A parametric study on a RC frame based on “PUSHOVER” analysis

Three commercial software packages (SAP 2000, SeismoStruck and MIDAS/CIVIL) universally used in the design of civil engineering structures, are applied on a parametric study of pushover analyses of a RC frame of an office building under a few evaluative phases. In order to represent the influence of the masonry infill panels the equivalent tie method is used; for a sensitivity study on the capacity curves, several values for the tie width are considered. The comprehensive parametric study also addresses the influence of other parameters, on the structural behavior and non linear capacity curves of the RC frame, namely: length and location of the plastic hinges forming near the end of the structural elements, and different loading patterns (with uniform, modal and triangular distributions)

Parameters optimization to minimize the vibrations E ects during the milling process

In nowadays the increasing productivity in the shortest possible time and with high quality is undoubtedly one of the biggest challenges for the industry. Recently, the industry has turned to CNC machines very often, since they work automatically and are able to achieve high precision with a high performance. In this sense, the vibration has been presented during the last decades as one of the main limiting factors for the improvement of productivity specially in machining operations. This work contributes to the reduction of vibrations, proposing the use of optimization methods to minimize vibrations using milling parameters (cutting speed,feed speed, axial penetration and radial penetration) related to the section area. This study presents a theoretical analysis on the materials and tools used throughout the experimental trials, as well as the methods and programs used. During this study, two optimization methods were used: the Taguchi method and the Response Surfaces method.info:eu-repo/semantics/publishedVersio

Avaliação do efeito de campos eléctricos pulsados no rendimento e na presença de compostos bioactivos no azeite virgem.

Avaliação do efeito de campos eléctricos pulsados no rendimento e na presença de compostos bioactivos no azeite virgem.info:eu-repo/semantics/publishedVersio

Factor V Leiden and prothrombin G20210A among Chilean patients with venous and arterial thrombosis

Iván Palomo. Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud. Universidad de Talca, Talca, Chile. Casilla 747,Talca, Chile.Factor V Leiden and G20210A mutation of prothrombin gene are two important genetic polymorphisms associated with an increased risk for thrombosis. Aim: To establish the prevalence of factor V Leiden and prothrombin G20210A mutation in the Chilean population and their association to venous and arterial thromboembolism. Material and methods: A case-control study was conducted where 149 patients with thrombosis (87 with arterial and 62 with venous thrombosis) confirmed by CAT-scan, electrocardiogram and cardiac enzymes or Doppler depending on the case, and 160 healthy blood donors were genetically analyzed for the presence of both polymorphisms. Results: Factor V Leiden mutation was found in 5.4% of patients and in 1.3% of healthy controls (p=0.04). Heterozygosity for G20210A prothrombin mutation was found in 5.4% of patients and in 2.5% of the control group (p=NS). When arterial and venous thrombosis were considered as separate entities, 4.6% of patients with arterial thrombosis and 6.5% with venous thrombosis presented factor V Leiden (p=NS). Likewise, 8.1% of patients with venous thrombosis and 3.5% of patients with arterial thrombosis had G20210A prothrombin mutation (p=NS). Conclusions: In non selected consecutive Chilean patients with arterial and venous thrombosis the frequency of factor V Leiden and prothrombin G20210A is less than we could expect from their prevalence in the general populatio

Are the liabilities of newness and smallness the same for male and female informal entrepreneurs? Evidence from Brazil

Though challenges to female entrepreneurship are widely acknowledged in the settings of developed countries or the context of formal firms, the challenges faced by female informal entrepreneurs in developing markets are less explored. Based on the liabilities of newness and smallness framework in organizational ecology, we draw on a sample of 2562 Brazilian informal firms, to examine the unique differences in the experience of newness and smallness between male and female informal entrepreneurs. With increasing firm age, female informal entrepreneurs realized lower firm revenues (inverted-U), however, the firm age and firm revenue association are linear for males. Informal firm performance did not vary by size between male and female informal entrepreneurs. The distinctive differences in firm revenues for male and female entrepreneurs have implications for informal entrepreneurship

