Transverse Radial Flow Effects on Two- and Three-Particle Angular Correlations

We use a simple a transverse radial boost scenario coupled to PYTHIA events to illustrate the impact radial flow may have on two- and three-particle correlation functions measured in heavy-ion collisions. We show that modest radial velocities can impart strong modifications to the correlation functions, some of which may be interpreted as same side ridge and away side structure that can mimic conical emission.Comment: 7 figures, 9 pages, Material presented in part by Pruneau at HOC 07, Montreal, Canada Accepted for publication in Nucl Phys A (Jan 2008

Monitoring the conformational ensemble and lipid environment of a mechanosensitive channel under cyclodextrin-induced membrane tension

This project was supported by a Biotechnology and Biological Sciences Research Council (BBSRC) grant (BB/S018069/1) to C.P., who acknowledges support from the Wellcome Trust (WT) (219999/Z/19/Z) in the form of studentship for B.J.L. We also acknowledge support from the Chinese Scholarship Council (CSC) in the form of studentships for N.Y., Y.M., B.W., respectively. T.K.K. is supported by a Sir Henry Dale Fellowship funded by the WT and the Royal Society (223268/Z/21/Z). B.E.B. and C.P. thank the Leverhulme Trust (RPG-2018-397) for support. Funding from BBSRC (BB/R013780/1; BB/T017740/1) equipment grants enabled the purchase of the Qband Bruker pulse EPR spectrometer and University of Leeds funding the Bruker 950 MHz NMR spectrometer.Membrane forces shift the equilibria of mechanosensitive channels enabling them to convert mechanical cues into electrical signals. Molecular tools to stabilize and methods to capture their highly dynamic states are lacking. Cyclodextrins can mimic tension through the sequestering of lipids from membranes. Here we probe the conformational ensemble of MscS by EPR spectroscopy, the lipid environment with NMR, and function with electrophysiology under cyclodextrin-induced tension. We show the extent of MscS activation depends on the cyclodextrin-to-lipid ratio, and that lipids are depleted slower when MscS is present. This has implications in MscS’ activation kinetics when distinct membrane scaffolds such as nanodiscs or liposomes are used. We find MscS transits from closed to sub-conducting state(s) before it desensitizes, due to the lack of lipid availability in its vicinity required for closure. Our approach allows for monitoring tension-sensitive states in membrane proteins and screening molecules capable of inducing molecular tension in bilayers.Peer reviewe

Space- and time-like electromagnetic pion form factors in light-cone pQCD

We present a combined analysis of the space- and time-like electromagnetic pion form factors in light-cone perturbative QCD with transverse momentum dependence and Sudakov suppression. Including the non-perturbative ``soft' QCD and power suppressed twist-3 corrections to the standard twist-2 perturbative QCD result, the experimental pion data available at moderate energies/momentum transfers can be explained reasonably well. This may help towards resolving the bulk of the existing discrepancy between the space- and time-like experimental data.Comment: 14 pages, 3 figure

Emergency ambulance service involvement with residential care homes in the support of older people with dementia : an observational study

© 2014 Amador et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.BACKGROUND: Older people resident in care homes have a limited life expectancy and approximately two-thirds have limited mental capacity. Despite initiatives to reduce unplanned hospital admissions for this population, little is known about the involvement of emergency services in supporting residents in these settings.METHODS: This paper reports on a longitudinal study that tracked the involvement of emergency ambulance personnel in the support of older people with dementia, resident in care homes with no on-site nursing providing personal care only. 133 residents with dementia across 6 care homes in the East of England were tracked for a year. The paper examines the frequency and reasons for emergency ambulance call-outs, outcomes and factors associated with emergency ambulance service use. RESULTS: 56% of residents used ambulance services. Less than half (43%) of all call-outs resulted in an unscheduled admission to hospital. In addition to trauma following a following a fall in the home, results suggest that at least a reasonable proportion of ambulance contacts are for ambulatory care sensitive conditions. An emergency ambulance is not likely to be called for older rather than younger residents or for women more than men. Length of residence does not influence use of emergency ambulance services among older people with dementia. Contact with primary care services and admission route into the care home were both significantly associated with emergency ambulance service use. The odds of using emergency ambulance services for residents admitted from a relative's home were 90% lower than the odds of using emergency ambulance services for residents admitted from their own home. CONCLUSIONS: Emergency service involvement with this vulnerable population merits further examination. Future research on emergency ambulance service use by older people with dementia in care homes, should account for important contextual factors, namely, presence or absence of on-site nursing, GP involvement, and access to residents' family, alongside resident health characteristics.Peer reviewedFinal Published versio

Multiple solutions to a magnetic nonlinear Choquard equation

We consider the stationary nonlinear magnetic Choquard equation [(-\mathrm{i}\nabla+A(x))^{2}u+V(x)u=(\frac{1}{|x|^{\alpha}}\ast |u|^{p}) |u|^{p-2}u,\quad x\in\mathbb{R}^{N}%] where $A\$is a real valued vector potential, $V$ is a real valued scalar potential$,$ $N\geq3$, $\alpha\in(0,N)$ and $2-(\alpha/N) <p<(2N-\alpha)/(N-2)$. \ We assume that both $A$ and $V$ are compatible with the action of some group $G$ of linear isometries of $\mathbb{R}^{N}$. We establish the existence of multiple complex valued solutions to this equation which satisfy the symmetry condition $$u(gx)=\tau(g)u(x)\text{\ \ \ for all}g\in G,\text{}x\in\mathbb{R}^{N},$$ where $\tau:G\rightarrow\mathbb{S}^{1}$ is a given group homomorphism into the unit complex numbers.Comment: To appear on ZAM

