I
- Cenci C
- Ceresa F
- Cereto Castro F
- Chacko J
- Champion O
- Chandra D
- Chanut M
- Charters F
- Chevalet P
- Church A
- Ciampa A
- Ciarambino T
- Cillari E
- Cisneros de la Fuente E
- Clemente M
- Clements J
- Clifford P
- Cohen At
- Connault J
- Constans J
- Conti F
- Cordeanu M
- Cosmi B
- Couturaud F
- Cox D
- Crouch M
- Crowther M
- D'Alessandro A
- D'Angelo A
- D'Antoni S
- Davies E
- Davies M
- de Ancos Aracil C
- De Bartolomeo G
- De Campora P
- de Daborenea González Md
- De Dedker L
- De Franciscis S
- De Gaudenzi E
- de la Fuente Aguado J
- De La Fuente T
- de las Revillas Fa
- De Santis F
- De Tommaso I
- Decoulx E
- del Carmen Fernández-Capitán M
- del Toro Cervera J
- Delgado Bregel Jl
- Delpin S
- Demann C
- Demmig A
- Derrien B
- Di Francesco L
- Di Maggio R
- Di Micco P
- Di Michele D
- Di Minno G
- Di Nisio M
- Di Salvo M
- Diamand Jm
- Diard A
- Dimitri S
- Donadio F
- Douadi Y
- Drebes A
- Dres P
- Dupas S
- Durant C
- Díez Fernández F
- D’Avino M
- Eberhad Rieker E
- Eberlein U
- Edhery S
- Eischer L
- Elias Hernández T
- Emter E
- Enea I
- Enger F
- Eschenburg J
- Eschenburg Ju
- Ewad H
- Fabbian F
- Falanga A
- Falvo N
- Farcas Taralunga C
- Felis S
- Fernández Iglesias A
- Ferrari E
- Ferri Bataler R
- Fiore V
- Fontanella A
- Forkmann L
- Franco E
- Frank J
- Frank U
- Franklin S
- Frausini G
- Freischmidt H
- Fritsche I
- Fronk Em
- Fuorlo M
- Gaillard C
- Gallerani M
- Gamberini S
- Garcia Ma
- García García Jm
- García Loizaga A
- García-Bragado Dalmau F
- Garrigues D
- Gassauer M
- George J
- Gerofke H
- Ghirarduzzi A
- Ghizzi G
- Gianniello F
- Gibbs C
- Gillet Jl
- Giordana P
- Girke F
- Gitt Ak
- Giudice G
- Goebels Mc
- Goh T
- González Porras Jr
- González Lg
- Grange C
- Grare F
- Grenot Mc
- Grün-Himmelmann K
- Guarnera G
- Guercini F
- Guggenbichler S
- Guil García M
- Gupta S
- Gutierrez Ja
- Hadj Henni A
- Hartmann K
- Heilberger P
- Heinsius A
- Held M
- Herman G
- Hernando López E
- Herold J
- Hertrich F
- Heuser S
- Hidden-Henic V
- Hirschl M
- Holmes J
- Holtea D
- Hommel H
- Hottin D
- Härtel D
- Hütte G
- Imbert B
- Imberti D
- Iosub Di
- Iozzi E
- Irvine N
- Jackson-Voyzey E
- Jacquinandi V
- Jakob D
- Jara Palomares L
- Jaras Mj
- Jeanneret C
- Jiménez Castro D
- Jiménez-Rodríguez Madridejos R
- Jones N
- Joya Seijo D
- Jungandreas K
- Jurus C
- Jörg Gr
- Kalka C
- Kallat A
- Karcher J
- Karl-Wollweber S
- Keilhau Da
- Kerr P
- Kesteven P
- Kittel K
- Knittel M
- Knolinski T
- Kopplin U
- Kroschel U
- Kröger K
- Kubicek–Hofmann C
- Köhler C
- Körner I
- La Forgia S
- La Regina M
- Lacoste A
- Lacut K
- Laeis P
- Landolfi R
- Laroche Jp
- Lecumberri R
- Lench T
- Leschke M
- Lester W
- Lewis M
- Lluís Padierna M
- Lodigiani C
- Lorenzo Hernández A
- Lowe G
- Lutz A
- López Castellanos Gt
- López Jiménez L
- López Gt
- López-Sáez Jb
- Lübbert G
- Madridano Cobo O
- Mainez Saiz C
- Mancuso G
- Manfredini R
- Manzano Espinosa L
- Marchena Yglesias Pj
- Marconi L
- Marcucci R
- Marencke Gh
- Margheriti R
- Marongiu S
- Marra A
- Marrocco F
- Martin M
- Martinelli I
- Martín del Pozo M
- Martínez N
- Masotti L
- Mazollier C
- McCormack T
- McCoye A
- McGrane F
- Mearelli F
- Mearns B
- Melibovsky L
- Mersel T
- Milesi V
- Millón Caño Ja
- Miserey G
- Mismetti P
- Modeliar Remond Ss
- Mommi V
- Monreal Bosch M
- Monreal M
- Montagna Es
- Monte Secades R
- Mora Luján Jm
- Moral Moral P
- Moreno Flores A
- Moriarty A
- Morretti T
- Morris W
- Mortensen K
- Mos L
- Moysidis T
- Mugno F
- Muñoz Rodríguez Fj
- Narayanan M
- Nedey C
- Nelles H
- Nestler K
- Neumeister A
- Nieto Rodríguez Ja
- Nitti C
- Nou M
- Núñez Fernández Mj
- Oettler W
- Olivieri O
- Oncala Sibajas E
- Onesta M
- Oo N
- Orlandini F
- Ortiz de Saracho J
- Ott I
- Otto A
- Ouvry P
- Pagliara V
- Paiella L
- Pala P
- Palasciano G
- Palla A
- Paoletti O
- Paolucci G
- Parisi R
- Parra Caballero P
- Pasca S
- Pasin M
- Pasligh M
- Patanè F
- Pedrajas Navas Jm
- Pennacchioni M
- Pepe C
- Pernod G
- Pertermann A
- Perticone F
