7 research outputs found
Method-specific Certification of Free Sugars and Starch/Glucose in Two Artificial Food Materials - BCR-644, BCR-645.
- Author
- Publication venue
- European Commission
- Publication date
- 04/11/2003
- Field of study
Abstract not availableJRC.D-Institute for Reference Materials and Measurements (Geel
Distributed electrothermal modeling methodology for MOS gated power devices simulations
- Publication venue
- Politechnika Łódzka. Wydział Mikroelektroniki i Informatyki
- Publication date
- 01/01/2013
- Field of study
Currently electro-thermal simulations performed with 3D FEM simulators like ANSYS or COMSOL Multiphysics are limited to an imposed current flow through resistive materials. However, in the case of power MOS gated transistors like VDMOS transistors or IGBT, the channel resistance evolves with the gate voltage. This phenomenon is usually neglected in ON-state applications but seems to be determinant in switching application. Furthermore all the MOS cells of the transistors are not at the same temperature. This paper deals with a methodology that could allow taking into account the impact of the gate control and the MOS cells current distribution during 3D FEM electro-thermal simulations
Worst Case Heavy Ion Testing Conditions for Normally Off GaN-Based High Electron Mobility Transistor
- Author
- Publication venue
- HAL CCSD
- Publication date
- 25/09/2023
- Field of study
The paper presents two alternatives SEE testing conditions on GaN power devices to investigate for the worst case that are switching and high tilt beam condition. Results obtained are discussed with the help of TCAD modeling
Second flight of the Spacelab Grille Spectrometer during the ATLAS-1 mission
- Author
- Publication venue
- 'American Geophysical Union (AGU)'
- Publication date
- Field of study
Combined Bacterial Meningitis and Infective Endocarditis: When Should We Search for the Other When Either One is Diagnosed?
- Author
- Abassade P.
- Abouliatim I.
- Abrial E.
- Acar C.
- Aissa N.
- Alexandra J.
- Alla F.
- Amireche N.
- Amrein D.
- Andre P.
- Anguel N.
- Appriou M.
- Argaud L.
- Arista S.
- Armand-Lefevre L.
- Arnould M.
- Atoui A.
- Aumaître H.
- Aziza F.
- Baehrel B.
- Baille N.
- Bajolle N.
- Balavoine S.
- Baraduc R.
- Barnaud G.
- Battistella P.
- Baumard S.
- Ben Ali A.
- Bernard L.
- Bernard Y.
- Bernars G.
- Bertei D.
- Bertrand J.
- Bes M.
- Bessede E.
- Bialek S.
- Billard Pomares T.
- Biron C.
- Bland S.
- Boileau J.
- Bois Grosse M.
- Boixados M.
- Bollaert P.-E.
- Bonacorsi S.
- Borlot F.
- Boubeau P.
- Bouchachi A.
- Bouche O.
- Bouchemal S.
- Bourdon J.
- Bourdon S.
- Bousquet A.
- Bouvet A.
- Boyer S.
- Bozorg-Grayeli A.
- Brasme L.
- Bret L.
- Bretonniere C.
- Bricaire F.
- Brocas E.
- Brun M.
- Bruntz J.
- Buret J.
- Burucoa C.
- Béraud Guillaume
- Cabalion J.
- Cabon M.
- Cailhol J.
- Cambau E.
- Camuset G.
- Canevet C.
- Caplan M.P.
- Carette B.
- Caron F.
- Carricajo A.
- Carteaux J.
- Cartry O.
- Castan B.
- Caumes E.
- Cazanave C.
- Cazorla C.
- Celard M.
- Chabrol A.
- Challan-Belval T.
- Chamagne H.
- Champagne H.
- Chanques G.
- Chanteperdrix-Marillier V.
- Chaplain C.
- Charlier-Woerther C.
- Chaussade H.
- Chevalier B.
- Chidiac C.
- Chirouze Catherine
- Chocron S.
- Chometon F.
- Christophe C.
- Clair B.
- Colin de Verdiere N.
- Colot J.
- Conil J.-M.
- Cordel H.
- Cormier P.
- Cousson J.
- Cronier P.
- Cua E.
- Danchin N.
- Daneluzzi V.
- Dao-Dubremetz A.
- Dargere S.
- David L.
- de Lentdecker P.
- de Place C.
- Debroucker T.
- Degand N.
- Dekeyser S.
- Delahaye F.
- Delaune D.
- Delcey V.
- Deleuze P.
- Denes E.
- Dequin P.-F.
- Deroure B.
- Descamps D.
- Descloux E.
- Descotes-Genon V.
- Desmaretz J.-L.
- Didier Petit K.
- Diehl J.-L.
- Dimet J.
- Dinh A.
- Doat V.
- Doco-Lecompte T.
- Donnio P.
- Duchene F.
- Duhoux F.
- Dupont M.
- Duval Xavier
- Ederhy S.
- Epaulard O.
- Erpelding Marie-Line
- Escaut L.
- Evest M.
- Fabe C.
- Faibis F.
- Faucher J.
- Fauveau E.
- Ferry T.
- Fillod M.
- Flateau C.
- Floch T.
- Fonsale N.
- Forestier E.
- Fortineau N.
- Frachet B.
- Fraisse T.
- Frapier J.
- Frappier J.
- Freysz L.
- Fumery B.
- Gachot B.
- Gagneux-Brunon A.
- Gaillot O.
- Gallien S.
- Gandjbakhch I.
- Garandeau C.
- Garcia M.
- Garcon P.
- Garot D.
- Gaubert A.
- Gaudry S.
- Genoud J.
- Gherissi D.
- Ghiglione S.
- Godreuil C.
