Interruptions Produced by the Mollucan Students in the Fellowship Meeting

This thesis is about a study of the interruptions produced by the Moluccan students in a fellowship meeting, consisting of fifteen students as the respondents, who are divided into two: the chairperson and the members. The purposes of the study are to know the tokens and the functions of interruptions used by the chairperson and the members of the meeting by considering social role as the social factor. The writer applies the theory of interruptions by Tannen (1990) and Wardhaugh (1985) as the main theories. Besides, the writer also uses the theory of social role by Johnstone (2008) and the theory of discourse markers by Schiffrin (2003) as the supporting theories. The writer used qualitative approach to conduct this research. The writer discovered that the chairperson produced more tokens (19) than the members (13). Moreover, the writer found that the respondents produced Ambonese tokens, such as “Hiii”, “Weee”, “Seng”, “Eee”, and Suroboyoan tokens, such as “Lho” and “Itulho”. Both the chairperson and the members produced “other” functions the most with 58.75% and 63.81%. In conclusion, social role influenced the interruptions and their functions, and the number of tokens produced by the participants

Symmetrical Drug-Related Intertriginous and Flexural Exanthema Induced by Cellulitis Prophylaxis

Penicillin VK and hydroxyzine are typically well-tolerated antipruritic agents that are indicated in the prophylaxis of cellulitis. We herein report a case of a unique rash occurring during penicillin VK and hydroxyzine treatment in combination with the ingestion of cashews. A 77-year-old male presented with new onset rash. Eleven days after the administration of penicillin VK and hydroxyzine for cellulitis prophylaxis, he developed a symmetric, erythematous, scaling rash on his buttocks and perineal region with associated pruritus and bleeding without fevers, chills, adenopathy, night sweats, or any other symptoms. He was diagnosed with symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) secondary to systemic treatment, an adverse drug reaction that presents as an erythematous rash involving the skin folds. The condition is also known as “baboon syndrome,” as it predominately affects the buttocks. A good outcome was achieved due to a thorough history and physical, timely diagnosis, and cessation of the offending agents

Modeling the radial abundance distribution of the transition galaxy ngc 1313

NGC 1313 is the most massive disk galaxy showing a flat radial abundance distribution in its interstellar gas, a behavior generally observed in magellanic and irregular galaxies. We have attempted to reproduce this flat abundance distribution using a multiphase chemical evolution model, which has been previously used sucessfully to depict other spiral galaxies along the Hubble morphological sequence. We found that it is not possible to reproduce the flat radial abundance distribution in NGC 1313, and at the same time, be consistent with observed radial distributions of other key parameters such the surface gas density and star formation profiles. We conclude that a more complicated galactic evolution model including radial flows, and possibly mass loss due to supernova explosions and winds, is necessary to explain the apparent chemical uniformity of the disk of NGC 1313Comment: 14 paginas, 4 figures, to be published in ApJ, apri

The isolated interacting galaxy pair NGC 5426/27 (Arp 271)

We present H alpha observations of the isolated interacting galaxy pair NGC 5426/27 using the scanning Fabry-Perot interferometer PUMA. The velocity field, various kinematical parameters and rotation curve for each galaxy were derived. The FWHM map and the residual velocities map were also computed to study the role of non-circular motions of the gas. Most of these motions can be associated with the presence of spiral arms and structure such as central bars. We found a small bar-like structure in NGC 5426, a distorted velocity field for NGC 5427 and a bridge-like feature between both galaxies which seems to be associated with NGC 5426. Using the observed rotation curves, a range of possible masses was computed for each galaxy. These were compared with the orbital mass of the pair derived from the relative motion of the participants. The rotation curve of each galaxy was also used to fit different mass distribution models considering the most common theoretical dark halo models. An analysis of the interaction process is presented and a possible 3D scenario for this encounter is also suggested.Comment: 27 pages, 15 figures, to be published in Astronomy & Astrophysic

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.

MAF1 is a global repressor of RNA polymerase III transcription that regulates the expression of highly abundant noncoding RNAs in response to nutrient availability and cellular stress. Thus, MAF1 function is thought to be important for metabolic economy. Here we show that a whole-body knockout of Maf1 in mice confers resistance to diet-induced obesity and nonalcoholic fatty liver disease by reducing food intake and increasing metabolic inefficiency. Energy expenditure in Maf1(-/-) mice is increased by several mechanisms. Precursor tRNA synthesis was increased in multiple tissues without significant effects on mature tRNA levels, implying increased turnover in a futile tRNA cycle. Elevated futile cycling of hepatic lipids was also observed. Metabolite profiling of the liver and skeletal muscle revealed elevated levels of many amino acids and spermidine, which links the induction of autophagy in Maf1(-/-) mice with their extended life span. The increase in spermidine was accompanied by reduced levels of nicotinamide N-methyltransferase, which promotes polyamine synthesis, enables nicotinamide salvage to regenerate NAD(+), and is associated with obesity resistance. Consistent with this, NAD(+) levels were increased in muscle. The importance of MAF1 for metabolic economy reveals the potential for MAF1 modulators to protect against obesity and its harmful consequences