- Peter Marschang P
- Peuch B
- Pfister R
- Piccinni Gc
- Pichot O
- Pierri F
- Piloquet Fx
- Pindur P
- Pinto A
- Piovella F
- Pivetti G
- Pizzini Am
- Placentino M
- Poli D
- Pons Martín del Campo I
- Porreca E
- Portillo Sánchez J
- Poulain V
- Pourhassan S
- Predel D
- Prisco D
- Pudollek T
- Pérez Rus G
- Quere I
- Quezada Loaiza A
- Quintavalla R
- Ramthor M
- Rancan E
- Ray P
- Reed M
- Reimer D
- Rennebaum C
- Reppel M
- Reynaldo P
- Ria L
- Richter R
- Rief P
- Riera Mestre A
- Rifai A
- Rivera Gallego A
- Rodríguez Beltrán Em
- Roldán Schilling V
- Romero Pizarro Y
- Roncero Lázaro A
- Rose P
- Rossetto V
- Rothenbücher G
- Rothhagen B
- Rovinelli M
- Roy Pm
- Rubino P
- Rudolff S
- Ruiz J
- Rupoli S
- Russo V
- Saby Jc
- Saccullo G
- Sada S
- Saja K
- Sala G
- Salmi R
- Salvi A
- Samaden A
- San Román Terán Cm
- Sangiuolo R
- Santalla Valle Ea
- Santini C
- Schafnitzl W
- Schellong S
- Schenone A
- Schiller M
- Schlosser A
- Schmeink P
- Schmeink T
- Schmidt J
- Schnabl S
- Schneider H
- Schnupp S
- Schulze M
- Schäfer A
- Schön N
- Sciacqua A
- Sechtem U
- Sedl S
- Serra R
- Severino S
- Sevestre Ma
- Signorelli Ss
- Silvestri E
- Silvestris F
- Simon F
- Simonot-Lalandec E
- Siniscalchi V
- Siragusa S
- Sivakumaran M
- Sohal M
- Sollazzo V
- Solomons G
- Sonnenschein K
- Sorvillo S
- Stachowitz J
- Staub D
- Stephan D
- Stoshikj S
- Strafino C
- Stücker M
- Sultanzadeh Sj
- Suriñach Caralt Jm
- Sánchez Fuentes D
- Sánchez Muñoz-Torrero Jf
- Sánchez Álvarez J
- Talerico A
- Testa S
- Thachil J
- Thieme M
- Tiefenbacher C
- Tirado Miranda R
- Tissot A
- Todolí Parra Ja
- Tonello C
- Tosi F
- Tropeano P
- Tsantilas D
- Tufano A
- Usandizaga de Antonio E
- Vallarelli S
- Vaquero de Sedas M
- Venton T
- Verdecchia P
- Vetrano V
- Vieth P
- Viganò S
- Villalta Blanch J
- Villalta S
- Villanueva Montes Ma
- Villaverde Álvarez I
- Vincentelli Gm
- Violo C
- Vital-Durand D
- Vodoungnon H
- Voigts B
- vom Dahl J
- von Bilderling P
- von Maltik T
- Wakeling J
- Walby C
- Waldron M
- Watt S
- Weber H
- Weinmann S
- Weinrich K
- Werner N
- Werno Hs
- Werth S
- Weyer M
- Willcock W
- Willich Sn
- Wirtz P
- Wittig I
- Wittig K
- Wucherpfennig P
- Zafar A.
- Zanatta N
- Zierock P
- Zingaretti O
- Zorzi F
- zur Nieden T
- Publication venue
- 'Georg Thieme Verlag KG'
- Publication date
- 01/01/2017
- Field of study
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes
Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries
- Author
- Ab Manan A
- Abdel-Rahman M
- Adamcik J
- Agius D
- Aitken J
- Al Khater Ahm
- Al-Eid H
- Aleinikova Ov
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- Zucchetto A
- Zvolský M
- Ólafsdóttir Ej
- Šekerija M
- Žagar T
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequalities globally for several subtypes of childhood leukaemia.
Methods Cancer registries participating in CONCORD were asked to submit tumour registrations for all children aged 0-14 years who were diagnosed with leukaemia between Jan 1, 1995, and Dec 31, 2009, and followed up until Dec 31, 2009. Haematological malignancies were defined by morphology codes in the International Classification of Diseases for Oncology, third revision. We excluded data from registries from which the data were judged to be less reliable, or included only lymphomas, and data from countries in which data for fewer than ten children were available for analysis. We also excluded records because of a missing date of birth, diagnosis, or last known vital status. We estimated 5-year net survival (ie, the probability of surviving at least 5 years after diagnosis, after controlling for deaths from other causes [background mortality]) for children by calendar period of diagnosis (1995-99, 2000-04, and 2005-09), sex, and age at diagnosis (< 1, 1-4, 5-9, and 10-14 years, inclusive) using appropriate life tables. We estimated age-standardised net survival for international comparison of survival trends for precursor-cell acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML).
