Understanding the Determinantsof Project Performance: Empirical Evidencesfrom Software Houses of Pakistan

Thisstudy is investigating the effects of project quality, project risk and project governance on project performance. Moreover, this study investigatesthe moderation effect of project leadership on these relationships. Data is collected from 354 respondents of software houses and structural equation modeling (SEM) technique is utilized for data analysis. Results suggest that project quality, project risk and project leadership have positive significant impact on project performance while project governance does not have significant impact on project performance. Significant moderation effect of project leadership on the relationship between project quality and project performance is proved but project leadership has no moderation effect on the relationship between project governance, project risk and project performance. The findings of the study provide significant insights forsoftware houses ofPakistan to formulate strategies in order to develop a governance framework and enhance project performance in IT project management

Controlling Mesenchyme Tissue Remodeling via Spatial Arrangement of Mechanical Constraints

Tissue morphogenetic remodeling plays an important role in tissue repair and homeostasis and is often governed by mechanical stresses. In this study, we integrated an in vitro mesenchymal tissue experimental model with a volumetric contraction-based computational model to investigate how geometrical designs of tissue mechanical constraints affect the tissue remodeling processes. Both experimental data and simulation results verified that the standing posts resisted the bulk contraction of the tissues, leading to tissue thinning around the posts as gap extension and inward remodeling at the edges as tissue compaction. We changed the geometrical designs for the engineered mesenchymal tissues with different shapes of posts arrangements (triangle vs. square), different side lengths (6 mm vs. 8 mm), and insertion of a center post. Both experimental data and simulation results showed similar trends of tissue morphological changes of significant increase of gap extension and deflection compaction with larger tissues. Additionally, insertion of center post changed the mechanical stress distribution within the tissues and stabilized the tissue remodeling. This experimental-computational integrated model can be considered as a promising initiative for future mechanistic understanding of the relationship between mechanical design and tissue remodeling, which could possibly provide design rationale for tissue stability and manufacturing

Dynamics of Bloch vectors and the channel capacity of a non identical charged qubit pair

We have considered a system of two superconducting charge qubits capacitively coupled to a microwave resonator. The dynamics of the Bloch vectors are investigated for different regimes. By means of the Bloch vectors and cross dyadic we quantify the degree of entanglement contained in the generated entangled state. We consider different values of the system parameters to discuss the dynamics of the channel capacity between the qubits. We show that there is an important role played by initial state settings, coupling constant and the mean photon number on generating entangled state with high degree of entanglement and high capacity

Management system for optimizing public transport networks: GPS record

As cities continue to grow in size and population, the design of public transport networks becomes complicated, given the wide diversity in the origins and destinations of users [1], as well as the saturation of vehicle infrastructure in large cities despite their attempts to adapt it according to population distribution. This indicates that, in order to reduce users’ travel time, it is necessary to implement alternative road solutions to the use of cars, increasing investment in public transportation [2, 3] by conducting a comprehensive analysis of the state of transportation. This situation has made appear the solutions and development oriented to transportation based on Internet of Things (IoT) which allows, in a first stage, monitoring of public transport systems, in order to optimize the deployment of transport units and thus reduce the time of transfer of users through the cities [4]. These solution proposals are focused on information collected from user resources (data collected through smart phones) to create a common database [5]. The present study proposes the development of an intelligent monitoring and management system for public transportation networks using a hybrid communication architecture based on wireless node networks using IPv6 and cellular networks (LTE, LTE-M)

Clinical trial of laronidase in Hurler syndrome after hematopoietic cell transplantation.

BackgroundMucopolysaccharidosis I (MPS IH) is a lysosomal storage disease treated with hematopoietic cell transplantation (HCT) because it stabilizes cognitive deterioration, but is insufficient to alleviate all somatic manifestations. Intravenous laronidase improves somatic burden in attenuated MPS I. It is unknown whether laronidase can improve somatic disease following HCT in MPS IH. The objective of this study was to evaluate the effects of laronidase on somatic outcomes of patients with MPS IH previously treated with HCT.MethodsThis 2-year open-label pilot study of laronidase included ten patients (age 5-13 years) who were at least 2 years post-HCT and donor engrafted. Outcomes were assessed semi-annually and compared to historic controls.ResultsThe two youngest participants had a statistically significant improvement in growth compared to controls. Development of persistent high-titer anti-drug antibodies (ADA) was associated with poorer 6-min walk test (6MWT) performance; when patients with high ADA titers were excluded, there was a significant improvement in the 6MWT in the remaining seven patients.ConclusionsLaronidase seemed to improve growth in participants <8 years old, and 6MWT performance in participants without ADA. Given the small number of patients treated in this pilot study, additional study is needed before definitive conclusions can be made

Recycling aluminium AA6061 chips with reinforced boron carbide (B4C) and zirconia (ZrO2) particles via hot extrusion

Compared to the recycling process by remelting, hot extrusion significantly reduces the energy consumption and CO2 emission and ensures good mechanical and microstructural properties. This study investigates the effects of reinforcing aluminium AA6061 chips with mixed boron carbide (B4C) and zirconia (ZrO2) particles by employing a design of experiment (DOE) under 550 °C processing temperature and three hours preheating time. The findings showed that compressive strength (CS) and hardness increased with up to 5% added particles, and beyond 5%, the yielded values decreased because of materials agglomeration. However, the decreasing density was dependent on the addition of ZrO2 particles. The distribution of particles with different volume fractions of mixed particles was investigated by employing SEM, AFM, and EDS tests. Thus, the process can produce a net shape structure that utilises material-bonding consolidation to provide sufficient support to reuse the recovered materials in engineering applications, such as in the automotive industry

Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level.

Cryptococcus neoformans var. grubii is the causative agent of cryptococcal meningitis, a significant source of mortality in immunocompromised individuals, typically HIV/AIDS patients from developing countries. Despite the worldwide emergence of this ubiquitous infection, little is known about the global molecular epidemiology of this fungal pathogen. Here we sequence the genomes of 188 diverse isolates and characterized the major subdivisions, their relative diversity and the level of genetic exchange between them. While most isolates of C. neoformans var. grubii belong to one of three major lineages (VNI, VNII, and VNB), some haploid isolates show hybrid ancestry including some that appear to have recently interbred, based on the detection of large blocks of each ancestry across each chromosome. Many isolates display evidence of aneuploidy, which was detected for all chromosomes. In diploid isolates of C. neoformans var. grubii (serotype A/A) and of hybrids with C. neoformans var. neoformans (serotype A/D) such aneuploidies have resulted in loss of heterozygosity, where a chromosomal region is represented by the genotype of only one parental isolate. Phylogenetic and population genomic analyses of isolates from Brazil reveal that the previously 'African' VNB lineage occurs naturally in the South American environment. This suggests migration of the VNB lineage between Africa and South America prior to its diversification, supported by finding ancestral recombination events between isolates from different lineages and regions. The results provide evidence of substantial population structure, with all lineages showing multi-continental distributions demonstrating the highly dispersive nature of this pathogen

Evaluating assumptions of scales for subjective assessment of thermal environments – Do laypersons perceive them the way, we researchers believe?

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