- Goehringer F.
- Gorenne Isabelle
- Gravet A.
- Gregoire-Faucher V.
- Grentzinger A.
- Groben L.
- Grosset M.
- Gubavu C.
- Gueit I.
- Guelon D.
- Guimard T.
- Guinard J.
- Hadou T.
- Hagege A.
- Hammoudi N.
- Helene J.-P.
- Heliot F.
- Henard S.
- Henry B.
- Henry P.
- Hochart A.-C.
- Hoen Bruno
- Houriez P.
- Hustache-Mathieu L.
- Huttin O.
- Illes G.
- Imbert S.
- Iung B.
- Jaffuel S.
- Jarrin I.
- Jaureguiberry S.
- Jaureguy F.
- Jaussaud R.
- Joseph C.
- Juvin M.-E.
- Kaaki M.
- Kayal S.
- Kerneis S.
- Konate A.
- Kuhn J.
- Kural Menasche S.
- Lacassin F.
- Lafitte A.
- Lafon B.
- Lamaury I.
- Lanotte P.
- Lanternier F.
- Laouenan C.
- Laurens E.
- Laurichesse H.
- Le Brun C.
- Le Chenault V.
- Le Moing Vincent
- Le Turnier P.
- Lechiche C.
- Lecuit M.
- Lecuyer H.
- Ledru S.
- Lefevre Thibaut S.
- Lefort A.
- Legrix C.
- Lemaignen A.
- Lemble C.
- Lemee L.
- Lemoine J.
- Lepage L.
- Leport C.
- Lepousé C.
- Leroy J.
- Lesens O.
- Lesprit P.
- Letranchant L.
- Levast M.
- Levy-Bruhl D.
- Lhommet C.
- Lion C.
- Loncar G.
- Lorentz C.
- Magnin-Poull I.
- Makinson A.
- Males S.
- Malpote E.
- Man H.
- Manchon Pauline
- Mansouri M.
- Marcault E.
- Maroni J.
- Martin-Blondel G.
- Marx M.
- Marçon O.
- Masse V.
- Masson R.
- Matray O.
- Maurier F.
- Mbadi A.
- Mechaï F.
- Mellon G.
- Mentre F.
- Merceron O.
- Merens A.
- Messika-Zeitoun D.
- Metref Z.
- Meyohas M.-C.
- Meyssonnier V.
- Mezher C.
- Micheli S.
- Michon A.
- Monsigny M.
- Mootien Yoganaden J.
- Morquin D.
- Mouly S.
- Mourvillier B.
- Mrozek N.
- Nallet O.
- Nataf P.
- Nazerollas P.
- Nazeyrollas P.
- Nguyen S.
- Nguyen Y.
- Noel V.
- Obadia J.
- Ogielska M.
- Oziol E.
- Page B.
- Pasquet B.
- Patrat-Delon S.
- Patry I.
- Payet B.
- Pechinot A.
- Pelletier A.
- Perez P.
- Petit J.
- Philippart F.
- Picot S.
- Pierrejean D.
- Piet E.
- Piroth L.
- Plainvert C.
- Plassart C.
- Plesiat P.
- Plessis P.
- Ploy M.-C.
- Popovic B.
- Porte J.
- Portel L.
- Poubeau P.
- Poupard M.
- Poyart C.
- Pradier P.
- Prazuck T.
- Preau M.
- Quaesaet L.
- Raffi F.
- Ramadan R.
- Ramanantsoa A.
- Rapp C.
- Raskine L.
- Raymond J.
- Revest M.
- Riche A.
- Richemond J.
- Robaday-Voisin S.
- Robin F.
- Rodermann M.
- Roigt I.
- Romaszko J.-P.
- Roncato M.
- Rousseau F.
- Roux A.-L.
- Roy C.
- Royer C.
- Ruyer O.
- Saada M.
- Salmon D.
- Saroufim C.
- Schmit J.-L.
- Schwartz J.
- Sebire M.
- Segonds C.
- Selton-Suty C.
- Simon M.
- Simorre B.
- Sivadon-Tardy V.
- Skalli S.
- Soismier N.
- Son O.
- Sotto A.
- Spatz F.
- Sportouch C.
- Strady C.
- Sudrial J.
- Sunder S.
- Suy F.
- Taha M.-K.
- Tande D.
- Tankovic J.
- Tartiere L.
- Tattevin Pierre
- Terrier de La Chaize A.
- Thiercelin M.
- Thomas D.
- Thomas M.
- Toko L.
- Tournoux F.
- Tristan A.
- Trouillet J.
- Tual L.
- Tubiana Sarah
- Valin N.
- van Grunderbeeck N.
- Vandenesch F.
- Varon Emmanuelle
- Verdier F.
- Verdon R.
- Vergnaud M.
- Vernet Garnier V.
- Vernet Veronique
- Vernet-Garnier V.
- Vidal M.
- Vidal V.
- Vitrat V.
- Vittecoq D.
- Vuotto F.
- Weyne P.
- Wolff M.
- Wynckel A.
- Zannad N.