Findings We analysed data from 89 828 children from 198 registries in 53 countries. During 1995-99, 5-year agestandardised net survival for all lymphoid leukaemias combined ranged from 10.6% (95% CI 3.1-18.2) in the Chinese registries to 86.8% (81.6-92.0) in Austria. International differences in 5-year survival for childhood leukaemia were still large as recently as 2005-09, when age-standardised survival for lymphoid leukaemias ranged from 52.4% (95% CI 42.8-61.9) in Cali, Colombia, to 91.6% (89.5-93.6) in the German registries, and for AML ranged from 33.3% (18.9-47.7) in Bulgaria to 78.2% (72.0-84.3) in German registries. Survival from precursor-cell ALL was very close to that of all lymphoid leukaemias combined, with similar variation. In most countries, survival from AML improved more than survival from ALL between 2000-04 and 2005-09. Survival for each type of leukaemia varied markedly with age: survival was highest for children aged 1-4 and 5-9 years, and lowest for infants (younger than 1 year). There was no systematic difference in survival between boys and girls.
Interpretation Global inequalities in survival from childhood leukaemia have narrowed with time but remain very wide for both ALL and AML. These results provide useful information for health policy makers on the effectiveness of health-care systems and for cancer policy makers to reduce inequalities in childhood survival
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
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- Abdallah RI
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- AKI Research Group
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- Di Mussi R
- Di Rosso R
- Diaz DD
- Diaz P
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- Dimitrov BD
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- Dimopoulou IK
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- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
- Erdogan M
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- Espinasse F
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- Fernández L
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- Fernández-Ortega JF
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- FINNRESUSCI Study Group
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- Fleischmann E
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- García MF
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- García-Olivares P
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- Gavrychenko D
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- GETGAG/SEMICYUC
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- Huang WC
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- Hung CY
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- Ibsen M
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- Idei M
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- Ignacio ML
- Iida A
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- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
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- IPREA Study Group
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- Jang BH
- Janotka M
- Janotka M
- Janotka M
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- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jardim M
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- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
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- Jiménez GJ
- Jo YH
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- Jochmans S
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- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
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- Judickas S
- Juez A
- Juliarena A
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- Junior JM
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- Kaminsky GE
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- Kolnikova I
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- Krishna B
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- Ku NS
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- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
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- Kwon HM
- Kwon WY
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- Labra C
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- Lafuente E