Monitoring Of Bcr-abl Levels In Chronic Myeloid Leukemia Patients Treated With Imatinib In The Chronic Phase - The Importance Of A Major Molecular Response

Background: Real time PCR has become the most common technique to monitor BCR-ABL transcript levels of patients treated with kinase inhibitors. The aim of this study was to evaluate BCR-ABL levels of chronic myeloid leukemia patients treated with imatinib in the chronic phase and correlate the response to therapy and event-free survival. Methods: BCR-ABL levels were measured in peripheral blood cell samples using Real time PCR at diagnosis and then every 3 months after starting therapy with imatinib. Major molecular response was defined as a three-log reduction from the standardized baseline value. Major molecular response values were adjusted to international scale using a conversion factor of 1.19. The results are reported as a BCR-ABL/ABL ratio (%). Results: Hematological, major cytogenetic and complete cytogenetic responses were achieved by 57 (95%), 45 (75%) and 38 (63%) patients, respectively. Twenty-four out of sixty patients achieved a major molecular response (40%) in a median time of 8.5 months. Overall survival and event free survival were higher for patients with (100%) versus patients without (77%) a complete cytogenetic response (p-value = 0.01) at 48 months. Patients with complete cytogenetic response and major molecular response had a higher event free survival compared to patients with complete cytogenetic response but without major molecular response (p-value = 0.007). Conclusion: In conclusion, the prognostic impact of achieving complete cytogenetic response and a major molecular response and also the importance of molecular monitoring in the follow-up of chronic myeloid leukemia patients were demonstrated.333211215Melo, J.V., The molecular biology of chronic myeloid leukaemia (1996) Leukemia, 10 (5), pp. 751-756Wang, L., Pearson, K., Pillitteri, L., Ferguson, J.E., Clark, R.E., Serial monitoring of BCR-ABL by peripheral blood real-time polymerase chain reaction predicts the marrow cytogenetic response to imatinib mesylate in chronic myeloid leukaemia (2002) Br J Haematol, 118 (3), pp. 771-777Muller, M.C., Gattermann, N., Lahaye, T., Deininger, M.W., Berndt, A., Fruehauf, S., Dynamics of BCR-ABL mRNA expression in firstline therapy of chronic myelogenous leukemia patients with imatinib or interferon alpha/ara-C (2003) Leukemia, 17 (12), pp. 2392-2400Branford, S., Hughes, T.P., Rudzki, Z., Monitoring chronic myeloid leukaemia therapy by real-time quantitative PCR in blood is a reliable alternative to bone marrow cytogenetics (1999) Br J Haematol, 107 (3), pp. 587-599Radich, J.P., Gooley, T., Bryant, E., Chauncey, T., Clift, R., Beppu, L., The significance of bcr-abl molecular detection in chronic myeloid leukemia patients late, 18 months or more after transplantation (2001) Blood, 98 (6), pp. 1701-1707Hughes, T.P., Kaeda, J., Branford, S., Rudzki, Z., Hochhaus, A., Hensley, M.L., Frequency of major molecular responses to imatinib or interferon-alpha plus cytarabine in newly diagnosed chronic myeloid leukemia (2003) N Engl J Med, 349 (15), pp. 1423-1432Press, R.D., Love, Z., Tronnes, A.A., Yang, R., Tran, T., Mongoue- tchokote, S., BCR-ABL mRNA levels at and after the time of a complete cytogenetic response predict the duration of CCR in imatinib mesylate-treated patients with CML (2006) Blood, 107 (11), pp. 4250-4256Cortes, J., Talpaz, M., O'Brien, S., Jones, D., Luthra, R., Shan, J., Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate (2005) Clin Cancer Res, 11 (9), pp. 3425-3432Iacobucci, I., Saglio, G., Rosti, G., Testoni, N., Pane, F., Amabile, M., Achieving a major molecular response at the time of a complete cytogenetic response (CCgR) predicts a better duration of CCgR in imatinib-treated chronic myeloid leukemia patients (2006) Clin Cancer Res, 12 (10), pp. 3037-3042Baccarani, M., Saglio, G., Goldman, J., Hochhaus, A., Simonsson, B., Appelbaum, F., Evolving concepts in the management of chronic myeloid leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet (2006) Blood, 108 (6), pp. 1809-1820Hughes, T., Deininger, M., Hochhaus, A., Branford, S., Radich, J., Kaeda, J., Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: Review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results (2006) Blood, 108 (1), pp. 28-37Branford, S., Cross, N.C., Hochhaus, A., Radich, J., Saglio, G., Kaeda, J., Rationale for the recommendations for harmonizing current methodology for detecting BCR-ABL transcripts in patients with chronic myeloid leukaemia (2006) Leukemia, 20 (11), pp. 1925-1930Cortes, J., Baccarani, M., Fea, G., (2008) A Phase III, Randomized, Openlabel Study of 400 Mg Versus 800 Mg of Imatinib Mesylate (IM) in Patients With Newly Diagnosed, Previously Untreated Chronic Myeloid Leukemia in Chronic Phase (CML-CP), Using Molecular Endpoints: One Year Results of TOPS (Tyrosine Kinase Inhibitor Optimization and Selectivity) Study, , 50th ASH Annual Meeting and Exposition Online program and Abstracts. San Francisco, CABranford, S., Fletcher, L., Cross, N.C., Muller, M.C., Hochhaus, A., Kim, D.W., Desirable performance characteristics for BCR-ABL measurement on an international reporting scale to allow consistent interpretation of individual patient response and comparison of response rates between clinical trials (2008) Blood, 112 (8), pp. 3330-3338O'Brien, S.G., Guilhot, F., Larson, R.A., Gathmann, I., Baccarani, M., Cervantes, F., Imatinib compared with interferon and lowdose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia (2003) N Engl J Med, 348 (11), pp. 994-1004Marin, D., Milojkovic, D., Olavarria, E., Khorashad, J.S., de Lavallade, H., Reid, A.G., European LeukemiaNet criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor (2008) Blood, 112 (12), pp. 4437-444