- Zinzius P.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Auteurs groupes collaboratifs AEPEI study group & the COMBAT study groupInternational audienc
Characteristics, management, and prognosis of elderly patients with COVID-19 admitted in the ICU during the first wave: insights from the COVID-ICU study
- Author
- Abbosh Nathalie
- Abraham Paul Samuel
- Achino Chloé
- Alexandru Nica
- Amoli Abolfazl Mohebbi
- Amouretti Marc
- Amélie Seguin
- Andremont Olivier
- Andreu Pascal
- Anghel Radu
- Annane Djillali
- Argaud Laurent
- Asfar Pierre
- Assefi Mona
- Attias Arié
- Aubron Cécile
- Aubrun Frédéric
- Auchabie Johann
- Avargues Patrick
- Avenel Alexandre
- Azoulay Élie
- Bajolet Marie France
- Baldacini Mathieu
- Barbarot Nicolas
- Baron Ėlodie
- Baudic Thibaut
- Baudry Thomas
- Bavozet Florent
- Bayle Frédérique
- Begot Emmanuelle
- Beilouny Bassem
- Beloncle François Michel
- Benchetrit Déborah
- Benhamida Sarah
- Benhamou Michel
- Benzidi Younès
- Bereiziat Marine
- Bergero Nicoletta
- Berteau Florin
- Bertrand Pierre Jean
- Besse Marie Catherine
- Beuret Pascal
- Beurton Alexandra
- Bigot Christelle
- Bionz Gauthier
- Biston Patrick
- Bitker Laurent
- Blanc Quentin
- Blayau Clarisse
- Bobet Mathieu
- Bodenes Laetitia
- Boiste Fabienne
- Bonnet Nicolas
- Bonnet-Chateau Justine
- Bornstain Caroline
- Bouar Gurvan Le
- Bouchet Bruno Julien
- Boudinaud Michel
- Bouglé Adrien
- Bougouin Wulfran
- Bouilland Anne Laure
- Boukhanza Messabi
- Bouniol François
- Bourdin Gaël
- Bourreau Anna
- Bouteloup Marie
- Bouzat Pierre
- Brou Marie Ange
- Bruckert Vincent
- Bruel Cédric
- Bruna Franklin
- Bruneau Amandine
- Bruneel Fabrice
- Brunet Jennifier
- Burtz Catherine Paugam
- Béduneau Gaëtan
- Cadoz Cyril
- Cady Julien
- Cailliez Pauline
- Calus Julien
- Cantier Marie
- Capellier Gilles
- Cardinale Mickaël
- Carenco Lisa
- Carles Michel
- Carreira Serge
- Carteaux Guillaume
- Casella Claudia
- Castanera Jermy
- Castelain Vincent
- Caulier Thomas
- Causeret Arnaud
- Chaalal Amina
- Chaignat Claire
- Chapelle Thibault
- Charlotte Garret
- Charrier Nathanaël L.
- Charron Cyril
- Charrrier Liliane
- Chaulier Kevin
- Chaussard Maïté
- Chelha Riad
- Chelly Jonathan
- Chemouni Frank
- Chiche Jean Daniel
- Chillet Patrick
- Cholet Clémentine
- Chommeloux Juliette
- Chousterman Benjamin Glenn
- Chudeau Nicolas
- Cohen Yves
- Cointault Olivier
- Colin Gwenhaël
- Collin Anthony
- Combes Alain
- Conrad Marie
- Constantin Jean Michel
- Contou Damien
- Cottrel Marjolaine
- Couadau Emmanuel
- Coudroy Rémi
- Coupez Elisabeth
- Courte Guilhem
- COUTROT Maxime
- Cracco Christophe
- Cravoisy Aurélie
- Cungi Pierre Julien
- Damoisel Charles
- Daniel Matthieu
- Dargent Auguste
- Darjent Barbara
- Darmon Michaël
- Darreau Cédric
- Dartevel Anaïs
- Daubin Cédric
- Dauger Stéphane
- Daviet Florence
- De La Chapelle Arnaud
- De Prost Nicolas
- de Roquetaillade Charles
- Debarre Matthieu
- Degoul Samuel
- Dekeyser Thibault
- Delaborde Bertrand P.
- Delbove Agathe
- Delforge Quentin
- Delignette Marie Charlotte
- Dellamonica Jean
- Delord Bertrand
- Demarest Elsa
- Demeret Sophie
- Demiri Suela
- Demiselle Julien
- Demoule Alexandre
- Descamps Richard
- Desmeules Isabelle
- Devaquet Jérôme
- Deye Nicolas
- Deyme Jean Pierre
- Dhelft François
- Diehl Jean Luc
- Dinh Alexy Tran
- Dlala Mohamed
- Donat Nicolas
- Dopeux Loïc
- Dres Martin
- Du Cheyron Damien
- Dubreuil Guillaume
- Dufour Nicolas
- Dupuis Claire
- Durand Michel
- Duranteau Jacques
- Dépret François
- Déserts Marc Danguy Des
- Ebstein Nathan
- Egreteau Pierre Yves
- Ehrmann Stéphan
- Elaroussi Djilali
- Emery Malo
- Emmanuel Canet
- Esnault Pierre
- Etienney Isabelle
- Faguer Stanislas
- Fartoukh Muriel Sarah
- Fatséas Jules
- Faure Henri
- Fayolle Pierre Marie
- Fedun Yannick
- Ferre Alexis
- Ferriere Nicolas
- Feuchere Philippe
- Filippelli Mathilde
- Fillatre Pierre
- Fleury Grégory
- Flurin Laure
- FONTAINE Candice
- Foucault Camille
- Frat Jean Pierre
- Freita-Ramos Santiago
- Frérou Aurélien
- Galbois Arnaud
- Galerneau Louis Marie
- Gallot Richard
- Gandonniere Charlotte
- Garcia Julie
- Garin Aude
- Garnier Marc
- Garrigou Sonia
- Garçon Pierre
- Gaudry Stéphane
- Gauss Tobias
- Gauthier Caroline
- Gauzi Maxime
- Gayat Étienne
- Geneau Isabelle
- Gentilhomme Angélie
- Georges Hugues
- Gergaud Soizic
- Gette Sébastien
- Gevrey Vincent
- Giacardi Christophe
- Gibot Sébastien
- Giovannangeli Luana
- Gissot Valérie
- Gobert Florent
- Godier Anne
- Goffin Pierre
- Goncalves Bruno
- Gouin Philippe
- Goutte Sylvie
- Grenot Romaric
- Gros Antoine
- Grégoire Céline
- Guidet Bertrand R.
