62 research outputs found
An A4 flavor model for quarks and leptons in warped geometry
We propose a spontaneous A4 flavor symmetry breaking scheme implemented in a
warped extra dimensional setup to explain the observed pattern of quark and
lepton masses and mixings. The main advantages of this choice are the
explanation of fermion mass hierarchies by wave function overlaps, the
emergence of tribimaximal neutrino mixing and zero quark mixing at the leading
order and the absence of tree-level gauge mediated flavor violations. Quark
mixing is induced by the presence of bulk flavons, which allow for cross-brane
interactions and a cross-talk between the quark and neutrino sectors, realizing
the spontaneous symmetry breaking pattern A4 --> nothing first proposed in
[X.G.\,He, Y.Y.\,Keum, R.R.\,Volkas, JHEP{0604}, 039 (2006)]. We show that the
observed quark mixing pattern can be explained in a rather economical way,
including the CP violating phase, with leading order cross-interactions, while
the observed difference between the smallest CKM entries V_{ub} and V_{td} must
arise from higher order corrections. We briefly discuss bounds on the
Kaluza-Klein scale implied by flavor changing neutral current processes in our
model and show that the residual little CP problem is milder than in flavor
anarchic models.Comment: 34 pages, 2 figures; version published in JHE
Kaluza-Klein gravitino production with a single photon at e^+ e^- colliders
In a supersymmetric large extra dimension scenario, the production of
Kaluza-Klein gravitinos accompanied by a photino at e^+ e^- colliders is
studied. We assume that a bulk supersymmetry is softly broken on our brane such
that the low-energy theory resembles the MSSM. Low energy supersymmetry
breaking is further assumed as in GMSB, leading to sub-eV mass shift in each KK
mode of the gravitino from the corresponding graviton KK mode. Since the
photino decays within a detector due to its sufficiently large inclusive decay
rate into a photon and a gravitino, the process e^+ e^- -> photino + gravitino
yields single photon events with missing energy. Even if the total cross
section can be substantial at sqrt(s)=500 GeV, the KK graviton background of
e^+ e^- -> photon + graviton is kinematically advantageous and thus much
larger. It is shown that the observable, sigma(e^-_L)-sigma(e^-_R), can
completely eliminate the KK graviton background but retain most of the KK
gravitino signal, which provides a unique and robust method to probe the
supersymmetric bulk.Comment: Reference added and typos correcte
Higher-Spin Fermionic Gauge Fields and Their Electromagnetic Coupling
We study the electromagnetic coupling of massless higher-spin fermions in
flat space. Under the assumptions of locality and Poincare invariance, we
employ the BRST-BV cohomological methods to construct consistent
parity-preserving off-shell cubic 1-s-s vertices. Consistency and
non-triviality of the deformations not only rule out minimal coupling, but also
restrict the possible number of derivatives. Our findings are in complete
agreement with, but derived in a manner independent from, the
light-cone-formulation results of Metsaev and the string-theory-inspired
results of Sagnotti-Taronna. We prove that any gauge-algebra-preserving vertex
cannot deform the gauge transformations. We also show that in a local theory,
without additional dynamical higher-spin gauge fields, the non-abelian vertices
are eliminated by the lack of consistent second-order deformations.Comment: 44 pages; references added, minor changes made, to appear in JHE
Seesaw Neutrino Signals at the Large Hadron Collider
We discuss the scenario with gauge singlet fermions (right-handed neutrinos)
accessible at the energy of the Large Hadron Collider. The singlet fermions
generate tiny neutrino masses via the seesaw mechanism and also have sizable
couplings to the standard-model particles. We demonstrate that these two facts,
which are naively not satisfied simultaneously, are reconciled in the
five-dimensional framework in various fashions, which make the seesaw mechanism
observable. The collider signal of tri-lepton final states with transverse
missing energy is investigated for two explicit examples of the observable
seesaw, taking account of three types of neutrino mass spectrum and the
constraint from lepton flavor violation. We find by showing the significance of
signal discovery that the collider experiment has a potential to find signals
of extra dimensions and the origin of small neutrino masses.Comment: 27 pages, 4 figure
Static Charges in the Low-Energy Theory of the S-Duality Twist
We continue the study of the low-energy limit of N=4 super Yang-Mills theory
compactified on a circle with S-duality and R-symmetry twists that preserve N=6
supersymmetry in 2+1D. We introduce external static supersymmetric quark and
anti-quark sources into the theory and calculate the Witten Index of the
resulting Hilbert space of ground states on a torus. Using these results we
compute the action of simple Wilson loops on the Hilbert space of ground states
without sources. In some cases we find disagreement between our results for the
Wilson loop eigenvalues and previous conjectures about a connection with
Chern-Simons theory.Comment: 73 pages, two paragraphs added, one to the introduction and one to
the discussio
Gravitational physics with antimatter
The production of low-energy antimatter provides unique opportunities to
search for new physics in an unexplored regime. Testing gravitational
interactions with antimatter is one such opportunity. Here a scenario based on
Lorentz and CPT violation in the Standard- Model Extension is considered in
which anomalous gravitational effects in antimatter could arise.Comment: 5 pages, presented at the International Conference on Exotic Atoms
(EXA 2008) and the 9th International Conference on Low Energy Antiproton
Physics (LEAP 2008), Vienna, Austria, September 200
Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets
Current work in elucidating relationships between diseases has largely been based on pre-existing knowledge of disease genes. Consequently, these studies are limited in their discovery of new and unknown disease relationships. We present the first quantitative framework to compare and contrast diseases by an integrated analysis of disease-related mRNA expression data and the human protein interaction network. We identified 4,620 functional modules in the human protein network and provided a quantitative metric to record their responses in 54 diseases leading to 138 significant similarities between diseases. Fourteen of the significant disease correlations also shared common drugs, supporting the hypothesis that similar diseases can be treated by the same drugs, allowing us to make predictions for new uses of existing drugs. Finally, we also identified 59 modules that were dysregulated in at least half of the diseases, representing a common disease-state “signature”. These modules were significantly enriched for genes that are known to be drug targets. Interestingly, drugs known to target these genes/proteins are already known to treat significantly more diseases than drugs targeting other genes/proteins, highlighting the importance of these core modules as prime therapeutic opportunities
Aripiprazole in the Maintenance Treatment of Bipolar Disorder: A Critical Review of the Evidence and Its Dissemination into the Scientific Literature
A systematic search of the literature reveals limited evidence to support use of
aripiprazole, a second-generation antipsychotic medication, in maintenance
therapy of bipolar disorder, despite widespread use
Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders:
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137310/1/jnr23877.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137310/2/jnr23877_am.pd
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