A comparison of SQUID imaging techniques for small defects in nonmagnetic tubes

Although superconducting quantum interference devices (SQUIDs) provide an exquisitively sensitive means for measuring magnetic fields, their usage in the past has been limited chiefly to biomagnetic research. However, over the past few years interest in applying SQUID techniques to the field of nondestructive evaluation (NDE) has blossomed [1]. Many experiments have exploited the sensitivity of SQUIDs for diverse NDE applications, especially those requiring large separation distances between the sensor and the item to be inspected. Our work instead has focused on the potential to detect very small defects with SQUIDs, specifically in thin-walled tubes. In this paper, we discuss three different methods for creating magnetic fields in tubes. The methods comprise (a) directly injecting a current through the tube, (b) using a separate induction coil to create induced currents in the tube, and (c) utilizing a ferromagnetic tracer technique. To illustrate the capabilities of each method, we present two-dimensional maps of the spatial distribution of the magnetic field as measured by a SQUID magnetometer — that is, SQUID images. The images will also be used to compare the sensing methods with respect to such practical considerations as relative sensitivity and signal-to-noise ratio

Nonlinear Ultrasonic Properties of As-Quenched Steels

We have investigated the effect of carbon content on the nonlinear ultrasonic parameter β and the longitudinal phase velocity v L in a series of martensitic steel specimens. The specimens were measured in the as-quenched state to insure that the carbon was present primarily as an interstitial in the martensite. Experimentally, β increased with increasing mass percent carbon (or hardness), while v Lremained virtually the same for all specimens. Therefore we conclude that β is sensitive to microstructural variations between the specimens, but v L is not. X-ray diffraction experiments indicate that the dislocation density in the specimens is high (∼1011/cm2) and increases with increasing carbon content. These results support the hypothesis that the observed increase in β may be attributed to dislocations affected by internal stresses in the quenched specimens

The Relationship between Health Plan Performance Measures and Physician Network Overlap: Implications for Measuring Plan Quality

To examine the extent to which health plan quality measures capture physician practice patterns rather than plan characteristics.We gathered and merged secondary data from the following four sources: a private firm that collected information on individual physicians and their health plan affiliations, The National Committee for Quality Assurance, InterStudy, and the Dartmouth Atlas.We constructed two measures of physician network overlap for all health plans in our sample and linked them to selected measures of plan performance. Two linear regression models were estimated to assess the relationship between the measures of physician network overlap and the plan performance measures.The results indicate that in the presence of a higher degree of provider network overlap, plan performance measures tend to converge to a lower level of quality.Standard health plan performance measures reflect physician practice patterns rather than plans' effort to improve quality. This implies that more provider-oriented measurement, such as would be possible with accountable care organizations or medical homes, may facilitate patient decision making and provide further incentives to improve performance.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79067/1/j.1475-6773.2010.01111.x.pd

A reference relative time-scale as an alternative to chronological age for cohorts with long follow-up

Background: Epidemiologists have debated the appropriate time-scale for cohort survival studies; chronological age or time-on-study being two such time-scales. Importantly, assessment of risk factors may depend on the choice of time-scale. Recently, chronological or attained age has gained support but a case can be made for a ‘reference relative time-scale’ as an alternative which circumvents difficulties that arise with this and other scales. The reference relative time of an individual participant is the integral of a reference population hazard function between time of entry and time of exit of the individual. The objective here is to describe the reference relative time-scale, illustrate its use, make comparison with attained age by simulation and explain its relationship to modern and traditional epidemiologic methods. Results: A comparison was made between two models; a stratified Cox model with age as the time-scale versus an un-stratified Cox model using the reference relative time-scale. The illustrative comparison used a UK cohort of cotton workers, with differing ages at entry to the study, with accrual over a time period and with long follow-up. Additionally, exponential and Weibull models were fitted since the reference relative time-scale analysis need not be restricted to the Cox model. A simulation study showed that analysis using the reference relative time-scale and analysis using chronological age had very similar power to detect a significant risk factor and both were equally unbiased. Further, the analysis using the reference relative time-scale supported fully-parametric survival modelling and allowed percentile predictions and mortality curves to be constructed. Conclusions: The reference relative time-scale was a viable alternative to chronological age, led to simplification of the modelling process and possessed the defined features of a good time-scale as defined in reliability theory. The reference relative time-scale has several interpretations and provides a unifying concept that links contemporary approaches in survival and reliability analysis to the traditional epidemiologic methods of Poisson regression and standardised mortality ratios. The community of practitioners has not previously made this connection

Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop adaptability in selective inhibition of bacterial enzymes