- Guilbart Mathieu
- Guilbert Arnaud
- Guillemet Lucie
- Guilmin-Crépon Sophie
- Guitard Pierre Gildas
- Guitton Christophe
- Guntz Julien
- Gutton Christophe
- Guérot Emmanuel
- Géri Guillaume
- Ha Vivien Hong Tuan
- Hage Rabih
- Hajage David
- Hamada Sophie Rym
- Hariri Geoffroy
- Harrois Anatole
- Hartman Otto
- Hausermann Marie Hélène
- Hauw-Berlemont Caroline
- Hayon Jan Hervé
- Hazera Pascal
- Heming Nicholas
- Her Benoït
- Herbrecht Jean Étienne
- Heron Anne
- Herzog Nicolas
- Hierle Lucie
- Hinard Sébastien
- Hoffmann Clément
- Houdou Lucie
- Hraiech Sami
- Huntzinger Julien
- Hérault Marie Christine
- Ibrahim Amr
- Jacquier Sophie
- Jacquot Audrey
- Jadot Laurent
- Jallot Anne
- Jamme Matthieu
- Jandeaux Louise Marie
- Jaubert Paul
- Jean Reignier
- Jean-Michel Vanessa
- Jeannot Matthieu
- Jochmans Sébastien
- Joosten Anne
- Joret Aurélie
- Jouan Mélanie Saint
- Jozwiak Mathieu
- Jung Camille
- Karoubi Philippe
- Kerroumi Younes
- Kherchache Aïssa
- Kimmoun Antoine
- Kisoka Grâce
- Knani Lyes
- Kouadri Geoffrey
- Kouchit Yanis
- Kuteifan Khaldoun
- La Combe Béatrice
- Labruyère Marie
- Lacave Guillaume
- Lacherade Jean Claude
- Lamacz Anna
- Lambermont Bernard C.
- Lamer Christian
- Lamhaut Lionel
- Lanaspre Bernard
- Lancelot Aymeric
- Landais Mickaël
- Langeron Olivier
- Lasocki Sigismond
- Laterrade Thomas
- Lavalard Alexandra
- Lavayssiere Laurence
- Lazard Thierry
- Le Floch Anne Sophie
- Le Meur Anthony
- Le Roy Charlotte
- Le Terrier Christophe
- Lebas Eddy
- Lebbah Saïd
- Leclerc Maxime
- Lecore Marine
- Legay François
- Leger Maxime
- Lejour Gabriel
- Leloup Guillaume
- Lemarie Pierre
- Lemoine Ludivine Chalumeau
- Lena Diane
- Lepecq Raphaël
- Lesieur Olivier
- Levesque Éric
- Levy Bruno
- Levy Michaël
- Liteaudon Jean Mathias
- Lombardi Romain
- Lortat-Jacob Brice
- Lory Cécile
- Louis Guillaume
- Lucas Nolwenn
- Luyt Charles Édouard
- L’Her Erwan
- Macq Pierre Yves
- Madeux Benjamin
- Maestraggi Quentin
- Mahler Juliette Courtiade
- Maiziere Eve Marie
- Malissin Isabelle
- Maquigneau Natacha
- Marcault Clémence
- Marchalot Antoine
- Marchetta Stella
- Marois Clémence
- Marsac Lucile
- Martinez T.
- Martino Frédéric
- Masse Anne Lyse
- Massou Nicole
- Mathais Quentin
- Mathieu Daniel
- Mathonnet Armelle
- Mattei Mathieu
- Mayaux Julien
- Mazard Tessa
- Mazerand Sandie
- Mazeraud Aurélien
- Mazzoni Thierry
- Mebazaa Alexandre
- Mekontso-Dessap Armand
- Melone Marie Anne
- Mentec Hervé
- Mercat Alain
- Mhamdi Kais
- Michard Baptiste
- Michelin Florian
- Moine Pierre
- Monard Céline
- Monchi Mehran
- Mongardon Nicolas
- Monnet Xavier
- Mons Sandrine
- Monsel Antoine
- Montini Florent
- Montravers Philippe
- Mootien Joy Yoganaden
- Morichau-Beauchant Tristan
- Moury Pierre Henri
- Moyer Jean Denis
- Muller Laura K.
- Muller Violaine
- Mégarbane Buno
- Neuville Mathilde
- Nguyen-Valat Thi My Hue
- Noel Cinderella
- Noel Thibaut
- Nogier Marie Béatrice
- Noublanche Julie
- Nougue Hélène
- Nseir Saad
- Omar Edris
- Ordan Marie Amélie
- Ouali Alexandre
- Ouchike Abdel
- Oufella Hafid Ait
- Outin Hervé D.
- Page Mathieu
- Paillot Jonathan
- Painvin Benoît
- Pajot Olivier
- Palmyre Jessica
- Pardo Emmanuel
- Parzy Gabriel
- Pascal Michel
- Pasem Ahmed
- Pasquier Pierre
- Paulet Rémi
- Pavot Arthur
- Payen Jean François
- Pene Frédéric
- Perez Severine
- Pernet Pierre
- Perrou Maya
- Persichini Romain
- Petua Philippe
- Pham Tài
- Piagnerelli Michaël
- Pichereau Claire
- Pignal Sylvain
- PiliFloury Sébastien
- Pillot Jérôme
- Piton Gaël
- Pitta Anaïs
- Plantefeve Gaétan
- Plouvier Fabienne
- Poignant Simon
- Pointurier Valentin
- Poirson Florent
- Poissy Julien
- Pommier Christian M.