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- Lagos R
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- Lake K
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- Lapteva K
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- Latini R
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- Latini R
- Latorre J
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- Lavrentieva A
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- Legrand M
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- Lombardo MD
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- Lopez-Gude MJ
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- MacKay A
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- Maghsoudi B
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- Martín-Loeches I
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- Martínez MP
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- Martínez-Carmona JF
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- Mercat A
- Mercat A
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- Messenger D
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- Midwinter MJ
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- Miguelena PR
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- Okayama Research Investigation Organizing Network (ORION)investigators
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- Perinel S
- Perivolioti E
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- Sciurti R
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- Tanaka H
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- Tapponnier R
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- Tarabrin O
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- Tavazzi G
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- Teboul JL
- Telli S
- Temprano-Gómez I
- Tena SA
- Tencé N
- Terzi N
- Terzi N
- Terzi N
- Terzi N
- Thabut G
- Thabut G
- Theodorakopoulou M
- Thies P
- Thilakasiri MC
- Thomas B
- Thompson E
- Thévenin D
- Tiainen M
- Timsit JF
- Tirkkonen J
- Tirumala S
- Tjepkema-Cloostermans MC
- Tobar M
- Tofiño AL
- Toh CH
- Tokyo Womens Medical University
- Tomas E
- Tomas E
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- Tominaga N
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- Tonelotto BF
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- Topcu L
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- van Wijk A
- Vandijck D
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- Vaporidi K
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- Vega LM
- Veigas P
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- Venkatesan K
- Venn R
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- Venrdramin A
- Ventura-Rosado A
- Vergani G
- Verginella F
- Verhaeghe R
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- Vezzani A
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- Vidal A
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- Villard I
- Villarreal E
- Villarreal E
- Vincent B
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vinje LJ
- Vinsonneau C
- Vitaller S
- Vittone F
- Vogelaers D
- Voiriot G
- Volker T
- Volta CA
- Volta CA
- Vondrakova D
- Vondrakova D
- Vondrakova D
- Vong LV
- Vourli S
- Vrettou C
- Vucic M
- Vázquez CF
- Vázquez CF
- Wada T
- Wada T
- Wada T
- Wada T
- Waldauf P
- Wand S
- Wang CH
- Wang H
- Wann SR
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- Wann SR
- Wann SR
- Wathanawatthu T
- Wee S
- Welte T
- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
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- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
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- Wray J
- Xie Z
- Xini A
- Xini A
- Xiol EA
- Xu M
- Yager T
- Yaguchi A
- Yaguchi A
- Yamaguchi O
- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
- Zhou JC
- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
- Zogheib E
- Zogheib E
- Zogheib E
- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Molecular variability in Amerindians: widespread but uneven information
- Author
- ADAMS EJ
- ADAMS EJ
- AGOSTINI HT
- ANTÚNEZ-DE-MAYOLO G
- ARMOUR JAL
- ARNAIZ-VILLENA A
- ARRUDA VR
- AZOFEIFA J
- BAILLIET G
- BARLEY J
- BASSÈRES DS
- BATISTA O
- BATTILANA J
- BATZER MA
- BELICH MP
- BEVILAQUA LRM
- BIANCHI NO
- BIANCHI NO
- BIANCHI NO
- BLACK FL
- BLAGITKO N
- BOGDAWA HM
- BOISSINOT S
- BONATTO SL