EXAME ANATOMOPATOLÓGICO, MICROBIOLÓGICO, CITOLÓGICO E FÍSICO-QUÍMICO DAS ARTICULAÇÕES DE SUÍNOS ARTRÍTICOS NO MATADOURO

Estudou-se por meio de exames anatomopatológico, microbiológico, citológico e físico-químico, as articulações de 130 suínos abatidos em um matadouro localizado em Concórdia SC. Os animais foram escolhidos de forma direcionada e as articulações foram classificadas macroscopicamente de acordo com as lesões presentes na membrana sinovial, cartilagem articular e no linfonodo regional. Dos 130 suínos escolhidos, 25 apresentavam-se com as articulações normais, 36 com artrite causada pela osteocondrose, 50 com artrite infecciosa e 19 com artrite traumática. Em todos os casos de artrite infecciosa havia reação do linfonodo regional e, da mesma forma, sempre que os linfonodos regionais estavam reativos, havia artrite infecciosa no membro relacionado. Dos 50 casos de artrite infecciosa, 40 (80%) eram assépticos, de sete (14%) foi isolado o Erysipelothrix rhusiopathiae e de três (6%), o Mycoplasma hyosynoviae, pela primeira vez isolado no Brasil. Nas demais categorias de artrite, não foram isolados nenhum agente infeccioso e nem visualizadas alterações nos linfonodos regionais. Conclui-se que as artrites infecciosas são acompanhadas de reação dos linfonodos regionais e as artrites causadas pela osteocondrose são estéreis. Pathological, microbiological, cytological and physical-chemical studies of joints from arthritic swines in the abattoir Abstract The joints of one hundred and thirty pigs from an abattoir in Concórdia - SC, were studied, by means of pathological, microbiological, cytological and physical-chemical procedures. The choice of the pigs was not made by random distribution and the joints were grouped grossly according of lesions of the synovial membrane, cartilage and of the draining lymph node. From 130 pigs, 36 showed lesions of osteochondrosis, 50 infectious arthritis, 19 traumatic arthritis and 25 normal joints. In all cases of infectious arthritis there was a reaction of the corresponding draining lymph node. Whenever the draining lymph node was reactive, there was infectious arthritis in the related limb. Of the 50 infectious arthritis, 40 (80%) were aseptic, 7 (14%) yielded Erysipelothrix rhusiopathiae and 3 (6%) yielded Mycoplasma hyosynoviae, for the first time isolated in Brazil. In the remaining arthritis categories, no infectious agents nor alterations in the draining lymph node was diagnosed