- Poupinel Virginie
- Pradel Gaël
- Preau Sebastien
- Prevost Florian
- Primmaz Steve
- Pugin Jeŕôme
- Pujol Wilfried
- Putegnat Jean Baptiste
- Péron Nicolas
- Quenet Audrey
- Quenot Jean Pierre
- Quentin Charlotte
- Quintard Hervé
- Rager Gwendoline
- Rahmani Imen
- Ramakers Michel
- Ravan Ramin
- Razazi Keyvan
- Repessé Xavier
- Resiere Dabor
- Rey Brice
- Ricard Jean Damien
- Richard Christian
- Ricome Sylvie
- Rimmele Thomas
- Rivera Caroline
- Robaux Marie Aline
- Robin Nicolas
- Roca-Cerezo Isabel
- Rodriguez Maeva
- Roger Pierre Alexandre
- Rohaut Benjamin
- Rolle Amélie
- Rosseli Sylvène
- Roth Christian
- Roucaud Nicolas
- Roudau Jean Baptiste
- Rouleau Stéphane
- Roux Damien
- Roux Delphine
- Runge Isabelle
- Rusel Leon
- Saccheri Clément
- Sacleux Sophie Caroline
- Saghi Tahar
- Sahraoui Abdlazize
- Saison Julien
- Saladin Cécile
- Santi Francesca
- Satre-Buisson Léa
- Sauneuf Bertrand
- Savida Anne Charlotte
- Schaack Emmanuelle
- Schenesse Déborah
- Schmidt Matthieu
- Schnell David
- Schortgen Frédérique
- Schwebel Carole
- Selves Agathe
- Sen Juliane
- Serpin Laurent
- Setti Jean Lou
- Sharshar Tarek
- Shi Ruiying
- Sma Nesrine
- Smonig Roland
- Soumagne Thibaud E.
- Stihle Xavier
- Stoclin Annabelle
- Suh Noémie
- Sumian Claude
- Sylvestre Aude
- Sztrymf Benjamin
- Sément Arnaud
- Série Mathieu
- Tachon Guillaume
- Tadie Jean Marc
- Tanaka Sebastien
- Terzi Nicolas
- Teulier Marion
- Textoris Julien
- Thao Ghyslaine
- Thierry Stéphane
- Thill Chloé
- Thille Arnaud W.
- Thouny Romain
- Thouy François
- Thyrault Martial
- Tientcheu Audrey
- Tran-Van David
- Trebbia Grégoire
- Trouiler Pierre
- Tubach Florence
- Urbina Tomas
- Valette Sarah
- Van Vong Ly Van Phach
- Veber Benoît
- Vettoretti Lucie
- Vezinet Corinne
- Vieillard-Baron Antoine
- VIMPERE Damien
- Vincent Arthur
- Vinclair Camille
- Vinclair Marc
- Vinsonneau Christophe
- Violleau Jade
- Vivet Bérengère
- Vivier Emmanuel
- Voiriot Guillaume
- Weiss Emmanuel
- Weiss Nicolas
- Werner Marie
- Winiszewski Hadrien
- Yvin Elise
- Zafimahazo Daniel
- Zlotnik Diane
- Zylberfajn Cécile
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
International audienceBackground: The COVID-19 pandemic is a heavy burden in terms of health care resources. Future decision-making policies require consistent data on the management and prognosis of the older patients (> 70 years old) with COVID-19 admitted in the intensive care unit (ICU). Methods: Characteristics, management, and prognosis of critically ill old patients (> 70 years) were extracted from the international prospective COVID-ICU database. A propensity score weighted-comparison evaluated the impact of intubation upon admission on Day-90 mortality. Results: The analysis included 1199 (28% of the COVID-ICU cohort) patients (median [interquartile] age 74 [72–78] years). Fifty-three percent, 31%, and 16% were 70–74, 75–79, and over 80 years old, respectively. The most frequent comorbidities were chronic hypertension (62%), diabetes (30%), and chronic respiratory disease (25%). Median Clinical Frailty Scale was 3 (2–3). Upon admission, the PaO2/FiO2 ratio was 154 (105–222). 740 (62%) patients were intubated on Day-1 and eventually 938 (78%) during their ICU stay. Overall Day-90 mortality was 46% and reached 67% among the 193 patients over 80 years old. Mortality was higher in older patients, diabetics, and those with a lower PaO2/FiO2 ratio upon admission, cardiovascular dysfunction, and a shorter time between first symptoms and ICU admission. In propensity analysis, early intubation at ICU admission was associated with a significantly higher Day-90 mortality (42% vs 28%; hazard ratio 1.68; 95% CI 1.24–2.27; p < 0·001). Conclusion: Patients over 70 years old represented more than a quarter of the COVID-19 population admitted in the participating ICUs during the first wave. Day-90 mortality was 46%, with dismal outcomes reported for patients older than 80 years or those intubated upon ICU admission
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
- Author
- Abad Jorge
- Abad Sebastien
- Abassi Radhiya
- Abdelhadi Nour Mekki
- Abdellaoui Abdelrafie
- Abdelmalek Abdelkrim
- Abdoul Hendy
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abergel Helene
- Abeud Fariza
- Abgrall Sophie
- Abisror Noemie
- Abolhassani Hassan
- Abou Tayoun Ahmad
- Accordino Giulia
- Achille Cristian
- Adechian Marylise
- Aderdour Nordine
- Admane Hakeem Farid
- Adnet Frederic
- Afritt Sara
- Agostini Helene
- Agra Juan José Cáceres
- Aguilar Claire
- Aguilera-Albesa Sergio
- Aguiló-Cucurull Aina
- Agut Sophie
- Aiello Tommaso Francesco
- Aiuti Alessandro
- Ajeenthiravasan Gokula
- Akcan Özge Metin
- Al-Muhsen Saleh
- Al-Muhsen Saleh Zaid
- Al-Mulla Fahd
- Alauzy Virginie
- Alavi Darazam Ilad
- Alavoine Loubna
- Alba Camille
- Albisures Jonathan Antonio Roblero
- Alby-Laurent Fanny
- Aldave Juan C.