- BONATTO SL
- BORTOLINI MC
- BORTOLINI MC
- BOWCOCK AM
- BRAVI CM
- BRAVI CM
- BRICENO I
- BROWN MD
- BUCHANAN AV
- BUROKER N
- CADAVID LF
- CALAFELL F
- CALAFELL F
- CARBONE MA
- CARVALHO-SILVA DR
- CASTAÑO AR
- CAVALLI-SFORZA LL
- CERNA M
- CHAKRABORTY R
- CHANG F-M
- CHEN JJ
- CHIBA AK
- CHOO SY
- COVAS DT
- CRAWFORD MH
- CREWS DE
- DE ANDRADE FM
- DE ANDRADE FM
- DEAN M
- DEKA R
- DEKA R
- DEKA R
- DEKA R
- DEKA R
- DEMARCHI DA
- DESTRO-BISTROL G
- DI RIENZO A
- DOMENA JD
- DORAN GH
- DORNELLES CL
- DUNCAN G
- EASTON RD
- ERLICH HA
- FAGUNDES NJR
- FERNÁNDEZ-VIÑA MA
- FORSTER P
- FRANCO RF
- FRANCO RF
- FRANCO RF
- FRÉGEAUX CJ
- FULLERTON SM
- GAEDIGK A
- GAMBOA R
- GARBER TL
- GASPAR PA
- GENÉ M
- GINTHER C
- GOLDMAN D
- GOMEZ-CASADO E
- GU X
- GUARINO FD
- GUERREIRO JF
- GUERREIRO JF
- GUÉDEZ YB
- GÓMEZ-CASADO E
- HAMMER MF
- HAMMER MF
- HAMMER MF
- HANDT O
- HARDING RM
- HARDY GH
- HAUSWIRTH WW
- HAUSWIRTH WW
- HEIDRICH EM
- HERRMANN B
- HERRMANN FH
- HIGUCHI R
- HILDEBRAND WH
- HILDEBRAND WH
- HORAI S
- HUOPONEN K
- HUTZ MH
- HUTZ MH
- HUTZ MH
- IMANISHI T
- IWANAGA KK
- JIN L
- JOBLING MA
- JOHNSON MJ
- JORGE LE
- JUUL L
- KARAFET T
- KARAFET T
- KARAFET TM
- KAUFMAN L
- KAUFMAN L
- KAYSER M
- KESSLER D
- KEYEUX G
- KIDD JR
- KIDD JR
- KIDD KK
- KITTLES RA
- KNIGHT A
- KOLMAN CJ
- KOLMAN CJ
- KOLMAN CJ
- KUNST CB
- KUWANO ST
- KVITKO K
- LALUEZA C
- LALUEZA C
- LALUEZA FOX C
- LALUEZA-FOX C
- LAYRISSE Z
- LAZARO AM
- LEBOUTE AP
- LELL JT
- LLEONART R
- LORENZ JG
- LUISELLI D
- MACK SJ
- MARCOS CY
- MARCOS CY
- MARIN GB
- MARTINEZ-LASO J
- MATEU E
- MATEU E
- MATHIAS N
- MATTEVI VS
- MATTEVI VS
- MCCOMB J
- MERCIER B
- MERRIWETHER DA
- MERRIWETHER DA
- MERRIWETHER DA
- MERRIWETHER DA
- MESA NR
- MEYER D
- MINGRONI-NETTO RC
- MITCHELL RJ
- MITCHELL RJ
- MITCHELL RJ
- MITCHELL RJ
- MIURA T
- MONSALVE MV
- MONSALVE MV
- MONSALVE MV
- MOURANT AE
- MOURANT AE
- MOURANT AE.
- MUÑOZ S
- NEEL JV
- NEEL JV.
- NEI M
- NOVICK GE
- O'ROURKE DH
- O'ROURKE DH
- OHTA T
- OHTA T
- OLIVEIRA SF.
- OLIVO A
- OLIVO-DÍAZ A
- OLSSON ML
- OSIER M
- PARHAM P
- PARHAM P
- PARR RL
- PENA SDJ
- PEPE G
- PEPE G
- PETERSON RJ
- PETZL-ERLER ML
- PETZL-ERLER ML.
- PÄÄBO S
- PÄÄBO S
- PÄÄBO S
- PÄÄBO S
- PÉREZ-LEZAUN A
- PÉREZ-LEZAUN A
- RAMON D
- RAMOS M
- RAMOS MD
- RANGEL-VILLALOBOS H
- RIBEIRO-DOS-SANTOS AKC
- RIBEIRO-DOS-SANTOS AKC
- RIBEIRO-DOS-SANTOS AKC
- RICKARDS O
- RIVAS F
- RODRIGUEZ-DELFIN L
- ROEWER L
- ROGAN PK
- ROGAN PK
- ROTHHAMMER F
- ROYCHOUDHURY AK
- RUIZ NARVAEZ EA
- RUIZ-LINARES A
- RUIZ-LINARES A
- RUPERT JL
- RUPERT JL
- RUPERT JL
- SALA A
- SALA A
- SALAMON H
- SALEMI M
- SALZANO FM
- SANTOS EJM
- SANTOS EJM
- SANTOS FR
- SANTOS FR
- SANTOS FR
- SANTOS FR
- SANTOS FR
- SANTOS FR
- SANTOS M
- SANTOS SEB
- SATTEN GA
- SCACCHI R
- SCHNEIDER JA
- SCOTT I
- SCOZZARI R
- SCOZZARI R
- SELVAKUMAR A
- SHEN P
- SHERRY ST
- SHIELDS GF
- SHIMIZU K
- SIMON D
- SMITH DG
- SOTOMAIOR VS
- STEPHENS JC
- STONE AC
- STONE AC
- STONE AC AND STONEKING M
- STONEKING M
- SU B
- SU B
- TARAZONA-SANTOS E
- THEILER GC
- THOMAS R
- TILLS D
- TISHKOFF SA
- TISHKOFF SA
- TISHKOFF SA
- TISHKOFF SA
- TITUS-TRACHTENBERG EA
- TORRONI A
- TORRONI A
- TORRONI A
- TRACHTENBERG EA
- TRACHTENBERG EA
- TRACHTENBERG EA
- UNDERHILL PA
- UNDERHILL PA
- URBANEK M
- VALDES AM
- VALLINOTO ACR
- VALLINOTO ACR
- VARGAS-ALARCÓN G
- VARGAS-ALARCÓN G
- VARGAS-ALARCÓN G
- VARGAS-ALARCÓN G
- VONA G
- VULLO CM
- WALL TL
- WALLACE DC
- WARD RH
- WARD RH
- WATKINS DI
- WEINBERG W
- YAGÜE J
- YAGÜE J
- YORK DS
- YUNIS JJ
- ZAGO MA
- ZERJAL T
- ZERJAL T
- ZHAO W
- ZHIVOTOVSKY LA
- ZIETKIEWICZ E
- ZIETKIEWICZ E
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-Gómez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
- Antas P
- Antebi A
- Antón Z
- Anwar T
- Apetoh L
- Apostolova N
- Araki T
- Araki Y
- Arasaki K
- Araya J
- Araújo WL
- Arden C
- Arguelles S
- Arias E
- Arikkath J
- Arimoto H
- Ariosa AR
- Armstrong-James D
- Arnauné-Pelloquin L
- Aroca A
- Arroyo DS
- Arsov I
- Artero R
- Arévalo M-A
- Asaro DML
- Aschner M
- Ashrafizadeh M
- Ashur-Fabian O
- Atanasov AG
- Au AK
- Auberger P
- Auner HW
- Aurelian L
- Autelli R
- Avagliano L
- Aveic S
- Aveleira CA
- Avin-Wittenberg T
- Aydin Y
- Ayton S
- Ayyadevara S
- Azzopardi M
- Baba M
- Backer JM
- Backues SK
- Bae D-H
- Bae O-N
- Bae SH
- Baehrecke EH
- Baek A
- Baek S-H
- Baek SH
- Bagetta G
- Bagniewska-Zadworna A
- Bai H