<p>Abstract</p> <p>Background</p> <p>Methionine aminopeptidase is a potential target of future antibacterial and anticancer drugs. Structural analysis of complexes of the enzyme with its inhibitors provides valuable information for structure-based drug design efforts.</p> <p>Results</p> <p>Five new X-ray structures of such enzyme-inhibitor complexes were obtained. Analysis of these and other three similar structures reveals the adaptability of a surface-exposed loop bearing Y62, H63, G64 and Y65 (the YHGY loop) that is an integral part of the substrate and inhibitor binding pocket. This adaptability is important for accommodating inhibitors with variations in size. When compared with the human isozymes, this loop either becomes buried in the human type I enzyme due to an N-terminal extension that covers its position or is replaced by a unique insert in the human type II enzyme.</p> <p>Conclusion</p> <p>The adaptability of the YHGY loop in <it>E. coli </it>methionine aminopeptidase, and likely in other bacterial methionine aminopeptidases, enables the enzyme active pocket to accommodate inhibitors of differing size. The differences in this adaptable loop between the bacterial and human methionine aminopeptidases is a structural feature that can be exploited to design inhibitors of bacterial methionine aminopeptidases as therapeutic agents with minimal inhibition of the corresponding human enzymes.</p

Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop adaptability in selective inhibition of bacterial enzymes

Background: Methionine aminopeptidase is a potential target of future antibacterial and anticancer drugs. Structural analysis of complexes of the enzyme with its inhibitors provides valuable information for structure-based drug design efforts. Results: Five new X-ray structures of such enzyme-inhibitor complexes were obtained. Analysis of these and other three similar structures reveals the adaptability of a surface-exposed loop bearing Y62, H63, G64 and Y65 (the YHGY loop) that is an integral part of the substrate and inhibitor binding pocket. This adaptability is important for accommodating inhibitors with variations in size. When compared with the human isozymes, this loop either becomes buried in the human type I enzyme due to an N-terminal extension that covers its position or is replaced by a unique insert in the human type II enzyme. Conclusion: The adaptability of the YHGY loop in E. coli methionine aminopeptidase, and likely in other bacterial methionine aminopeptidases, enables the enzyme active pocket to accommodate inhibitors of differing size. The differences in this adaptable loop between the bacterial and human methionine aminopeptidases is a structural feature that can be exploited to design inhibitors of bacterial methionine aminopeptidases as therapeutic agents with minimal inhibition of the corresponding human enzymes

Phonon thermal transport in UO2_2 via self-consistent perturbation theory

Computing thermal transport from first-principles in UO$_2$ is complicated due to the challenges associated with Mott physics. Here we use irreducible derivative approaches to compute the cubic and quartic phonon interactions in UO$_2$ from first-principles, and we perform enhanced thermal transport computations by evaluating the phonon Green's function via self-consistent diagrammatic perturbation theory. Our predicted phonon lifetimes at $T=600$ K agree well with our inelastic neutron scattering measurements across the entire Brillouin zone, and our thermal conductivity predictions agree well with previous measurements. Both the changes due to thermal expansion and self-consistent contributions are nontrivial at high temperatures, though the effects tend to cancel, and interband transitions yield a substantial contribution

Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells

Lack of sensitive single-cell analysis tools has limited the characterization of metabolic activity in cancer stem cells. By hyperspectral stimulated Raman scattering imaging of single living cells and mass spectrometry analysis of extracted lipids, we report here significantly increased levels of unsaturated lipids in ovarian cancer stem cells (CSCs) as compared to non-CSCs. Higher lipid unsaturation levels were also detected in CSC-enriched spheroids compared to monolayer cultures of ovarian cancer cell lines or primary cells. Inhibition of lipid desaturases effectively eliminated CSCs, suppressed sphere formation in vitro, and blocked tumor initiation capacity in vivo. Mechanistically, we demonstrate that NF-κB directly regulates the expression levels of lipid desaturases and that inhibition of desaturases blocks NF-κB signaling. Collectively, our findings reveal that increased lipid unsaturation is a metabolic marker for ovarian CSCs and a target for CSC-specific therapy.

Intermediate-Mass Black Holes in Globular Clusters

There have been reports of possible detections of intermediate-mass black holes (IMBHs) in globular clusters (GCs). Empirically, there exists a tight correlation between the central supermassive black hole (SMBH) mass and the mean velocity dispersion of elliptical galaxies, "pseudobulges" and classical bulges of spiral galaxies. We explore such a possible correlation for IMBHs in spherical GCs. In our model of self-similar general polytropic quasi-static dynamic evolution of GCs, a criterion of forming an IMBH is proposed. The key result is M(BH) = L o^1/(1-n) where M(BH) is the IMBH mass, o is the GC mean stellar velocity, L is a coefficient, and 2/3 < n < 1

Young neutron stars with soft gamma ray emission and anomalous X-ray pulsar

The observational properties of Soft Gamma Repeaters and Ano\-malous X-ray Pulsars (SGR/AXP) indicate to necessity of the energy source different from a rotational energy of a neutron star. The model, where the source of the energy is connected with a magnetic field dissipation in a highly magnetized neutron star (magnetar) is analyzed. Some observational inconsistencies are indicated for this interpretation. The alternative energy source, connected with the nuclear energy of superheavy nuclei stored in the nonequilibrium layer of low mass neutron star is discussed.Comment: 29 pages, 13 figures, Springer International Publishing Switzerland 2016 A.W. Alsabti, P. Murdin (eds.), Handbook of Supernova