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- AlKhater Suzan A.
- Allard Lucie
- Allardet-Servent Jerome
- Allende Luis M.
- Alonso-Arias Rebeca
- Alosaimi Mohammed Faraj
- Alshahrani Mohammed S.
- Alsina Laia
- Alsohime Fahad M.
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Alyanakian Marie-Alexandra
- Amam Sabrina
- Amara Yasmina Ould
- Amat Karine
- Amoura Zahir
- Amrouche Lucile
- Amsterdam UMC Covid-19 Biobank [missing]
- Anderson Mark S.
- Andreakos Evangelos
- Andrejak Claire
- Andronikof Marc
- Anglicheau Dany
- Angoulvant François
- Anguel Nadia
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- Antolí Arnau
- Aounzou Mohammed
- Aparicio Caroline
- Appelman Brent
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- Arias Andrés Augusto
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- Megarbane Bruno
- Meghadecha Mohamed
- Mejean Élodie
- Mekinian Arsene
- Mekni Rania
- Mekontso-Dessap Armand
- Meliti Thinhinan Sabrina
- Melián Abián Montesdeoca
- Melki Isabelle
- Meloni Federica
- Meng Paris
- Mentre France
- Mentré France
- Merbah Soraya
- Mergeay-Fabre Mayka
- Meritet Jean-François
- Merlani Paolo
- Messani Fadhila
- Messaoudi Yasmine
- Metin Akcan Ozge
- Meunier Alexandre
- Mewasing Baboo-Irwinsingh
- Meyts Isabelle
- Meyts Isabelle
- Meyts Isabelle
- Meziane Amina
- Meziane Lydia
- Mezidi Mehdi
- Michelot-Burger Carole
- Migaud Maria-Claire
- Migeotte Isabelle
- Mignot Françoise
- Milisavljevic Baptiste
- Milla Sonia Ayllon
- Millereux Maude
- Million Matthieu
- Milner Joshua D.
- Minka Fadi Hillary
- Mirault Tristan
- Mircher Clotilde
- Mironska Kristina
- Mirsaeidi Mehdi
- Miyara Makoto
- Mizoguchi Yoko
- Modi Bhavi P.
- Mogensen Trine H.
- Moine Pierre
- Mojoli Francesco
- Molina Jean-Michel
- Moncomble Elsa
- Monnory Fatima-Zohra Djamouri
- Montagne Samatha
- Montegnies-Boulet Anaïs
- Monti Alexandra
- Montlahuc Claire
- Montout Anne-Lise
- Moores Alexandre
- Morandeira Francisco
- Morange Pierre-Emmanuel
- Morbieu Caroline
- Mordacq Cléemence
- Morelle Guillaume
- Morio Tomohiro
- Mortelette Helene
- Mouly Stéphane
- Mouly Stéphane J.
- Mouquet Hugo
- Mullaert Jimmy
- Muzaffar Rosita
- Muñoz-Barrera Adrián
- Mège Jean-Louis
- Nacerddine Cherifa Iness
- Nadal Marine
- Nadif Hajer
- Nadji Seyed Alireza
- Naesens Leslie
- Nafati Cyril
- Nagashima Shintaro
- Nakagama Yu
- Narvaez Rafael Usubillaga
- Nassarmadji Kladoum
- Natella Pierre
- Ndingamondze Sandrine
- Neant Nadège
- Nellen Jeaninne
- Neraal Stefan
- Neven Bénédicte
- Neves João Farela
- Ng Lisa F. P.
- Ng Lisa F. P.
- Ng Yuk-Yung
- Nguyen Caroline
- Nguyen Duc
- Nguyen Duc
- NIAID-USUHS COVID Study Group [missing]
- Nicolas Leturque
- Nielly hubert
- Nlomenyengue Luc
- Noel Nicolas
- Noret Marion
- Nossent Esther J.
- Notarangelo Luigi D.
- Notarangelo Luigi D.
- Nouroudine Mariama
- Novelli Antonio
- Novelli Giuseppe
- Nseir Saad
- Nunes Hilario
- Nussbaum Robert
- N’Guyen Bao
- Ocejo-Vinyals J. Gonzalo
- Okada Satoshi
- Okamoto Keisuke
- Oler Andrew J.