- Bai J
- Bai X
- Bai Y
- Bairagi N
- Baksi S
- Balazadeh S
- Balbi T
- Baldari CT
- Balduini W
- Ballabio A
- Ballester M
- Balzan R
- Bandopadhyay R
- Banerjee S
- Banerjee S
- Bao Y
- Baptista MS
- Baracca A
- Barbati C
- Bargiela A
- Barilà D
- Barlow PG
- Barmada SJ
- Barreiro E
- Barreto GE
- Bartek J
- Bartel B
- Bartolome A
- Barve GR
- Basagoudanavar SH
- Bassham DC
- Bast RC
- Basu A
- Batoko H
- Batten I
- Baulieu EE
- Baumgarner BL
- Bayry J
- Beale R
- Beau I
- Beaumatin F
- Bechara LRG
- Beck GR
- Beers MF
- Begun J
- Behl C
- Behrends C
- Behrens GMN
- Bei R
- Bejarano E
- Bel S
- Belaid A
- Belgareh-Touzé N
- Bellarosa C
- Belleudi F
- Bello-Morales R
- Belló Pérez M
- Beltran JSDO
- Beltran S
- Benbrook DM
- Bendorius M
- Benitez BA
- Benito-Cuesta I
- Bensalem J
- Berchtold MW
- Berezowska S
- Bergamaschi D
- Bergami M
- Bergmann A
- Berliocchi L
- Berlioz-Torrent C
- Bernard A
- Berthoux L
- Besirli CG
- Besteiro S
- Betin VM
- Beyaert R
- Bezbradica JS
- Bhaskar K
- Bhatia-Kissova I
- Bhattacharya R
- Bhattacharya S
- Bhattacharyya S
- Bhuiyan MS
- Bhutia SK
- Bi L
- Bi X
- Biden TJ
- Bijian K
- Billes VA
- Binart N
- Bincoletto C
- Birgisdottir AB
- Bjorkoy G
- Blanco G
- Blas-Garcia A
- Blasiak J
- Blomgran R
- Blomgren K
- Blum JS
- Boada-Romero E
- Boban M
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- Boeuf P
- Boland B
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- Bonam SR
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- Bonifacino JS
- Boone BA
- Bootman MD
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- Bornhauser BC
- Borthakur G
- Bosch J
- Bose S
- Botana LM
- Botas J
- Boulanger CM
- Boulton ME
- Bourdenx M
- Bourgeois B
- Bourke NM
- Bousquet G
- Boya P
- Bozhkov PV
- Bozi LHM
- Bozkurt TO
- Brackney DE
- Brand-Saberi B
- Brandts CH
- Braun RJ
- Braus GH
- Bravo-Sagua R
- Bravo-San Pedro JM
- Brest P
- Bringer M-A
- Briones-Herrera A
- Broaddus VC
- Brodersen P
- Brodsky JL
- Brody SL
- Bronson PG
- Bronstein JM
- Brown CN
- Brown RE
- Brum PC
- Brumell JH
- Brunetti-Pierri N
- Bruno D
- Bryson-Richardson RJ
- Bucci C
- Buch S
- Buchan JR
- Buchrieser C
- Buckingham EM
- Budak H
- Budini M
- Bueno M
- Buitrago-Molina LE
- Bultynck G
- Burada F
- Buraschi S
- Burgoyne JR
- Burón MI
- Bustos V
- Butturini E
- Byrd A
- Bánréti Á
- Büttner S
- Cabas I
- Cabrera-Benitez S
- Cadwell K
- Cai J
- Cai L
- Cai Q
- Cairó M
- Calbet JA
- Caldwell GA
- Caldwell KA
- Call JA
- Calvani R
- Calvo AC
- Calvo-Rubio Barrera M
- Camara NO
- Camonis JH
- Camougrand N
- Campanella M
- Campbell EM
- Campbell-Valois F-X
- Campello S
- Campesi I
- Campos JC
- Camuzard O
- Cancino J
- Candido de Almeida D
- Canesi L
- Caniggia I
- Canonico B
- Cantí C
- Cao B
- Caraglia M
- Caramés B
- Carchman EH
- Cardenal-Muñoz E
- Cardenas C
- Cardenas L
- Cardoso SM
- Carew JS
- Carle GF
- Carleton G
- Carloni S
- Carmona-Gutierrez D
- Carneiro LA
- Carnevali O
- Carosi JM
- Carra S
- Carrier A
- Carrier L
- Carroll B
- Carter AB
- Carvalho AN
- Casanova M
- Casas C
- Casas J
- Cassioli C
- Castillo EF
- Castillo K
- Castillo-Lluva S
- Castoldi F
- Castori M
- Castro AF
- Castro-Caldas M
- Castro-Hernandez J
- Castro-Obregon S
- Catz SD
- Cavadas C
- Cavaliere F
- Cavallini G
- Cavinato M
- Cayuela ML
- Cebollada Rica P
- Cecarini V
- Cecconi F
- Cechowska-Pasko M
- Cenci S
- Ceperuelo-Mallafré V
- Cerqueira JJ
- Cerutti JM
- Cervia D
- Cetintas VB
- Cetrullo S
- Chae H-J
- Chagin AS
- Chai C-Y
- Chakrabarti G
- Chakrabarti O
- Chakraborty T
- Chakraborty T
- Chami M
- Chamilos G
- Chan DW
- Chan ED
- Chan EYW
- Chan H
- Chan HH
- Chan HYE
- Chan MTV
- Chan YS
- Chandra PK
- Chang C
- Chang C-P
- Chang H-C
- Chang K
- Chao J
- Chapman T
- Charlet-Berguerand N
- Chatterjee S
- Chaube SK
- Chaudhary A
- Chauhan S
- Chaum E
- Checler F
- Cheetham ME
- Chen C-S
- Chen G-C
- Chen J-F
- Chen L
- Chen L
- Chen LL
- Chen M
- Chen M-K
- Chen N
- Chen Q
- Chen R-H
- Chen S
- Chen W
- Chen W
- Chen X
- Chen X-M
- Chen X-W
- Chen Y
- Chen Y
- Chen Y
- Chen Y-G
- Chen Y-J
- Chen Y-Q
- Chen Z
- Chen Z
- Chen Z
- Chen Z-H
- Chen ZJ
- Chen ZS
- Cheng H
- Cheng J
- Cheng S-Y
- Cheng W
- Cheng X
- Cheng X-T
- Cheng Y
- Cheng Z
- Cheong H
- Cheong JK
- Chernyak BV
- Cherry S
- Cheung CFR
- Cheung CHA
- Cheung K-H
- Chevet E
- Chi RJ
- Chiang AKS
- Chiaradonna F
- Chiarelli R
- Chiariello M
- Chica N
- Chiocca S
- Chiong M