Successful treatment of HIV-associated multicentric Castleman's disease and multiple organ failure with rituximab and supportive care: a case report

<p>Abstract</p> <p>Introduction</p> <p>Multicentric Castleman's Disease (MCD), a lymphoproliferative disorder associated with Human Herpes Virus-8 (HHV-8) infection, is increasing in incidence amongst HIV patients. This condition is associated with lymphadenopathy, polyclonal gammopathy, hepato-splenomegaly and systemic symptoms. A number of small studies have demonstrated the efficacy of the anti-CD20 monoclonal antibody, rituximab, in treating this condition.</p> <p>Case presentation</p> <p>We report the case of a 46 year old Zambian woman who presented with pyrexia, diarrhoea and vomiting, confusion, lymphadenopathy, and renal failure. She rapidly developed multiple organ failure following the initiation of treatment of MCD with rituximab. Following admission to intensive care (ICU), she received prompt multi-organ support. After 21 days on the ICU she returned to the haematology medical ward, and was discharged in remission from her disease after 149 days in hospital.</p> <p>Conclusion</p> <p>Rituximab, the efficacy of which has thus far been examined predominantly in patients <it>outside </it>the ICU, in conjunction with extensive organ support was effective treatment for MCD with associated multiple organ failure. There is, to our knowledge, only one other published report of its successful use in an ICU setting, where it was combined with cyclophosphamide, adriamycin and prednisolone. Reports such as ours support the notion that critically unwell patients with HIV and haematological disease <it>can </it>benefit from intensive care.</p

A Counter-rotating Bulge in the Sb Galaxy NGC 7331

We have found that the bulge of the large, nearby Sb galaxy NGC 7331 rotates retrograde to its disk. Analysis of spectra in the region of the near-IR Ca II triplet along the major axis shows that, in the radial range between 5'' and ~20'', the line of sight velocity distribution of the absorption lines has two distinct peaks, and can be decomposed into a fast-rotating component with v/sigma > 3, and a slower rotating, retrograde component with v/sigma between 1 -- 1.5. The radial surface brightness profile of the counter-rotating component follows that of the bulge, obtained from a 2-dimensional bulge-disk decomposition of a near-infrared K-band image, while the fast rotating component follows the disk. At the radius where the disk starts to dominate the isophotes change from being considerably boxy to very disky. Although a number of spiral galaxies have been found that contain cold, couter-rotating disks, this is the first galaxy known to have a boxy, probably triaxial, fairly warm, counter-rotating component, which is dominating in the central regions. If it is a bar seen end-on, this bar has to be thicker than the disk. We find that NGC 7331, even though it is a fairly early-type spiral, does not have a conventional, co-rotating bulge. The fact that the inner component is retrograde makes us believe that it was formed from infalling material, in either stellar or gaseous form (e.g. Balcells & Quinn 1990). Another possibility however is that the structure has been there since the formation of the galaxy. In this case it will be a challenge to explain the large change in orientation of the angular momentum when going outward radially.Comment: 13 pages latex, including 4 figures and 1 B/W plate. Accepted for Astrophysical Journal Letters. Revised version incorporating some small last-minute change

How the field of infectious diseases can leverage digital strategy and social media use during a pandemic

Rapid information dissemination is critical in a world changing rapidly due to global threats. Ubiquitous internet access has created new methods of information dissemination that are rapid, far-reaching, and universally accessible. However, inaccuracies may accompany rapid information dissemination, and rigorous evaluation of primary data through various forms of peer review is crucial. In an era in which high-quality information can save lives, it is critical that infectious diseases specialists are well versed in digital strategy to effectively disseminate information to colleagues and the community and diminish voices spreading misinformation. In this study, we review how social media can be used for rapid dissemination of quality information, benefits and pitfalls of social media use, and general recommendations for developing a digital strategy as an infectious diseases specialist. We will describe how the Infectious Diseases Society of America has leveraged digital strategy and social media and how individuals can amplify these resources to disseminate information, provide clinical knowledge, community guidance, and build their own person brand. We conclude in providing guidance to infectious diseases specialists in aiming to build and preserve public trust, consider their audience and specific goals, and use social media to highlight the value of the field of infectious diseases

Performance of the First ANTARES Detector Line

In this paper we report on the data recorded with the first Antares detector line. The line was deployed on the 14th of February 2006 and was connected to the readout two weeks later. Environmental data for one and a half years of running are shown. Measurements of atmospheric muons from data taken from selected runs during the first six months of operation are presented. Performance figures in terms of time residuals and angular resolution are given. Finally the angular distribution of atmospheric muons is presented and from this the depth profile of the muon intensity is derived.Comment: 14 pages, 9 figure