- Omar Edris
- Orchestra Working Group [missing]
- Oualha Mehdi
- Ouazene Zineb
- Ouedrani Amani
- Ouedraogo Elise
- Ouelaa Wassila
- Oufella Hafid Ait
- Oukhedouma Anissa
- Oya Herve
- Ozcelik Tayfun
- Oziel Johanna
- Ozkaya-Parlakay Aslinur
- O’Farrelly Cliona
- Padilla Thomas
- Pagani Michele
- Paillaud Elena
- Paiva Solenne
- Palabiyik Figen
- Pan-Hammarström Qiang
- Papadaki Maria
- Papadopoulos Aurélie
- Parfait Beatrice
- Paris Christophe
- Parize Perrine
- Parizot Christophe
- Parizot Christophe
- Parola Philippe
- Parrot Antoine
- Pascreau Tiffany
- Paul Christelle
- Paul Stéphane
- Paulus Frederique
- Pavot Arthur
- Payet Christine
- Paz-Artal Estela
- Peaudecerf Laetitia
- Pedraza Sigifredo
- Peiffer-Smadja Nathan
- Pellecer Nancy Carolina González
- Pellegrini Silvia
- Pene Frédéric
- Pepin Marion
- Pereira Jesus Marquez
- Pernet Julie
- Pernin Claire
- Perpoint Thomas
- Perreau Pauline
- Pesci Alberto
- Peters Edgar
- Petit Mylène
- Petrov-Sanchez Ventzislava
- Peyrony Olivier
- Peytavin Gilles
- Pham Huong
- Philippe Aurélien
- Philippot Quentin
- Picod Adrien
- Picone Olivier
- Pietri Marie-Pierre
- Pietri Olivia
- Pina-Fuentes Dan A. I.
- Pinson Michelle
- Pintado Claire
- Pippucci Tommaso
- Piquard Valentine
- Piquard Valentine
- Piquard Valentine
- Piralla Antonio
- Pires Christine
- Pistone Thierry
- Planas Anna M.
- Planas-Serra Laura
- Planquette Benjamin
- Pleguezuelo Daniel E.
- Ploin Dominique
- Poirier Sandrine
- Poissy Julien
- Pomel Anne-Laure
- Poncelet Géraldine
- Pons Stéphanie
- Ponscarme Diane
- Poulakou Garyphallia
- Pouletty Marie S.
- Pourcelot Annegaelle
- Pourcher Valérie
- Pourshahnazari Persia
- Pouvaret Anne
- Prando Carolina
- Preckel Bennedikt
- Prever Florian
- Previlon Miresta
- Prevost Margot
- Prins Jan M.
- Provoost Marie-Julie
- Puel Anne
- Pueyo David Martínez
- Pujol Aurora
- Puéchal Oriane
- Pérez-Fernández Xosé Luis
- Qiu-Chen Jia Li
- Quaresima Virginia
- Quemeneur Cyril
- Quentric Paul
- Quintana-Murci Lluis
- Quintin Caroline
- Quiros-Roldan Eugenia
- Raasveld Jorinde
- Rabaud Christian
- Rafat Cédric
- Ramaswamy Sathishkumar
- Rambaud Thomas
- Rami Agathe
- Ramos Miquel Alfonso
- Ranque Brigitte
- Raoult Didier
- Raoult Violette
- Raphael Maurice
- Raphalen Jean Herle
- Rastoin Anna
- Raux Mathieu
- Rebai Amani
- Rebillat Anne-Sophie
- Reby Michael
- Redin Claire
- Regent Alexis
- Regrag Asma
- Reijnders Tom
- Renia Laurent
- Resche-Rigon Matthieu
- Resmini Léa
- Resnick Igor
- Ressaire Quentin
- Reyes Luis Felipe
- Ricart Pilar
- Richard Christian
- Richard Jean-Christophe
- Richard Lucie
- Richard Mariecaroline
- Rigo-Bonnin Raúl
- rivet Nadia
- Rivière Jacques G.
- Robert Maxence
- Rocamora-Blanch Gemma
- Rodero Mathieu P.
- Rodrigo Carlos
- Rodriguez Luis Antonio
- Rodriguez-Gallego Carlos
- Rodriguez-Palmero Agustí
- Rodríguez-Gallego Carlos
- Rohaut Benjamin
- Rojas Julian
- Rolland-Debord Camille
- Romero Carolina Soledad
- Ropers Jacques
- Roque-Afonso Anne-Marie
- Rosa-Calatrava Manuel
- Rosenberger John
- Rossi Camillo
- Rossignol Bénédicte
- Rossignol Patrick
- Rosso Charlotte
- Rothenbuhler Anya
- Roufai Layidé
- Rousseaux Mélanie
- Rousseaux Nabila
- Roux Damien
- Roux Lorène
- Roux Swasti
- Rouzaud Claire
- Rovere-Querini Patrizia
- Rovina Nikoletta
- Roy Carine
- Rozenberg Flore
- Rozes Antoine
- Rubenstein Emma
- Ruch Yvon
- Ruiz Montse
- Ruiz-Rodriguez Juan Carlos
- Sabate Jean-Marc
- Sabater-Riera Joan
- Sabet Sheila
- Sacleux Sophie-Caroline
- Saied Wafa Ibn
- Saks Kai
- Salagianni Maria
- Saliba Faouzi
- Salmon Dominique
- Sanchez Oliver
- Sancho-Shimizu Vanessa
- Savale Laurent
- Savary Guillaume
- Sberro Rebecca
- Scemla Anne
- Schidlowski Laire
- Schinkel Michiel
- Schlemmer Frederic
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- Schlüter Agatha
- Schmidt Julien
- Schmidt Matthieu
- Schneider Marion
- Schrauwen Femke A. P.
- Schuetz Catharina
- Schultz Marcus J.
- Schuurmans Alex
- Schuurmans Jaap
- Schwartz Mathieu
- Schweitzer Cyril E.
- Scolari Francesco
- Sedfi Saïd
- Sediva Anna
- Sediva Anna
- Seeleuthner Yoann
- Sefir-Kribel Samia
- Seijo Luis
- Seksik Philippe
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- Seminario Analia Gisela
- Senat Marie-Victoire
- Sene Damien
- Sene Damien
- Seng Piseth
- Senoglu Sevtap
- Seppänen Mikko
- Seppänen Mikko R. J.