- Chiou S-H
- Chiramel AI
- Chiurchiù V
- Cho D-H
- Choe S-K
- Choi AMK
- Choi ME
- Choudhury KR
- Chow NS
- Chu CT
- Chua JJE
- Chua JP
- Chung H
- Chung KP
- Chung S
- Chung S-H
- Chung Y-L
- Cianfanelli V
- Ciechomska IA
- Cifuentes M
- Cinque L
- Cirak S
- Cirone M
- Clague MJ
- Clarke R
- Clementi E
- Coccia EM
- Codogno P
- Cohen E
- Cohen MM
- Colasanti T
- Colasuonno F
- Colbert RA
- Colell A
- Coll NS
- Collins MO
- Colombo MI
- Colón-Ramos DA
- Combaret L
- Comincini S
- Cominetti MR
- Consiglio A
- Conte A
- Conti F
- Contu VR
- Cookson MR
- Coombs KM
- Coppens I
- Corasaniti MT
- Cordes N
- Corkery DP
- Cortese K
- Costa MDC
- Costantino S
- Costelli P
- Coto-Montes A
- Crack PJ
- Crespo JL
- Criollo A
- Crippa V
- Cristofani R
- Csizmadia T
- Cuadrado A
- Cui B
- Cui J
- Cui Y
- Cui Y
- Culetto E
- Cumino AC
- Cybulsky AV
- Czaja MJ
- Czuczwar SJ
- D'Adamo S
- D'Amelio M
- D'Arcangelo D
- D'Lugos AC
- D'Orazi G
- da Silva JA
- Dafsari HS
- Dagda RK
- Dagdas Y
- Daglia M
- Dai X
- Dai Y
- Dai Y
- Dal Col J
- Dalhaimer P
- Dalla Valle L
- Dallenga T
- Dalmasso G
- Damme M
- Dando I
- Dantuma NP
- Darling AL
- Das H
- Dasarathy S
- Dasari SK
- Dash S
- Daumke O
- Dauphinee AN
- Davies JS
- Davis RJ
- Davis T
- Dayalan Naidu S
- De Amicis F
- De Bosscher K
- De Felice F
- De Franceschi L
- De Leonibus C
- de Mattos Barbosa MG
- De Meyer GRY
- De Milito A
- De Nunzio C
- De Palma C
- De Santi M
- De Virgilio C
- De Zio D
- Debnath J
- DeBosch BJ
- Decuypere J-P
- Deehan MA
- Deflorian G
- DeGregori J
- Dehay B
- Del Rio G
- Delaney JR
- Delbridge LMD
- Delorme-Axford E
- Delpino MV
- Demarchi F
- Dembitz V
- Demers ND
- Deng H
- Deng Z
- Dengjel J
- Dent P
- Denton D
- DePamphilis ML
- Der CJ
- Deretic V
- Descoteaux A
- Devis L
- Devkota S
- Devuyst O
- Dewson G
- Dharmasivam M
- Dhiman R
- di Bernardo D
- Di Cristina M
- Di Domenico F
- Di Fazio P
- Di Fonzo A
- Di Guardo G
- Di Guglielmo GM
- Di Leo L
- Di Malta C
- Di Nardo A
- Di Rienzo M
- Di Sano F
- Diallinas G
- Diao J
- Diaz-Araya G
- Dickinson JM
- Diederich M
- Dieudé M
- Dikic I
- Ding S
- Ding W-X
- Dini L
- Dinic M
- Dinić J
- Dinkova-Kostova AT
- Dionne MS
- Distler JHW
- Diwan A
- Dixon IMC
- Djavaheri-Mergny M
- Dobrinski I
- Dobrovinskaya O
- Dobrowolski R
- Dobson RCJ
- Dokmeci Emre S
- Donadelli M
- Dong B
- Dong X
- Dong XC
- Dong Z
- Dorn Ii GW
- Dotsch V
- Dou H
- Dou J
- Dowaidar M
- Dridi S
- Drucker L
- du Toit A
- Du A
- Du C
- Du G
- Du H-N
- Du L-L
- Duan S-B
- Duan X
- Duarte SP
- Dubrovska A
- Dunlop EA
- Dupont N
- Durán RV
- Dwarakanath BS
- Dyshlovoy SA
- Dávila VA
- Díaz-Laviada I
- Ebrahimi-Fakhari D
- Eckhart L
- Edelstein CL
- Efferth T
- Eftekharpour E
- Eichinger L
- Eid N
- Eisenberg T
- Eissa NT
- Eissa S
- Ejarque M
- El Andaloussi A
- El-Hage N
- El-Naggar S
- El-Shafey ES
- Eleuteri AM
- Elgendy M
- Eliopoulos AG
- Elizalde MM
- Elks PM
- Elsasser H-P
- Elsherbiny ES
- Emerling BM
- Emre NCT
- Eng CH
- Engedal N
- Engelbrecht A-M
- Engelsen AST
- Enserink JM
- Escalante R
- Esclatine A
- Escobar-Henriques M
- Eskelinen E-L
- Espert L
- Eusebio M-O
- Fabrias G
- Fabrizi C
- Facchiano A
- Facchiano F
- Fadeel B
- Fader C
- Faesen AC
- Fairlie WD
- Falcó A
- Falkenburger BH
- Fan D
- Fan J
- Fan Y
- Fang EF
- Fang Y
- Fang Y
- Fanto M
- Farfel-Becker T
- Faure M
- Fazeli G
- Fedele AO
- Feldman AM
- Feng D
- Feng J
- Feng L
- Feng W
- Feng Y
- Feng Y
- Fenz Araujo T
- Ferguson TA
- Fernandez-Checa JC
- Fernie AR
- Fernández ÁF
- Fernández-Veledo S
- Ferrante AW
- Ferraresi A
- Ferrari MF
- Ferreira JCB
- Ferro-Novick S
- Figueras A
- Filadi R
- Filigheddu N
- Filippi-Chiela E
- Filomeni G
- Fimia GM
- Fineschi V
- Finetti F
- Finkbeiner S
- Fisher EA
- Fisher PB
- Flamigni F
- Fliesler SJ
- Flo TH
- Florance I
- Florey O
- Florio T
- Fodor E
- Follo C
- Fon EA
- Forlino A
- Fornai F
- Fortini P
- Fracassi A
- Fraldi A
- Franco B
- Franco R
- Franconi F
- Frankel LB
- Friedman SL
- Fröhlich LF
- Frühbeck G
- Fuentes JM
- Fujiki Y
- Fujita N
- Fujiwara Y
- Fukuda M
- Fulda S
- Furic L
- Furuya N
- Fusco C
- Gack MU
- Gaffke L
- Galadari S
- Galasso A
- Galindo MF
- Gallolu Kankanamalage S
- Galluzzi L
- Galy V
- Gammoh N
- Gan B
- Ganley IG
- Gao F
- Gao H
- Gao M
- Gao P
- Gao S-J
- Gao W
- Gao X
- Garcera A
- Garcia MN
- Garcia VE
- Garcia-Escudero V
- Garcia-Garcia A
- Garcia-Macia M
- Garcia-Ruiz C
- García-Del Portillo F
- García-Moreno D