ϕ\phi meson production in sNN\sqrt{s_{NN}} = 200 GeV Au+Au and pp collisions at RHIC

We present the results for the measurement of $\phi$ meson production in $\sqrt{s_{NN}}$ = 200 GeV Au+Au and pp collisions at the Relativistic Heavy Ion Collider (RHIC). Using the event mixing technique, spectra and yields are obtained from the $\phi\to K^{+}K^{-}$ decay channel for different centrality bins in Au+Au collisions and in pp collisions. We observe that the spectrum shape in Au+Au collisions depends weakly on the centrality and the shape of the spectrum in pp collisions is significantly different from that in Au+Au collisions. In Au+Au collisions, the extracted yield of $\phi$ meson is flat as a function of rapidity; The $$ of $\phi$, extracted from the fit function to the spectra, shows a different behavior as a function of centrality than that of $\pi^-$, $K^-$ and $\bar{p}$Comment: Proceedings for the 7th International Conference on Strangeness in Quark Matte

Application of adaptive neuro-fuzzy inference for wind power short-term forecasting

The increased integration of wind power into the electric grid, as nowadays occurs in Portugal, poses new challenges due to its intermittency and volatility. Hence, good forecasting tools play a key role in tackling these challenges. In this paper, an adaptive neuro-fuzzy inference approach is proposed for short-term wind power forecasting. Results from a real-world case study are presented. A thorough comparison is carried out, taking into account the results obtained with other approaches. Numerical results are presented and conclusions are duly drawn. (C) 2011 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc

Growth dynamics and the evolution of cooperation in microbial populations

Microbes providing public goods are widespread in nature despite running the risk of being exploited by free-riders. However, the precise ecological factors supporting cooperation are still puzzling. Following recent experiments, we consider the role of population growth and the repetitive fragmentation of populations into new colonies mimicking simple microbial life-cycles. Individual-based modeling reveals that demographic fluctuations, which lead to a large variance in the composition of colonies, promote cooperation. Biased by population dynamics these fluctuations result in two qualitatively distinct regimes of robust cooperation under repetitive fragmentation into groups. First, if the level of cooperation exceeds a threshold, cooperators will take over the whole population. Second, cooperators can also emerge from a single mutant leading to a robust coexistence between cooperators and free-riders. We find frequency and size of population bottlenecks, and growth dynamics to be the major ecological factors determining the regimes and thereby the evolutionary pathway towards cooperation.Comment: 26 pages, 6 figure

Activated mutant NRasQ61K drives aberrant melanocyte signaling, survival, and invasiveness via a rac1-Dependent mechanism

Around a fifth of melanomas exhibit an activating mutation in the oncogene NRas that confers constitutive signaling to proliferation and promotes tumor initiation. NRas signals downstream of the major melanocyte tyrosine kinase receptor c-kit and activated NRas results in increased signaling via the extracellular signal–regulated kinase (ERK)/MAPK/ERK kinase/mitogen-activated protein kinase (MAPK) pathways to enhance proliferation. The Ras oncogene also activates signaling via the related Rho GTPase Rac1, which can mediate growth, survival, and motility signaling. We tested the effects of activated NRasQ61K on the proliferation, motility, and invasiveness of melanoblasts and melanocytes in the developing mouse and ex vivo explant culture as well as in a melanoma transplant model. We find an important role for Rac1 downstream of NRasQ61K in mediating dermal melanocyte survival in vivo in mouse, but surprisingly NRasQ61K does not appear to affect melanoblast motility or proliferation during mouse embryogenesis. We also show that genetic deletion or pharmacological inhibition of Rac1 in NRasQ61K induced melanoma suppresses tumor growth, lymph node spread, and tumor cell invasiveness, suggesting a potential value for Rac1 as a therapeutic target for activated NRas-driven tumor growth and invasiveness

Single-epoch VLBI imaging study of bright active galactic nuclei at 2 and 8 GHz

We investigate statistical and individual astrophysical properties of active galactic nuclei (AGNs), such as parsec-scale flux density, core dominance, angular and linear sizes, maximum observed brightness temperatures of VLBI core components, spectral index distributions for core and jet components, and evolution of brightness temperature along the jets. Furthermore, we statistically compare core flux densities and brightness temperature as well as jet spectral indices of gamma-ray bright and weak sources. We used 19 very long baseline interferometry (VLBI) observing sessions carried out simultaneously at 2.3 and 8.6 GHz with the participation of 10 Very Long Baseline Array (VLBA) stations and up to 10 additional geodetic telescopes. The observations span the period 1998-2003. We present here single-epoch results from high-resolution radio observations of 370 AGNs. Our VLBI images at 2.3 and 8.6 GHz as well as Gaussian models are presented and analyzed. At least one-fourth of the cores are completely unresolved on the longest baselines of the global VLBI observations. The VLBI core components are partially opaque with the median value of spectral index of alpha_core=0.3, while the jet features are usually optically thin alpha_jet=-0.7. The spectral index typically decreases along the jet ridge line owing to the spectral aging, with a median value of -0.05 mas^-1. Brightness temperatures are found to be affected by Doppler boosting and reaching up to \sim10^13 K with a median of \sim2.5x10^11 K at both frequencies. The brightness temperature gradients along the jets typically follow a power law T_b\simr^-2.2 at both frequencies. 147 sources (40%) positionally associated with gamma-ray detections from the Fermi LAT Second Source Catalog have higher core flux densities and brightness temperatures, and are characterized by the less steep radio spectrum of the optically thin jet emission.Comment: 15 pages, 21 figures, accepted by A&A on May 22, 2012, machine readable tables are available from the source of the pape