- Seri Marco
- Serris Alexandra
- Sese Lucile
- Sghiouar Naima
- Shahrooei Mohammad
- Shcherbina Anna
- Shcherbina Anna
- Sigaloff Kim
- Sigaux Johanna
- Siguier Martin
- Siguret Virginie
- Silvain Johanne
- Simon Noémie
- Simon Tabassome
- Siouti Eleni
- Skandri Lina Innes
- Slabbynck Hans
- Slaby Ondrej
- Slim Marleen A.
- Slimani Miassa
- Smadja David M.
- Smeele Patrick
- Smit Marry
- Smith Nikaia
- Snauwaert Aurélie
- Snow Andrew L.
- Snow Andrew L.
- Sobh Ali
- Sokol Harry
- Solanich Xavier
- Soler Catherine
- Soler-Palacin Pere
- Soler-Palacín Pere
- Soler-Palacín Pere
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- Soltani Nisrine
- Solé-Violán Jordi
- Sottini Alessandra
- Soyer Benjamin
- Sozeri Betul
- Spaan András N.
- Steg Gabriel
- Stella Giulia Maria
- Stepanovskiy Yuriy
- Stijnis Cornelis S.
- Stilma Willemke
- Stoclin Annabelle
- Su Helen C.
- Su Helen C.
- Su Richa
- Suarez Lydia
- Sukumar Gauthaman
- Szwebel Tali-Anne
- Sánchez-Montalvá Adrián
- Sánchez-Ramón Silvia
- Sözeri Betül
- Taccone Fabio
- Tacconelli Evelina
- Taffame Kossi
- Talouarn Estelle
- Tancevski Ivan
- Tandjaoui-Lambiotte Yacine
- Tangye Stuart G.
- Tantet Claire
- Tardivon Coralie
- Tardy Bernard
- Tateo Mariagrazia
- Taupin Jean-Luc
- Tavernier Simon
- Tellier Marie-Capucine
- Tello Loreto Vidaur
- Terrier Benjamin
- Terrier Olivier
- Teunissen Charlotte
- Theodose Igor
- Thiebaud Pierre clement
- Thiery Guillaume
- Thomas Caroline
- Thoral Patrick
- Thorball Christian
- Thorn Karolina
- Thumerelle Caroline
- Thy Michael
- Tiercelet Kelly
- Timsit Jean-François
- Tipu Imran
- Tisserand Julie
- Tolstrup Martin
- Tomasoni Gabriele
- Tomczak Carole
- Tompkins Miranda F.
- Torelino Krystel
- Touam-Ext Fatima
- Toubiana Julie
- Toumi Lilia
- Toury Gustave
- Toy-Miou Mireille
- Trandinh Alexy
- Treluyer Jean-Marc
- Tresoldi Cristina
- Triantafyllia Vasiliki
- Trinque Baptiste
- Trouillet-Assant Sophie
- Troya Jesus
- Troya Jesús
- Truchot Jennifer
- Tsang Owen T. Y.
- Tserel Liina
- Tso Eugene Y. K.
- Tsonas Anissa M.
- Tual Christelle
- Tubach Florence
- Tubiana Sarah
- Tucci Alessandra
- Tuinman Pieter R.
- Tunesi Simone
- Turpin Agathe
- Turpin Matthieu
- Turvey Stuart E.
- Téoulé François
- Uddin Furkan
- Uddin Mohammed J.
- Urbina Tomas
- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Uzunhan Yurdagul
- Vabres Pierre
- Vacher Yannick
- Vaittinadaayar Prabakar
- Valencia-Ramos Juan
- Valent Arnaud
- Valentian Maelle
- Valin Nadia
- Vallet Hélène
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- Van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- Van Den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- Van Der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- Van Praet Jens
- van Vugt Michèle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vaz Marina
- Vazquezibarra Miguel-Alejandro
- Vedie Benoit
- Veelo Denise
- Vega Clara Campos
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Velly Laetitia
- Verstuyft Celine
- Viallette Cedric
- Vicaut Eric
- Vidaud Michel
- Vidigal Mateus C.
- Viel Sébastien
- Vignali Valérie
- Vignes Dorothee
- Vilaire-Meunier Marie E.
- Villain Cédric
- Villar-García Judit
- Vimpere Damien
- Vincent Audrey
- Vinh Donald C.
- Virlouvet Myriam
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander P. J.
- Voiriot Guillaume
- Voiriot Guillaume
- Voisot Lena
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- Vught Lonneke A.
- Vuotto Fanny
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Weiss Emmanuel
- Weiss Nicolas
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wilkerson Matthew D.
- Winchenne Anaïs
- Wouters Dorien
- Wu Alan K. L.
- Wu Tak-Chiu
- Yahşi Aysun
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yesilbas Osman
- Yildiz Mehmet
- Yordanov Youri
- Youkou Christy Gaëlla Kotokpo
- Young Barnaby E.
- Yüksek Saliha Kanık
- Yükselmiş Ufuk
- Zafrani Lara
- Zaidan Mohamad
- Zaidi Wissem
- Zak Cathia
- Zarhrate-Ghoul Aida
- Zatout Ouassila
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zecca Marco
- Zeino Suzanne
- Zeitouni Michel
- Zemirli Naïma
- Zerah Lorene
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Xijun
- Zhang Yu
- Zia Ounsa
- Ziol Marianne
- Zolario Oceane
- Zuber Julien
- Zuccaro Valentina
- Zwinderman A. H.
- Íñigo-Campos Antonio
- Öz Şadiye Kübra Tüter
- Özkan Esra Akyüz
- Özçelik Tayfun
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 01/01/2023
- Field of study
BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old