- García-Sanz P
- Garg AD
- Gargini R
- Garofalo T
- Garry RF
- Gassen NC
- Gatica D
- Ge L
- Ge W
- Geiss-Friedlander R
- Gelfi C
- Genschik P
- Gentle IE
- Gerbino V
- Gerhardt C
- Germain K
- Germain M
- Gewirtz DA
- Ghasemipour Afshar E
- Ghavami S
- Ghigo A
- Ghosh M
- Giamas G
- Giampietri C
- Giatromanolaki A
- Gibson GE
- Gibson SB
- Ginet V
- Giniger E
- Giorgi C
- Girao H
- Girardin SE
- Giridharan M
- Giuliano S
- Giulivi C
- Giuriato S
- Giustiniani J
- Gluschko A
- Goder V
- Goginashvili A
- Golab J
- Goldstone DC
- Golebiewska A
- Gomes LR
- Gomez R
- Gomez-Puerto MC
- Gomez-Sintes R
- Gong Q
- Goni FM
- Gonzalez-Hernandez T
- Gonzalez-Polo RA
- Gonzalez-Reyes JA
- González-Gallego J
- González-Rodríguez P
- Goping IS
- Gorbatyuk MS
- Gorbunov NV
- Gorojod RM
- Gorski SM
- Goruppi S
- Gotor C
- Gottlieb RA
- Gozes I
- Gozuacik D
- Graef M
- Granatiero V
- Grasso D
- Gray JP
- Green DR
- Greenhough A
- Gregory SL
- Griffin EF
- Grinstaff MW
- Gros F
- Grose C
- Gross AS
- Gruber F
- Grumati P
- Grune T
- Gräler MH
- Gu X
- Guan J-L
- Guardia CM
- Guda K
- Guerra F
- Guerri C
- Guha P
- Guillén C
- Gujar S
- Gukovskaya A
- Gukovsky I
- Gunst J
- Guntur AR
- Guo C
- Guo C
- Guo H
- Guo L-W
- Guo M
- Gupta P
- Gupta S
- Gupta SK
- Gupta V
- Gupta VB
- Gustafsson AB
- Gutterman DD
- Gómez-Sánchez R
- Görgülü K
- Günther A
- H B R
- Haapasalo A
- Haber JE
- Hadano S
- Hafrén AJ
- Haidar M
- Hall BS
- Halldén G
- Hamacher-Brady A
- Hamann A
- Hamasaki M
- Han W
- Hansen M
- Hanson PI
- Hao Z
- Harada M
- Harhaji-Trajkovic L
- Hariharan N
- Haroon N
- Harris J
- Hasegawa T
- Hasima Nagoor N
- Haspel JA
- Haucke V
- Hawkins WD
- Hay BA
- Haynes CM
- Hayrabedyan SB
- Hays TS
- Hać A
- He C
- He Q
- He R-R
- He Y-W
- He Y-Y
- Heakal Y
- Heberle AM
- Hejtmancik JF
- Helgason GV
- Henkel V
- Herb M
- Hergovich A
- Herman-Antosiewicz A
- Hernandez C
- Hernandez-Diaz S
- Hernandez-Gea V
- Hernández A
- Herpin A
- Herreros J
- Hervás JH
- Hesselson D
- Hetz C
- Heussler VT
- Higuchi Y
- Hilfiker S
- Hill JA
- Hlavacek WS
- Ho EA
- Ho IHT
- Ho PW-L
- Ho S-L
- Ho WY
- Hobbs GA
- Hochstrasser M
- Hoet PHM
- Hofius D
- Hofman P
- Holmberg CI
- Hombrebueno JR
- Hooper LV
- Hoppe T
- Horos R
- Hoshida Y
- Hsin I-L
- Hsu H-Y
- Hu B
- Hu D
- Hu L-F
- Hu MC
- Hu R
- Hu W
- Hu Y-C
- Hu Z-W
- Hua F
- Hua J
- Hua Y
- Huan C
- Huang C
- Huang C
- Huang C
- Huang C
- Huang H
- Huang K
- Huang MLH
- Huang R
- Huang S
- Huang T
- Huang X
- Huang YJ
- Huber TB
- Hubert V
- Hubner CA
- Hughes SM
- Hughes WE
- Humbert M
- Hummer G
- Hurley JH
- Hussain S
- Hussain S
- Hussey PJ
- Hutabarat M
- Hwang H-Y
- Hwang S
- Hyung-Ryong Kim
- Höhn A
- Ieni A
- Ikeda F
- Imagawa Y
- Imai Y
- Imbriano C
- Imoto M
- Inman DM
- Inoki K
- Iovanna J
- Iozzo RV
- Ippolito G
- Irazoqui JE
- Iribarren P
- Ishaq M
- Ishikawa M
- Ishimwe N
- Isidoro C
- Ismail N
- Issazadeh-Navikas S
- Itakura E
- Ito D
- Ivankovic D
- Ivanova S
- Iyer AKV
- Izquierdo JM
- Izumi M
- Jabir MS
- Jackson WT
- Jacobo-Herrera N
- Jacomin A-C
- Jacquin E
- Jadiya P
- Jaeschke H
- Jagannath C
- Jakobi AJ
- Jakobsson J
- Janji B
- Jansen-Dürr P
- Jansson PJ
- Jantsch J
- Januszewski S
- Jassey A
- Jean S
- Jeltsch-David H
- Jendelova P
- Jenny A
- Jensen TE
- Jessen N
- Jewell JL
- Ji J
- Jia L
- Jia R
- Jiang L
- Jiang Q
- Jiang R
- Jiang T
- Jiang X
- Jiang Y
- Jimenez-Sanchez M
- Jin E-J
- Jin F
- Jin H
- Jin L
- Jin L
- Jin M
- Jin S
- Jo E-K
- Joffre C
- Johansen T
- Johnson GVW
- Johnston SA
- Jokitalo E
- Jolly MK
- Joosten LAB
- Jordan J
- Joseph B
- Ju D
- Ju J
- Ju J-S
- Judith D
- Juhász G
- Jun Y
- Jung CH
- Jung S-C
- Jung YK
- Jungbluth H
- Jungverdorben J
- Just S
- Juárez E
- Jäättelä M
- Kaarniranta K
- Kaasik A
- Kabuta T
- Kaganovich D
- Kahana A
- Kain R
- Kajimura S
- Kalamvoki M
- Kalia M
- Kalinowski DS
- Kaludercic N
- Kalvari I
- Kaminska J
- Kaminskyy VO
- Kanamori H
- Kanasaki K
- Kang C
- Kang R
- Kang SS
- Kaniyappan S
- Kanki T
- Kanneganti T-D
- Kanthasamy A
- Kanthasamy AG
- Kantorow M
- Kapuy O
- Karamouzis MV
- Karim MR
- Karmakar P
- Katare RG
- Kato M
- Kaufmann SHE
- Kauppinen A
- Kaushal GP
- Kaushik S
- Kawasaki K
- Kazan K
- Ke P-Y
- Keating DJ
- Keber U
- Kehrl JH
- Keller CW
- Keller KE
- Kemper JK
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- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
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