Pd and Pd-Cu supported on different carbon materials and immobilized as flow-through catalytic membranes for the chemical reduction of NO3, NO2-and BrO3- in drinking water treatment

Powdered catalysts are commonly used in lab-scale tests for the catalytic reduction of oxoanions in drinking water, but their powder nature limits their application at full scale. In this work, Pd and Pd-Cu catalysts (5% wt.) supported on carbon materials with different structural properties, in powder form, were used to prepare catalytic membranes that were tested in a reactor with flow-through configuration (FTCMR) to study their performance in the reduction of NO3-, NO2- and BrO3-. Pd catalytic membranes showed high activity in the reduction of NO2-, being the selectivity to NH4+ lower than 2% at 80% NO2- conversion in all cases. In BrO3- reduction, they exhibited a wide range of conversions being the catalyst supported on materials with high conductivity the most active ones, which may be ascribed to the charge distribution at the metal-carbon interface. NO3- reduction using Pd-Cu catalytic membranes showed that catalysts supported on materials with small nanoparticle size and low electrical conductivity exhibited higher selectivity to NH4+. FTCMR led to a good control of H2 transfer and availability in the active sites, facilitating the tuning of H2 availability conditions to preserve the activity, while maintaining/diminishing selectivity to NH4+. In simultaneous oxoanions reduction tests, NO3- reduction was inhibited by Br species, probably by affection of the Pd-Cu redox cycle. This fact could be crucial to the future development of drinking water treatment processes, as conditions the order of the disinfection and NO3- reduction stepsThe authors greatly appreciate the support from Spanish Agencia Estatal de Investigacion ´ (AEI, RTI2018–098431-BI00). Adrian ´ Marí thanks the Spanish AEI for a research grant (PRE-2019-088601). This work was also financially supported by: LA/P/0045/2020 (ALiCE), UIDB/50020/2020 and UIDP/50020/2020 (LSRE-LCM) and funded by national funds through FCT/MCTES (PIDDAC), and project NORTE01–0145-FEDER-000069 (Healthy Waters) co-funded by European Regional Development Fund (ERDF), through North Portugal Regional Operational Program (NORTE2020), under the PORTUGAL 2020 Partnership Agreemen

Breast cancer in very young women—a multicenter 10-year experience

Background: Breast cancer (BC) is the most prevalent cancer in adult young women in Europe. Although rare, it is one of the leading causes of death in this age group. The aim of this study is to characterize a cohort of young women regarding tumor stage, biology, treatment and survival. Patients and methods: We present a multicenter retrospective analysis of women <35 years of age, diagnosed with BC between 2008 and 2017. A total of 207 patients from five Portuguese centers were included, from whom 172 were eligible for analysis. Data were analyzed using IBM SPPSS statistics. Results: Median age at diagnosis was 31 years. Fifty-one percent of tumors were hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative, 20% HR-positive/HER2-positive, 8% HR-negative/HER2-positive and 20% triple-negative BC. Twenty-two percent of patients were diagnosed in stage I, 26% stage II, 45% stage III and 6% had de novo metastatic cancer. Thirty-nine percent of patients were treated with neoadjuvant chemotherapy. Mean follow-up time was 64.9 months and overall survival at 5 years, of the entire cohort and metastatic patients, was 86.5% and 26%, respectively. Conclusions: In our study we found similar population characteristics to other cohorts <35 years of age. To our knowledge, this is one of the largest cohorts in very young women. BC in young women is an important issue and further studies are needed to provide better care and survivorship to patients.info:eu-repo/semantics/publishedVersio